877 research outputs found
Lifestyle intervention in individuals with impaired glucose regulation affects Caveolin-1 expression and DNA methylation
© 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Aims: We investigated whether a lifestyle intervention could influence expression and DNA methylation of diabetes-related genes in patients with impaired glucose regulation (IGR), the results were compared to bariatric surgery, considering it an intensive change. Methods: Twenty participants with IGR had adipose tissue biopsy and blood collected pre- and post-lifestyle (6 months) intervention; 12 obese patients had subcutaneous fat taken before and after bariatric surgery. RNA/DNA was extracted from all samples and underwent qPCR. DNA was bisulphite converted and 12 CpG sites of Caveolin-1 (CAV1) promoter were pyrosequenced. Results: lifestyle intervention resulted in opposite direction changes in fat tissue and blood for CAV1 expression and DNA methylation and these changes were correlated between tissues, while no significative differences were found in CAV1 expression after bariatric surgery. Conclusions: Our findings suggest a role for CAV1 in modulating adipocyte function as a consequence of lifestyle changes, as exercises and diet. These results may provide insights into new therapeutic targets for diabetes prevention
Progressive transformation of a flux rope to an ICME
The solar wind conditions at one astronomical unit (AU) can be strongly
disturbed by the interplanetary coronal mass ejections (ICMEs). A subset,
called magnetic clouds (MCs), is formed by twisted flux ropes that transport an
important amount of magnetic flux and helicity which is released in CMEs. At 1
AU from the Sun, the magnetic structure of MCs is generally modeled neglecting
their expansion during the spacecraft crossing. However, in some cases, MCs
present a significant expansion. We present here an analysis of the huge and
significantly expanding MC observed by the Wind spacecraft during 9 and 10
November, 2004. After determining an approximated orientation for the flux rope
using the minimum variance method, we precise the orientation of the cloud axis
relating its front and rear magnetic discontinuities using a direct method.
This method takes into account the conservation of the azimuthal magnetic flux
between the in- and out-bound branches, and is valid for a finite impact
parameter (i.e., not necessarily a small distance between the spacecraft
trajectory and the cloud axis). Moreover, using the direct method, we find that
the ICME is formed by a flux rope (MC) followed by an extended coherent
magnetic region. These observations are interpreted considering the existence
of a previous larger flux rope, which partially reconnected with its
environment in the front. These findings imply that the ejected flux rope is
progressively peeled by reconnection and transformed to the observed ICME (with
a remnant flux rope in the front part).Comment: Solar Physics (in press
Capability, opportunity, and motivation to enact hygienic practices in the early stages of the COVIDâ19 outbreak in the United Kingdom
Objectives
The COVIDâ19 pandemic is one of the greatest global health threats facing humanity in recent memory. This study aimed to explore influences on hygienic practices, a set of key transmission behaviours, in relation to the Capability, Opportunity, MotivationâBehaviour (COMâB) model of behaviour change (Michie et al., 2011).
Design
Data from the first wave of a longitudinal survey study were used, launched in the early stages of the UK COVIDâ19 pandemic.
Methods
Participants were 2025 adults aged 18 and older, representative of the UK population, recruited by a survey company from a panel of research participants. Participants selfâreported motivation, capability, and opportunity to enact hygienic practices during the COVIDâ19 outbreak.
Results
Using regression models, we found that all three COMâB components significantly predicted good hygienic practices, with motivation having the greatest influence on behaviour. Breaking this down further, the subscales psychological capability, social opportunity, and reflective motivation positively influenced behaviour. Reflective motivation was largely driving behaviour, with those highest in reflective motivation scoring 51% more on the measure of hygienic practices compared with those with the lowest scores.
