189 research outputs found

    Fieldwork Educators\u27 Perspectives: Professional Behavior Attributes of Level II Fieldwork Students

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    A review of the literature revealed a lack of consistent expectations for professional behaviors required of level II fieldwork students. This study sought to obtain a consensus of perspectives of level II fieldwork educators by asking, “What are the essential professional behavior attributes for level II fieldwork students?” Delphi methodology was used to collect data in two rounds of surveys. In the first, 49 fieldwork educators listed professional behavior attributes they believed to be important for fieldwork students. The data was synthesized into themes for distribution in the second survey, which were identified as essential, non-essential, or site-specific by 53 participants. The 218 different professional behavior attributes provided by Survey 1 respondents were categorized into 22 attribute themes. In Survey 2, 20 of the 22 attribute themes reached a consensus level of at least 75% and five reached 100% agreement. These results show a current perspective of what fieldwork educators value in level II fieldwork students and may be informative to occupational therapy faculty, students, and fieldwork educators

    City of Frederick Downtown Hotel and Conference Center Demand Analysis

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    Final project for BUMO758K (Fall 2014). University of Maryland, College Park.The City of Frederick is pursuing the development of a downtown hotel and conference center (DHCC). The City has tapped as its project lead the Plamondon Companies, a local developer with a wealth of relevant experience in the hospitality industry. Plamondon has proposed a 207-room hotel bearing the Marriott brand and an attached conference center of about 23,500 square feet. The City and its Department of Economic Development are pursuing necessary approvals to build on the proposed site but it also must convince key stakeholders of the project’s viability. Development of the conference center portion of the DHCC will require significant public subsidy from the City, Frederick County, and the State of Maryland. The local business community, particularly existing hoteliers, will be greatly affected by the DHCC. What types of meetings and events will the DHCC host? And will the conference center attract visitors who fill not only the Marriott’s beds, bars, and dining tables, but induce spillover business for the other restaurants, hotels, and local attractions already established in and around Frederick? The DHCC faces competition locally and across the State from facilities similar to that proposed by Plamondon. But Frederick, the project’s developer, and its eventual operator, can leverage the City’s existing strengths and position the DHCC to be an economic engine for the City. First, the City and DHCC should forge connections with key nonprofits and regional organizations as well as meeting planners, who are the gatekeepers to much of the conference center industry and are invaluable advocates for locations such as Frederick. Building these relationships and dutifully maintaining them will keep Frederick in the rotation as groups like the Maryland Economic Development Association and Maryland Municipal League schedule regular meetings across the State. Second, the pitch to these groups must be about Frederick—not ballrooms or hotel suites. The lively downtown, historical sites, nearby natural beauty and other attractions can differentiate Frederick from other cities with similar conference facilities. And third, the City and DHCC should make a play for government business in the long-term. Tighter budgets in Washington and meeting and events restrictions following a string of conference scandals across a number of agencies have slowed the federal meeting business to a trickle. But Fort Detrick cannot be ignored. Its unique and essential leadership in biotechnology could bring the DHCC some business in the short-term. It is, however, much more likely to yield greater dividends in the long-term as spending once again opens up. Positioning the DHCC to capture the eventual increase in demand from the Fort and other local agencies will help ensure the long-term viability of the facility. Pursuit of the strategies outlined above will put the DHCC on solid footing to attract meeting and event business from its four core market segments. Special events, such as weddings, are a natural source of business for the Center and will likely fill much of its calendar. Local businesses led by the largest employers in the County are a key driving force behind the project and will use the DHCC and Marriott regularly for a number of purposes. The DHCC and City as a whole will have the opportunity to attract significant conference and meeting business from regional and statewide nonprofits and organizations. And while demand will be slack in the short-term, government business could be a boon for the DHCC as the federal dollars start to flow once again.The City of Frederic

    Effects of Timber Harvest on Amphibian Populations: Understanding Mechanisms from Forest Experiments

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    Accompanying appendix may be accessed at: http://hdl.handle.net/10355/1365Harvesting timber is a common form of land use that has the potential to cause declines in amphibian populations. It is essential to understand the behavior and fate of individuals and the resulting consequences for vital rates (birth, death, immigration, emigration) under different forest management conditions.We report on experimental studies conducted in three regions of the United States to identify mechanisms of responses by pond-breeding amphibians to timber harvest treatments. Our studies demonstrate that life stages related to oviposition and larval performance in the aquatic stage are sometimes affected positively by clearcutting, whereas effects on juvenile and adult terrestrial stages are mostly negative

    The clock gene <i>Bmal1</i> inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia

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    The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against pneumococcal pneumonia. Infected mice show both reduced weight loss and lower bacterial burden in circulating blood. In vivo studies of macrophage phagocytosis reveal increased bacterial ingestion following Bmal1 deletion, which was also seen in vitro. BMAL1−/− macrophages exhibited marked differences in actin cytoskeletal organization, a phosphoproteome enriched for cytoskeletal changes, with reduced phosphocofilin and increased active RhoA. Further analysis of the BMAL1−/− macrophages identified altered cell morphology and increased motility. Mechanistically, BMAL1 regulated a network of cell movement genes, 148 of which were within 100 kb of high-confidence BMAL1 binding sites. Links to RhoA function were identified, with 29 genes impacting RhoA expression or activation. RhoA inhibition restored the phagocytic phenotype to that seen in control macrophages. In summary, we identify a surprising gain of antibacterial function due to loss of BMAL1 in macrophages, associated with a RhoA-dependent cytoskeletal change, an increase in cell motility, and gain of phagocytic function

