A computational vector-map model of neonate saccades: Modulating the externality effect through refraction periods

AbstractThe present study develops an explicit and predictive computational model of neonate saccades based on the interaction of several simple mechanisms, including the tendency to fixate towards areas of high contrast, and the decay and recovery of a world-centered contrast representation simulating a low-level inhibition of return mechanism. Emergent properties similar to early visual behaviors develop, including the externality effect (or tendency to focus on external then internal features). The age-associated progression of this effect is modulated by the decay period of the model’s contrast representation, where the high-level behavior of either scanning broadly or locally is modulated by a single decay parameter

Helicoidal magnetic order in a clean copper oxide spin chain compound

We report susceptibility, specific heat, and neutron diffraction measurements on NaCu$_2$O$_2$, a spin-1/2 chain compound isostructural to LiCu$_2$O$_2$, which has been extensively investigated. Below 13 K, we find a long-range ordered, incommensurate magnetic helix state with a propagation vector similar to that of LiCu$_2$O$_2$. In contrast to the Li analogue, substitutional disorder is negligible in NaCu$_2$O$_2$. We can thus rule out that the helix is induced by impurities, as was claimed on the basis of prior work on LiCu$_2$O$_2$. A spin Hamiltonian with frustrated longer-range exchange interactions provides a good description of both the ordered state and the paramagnetic susceptibility.Comment: 4 pages, 4 figures Improved Fig.1 and 4. Minor rephrasing. Reference adde

Neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase (SSADH) deficiency suggest a heightened excitatory state during development

<p>Abstract</p> <p>Background</p> <p>SSADH (aldehyde dehydrogenase 5a1 (Aldh5a1); γ-hydroxybutyric (GHB) aciduria) deficiency is a defect of GABA degradation in which the neuromodulators GABA and GHB accumulate. The human phenotype is that of nonprogressive encephalopathy with prominent bilateral discoloration of the globi pallidi and variable seizures, the latter displayed prominently in Aldh5a1^-/-mice with lethal convulsions. Metabolic studies in murine neural tissue have revealed elevated GABA [and its derivatives succinate semialdehyde (SSA), homocarnosine (HC), 4,5-dihydroxyhexanoic acid (DHHA) and guanidinobutyrate (GB)] and GHB [and its analogue D-2-hydroxyglutarate (D-2-HG)] at birth. Because of early onset seizures and the neurostructural anomalies observed in patients, we examined metabolite features during Aldh5a1^-/-embryo development.</p> <p>Methods</p> <p>Embryos were obtained from pregnant dams sacrificed at E (embryo day of life) 10–13, 14–15, 16–17, 18–19 and newborn mice. Intact embryos were extracted and metabolites quantified by isotope dilution mass spectrometry (n = 5–15 subjects, Aldh5a1^+/+and Aldh5a1^-/-) for each gestational age group. Data was evaluated using the <it>t </it>test and one-way ANOVA with Tukey post hoc analysis. Significance was set at the 95^thcentile.</p> <p>Results</p> <p>GABA and DHHA were significantly elevated at all gestational ages in Aldh5a1^-/-mice, while GB was increased only late in gestation; SSA was not elevated at any time point. GHB and D-2-HG increased in an approximately linear fashion with gestational age. Correlative studies in human amniotic fluid from SSADH-deficient pregnancies (n = 5) also revealed significantly increased GABA.</p> <p>Conclusion</p> <p>Our findings indicate early GABAergic alterations in Aldh5a1^-/-mice, possibly exacerbated by other metabolites, which likely induce a heightened excitatory state that may predispose neural networks to epilepsy in these animals.</p

Climate response to the 8.2 ka event in coastal California

A fast-growing stalagmite from the central California coast provides a high-resolution record of climatic changes synchronous with global perturbations resulting from the catastrophic drainage of proglacial Lake Agassiz at ca. 8.2 ka. High frequency, large amplitude variations in carbon isotopes during the 8.2 ka event, coupled with pulsed increases in phosphorus concentrations, indicate more frequent or intense winter storms on the California coast. Decreased magnesium-calcium ratios point toward a sustained increase in effective moisture during the event, however the magnitude of change in Mg/Ca suggests this event was not as pronounced on the western North American coast as anomalies seen in the high northern latitudes and monsoon-influenced areas. Nevertheless, shifts in the White Moon Cave record that are synchronous within age uncertainties with cooling of Greenland, and changes in global monsoon systems, suggest rapid changes in atmospheric circulation occurred in response to freshwater input and associated cooling in the North Atlantic region. Our record is consistent with intensification of the Pacific winter storm track in response to North Atlantic freshwater forcing, a mechanism suggested by simulations of the last deglaciation, and indicates this intensification led to increases in precipitation and infiltration along the California coast during the Holocene

A log analysis study of 10 years of ebook consumption in academic library collections

Even though libraries have been offering eBooks for more than a decade, very little is known about eBook access and consumption in academic library collections. This paper addresses this gap with a log analysis study of eBook access at the library of the University of Waikato. This in-depth analysis covers a period spanning 10 years of eBook use at this university. We draw conclusions about the use of eBooks at this institution and compare the results with other published studies of eBook usage at tertiary institutes