Conclusions
Our findings have clear implications for the design of behaviour change interventions to promote hygienic practices. Interventions should focus on increasing and maintaining motivation to act and include elements that promote and maintain social support and knowledge of COVIDâ19 transmission. Groups in particular need of targeting for interventions to increase hygienic practices are males and those living in cities and suburbs
Role of negative ion resonances in electron scattering from atoms and molecules
Transient negative ions (resonances) formed during the collision of an electron with an atom or molecule have been extensively studied for over thirty years. The continued interest in these states, both experimentally and theoretically, stems from the profound effects that they can have on electron scattering cross sections and the role that electron-electron correlations play in their formation and quasi-stability. A selective discussion of examples of such resonances, involving one, two and three excited electrons is given for a wide range of atomic and molecular systems. © CSIRO 1999
Factors impacting resilience as a result of exposure to COVID-19 : the ecological resilience model
Despite the severe psychological impact of the COVID-19 pandemic, some individuals do not develop high levels of psychological distress and can be termed resilient. Using the ecological resilience model, we examined factors promoting or hindering resilience in the COVID-19 pandemic. Of the 1034 participants (49.9±16.2 years; females 51.2%) from Italian general population, 70% displayed resilient outcomes and 30% reported moderate-severe anxiety and/or depression. A binary regression model revealed that factors promoting resilience were mostly psychological (e.g., trait resilience, conscientiousness) together with social distancing. Conversely, factors hindering resilience included COVID-19-anxiety, COVID-19-related PTSD symptoms, intolerance of uncertainty, loneliness, living with children, higher education, and living in regions where the virus was starting to spread. In conclusion, the ecological resilience model in the COVID-19 pandemic explained 64% of the variance and identified factors promoting or hindering resilient outcomes. Critically, these findings can inform psychological interventions supporting individuals by strengthening factors associated with resilience
Homologous Flares and Magnetic Field Topology in Active Region NOAA 10501 on 20 November 2003
We present and interpret observations of two morphologically homologous
flares that occurred in active region (AR) NOAA 10501 on 20 November 2003. Both
flares displayed four homologous H-alpha ribbons and were both accompanied by
coronal mass ejections (CMEs). The central flare ribbons were located at the
site of an emerging bipole in the center of the active region. The negative
polarity of this bipole fragmented in two main pieces, one rotating around the
positive polarity by ~ 110 deg within 32 hours. We model the coronal magnetic
field and compute its topology, using as boundary condition the magnetogram
closest in time to each flare. In particular, we calculate the location of
quasiseparatrix layers (QSLs) in order to understand the connectivity between
the flare ribbons. Though several polarities were present in AR 10501, the
global magnetic field topology corresponds to a quadrupolar magnetic field
distribution without magnetic null points. For both flares, the photospheric
traces of QSLs are similar and match well the locations of the four H-alpha
ribbons. This globally unchanged topology and the continuous shearing by the
rotating bipole are two key factors responsible for the flare homology.
However, our analyses also indicate that different magnetic connectivity
domains of the quadrupolar configuration become unstable during each flare, so
that magnetic reconnection proceeds differently in both events.Comment: 24 pages, 10 figures, Solar Physics (accepted
How Many CMEs Have Flux Ropes? Deciphering the Signatures of Shocks, Flux Ropes, and Prominences in Coronagraph Observations of CMEs
We intend to provide a comprehensive answer to the question on whether all
Coronal Mass Ejections (CMEs) have flux rope structure. To achieve this, we
present a synthesis of the LASCO CME observations over the last sixteen years,
assisted by 3D MHD simulations of the breakout model, EUV and coronagraphic
observations from STEREO and SDO, and statistics from a revised LASCO CME
database. We argue that the bright loop often seen as the CME leading edge is
the result of pileup at the boundary of the erupting flux rope irrespective of
whether a cavity or, more generally, a 3-part CME can be identified. Based on
our previous work on white light shock detection and supported by the MHD
simulations, we identify a new type of morphology, the `two-front' morphology.