    Testing, stretching, and aligning:Using ‘ironic personae’ to make sense of complicated issues

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    Irony and humor play an important role in both organizing and organizations, because they both help to collide and contrast ideas as well as mitigate and moderate criticism. Our empirical observations of a senior management team suggest participants frequently use verbal irony and aggressive conversational humor through ‘ironic personae’ – a cast of characters, real or imaginary – as a vehicle for pragmatically making sense of complicated topics. We show how ironic personae perform three functions: (i) testing new positions on topics in a non-committal way; (ii) stretching the frame of comparison of a group; and (iii) aligning shared understanding and commitment. Thus, our analysis sheds light on an underexplored and undertheorised pragmatic vehicle for the expression of humorous verbal irony and aggressive conversational humor

    The histone methyltransferase Ezh2 restrains macrophage inflammatory responses

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    From Wiley via Jisc Publications RouterHistory: received 2021-02-16, rev-recd 2021-07-06, accepted 2021-07-23, pub-electronic 2021-08-31, pub-print 2021-10Article version: VoRPublication status: PublishedFunder: Medical Research Council Canada (MRC); Id: http://dx.doi.org/10.13039/501100007155; Grant(s): MR/N002024/1Funder: RCUK | Medical Research Council (MRC); Id: http://dx.doi.org/10.13039/501100000265; Grant(s): MRNO2995X/1Funder: Wellcome Trust (Wellcome); Id: http://dx.doi.org/10.13039/100010269; Grant(s): 107849/Z/15/Z, 107851/Z/15/ZFunder: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC); Id: http://dx.doi.org/10.13039/501100000268; Grant(s): BB/L000954/1, BB/K003097/1Abstract: Robust inflammatory responses are critical to survival following respiratory infection, with current attention focused on the clinical consequences of the Coronavirus pandemic. Epigenetic factors are increasingly recognized as important determinants of immune responses, and EZH2 is a prominent target due to the availability of highly specific and efficacious antagonists. However, very little is known about the role of EZH2 in the myeloid lineage. Here, we show EZH2 acts in macrophages to limit inflammatory responses to activation, and in neutrophils for chemotaxis. Selective genetic deletion in macrophages results in a remarkable gain in protection from infection with the prevalent lung pathogen, pneumococcus. In contrast, neutrophils lacking EZH2 showed impaired mobility in response to chemotactic signals, and resulted in increased susceptibility to pneumococcus. In summary, EZH2 shows complex, and divergent roles in different myeloid lineages, likely contributing to the earlier conflicting reports. Compounds targeting EZH2 are likely to impair mucosal immunity; however, they may prove useful for conditions driven by pulmonary neutrophil influx, such as adult respiratory distress syndrome

    The Vehicle, 1967, Vol. 9 no. 2

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    Table of Contents Commentarypage 3 SketchAnn Butlerpage 4 I Take A Long-Out-of-Use BookAnthony Griggspage 5 The Leaf StemDianne Cochranpage 6 The Four MusketeersJim Courterpage 7 Status QuoAdrian Beardpage 7 SketchAnn Butlerpage 8 NocturneMike Baldwinpage 9 Oh Impatient HeartK. H. Shariffpage 9 Letter to a FianceeMaurice Snivelypage 10 Listen!Bonnie Blackpage 11 The Water\u27s EdgeStephen W. Gibbspage 12 TogetherDavid Reifpage 13 SketchAnn Butlerpage 14 Evening TimeSharon Nelsonpage 15 Japanese HaikuBev Hensonpage 15 Of Love and WarBruce Czeluscinskipage 16 Always AloneKib Voorheespage 17 the end of loveJackie Bratcherpage 18 1-20-66Sharon Nelsonpage 19 Blessed Are WeBonnie Marie Beckpage 19 The Time To LiveNeil Tracypage 20 Imminent AwakeningHelen Coxpage 21 The Dead Panther LairMolly J. Evanspage 21 Good SheepMike Tilfordpage 22 The Flame of LifeJacki Jacquespage 23 Then Arrives The Day Of DarkMolly J. Evanspage 23 Sketch: To love is to rememberAnn Butlerpage 24 Hidden RiversCharles J. Mertzpage 25 SilenceLinda G. Phillipspage 26 December - 1964Bonnie Blackpage 26 LoveHazel Thomaspage 27 To Praise A Good Man Neil Tracypage 28 Definitions \u2767Sharon Nelsonpage 29 To Wish Is a CrimeBonnie Marie Beckpage 30 College MadhatterMaurice Snivelypage 31 No. 8Sharon Nelsonpage 32 The Open FireSusan Williamspage 32https://thekeep.eiu.edu/vehicle/1017/thumbnail.jp
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