Erratum to nodal management and upstaging of disease. Initial results from the Italian VATS Lobectomy Registry

[This corrects the article DOI: 10.21037/jtd.2017.06.12.]

Closing gaps to our origins : EUVO: the ultraviolet-visible window into the Universe

This article reproduces the contents of the White Paper entitled by the same name submitted to the call issued by the European Space Agency soliciting ideas from the scientific community for the science themes that should be covered during the Voyage 2050 planning cycle. This contribution focus in the investigation of the emergence of life and the role that astronomy has to play in it. Three fundamental areas of activity are identified: [1] measuring the chemical enrichment of the Universe, [2] investigating planet formation and searching for exoplanets with signatures of life and, [3] determining the abundance of amino acids and the chemical routes to amino acid and protein growth in astronomical bodies. This proposal deals with the first two. The building blocks of life in the Universe began as primordial gas processed in stars and mixed at galactic scales. The mechanisms responsible for this development are not well-understood and have changed over the intervening 13 billion years. To follow the evolution of matter over cosmic time, it is necessary to study the strongest (resonance) transitions of the most abundant species in the Universe. Most of them are in the ultraviolet (UV; 950 Å - 3000 Å ) spectral range that is unobservable from the ground; the “missing” metals problem cannot be addressed without this access. Habitable planets grow in protostellar discs under ultraviolet irradiation, a by-product of the accretion process that drives the physical and chemical evolution of discs and young planetary systems. The electronic transitions of the most abundant molecules are pumped by this UV field that is the main oxidizing agent in the disc chemistry and provides unique diagnostics of the planet-forming environment that cannot be accessed from the ground. Knowledge of the variability of the UV radiation field is required for the astrochemical modelling of protoplanetary discs, to understand the formation of planetary atmospheres and the photochemistry of the precursors of life. Earth’s atmosphere is in constant interaction with the interplanetary medium and the solar UV radiation field. The exosphere of the Earth extends up to 35 planetary radii providing an amazing wealth of information on our planet’s winds and the atmospheric compounds. To access to it in other planetary systems, observation of the UV resonance transitions is required. The investigation for the emergence of life calls for the development of large astronomical facilities, including instrumentation in optical and UV wavelengths. In this contribution, the need to develop a large observatory in the optical and in the UV is revealed, in order to complete the scientific goals to investigate the origin of life, inaccessible through other frequencies in the electromagnetic spectrum

UV Sensor Based on Surface Acoustic Waves in ZnO/Fused Silica

Zinc oxide (ZnO) thin films have been grown by radio frequency sputtering technique on fused silica substrates. Optical and morphological characteristics of as-grown ZnO samples were measured by various techniques; an X-ray diffraction spectrum showed that the films exhibited hexagonal wurtzite structure and were c-axis-oriented normal to the substrate surface. Scanning electron microscopy images showed the dense columnar structure of the ZnO layers, and light absorption measurements allowed us to estimate the penetration depth of the optical radiation in the 200 to 480 nm wavelength range and the ZnO band-gap. ZnO layers were used as a basic material for surface acoustic wave (SAW) delay lines consisting of two Al interdigitated transducers (IDTs) photolithographically implemented on the surface of the piezoelectric layer. The Rayleigh wave propagation characteristics were tested in darkness and under incident UV light illumination from the top surface of the ZnO layer and from the fused silica/ZnO interface. The sensor response, i.e., the wave velocity shift due to the acoustoelectric interaction between the photogenerated charge carriers and the electric potential associated with the acoustic wave, was measured for different UV power densities. The reversibility and repeatability of the sensor responses were assessed. The time response of the UV sensor showed a rise time and a recovery time of about 10 and 13 s, respectively, and a sensitivity of about 318 and 341 ppm/(mW/cm2) for top and bottom illumination, respectively. The ZnO/fused silica-based SAW UV sensors can be interrogated across the fused silica substrate thanks to its optical transparency in the UV range. The backlighting interrogation can find applications in harsh environments, as it prevents the sensing photoconductive layer from aggressive environmental effects or from any damage caused by cleaning the surface from dust which could deteriorate the sensor’s performance. Moreover, since the SAW sensors, by their operating principle, are suitable for wireless reading via radio signals, the ZnO/fused-silica-based sensors have the potential to be the first choice for UV sensing in harsh environments

