280 research outputs found
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Acceptance and Commitment Therapy: Applications for Educational Psychologists within Schools
© 2018, © 2018 Association of Educational Psychologists. Guidance for schools regarding the promotion and enhancement of psychological wellbeing represents an invitation to intervene to promote effective, evidence-informed, whole-school approaches for school staff, students and parents. With its transdiagnostic approach and evidence from empirical literature, Acceptance and Commitment Therapy (ACT) is asserted as a coherent psychological model that has potential to support schools in developing effective and sustainable practices to promote psychological wellbeing. Three ways of applying ACT within educational contexts are discussed, demonstrating potential utility of the model: supporting school staff wellbeing; targeted interventions for children and young people; and a potential universal application, through the development of an ACT-based emotional health and wellbeing curriculum
Hopf solitons in the Nicole model
The Nicole model is a conformal field theory in a three-dimensional space. It has topological soliton solutions classified by the integer-valued Hopf charge, and all currently known solitons are axially symmetric. A volume-preserving flow is used to construct soliton solutions numerically for all Hopf charges from 1 to 8. It is found that the known axially symmetric solutions are unstable for Hopf charges greater than 2 and new lower energy solutions are obtained that include knots and links. A comparison with the Skyrme–Faddeev model suggests many universal features, though there are some differences in the link types obtained in the two theories
An Efficient Numerical Technique to Predict Phase Responses of Reconfigurable Reflectarray Cells with Mutual Coupling
International audienceThis paper presents a numerical technique to predict realistic phase responses of active cells within a reflectarray. The phase responses of an active cell are determined as a function of the states of the neighboring cells. The phase probability distributions are computed and realistic phase responses are then evaluated. A synthesis application is presented in order to highlight the interest of the realistic phase responses
Global technique analysis for reconfigurable reflectarray antennas
International audienceThis paper focuses on the simulation of reconfigurable reflectarrays. A new method combining the 'surrounded-cell' approach and the compression method is presented. The method considers the real environment of the radiated elements and it only requires one lightweight electromagnetic simulation for the whole reflectarray
Effect of human rotavirus vaccine on severe diarrhea in African infants.
BACKGROUND: Rotavirus is the most common cause of severe gastroenteritis among young children worldwide. Data are needed to assess the efficacy of the rotavirus vaccine in African children. METHODS: We conducted a randomized, placebo-controlled, multicenter trial in South Africa (3166 infants; 64.1% of the total) and Malawi (1773 infants; 35.9% of the total) to evaluate the efficacy of a live, oral rotavirus vaccine in preventing severe rotavirus gastroenteritis. Healthy infants were randomly assigned in a 1:1:1 ratio to receive two doses of vaccine (in addition to one dose of placebo) or three doses of vaccine--the pooled vaccine group--or three doses of placebo at 6, 10, and 14 weeks of age. Episodes of gastroenteritis caused by wild-type rotavirus during the first year of life were assessed through active follow-up surveillance and were graded with the use of the Vesikari scale. RESULTS: A total of 4939 infants were enrolled and randomly assigned to one of the three groups; 1647 infants received two doses of the vaccine, 1651 infants received three doses of the vaccine, and 1641 received placebo. Of the 4417 infants included in the per-protocol efficacy analysis, severe rotavirus gastroenteritis occurred in 4.9% of the infants in the placebo group and in 1.9% of those in the pooled vaccine group (vaccine efficacy, 61.2%; 95% confidence interval, 44.0 to 73.2). Vaccine efficacy was lower in Malawi than in South Africa (49.4% vs. 76.9%); however, the number of episodes of severe rotavirus gastroenteritis that were prevented was greater in Malawi than in South Africa (6.7 vs. 4.2 cases prevented per 100 infants vaccinated per year). Efficacy against all-cause severe gastroenteritis was 30.2%. At least one serious adverse event was reported in 9.7% of the infants in the pooled vaccine group and in 11.5% of the infants in the placebo group. CONCLUSIONS: Human rotavirus vaccine significantly reduced the incidence of severe rotavirus gastroenteritis among African infants during the first year of life. (ClinicalTrials.gov number, NCT00241644.
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Role of biomechanical forces in the natural history of coronary atherosclerosis.
Atherosclerosis remains a major cause of morbidity and mortality worldwide, and a thorough understanding of the underlying pathophysiological mechanisms is crucial for the development of new therapeutic strategies. Although atherosclerosis is a systemic inflammatory disease, coronary atherosclerotic plaques are not uniformly distributed in the vascular tree. Experimental and clinical data highlight that biomechanical forces, including wall shear stress (WSS) and plaque structural stress (PSS), have an important role in the natural history of coronary atherosclerosis. Endothelial cell function is heavily influenced by changes in WSS, and longitudinal animal and human studies have shown that coronary regions with low WSS undergo increased plaque growth compared with high WSS regions. Local alterations in WSS might also promote transformation of stable to unstable plaque subtypes. Plaque rupture is determined by the balance between PSS and material strength, with plaque composition having a profound effect on PSS. Prospective clinical studies are required to ascertain whether integrating mechanical parameters with medical imaging can improve our ability to identify patients at highest risk of rapid disease progression or sudden cardiac events.This work was supported by the British Heart Foundation (FS/13/33/30168), Heart Research UK (RG2638/14/16), the Cambridge NIHR Biomedical Research Centre, and the BHF Cambridge Centre for Research Excellence.This is the author accepted manuscript. The final version is available from Nature Publishing Group at http://dx.doi.org/10.1038/nrcardio.2015.203
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