Primary biliary cirrhosis

Primary biliary cirrhosis (PBC) is an immune-mediated chronic cholestatic liver disease with a slowly progressive course. Without treatment, most patients eventually develop fibrosis and cirrhosis of the liver and may need liver transplantation in the late stage of disease. PBC primarily affects women (female preponderance 9–10:1) with a prevalence of up to 1 in 1,000 women over 40 years of age. Common symptoms of the disease are fatigue and pruritus, but most patients are asymptomatic at first presentation. The diagnosis is based on sustained elevation of serum markers of cholestasis, i.e., alkaline phosphatase and gamma-glutamyl transferase, and the presence of serum antimitochondrial antibodies directed against the E2 subunit of the pyruvate dehydrogenase complex. Histologically, PBC is characterized by florid bile duct lesions with damage to biliary epithelial cells, an often dense portal inflammatory infiltrate and progressive loss of small intrahepatic bile ducts. Although the insight into pathogenetic aspects of PBC has grown enormously during the recent decade and numerous genetic, environmental, and infectious factors have been disclosed which may contribute to the development of PBC, the precise pathogenesis remains enigmatic. Ursodeoxycholic acid (UDCA) is currently the only FDA-approved medical treatment for PBC. When administered at adequate doses of 13–15 mg/kg/day, up to two out of three patients with PBC may have a normal life expectancy without additional therapeutic measures. The mode of action of UDCA is still under discussion, but stimulation of impaired hepatocellular and cholangiocellular secretion, detoxification of bile, and antiapoptotic effects may represent key mechanisms. One out of three patients does not adequately respond to UDCA therapy and may need additional medical therapy and/or liver transplantation. This review summarizes current knowledge on the clinical, diagnostic, pathogenetic, and therapeutic aspects of PBC

Evidence for widespread hydrated minerals on asteroid (101955) Bennu

Early spectral data from the Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) mission reveal evidence for abundant hydrated minerals on the surface of near-Earth asteroid (101955) Bennu in the form of a near-infrared absorption near 2.7 µm and thermal infrared spectral features that are most similar to those of aqueously altered CM-type carbonaceous chondrites. We observe these spectral features across the surface of Bennu, and there is no evidence of substantial rotational variability at the spatial scales of tens to hundreds of metres observed to date. In the visible and near-infrared (0.4 to 2.4 µm) Bennu’s spectrum appears featureless and with a blue (negative) slope, confirming previous ground-based observations. Bennu may represent a class of objects that could have brought volatiles and organic chemistry to Earth

The dynamic geophysical environment of (101955) Bennu based on OSIRIS-REx measurements

The top-shaped morphology characteristic of asteroid (101955) Bennu, often found among fast-spinning asteroids and binary asteroid primaries, may have contributed substantially to binary asteroid formation. Yet a detailed geophysical analysis of this morphology for a fast-spinning asteroid has not been possible prior to the Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) mission. Combining the measured Bennu mass and shape obtained during the Preliminary Survey phase of the OSIRIS-REx mission, we find a notable transition in Bennu’s surface slopes within its rotational Roche lobe, defined as the region where material is energetically trapped to the surface. As the intersection of the rotational Roche lobe with Bennu’s surface has been most recently migrating towards its equator (given Bennu’s increasing spin rate), we infer that Bennu’s surface slopes have been changing across its surface within the last million years. We also find evidence for substantial density heterogeneity within this body, suggesting that its interior is a mixture of voids and boulders. The presence of such heterogeneity and Bennu’s top shape are consistent with spin-induced failure at some point in its past, although the manner of its failure cannot yet be determined. Future measurements by the OSIRIS-REx spacecraft will provide insight into and may resolve questions regarding the formation and evolution of Bennu’s top-shape morphology and its link to the formation of binary asteroids

Young lunar volcanic features: Thermophysical properties and formation

Irregular mare patches (IMPs) are small volcanic features on the lunar nearside with young model ages. Several formation mechanisms have been proposed including: caldera collapse, explosive outgassing, lava flow inflation, pyroclastic eruption, and regolith drainage. We present new observations of the four largest IMPs (Sosigenes, In a, Cauchy-5, and Maskelyne) using the Lunar Reconnaissance Orbiter (LRO) Diviner Lunar Radiometer (Diviner) and evaluate the formation hypotheses in the context of both previous results and the results presented here. We find that the IMPs have a rock abundance slightly higher than their surrounding terrain. Comparison of the Diviner data with thermal models excludes the possibility of extensive competent rocks within ∼15 cm of the surface at the IMPs. We also derive the thermal inertia at the four largest IMPs. Three appear to have thermal inertias slightly higher than typical regolith due to alteration by nearby craters or mass wasting from surrounding steep slopes, but Ina has a thermal inertia lower than the surrounding terrain. In particular, the largest smooth mound in Ina is the area with the lowest thermal inertia, suggesting that the material on the mound is less consolidated than typical regolith and/or contains fewer small rocks ( < 1 m). Formation by lava flows or regolith drainage is not expected to result in material with a lower thermal inertia than pre-existing regolith, so some other process such as explosive outgassing or pyroclastic eruptions must have occurred