Closing gaps to our origins. The UV window into the Universe

International audienceThe investigation of the emergence of life is a major endeavour of science. Astronomy is contributing to it in three fundamental manners: (1) by measuring the chemical enrichment of the Universe, (2) by investigating planet formation and searching for exoplanets with signatures of life and, (3) by determining the abundance of aminoacids and the chemical routes to aminoacid and protein growth in astronomical bodies. This proposal deals with the first two. In the Voyage to 2050, the world-wide scientific community is getting equipped with large facilities for the investigation of the emergence of life in the Universe (i.e. VLT, JWST, ELT, GMT, TMT, ALMA, FAST, VLA, ATHENA, SKA) including the ESA's CHEOPS, PLATO and ARIEL missions. This white paper is a community effort to call for the development of a large ultraviolet optical observatory to gather fundamental data for this investigation that will not be accessible through other ranges of the electromagnetic spectrum. A versatile space observatory with UV sensitivity a factor of 50-100 greater than existing facilities will revolutionize our understanding of the pathway to life in the Universe

Closing gaps to our origins

CRUE-CSIC (Acuerdos Transformativos 2022)This article reproduces the contents of the White Paper entitled by the same name submitted to the call issued by the European Space Agency soliciting ideas from the scientific community for the science themes that should be covered during the Voyage 2050 planning cycle. This contribution focus in the investigation of the emergence of life and the role that astronomy has to play in it. Three fundamental areas of activity are identified: [1] measuring the chemical enrichment of the Universe, [2] investigating planet formation and searching for exoplanets with signatures of life and, [3] determining the abundance of amino acids and the chemical routes to aminoacid and protein growth in astronomical bodies. This proposal deals with the first two. The building blocks of life in the Universe began as primordial gas processed in stars and mixed at galactic scales. The mechanisms responsible for this development are not well-understood and have changed over the intervening 13 billion years. To follow the evolution of matter over cosmic time, it is necessary to study the strongest (resonance) transitions of the most abundant species in the Universe. Most of them are in the ultraviolet (UV; 950 Å - 3000 Å ) spectral range that is unobservable from the ground; the “missing” metals problem cannot be addressed without this access. Habitable planets grow in protostellar discs under ultraviolet irradiation, a by-product of the accretion process that drives the physical and chemical evolution of discs and young planetary systems. The electronic transitions of the most abundant molecules are pumped by this UV field that is the main oxidizing agent in the disc chemistry and provides unique diagnostics of the planet-forming environment that cannot be accessed from the ground. Knowledge of the variability of the UV radiation field is required for the astrochemical modelling of protoplanetary discs, to understand the formation of planetary atmospheres and the photochemistry of the precursors of life. Earth’s atmosphere is in constant interaction with the interplanetary medium and the solar UV radiation field. The exosphere of the Earth extends up to 35 planetary radii providing an amazing wealth of information on our planet’s winds and the atmospheric compounds. To access to it in other planetary systems, observation of the UV resonance transitions is required. The investigation for the emergence of life calls for the development of large astronomical facilities, including instrumentation in optical and UV wavelengths. In this contribution, the need to develop a large observatory in the optical and in the UV is revealed, in order to complete the scientific goals to investigate the origin of life, inaccessible through other frequencies in the electromagnetic spectrum.Unidad Deptal. de Astronomía y GeodesiaFac. de Ciencias MatemáticasTRUEpu

Conversion due to vascular injury during video-assisted thoracic surgery lobectomy: A multicentre retrospective analysis from the Italian video-assisted thoracic surgery group registry

Objectives: Vascular injuries are among the most severe causes of unplanned conversion during VATS lobectomies. The study aimed to analyse the incidence of vascular injuries and their risk factors during VATS lobectomy. Methods: The Italian VATS lobectomy Registry was used to collect data from 66 Thoracic Surgery Units. From 2013 to October 2016 (out of more than 3,700 patients enrolled) only information from Units with an enrollment >100 VATS lobectomies were retrospectively analysed. Logistic regression analysis was performed on selected variables of the univariate analysis. Results: Ten institutions contributed a total of 1,679 patients. Vascular injuries leading to conversion occurred in 44 (2.6%) patients. Years of experiences were inversely related to the risk of vascular injuries. Univariate analysis showed age, gender, surgical activity, Charlson Index Score and number of resected lymph nodes like significantly associated variables. Multivariate analysis revealed that number of resected lymph nodes, VATS experience ratio (number of VATS lobectomies/total lobectomies performed in the same year at same centre), and surgical activity of the centre were significantly associated with the risk of conversion. Unplanned thoracotomy was correlated with postoperative morbidity. Conclusion: Vascular injuries in VATS lobectomies represented a rare complication which could directly affect the postoperative outcomes. The predictive factors for conversion were multifactorial and depended on characteristics of centres and surgeons’ seniority. Minimally invasive VATS lobectomy approaches did not influence the risk of vascular damages

