518 research outputs found
Planet Detectability in the Alpha Centauri System
Indexación: Scopus.We use more than a decade of radial-velocity measurements for α Cen A, B, and Proxima Centauri from the High Accuracy Radial Velocity Planet Searcher, CTIO High Resolution Spectrograph, and the Ultraviolet and Visual Echelle Spectrograph to identify the M i sin and orbital periods of planets that could have been detected if they existed. At each point in a mass-period grid, we sample a simulated, Keplerian signal with the precision and cadence of existing data and assess the probability that the signal could have been produced by noise alone. Existing data places detection thresholds in the classically defined habitable zones at about M i sin of 53 M· for a Cen A, 8.4 M· for a Cen B, and 0.47 M· for Proxima Centauri. Additionally, we examine the impact of systematic errors, or "red noise" in the data. A comparison of white- and red-noise simulations highlights quasi-periodic variability in the radial velocities that may be caused by systematic errors, photospheric velocity signals, or planetary signals. For example, the red-noise simulations show a peak above white-noise simulations at the period of Proxima Centauri b. We also carry out a spectroscopic analysis of the chemical composition of the a Centauri stars. The stars have supersolar metallicity with ratios of C/O and Mg/Si that are similar to the Sun, suggesting that any small planets in the a Cen system may be compositionally similar to our terrestrial planets. Although the small projected separation of a Cen A and B currently hampers extreme-precision radial-velocity measurements, the angular separation is now increasing. By 2019, a Cen A and B will be ideal targets for renewed Doppler planet surveys.http://iopscience.iop.org/article/10.3847/1538-3881/aa9bea/met
Observation of a Griffiths-like phase in the paramagnetic regime of ErCo_2
A systematic x-ray magnetic circular dichroism study of the paramagnetic
phase of ErCo2 has recently allowed to identify the inversion of the net
magnetization of the Co net moment with respect to the applied field well above
the ferrimagnetic ordering temperature, Tc. The study of small angle neutron
scattering measurements has also shown the presence of short range order
correlations in the same temperature region. This phenomenon, which we have
denoted parimagnetism, may be related with the onset of a Griffiths-like phase
in paramagnetic ErCo2. We have measured ac susceptibility on ErCo2 as a
function of temperature, applied field, and excitation frequency. Several
characteristics shared by systems showing a Griffiths phase are present in
ErCo2, namely the formation of ferromagnetic clusters in the disordered phase,
the loss of analyticity of the magnetic susceptibility and its extreme
sensitivity to an applied magnetic field. The paramagnetic susceptibility
allows to establish that the magnetic clusters are only formed by Co moments as
well as the intrinsic nature of those Co moments
Planets in Mean-Motion Resonances and the System Around HD45364
In some planetary systems, the orbital periods of two of its members present
a commensurability, usually known by mean-motion resonance. These resonances
greatly enhance the mutual gravitational influence of the planets. As a
consequence, these systems present uncommon behaviors, and their motions need
to be studied with specific methods. Some features are unique and allow us a
better understanding and characterization of these systems. Moreover,
mean-motion resonances are a result of an early migration of the orbits in an
accretion disk, so it is possible to derive constraints on their formation.
Here we review the dynamics of a pair of resonant planets and explain how their
orbits evolve in time. We apply our results to the HD 45365 planetary system.Comment: invited review, 17 pages, 6 figure
Book Reviews
Reviews of the following books: Mount Hope Cemetery of Bangor, Maine: The Complete History by Trudy Irene Scee; The Reverend Jacob Bailey, Maine Loyalist: For God, King, Country and for Self by James S. Leamon; The Barns of Maine: Our History, Our Stories by Don Perkins; Gateway to Vacationland: The Making of Portland, Maine by John F. Bauman; Maine: The Wilder Half of New England by William David Berry; The Cross of War: Christian Nationalism and U.S. Expansion in the Spanish-American War by Matthew McCullough; Omaha Beach: The Life and Military Service of a Penobscot Indian Elder by Charles Norman Shay
In human autoimmunity, a substantial component of the B cell repertoire consists of polyclonal, barely mutated IgG+ve B cells
B cells are critical for promoting autoimmunity and the success of B cell depletion therapy in rheumatoid arthritis (RA) confirms their importance in driving chronic inflammation. Whilst disease specific autoantibodies are useful diagnostically, our understanding of the pathogenic B cell repertoire remains unclear. Defining it would lead to novel insights and curative treatments. To address this, we have undertaken the largest study to date of over 150 RA patients, utilizing next generation sequencing (NGS) to analyze up to 200,000 BCR sequences per patient. The full-length antigen-binding variable region of the heavy chain (IgGHV) of the IgG B cell receptor (BCR) were sequenced. Surprisingly, RA patients do not express particular clonal expansions of B cells at diagnosis. Rather they express a polyclonal IgG repertoire with a significant increase in BCRs that have barely mutated away from the germline sequence. This pattern remains even after commencing disease modifying therapy. These hypomutated BCRs are expressed by TNF-alpha secreting IgG+veCD27−ve B cells, that are expanded in RA peripheral blood and enriched in the rheumatoid synovium. A similar B cell repertoire is expressed by patients with Sjögren's syndrome. A rate limiting step in the initiation of autoimmunity is the activation of B cells and this data reveals that a sizeable component of the human autoimmune B cell repertoire consists of polyclonal, hypomutated IgG+ve B cells, that may play a critical role in driving chronic inflammation
An Eccentric Binary Millisecond Pulsar in the Galactic Plane
Binary pulsar systems are superb probes of stellar and binary evolution and
the physics of extreme environments. In a survey with the Arecibo telescope, we
have found PSR J1903+0327, a radio pulsar with a rotational period of 2.15 ms
in a highly eccentric (e = 0.44) 95-day orbit around a solar mass companion.