Young lunar volcanic features: Thermophysical properties and formation

Irregular mare patches (IMPs) are small volcanic features on the lunar nearside with young model ages. Several formation mechanisms have been proposed including: caldera collapse, explosive outgassing, lava flow inflation, pyroclastic eruption, and regolith drainage. We present new observations of the four largest IMPs (Sosigenes, In a, Cauchy-5, and Maskelyne) using the Lunar Reconnaissance Orbiter (LRO) Diviner Lunar Radiometer (Diviner) and evaluate the formation hypotheses in the context of both previous results and the results presented here. We find that the IMPs have a rock abundance slightly higher than their surrounding terrain. Comparison of the Diviner data with thermal models excludes the possibility of extensive competent rocks within ∼15 cm of the surface at the IMPs. We also derive the thermal inertia at the four largest IMPs. Three appear to have thermal inertias slightly higher than typical regolith due to alteration by nearby craters or mass wasting from surrounding steep slopes, but Ina has a thermal inertia lower than the surrounding terrain. In particular, the largest smooth mound in Ina is the area with the lowest thermal inertia, suggesting that the material on the mound is less consolidated than typical regolith and/or contains fewer small rocks ( < 1 m). Formation by lava flows or regolith drainage is not expected to result in material with a lower thermal inertia than pre-existing regolith, so some other process such as explosive outgassing or pyroclastic eruptions must have occurred

The Effects of Terrain Properties Upon the Small Crater Population Distribution at Giordano Bruno: Implications for Lunar Chronology

The distribution of impact craters on the ejecta of Giordano Bruno, a recent (&lt;10&nbsp;Ma) 22-km diameter crater within the lunar highlands, exhibits substantial variations. We surveyed craters D&nbsp;≥&nbsp;10&nbsp;m across a 1,323&nbsp;km2 area of Giordano Bruno's ejecta and compared the distribution of craters with variations in thermophysical properties derived from the Lunar Reconnaissance Orbiter Diviner instrument. We used Diviner-derived rock abundance and nighttime regolith temperatures along with thermal model-predicted surface temperatures for a diversity of terrains to identify and isolate areas of the ejecta based on thermophysical properties such as bulk density and thermal conductivity. We found that thermophysical properties of the ejecta vary considerably both laterally and vertically, and consistently differ from typical regolith, indicating the presence of higher thermal inertia materials. Crater-size frequencies are significantly lower in areas with terrain properties exhibiting higher: rock abundance, nighttime temperatures, and/or modeled thermal inertia. This discrepancy in crater distribution increases for craters smaller than ∼25&nbsp;m. These thermophysical variations indicate changes in the mechanical properties of the target materials. We suggest that these variations-specifically, terrain-dependent crater scaling variations and impactor-scale heterogeneities in material properties such as the presence or absence of large boulders-may influence crater diameters or inhibit crater production altogether in Giordano Bruno's ejecta; furthermore, these factors are size-dependent

Complete chemical analyses of metamorphic hornblendes: implications for normalizations, calculated H 2 O activities, and thermobarometry

Twenty-two hornblendes separated from amphibolites and granulites of the Grenville Orogen of Ontario have been quantitatively analyzed for major and minor elements by electron microprobe, for FeO/Fe 2 O 3 by wet chemistry, and for H 2 O by manometric measurement as H 2 . Hornblende formulae were calculated on the basis of 24O+OH+Cl+F. Most samples are magnesio-hornblendes, ferroan pargasitic hornblendes and ferroan hastingsitic hornblendes, with weight fractions of Fe 3+ /(Fe 2+ +Fe 3+ ) ranging from 0.15 to 0.50. An oxy-amphibole component of 0–25 mol%, with an average value of 17 mol%, is obtained for these complete analyses. When compared with structural formulae determined solely from microprobe data, normalization based on 13=Si+Ti+Al+Fe+Mn+Mg cations provides the best approximation to hornblende formulae calculated from the complete analyses. Less satisfactory agreement is obtained from a normalization scheme based on 15=Si+Ti+Al+Fe+Mn+Mg+Ca, while worst agreement is obtained from normalization to 23 oxygens assuming all Fe is Fe 2+ . No normalization scheme based on microprobe data alone consistently replicates the measured FeO, Fe 2 O 3 , and H 2 O; accurate determination of these values requires complete chemical analysies. Ionic solution models previously have been proposed to evaluate the activity of Ca 2 Mg 5 Si 8 O 22 (OH) 2 ( a Trem ) in hornblende for use in equilibria that constrain the activity of H 2 O ( a H 2 O) in igneous and metamorphic rocks. Application of ionic models to typical hornblendes produces low a Trem (usually<0.01), consequetly yielding extremely low a H 2 O. If an oxy-amphibole component is present, the calculated a Trem and H 2 O is further reduced. An oxy-amphibole component of 25% reduces the calculated H 2 O activity and that of any hydroxyl-amphibole component by 50% below that calculated with simplified assumptions regarding X OH in the hydroxyl site (i.e., X OH =1, or X OH =1− X Cl − X f ). Thus, methods of amphibole normalizations appear to have a substantial effect on calculated amphibole and H 2 O activites. Before quantitative hornblende thermobarometry can be calibrated and applied, the amounts of FeO, Fe 2 O 3 and H 2 O must be measured in order to fully characterize hornblende solid solutions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47296/1/410_2004_Article_BF00303451.pd