The elemental abundances in the intracluster medium as observed with XMM-Newton

XMM-Newton observations of 19 galaxy clusters are used to measure the elemental abundances and their spatial distributions in the intracluster medium. The sample mainly consists of X-ray bright and relaxed clusters with a cD galaxy. Along with detailed Si, S and Fe radial abundance distributions within 300-700 kpc in radius, the O abundances are accurately derived in the central region of the clusters. The Fe abundance maxima towards the cluster center, possibly due to the metals from the cD galaxy,are spatially resolved. The Si and S abundances also exhibit central increases in general, resulting in uniform Fe-Si-S ratios within the cluster. In contrast, the O abundances are in general uniform over the cluster. The mean O to Fe ratio within the cluster core is sub-solar, while that of the cluster scale is larger than the solar ratio. These measurements indicate that most of the Fe-Si-S and O in the intracluster medium have different origins, presumably in supernovae Ia and II, respectively. The obtained Fe and O mass are also used to discuss the past star formation history in clusters.Comment: Accepted for publication in Astronomy and Astrophysic

Expression quantitative trait loci are highly sensitive to cellular differentiation state

Blood cell development from multipotent hematopoietic stem cells to specialized blood cells is accompanied by drastic changes in gene expression for which the triggers remain mostly unknown. Genetical genomics is an approach linking natural genetic variation to gene expression variation, thereby allowing the identification of genomic loci containing gene expression modulators (eQTLs). In this paper, we used a genetical genomics approach to analyze gene expression across four developmentally close blood cell types collected from a large number of genetically different but related mouse strains. We found that, while a significant number of eQTLs (365) had a consistent “static” regulatory effect on gene expression, an even larger number were found to be very sensitive to cell stage. As many as 1,283 eQTLs exhibited a “dynamic” behavior across cell types. By looking more closely at these dynamic eQTLs, we show that the sensitivity of eQTLs to cell stage is largely associated with gene expression changes in target genes. These results stress the importance of studying gene expression variation in well-defined cell populations. Only such studies will be able to reveal the important differences in gene regulation between different ce

X-ray Evidence for Spectroscopic Diversity of Type Ia Supernovae: XMM observation of the elemental abundance pattern in M87

We present the results of a detailed element abundance study of hot gas in M87, observed by XMM-Newton. We choose two radial bins, 1'-3' and 8'-16' (8'-14' for EMOS; hereafter the central and the outer zones), where the temperature is almost constant, to carry out the detailed abundance measurements of O, Ne, Mg, Si, S, Ar, Ca, Fe and Ni using EPIC-PN (EPN) and -MOS (EMOS) data. First, we find that the element abundance pattern in the central compared to the outer zone in M87 is characterized by SN Ia enrichment of a high (roughly solar) ratio of Si-group elements (Si, S, Ar, Ca) to Fe, implying that Si burning in SN Ia is highly incomplete. In nucleosynthesis modeling this is associated with either a lower density of the deflagration-detonation transition and/or lower C/O and/or lower central ignition density and observationally detected as optically subluminous SNe Ia in early-type galaxies. Second, we find that SN Ia enrichment has a systematically lower ratio of the Si-group elements to Fe by 0.2 dex in the outer zone associated with the ICM of the Virgo cluster. We find that such a ratio and even lower values by another 0.1 dex are a characteristic of the ICM in many clusters using observed Si:S:Fe ratios as found with ASCA. Third, the Ni/Fe ratio in the central zone of M87 is 1.5+/-0.3 solar (meteoritic), while values around 3 times solar are reported for other clusters. In modeling of SN Ia, this implies a reduced influence of fast deflagration SN Ia models in the chemical enrichment of M87's ISM. Thus, to describe the SN Ia metal enrichment in clusters, both deflagration as well as delayed detonation scenarios are required, supporting a similar conclusion, derived from optical studies on SNe Ia. Abridged.Comment: 11 pages, A&A, in pres

Young children’s food brand knowledge. Early development and associations with television viewing and parent’s diet

Brand knowledge is a prerequisite of children’s requests and choices for branded foods. We explored the development of young children’s brand knowledge of foods highly advertised on television – both healthy and less healthy. Participants were 172 children aged 3–5 years in diverse socio-economic settings, from two jurisdictions on the island of Ireland with different regulatory environments. Results indicated that food brand knowledge (i) did not differ across jurisdictions; (ii) increased significantly between 3 and 4 years; and (iii) children had significantly greater knowledge of unhealthy food brands, compared with similarly advertised healthy brands. In addition, (iv) children’s healthy food brand knowledge was not related to their television viewing, their mother’s education, or parent or child eating. However, (v) unhealthy brand knowledge was significantly related to all these factors, although only parent eating and children’s age were independent predictors. Findings indicate that effects of food marketing for un- healthy foods take place through routes other than television advertising alone, and are present before pre-schoolers develop the concept of healthy eating. Implications are that marketing restrictions of un- healthy foods should extend beyond television advertising; and that family-focused obesity prevention programmes should begin before children are 3 years of age