Building galaxies, stars, planets and the ingredients for life between the stars. A scientific proposal for a European Ultraviolet-Visible Observatory (EUVO)

The growth of luminous structures and the building blocks of life in the Universe began as primordial gas was processed in stars and mixed at galactic scales. The mechanisms responsible for this development are not well understood and have changed over the intervening 13 billion years. To follow the evolution of matter over cosmic time, it is necessary to study the strongest (resonance) transitions of the most abundant species in the Universe. Most of them are in the ultraviolet (UV; 950A-3000A) spectral range that is unobservable from the ground. A versatile space observatory with UV sensitivity a factor of 50-100 greater than existing facilities will revolutionize our understanding of the Universe. Habitable planets grow in protostellar discs under ultraviolet irradiation, a by-product of the star-disk interaction that drives the physical and chemical evolution of discs and young planetary systems. The electronic transitions of the most abundant molecules are pumped by the UV field, providing unique diagnostics of the planet-forming environment that cannot be accessed from the ground. Earth's atmosphere is in constant interaction with the interplanetary medium and the solar UV radiation field. A 50-100 times improvement in sensitivity would enable the observation of the key atmospheric ingredients of Earth-like exoplanets (carbon, oxygen, ozone), provide crucial input for models of biologically active worlds outside the solar system, and provide the phenomenological baseline to understand the Earth atmosphere in context. In this white paper, we outline the key science that such a facility would make possible and outline the instrumentation to be implemented

Building galaxies, stars, planets and the ingredients for life between the stars. The science behind the European Ultraviolet-Visible Observatory

This contribution gathers the contents of the white paper submitted by the UV community to the Call issued by the European Space Agency in March 2013, for the definition of the L2 and L3 missions in the ESA science program. We outlined the key science that a large UV facility would make possible and the instrumentation to be implemented. The growth of luminous structures and the building blocks of life in the Universe began as primordial gas was processed in stars and mixed at galactic scales. The mechanisms responsible for this development are not wellunderstood and have changed over the intervening 13 billion years. To follow the evolution of matter over cosmic time, it is necessary to study the strongest (resonance) transitions of the most abundant species in the Universe. Most of them are in the ultraviolet (UV; 950 \uc5\u20133000 \uc5) spectral range that is unobservable from the ground. A versatile space observatory with UV sensitivity a factor of 50\u2013100 greater than existing facilities will revolutionize our understanding of the Universe. Habitable planets grow in protostellar discs under ultraviolet irradiation, a by-product of the star-disk interaction that drives the physical and chemical evolution of discs and young planetary systems. The electronic transitions of the most abundant molecules are pumped by this UV field, providing unique diagnostics of the planet-forming environment that cannot be accessed from the ground. Earth\u2019s atmosphere is in constant interaction with the interplanetary medium and the solar UV radiation field. A 50\u2013100 times improvement in sensitivity would enable the observation of the key atmospheric ingredients of Earth-like exoplanets (carbon, oxygen, ozone), provide crucial input for models of biologically active worlds outside the solar system, and provide the phenomenological baseline to understand the Earth atmosphere in context

National adoption of video-assisted thoracoscopic surgery (VATS) lobectomy: The Italian VATS register evaluation

Background: The expertise curve of video-assisted thoracoscopic surgery (VATS) lobectomies still stirs debate and controversy both because of the number of procedures to carry out and of the evaluation of the learning threshold. The purpose of our study was the examination of the variables related to the learning curve of the video-assisted approach, to establish what may be an expression of the technical maturity of the surgeon. Methods: The National Register for VATS lobectomy built in 2013 was used to collect data from 65 Thoracic Surgery Units. Out of more than 3,700 patients enrolled, only information from Units with \ue2\u89\ua5100 VATS lobectomies were retrospectively analysed. Unpaired Student's t-tests, Fisher's exact tests, Pearson's \ucf\u872were applied as needed. Cumulative summative analysis and one-way ANOVA were used to identify the expertise curve of VATS lobectomy. Results: Ten institutions contributed a total of 1,679 patients, who were divided into three uniform groups according to the chronological sequence of surgery. The length of utility incision, the number of dissected lymph nodes and the operative time were not statistically significant (P=0.999, P=0.972 and P=0.307, respectively) among groups. Conversion to thoracotomy and postoperative air leaks occurred in 125 (7.44%) and 109 (6.49%) patients, gradually declined in Group 3 with statistical significance (P=0.048 and P=0.00086). Conclusions: The conversion rate and the percentage of air leaks seem to define the expertise of VATS lobectomy, being linked to the ability to manage more complicated surgical cases or intraoperative adverse events