‘Living in crisis’: Introduction to a special section

[Extract] This special section began to take shape sometime in mid-2020. Much of Australia was then in lockdown, we were working from home, national borders were closed, and it was looking increasingly likely that the annual conference for The Australian Sociological Association (TASA) would not go ahead. At the time, the spread of COVID-19 within Australia was very limited, especially compared to much of the rest of the world. Yet the pandemic had nonetheless brought unprecedented disruption to our everyday lives

Small polar hits against <i>S. aureus</i>:Screening, initial hit optimization and metabolomic studies

The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chemical scaffolds and modes of action. It is also vital to design compounds with optimal physicochemical properties to permeate the bacterial cell envelope. We described an approach of combining and integrating whole cell screening and metabolomics into early antibacterial drug discovery using a library of small polar compounds. Whole cell screening of a diverse library of small polar compounds against Staphylococcus aureus gave compound 2. Hit expansion was carried out to determine structure–activity relationships. A selection of compounds from this series, together with other screened active compounds, was subjected to an initial metabolomics study to provide a metabolic fingerprint of the mode of action. It was found that compound 2 and its analogues have a different mode of action from some of the known antibacterial compounds tested. This early study highlighted the potential of whole cell screening and metabolomics in early antibacterial drug discovery. Future works will require improving potency and performing orthogonal studies to confirm the modes of action

A Survey of UV Bright Sources Behind the Halo of M31

We have performed a wide-area ultraviolet (UV) imaging survey using the GALaxy Evolution eXplorer (GALEX) to search for bright, point-like UV sources behind M31's extended halo. Our survey consisted of 46 pointings covering an effective area of ~50 deg^2, in both the far-UV and near-UV channels. We combined these data with optical R-band observations acquired with the WIYN Mosaic-1 imager on the Kitt Peak National Observatory 0.9m WIYN telescope. An analysis of the brightness and colors of sources matched between our photometric catalogs yielded ~100 UV-bright quasar candidates. We have obtained discovery spectra for 76 of these targets with the Kast spectrometer on the Lick 3m telescope and confirm 30 active galactic nuclei and quasars, 29 galaxies at z > 0.02 including several early-type systems, 16 Galactic stars (hot main-sequence stars), and one featureless source previously identified as a BL Lac object. Future UV spectroscopy of the brightest targets with the Cosmic Origins Spectrograph on the Hubble Space Telescope will enable a systematic search for diffuse gas in the extended halo of M31.Comment: 10 pages, 10 figures. Accepted to MNRA

Self-care habits among people who inject drugs with skin and soft tissue infections: a qualitative analysis.

BACKGROUND:Injection drug use is on the rise in the USA, and skin and soft tissue infections (SSTI) are a common complication, resulting in significant morbidity and mortality. Due to structural barriers to care-seeking, many people who inject drugs avoid formal care and resort to self-care techniques, but little is known about the nature of these techniques, or more generally about the accuracy or breadth of this population's knowledge of SSTIs. METHODS:Semi-structured qualitative interviews were conducted with 12 people who inject heroin in two metropolitan areas: Sacramento and Boston, USA. RESULTS:These interviews reveal a robust and accurate knowledge base regarding skin infections, including the progression from simple cellulitis to an abscess, and acknowledgment of the possibility of serious infections. Nonetheless, there remains a reticence to seek care secondary to past traumatic experiences. A step-wise approach to self-care of SSTI infections was identified, which included themes of whole-body health, topical applications, use of non-prescribed antibiotics, and incision and drainage by non-medical providers. CONCLUSIONS:The reported SSTI self-care strategies demonstrate resilience and ingenuity, but also raise serious concerns about inappropriate antibiotic consumption and complications of invasive surgical procedures performed without proper training, technique, or materials. Harm reduction agencies and health care providers should work to obviate the need for these potentially dangerous practices by improving healthcare access for this population. In the absence of robust solutions to meet the needs of this population, education materials should be developed to optimize the efficacy and minimize the harms of these practices, while empowering and supporting the autonomy of people who use drugs and providing clear guidance on when self-care should be abandoned in favor of formal medical care

Use of Surface Motion Characteristics Determined by InSAR to Assess Peatland Condition