It consists of a faint front followed by diffuse emission and the bright
loop-like CME leading edge. We show that the faint front is caused by density
compression at a wave (or possibly shock) front driven by the CME. We also
present high-detailed multi-wavelength EUV observations that clarify the
relative positioning of the prominence at the bottom of a coronal cavity with
clear flux rope structure. Finally, we visually check the full LASCO CME
database for flux rope structures. In the process, we classify the events into
two clear flux rope classes (`3-part', `Loop'), jets and outflows (no clear
structure). We find that at least 40% of the observed CMEs have clear flux rope
structures. We propose a new definition for flux rope CMEs (FR-CMEs) as a
coherent magnetic, twist-carrying coronal structure with angular width of at
least 40 deg and able to reach beyond 10 Rsun which erupts on a time scale of a
few minutes to several hours. We conclude that flux ropes are a common
occurrence in CMEs and pose a challenge for future studies to identify CMEs
that are clearly not FR-CMEs.Comment: 26 pages, 9 figs, to be published in Solar Physics Topical Issue
"Flux Rope Structure of CMEs
A Helicity-Based Method to Infer the CME Magnetic Field Magnitude in Sun and Geospace: Generalization and Extension to Sun-Like and M-Dwarf Stars and Implications for Exoplanet Habitability
Patsourakos et al. (Astrophys. J. 817, 14, 2016) and Patsourakos and
Georgoulis (Astron. Astrophys. 595, A121, 2016) introduced a method to infer
the axial magnetic field in flux-rope coronal mass ejections (CMEs) in the
solar corona and farther away in the interplanetary medium. The method, based
on the conservation principle of magnetic helicity, uses the relative magnetic
helicity of the solar source region as input estimates, along with the radius
and length of the corresponding CME flux rope. The method was initially applied
to cylindrical force-free flux ropes, with encouraging results. We hereby
extend our framework along two distinct lines. First, we generalize our
formalism to several possible flux-rope configurations (linear and nonlinear
force-free, non-force-free, spheromak, and torus) to investigate the dependence
of the resulting CME axial magnetic field on input parameters and the employed
flux-rope configuration. Second, we generalize our framework to both Sun-like
and active M-dwarf stars hosting superflares. In a qualitative sense, we find
that Earth may not experience severe atmosphere-eroding magnetospheric
compression even for eruptive solar superflares with energies ~ 10^4 times
higher than those of the largest Geostationary Operational Environmental
Satellite (GOES) X-class flares currently observed. In addition, the two
recently discovered exoplanets with the highest Earth-similarity index, Kepler
438b and Proxima b, seem to lie in the prohibitive zone of atmospheric erosion
due to interplanetary CMEs (ICMEs), except when they possess planetary magnetic
fields that are much higher than that of Earth.Comment: http://adsabs.harvard.edu/abs/2017SoPh..292...89
A network approach to understanding social distancing behaviour during the first UK lockdown of the COVID-19 pandemic
Objective
Given the highly infectious nature of COVID-19, social distancing practices are key in stemming the spread of the virus. We aimed to assess the complex interplay among psychological factors, socio-demographic characteristics and social distancing behaviours within the framework of the widely used Capability, Opportunity, Motivation-Behaviour (COM-B) model.
Design
The present research employed network psychometrics on data collected during the first UK lockdown in April 2020 as part of the COVID-19 Psychological Research Consortium (C19PRC) Study. Using a network approach, we examined the predictions of psychological and demographic variables onto social distancing practices at two levels of analysis: macro and micro.
Design
The present research employed network psychometrics on data collected during the first UK lockdown in April 2020 as part of the COVID-19 Psychological Research Consortium (C19PRC) Study. Using a network approach, we examined the predictions of psychological and demographic variables onto social distancing practices at two levels of analysis: macro and micro.
Results
Our findings revealed several factors that influenced social distancing behaviour during the first UK lockdown. The COM-B model was successful in predicting particular aspects of social-distancing via the influence of psychological capability and motivation at the macro-and micro-levels, respectively. Notably, demographic variables, such as education, income, and age, were directly and uniquely predictive of certain social distancing behaviours.
Conclusion
Our findings reveal psychological factors that are key predictors of social distancing behaviour and also illustrate how demographic variables directly influence such behaviour. Our research has implications for the design of empirically-driven interventions to promote adherence to social distancing practices in this and future pandemics
- âŠ