Infrared observations identify a possible main-sequence companion star.
Conventional binary stellar evolution models predict neither large orbital
eccentricities nor main-sequence companions around millisecond pulsars.
Alternative formation scenarios involve recycling a neutron star in a globular
cluster then ejecting it into the Galactic disk or membership in a hierarchical
triple system. A relativistic analysis of timing observations of the pulsar
finds its mass to be 1.74+/-0.04 Msun, an unusually high value.Comment: 28 pages, 4 figures inc Supplementary On-Line Material. Accepted for
publication in Science, published on Science Express: 10.1126/science.115758
Arecibo Pulsar Survey Using ALFA. I. Survey Strategy and First Discoveries
We report results from the initial stage of a long-term pulsar survey of the
Galactic plane using the Arecibo L-band Feed Array (ALFA), a seven-beam
receiver operating at 1.4 GHz with 0.3 GHz bandwidth. The search targets
Galactic latitudes |b| < 5 deg in the longitude ranges 32 deg < l < 77 deg and
168 deg < l < 77 deg. Data discussed here were collected over a 100 MHz
passband centered on 1.42 GHz using a spectrometer that recorded 256 channels
every 64 microsec. In a preliminary, standard period-DM analysis, we have
detected 29 previously known pulsars and discovered 11 new ones. One of these,
with a period of 69 ms and a low characteristic age of 82 kyr, is a plausible
candidate for association with the unidentified EGRET source 3EG J1928+1733.
Another is a non-recycled pulsar in a relativistic binary with orbital period
of 3.98 hr. We also search the data for isolated dispersed pulses, a technique
that yielded discovery of an extremely sporadic radio emitter with a spin
period of 1.2 s. Simulations we have carried out indicate that about 1000 new
pulsars will be found in the ALFA survey. In addition to providing a large
sample for use in population analyses and for probing the magnetoionic
interstellar medium, the survey maximizes the chances of finding rapidly
spinning millisecond pulsars and pulsars in compact binary systems. Our search
algorithms will exploit the multiple data streams from ALFA to discriminate
between radio frequency interference and celestial signals, including pulsars
and possibly new classes of transient radio sources.Comment: 10 pp, 9 figures, accepted by the Astrophysical Journa
Birth and Evolution of Isolated Radio Pulsars
We investigate the birth and evolution of Galactic isolated radio pulsars. We
begin by estimating their birth space velocity distribution from proper motion
measurements of Brisken et al. (2002, 2003). We find no evidence for
multimodality of the distribution and favor one in which the absolute
one-dimensional velocity components are exponentially distributed and with a
three-dimensional mean velocity of 380^{+40}_{-60} km s^-1. We then proceed
with a Monte Carlo-based population synthesis, modelling the birth properties
of the pulsars, their time evolution, and their detection in the Parkes and
Swinburne Multibeam surveys. We present a population model that appears
generally consistent with the observations. Our results suggest that pulsars
are born in the spiral arms, with a Galactocentric radial distribution that is
well described by the functional form proposed by Yusifov & Kucuk (2004), in
which the pulsar surface density peaks at radius ~3 kpc. The birth spin period
distribution extends to several hundred milliseconds, with no evidence of
multimodality. Models which assume the radio luminosities of pulsars to be
independent of the spin periods and period derivatives are inadequate, as they
lead to the detection of too many old simulated pulsars in our simulations.
Dithered radio luminosities proportional to the square root of the spin-down
luminosity accommodate the observations well and provide a natural mechanism
for the pulsars to dim uniformly as they approach the death line, avoiding an
observed pile-up on the latter. There is no evidence for significant torque
decay (due to magnetic field decay or otherwise) over the lifetime of the
pulsars as radio sources (~100 Myr). Finally, we estimate the pulsar birthrate
and total number of pulsars in the Galaxy.Comment: 27 pages, including 15 figures, accepted by Ap
Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice
We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment. Multilevel bioinformatical analysis and stringent selection criteria (2-fold change, 0% false discovery rate) identified 267 significantly changed genes involved in several molecular pathways. The fenofibrate-treated group did not have significantly altered levels of hepatic human APOA-I mRNA and plasma ApoA-I compared with the control group. However, the treatment increased cholesterol levels to 1.95-fold mainly due to the increase in high-density lipoprotein (HDL) cholesterol. The observed changes in HDL are associated with the upregulation of genes involved in phospholipid biosynthesis and lipid hydrolysis, as well as phospholipid transfer protein. Significant upregulation was observed in genes involved in fatty acid transport and β-oxidation, but not in those of fatty acid and cholesterol biosynthesis, Krebs cycle and gluconeogenesis. Fenofibrate changed significantly the expression of seven transcription factors. The estrogen receptor-related gamma gene was upregulated 2.36-fold and had a significant positive correlation with genes of lipid and lipoprotein metabolism and mitochondrial functions, indicating an important role of this orphan receptor in mediating the fenofibrate-induced activation of a specific subset of its target genes.National Institutes of Health (HL48739 and HL68216); European Union (LSHM-CT-2006-0376331, LSHG-CT-2006-037277); the Biomedical Research Foundation of the Academy of Athens; the Hellenic Cardiological Society; the John F Kostopoulos Foundatio
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