Peatland surface motion is a key property of peatland that relates to condition. However, field‐based techniques to measure surface motion are not cost‐effective over large areas and long time periods. An alternative method that can quantify peatland surface motion over large areas is interferometric synthetic aperture radar. Although field validation of the accuracy of this method is difficult, the value of InSAR as a means of quantifying peat condition can be tested. To achieve this the characteristics of InSAR time series measured over an18‐month period at 22 peatland sites in the Flow Country northern Scotland were compared to site condition assessment based on plant functional type and site management history. Sites in good condition dominated by Sphagnum display long‐term stability or growth and a seasonal cycle with maximum uplift and subsidence in Aug‐Nov and April‐June respectively. Drier and partially drained sites dominated by shrubs display long‐term subsidence with maximum uplift and subsidence in July‐Oct and Feb‐June respectively. Heavily degraded sites with large bare peat extent display subsidence with no distinct seasonal oscillations. Seasonal oscillation in surface motion at sites with a dominant non‐vascular plant community is interpreted as resulting from changes in seasonal evaporative demand. On sites with extensive vascular plants cover and falling water table, surface oscillations are interpreted as representing sustained drawdown during the growing season and subsequent recharge in late winter. This study highlights the potential to use InSAR to characterize peatland condition and provide a new view of the surface dynamics of peatland landscapes

Association Between Residential Greenness and Cardiovascular Disease Risk

Background Exposure to green vegetation has been linked to positive health, but the pathophysiological processes affected by exposure to vegetation remain unclear. To study the relationship between greenness and cardiovascular disease, we examined the association between residential greenness and biomarkers of cardiovascular injury and disease risk in susceptible individuals. Methods and Results In this cross-sectional study of 408 individuals recruited from a preventive cardiology clinic, we measured biomarkers of cardiovascular injury and risk in participant blood and urine. We estimated greenness from satellite-derived normalized difference vegetation index ( NDVI ) in zones with radii of 250 m and 1 km surrounding the participants' residences. We used generalized estimating equations to examine associations between greenness and cardiovascular disease biomarkers. We adjusted for residential clustering, demographic, clinical, and environmental variables. In fully adjusted models, contemporaneous NDVI within 250 m of participant residence was inversely associated with urinary levels of epinephrine (-6.9%; 95% confidence interval, -11.5, -2.0/0.1 NDVI ) and F2-isoprostane (-9.0%; 95% confidence interval, -15.1, -2.5/0.1 NDVI ). We found stronger associations between NDVI and urinary epinephrine in women, those not on β-blockers, and those who had not previously experienced a myocardial infarction. Of the 15 subtypes of circulating angiogenic cells examined, 11 were inversely associated (8.0-15.6% decrease/0.1 NDVI ), whereas 2 were positively associated (37.6-45.8% increase/0.1 NDVI ) with contemporaneous NDVI . Conclusions Independent of age, sex, race, smoking status, neighborhood deprivation, statin use, and roadway exposure, residential greenness is associated with lower levels of sympathetic activation, reduced oxidative stress, and higher angiogenic capacity

Genetic Predisposition Impacts Clinical Changes in a Lifestyle Coaching Program.

Both genetic and lifestyle factors contribute to an individual\u27s disease risk, suggesting a multi-omic approach is essential for personalized prevention. Studies have examined the effectiveness of lifestyle coaching on clinical outcomes, however, little is known about the impact of genetic predisposition on the response to lifestyle coaching. Here we report on the results of a real-world observational study in 2531 participants enrolled in a commercial Scientific Wellness program, which combines multi-omic data with personalized, telephonic lifestyle coaching. Specifically, we examined: 1) the impact of this program on 55 clinical markers and 2) the effect of genetic predisposition on these clinical changes. We identified sustained improvements in clinical markers related to cardiometabolic risk, inflammation, nutrition, and anthropometrics. Notably, improvements in HbA1c were akin to those observed in landmark trials. Furthermore, genetic markers were associated with longitudinal changes in clinical markers. For example, individuals with genetic predisposition for higher LDL-C had a lesser decrease in LDL-C on average than those with genetic predisposition for average LDL-C. Overall, these results suggest that a program combining multi-omic data with lifestyle coaching produces clinically meaningful improvements, and that genetic predisposition impacts clinical responses to lifestyle change