Energy Efficient Clustering and Routing in Mobile Wireless Sensor Network

A critical need in Mobile Wireless Sensor Network (MWSN) is to achieve energy efficiency during routing as the sensor nodes have scarce energy resource. The nodes' mobility in MWSN poses a challenge to design an energy efficient routing protocol. Clustering helps to achieve energy efficiency by reducing the organization complexity overhead of the network which is proportional to the number of nodes in the network. This paper proposes a novel hybrid multipath routing algorithm with an efficient clustering technique. A node is selected as cluster head if it has high surplus energy, better transmission range and least mobility. The Energy Aware (EA) selection mechanism and the Maximal Nodal Surplus Energy estimation technique incorporated in this algorithm improves the energy performance during routing. Simulation results can show that the proposed clustering and routing algorithm can scale well in dynamic and energy deficient mobile sensor network.Comment: 9 pages, 4 figure

Urban and Rural Riparian Forests: Coleoptera Communities and Soil Characteristics

Urbanization has been shown to be detrimental to ecosystems and to negatively impact ecosystem services and biodiversity, contributing to biological homogenization. This study focused on Coleoptera communities and soil characteristics (pH and conductivity) in urban and rural riparian forests, which are streamside forests that serve as transitional zones between aquatic and terrestrial ecosystems. Urbanization in these areas can lead to habitat loss, increased pollution, excess nutrients, and altered hydrology. Beetles (order Coleoptera) in these ecosystems can be affected by urbanization and preserving their biodiversity is important since they provide essential services such as decomposition and nutrient cycling. In 2019, beetles were collected once a month from June to August in urban and rural riparian forests in the Greater Binghamton area. In 2020, soil samples were collected to determine the differences between urban and rural riparian forests. We hypothesized Coleoptera communities would be less abundant and less diverse in urban habitats. Additionally, we predicted that urban soils would have a lower pH and higher conductivity compared to rural soils. We collected 1310 beetles and 11 families were identified. Family Carabidae was the most abundant (59.8%). Results are inconclusive on trends of urbanization since we observed comparable levels of abundance and taxon richness. However, abundance and richness were, on average, higher in urban sites which could be due to excess nutrients, diverse vegetation, and other subsidies in urban riparian forests. We found that on average, pH was higher and conductivity was lower in urban soil samples. The higher pH could be due to better than previously thought buffering capacity in urban areas and low conductivity could be due to runoff over impermeable urban land cover.https://orb.binghamton.edu/research_days_posters_2021/1010/thumbnail.jp

Efecto de la rehabilitación oral con prótesis removibles sobre el estado nutricional del adulto mayor en el Centro de Salud Ermitaño Bajo Lima 2015

El objetivo del presente trabajo de investigación es determinar el nivel de efectividad de la rehabilitación oral con prótesis removibles sobre el estado nutricional del adulto mayor en el Centro de Salud Ermitaño Bajo Lima 2015. El tipo de investigación es aplicada, de diseño pre experimental, explicativo de corte longitudinal. La población para el periodo 2015: 20 personas beneficiadas con el programa rehabilitación oral con prótesis removibles sobre el estado nutricional del adulto mayor en el Centro de Salud Ermitaño Bajo; muestra seleccionada 20. Técnica: observación, instrumento: ficha de observación. Con la información recogida se obtuvo la validez de constructo y la confiabilidad del instrumento, utilizándose el Paquete Estadístico para las Ciencias Sociales (SPSS), versión 23. Se adjunta tabla de confiabilidad y la validez de constructo del instrumento; Se utilizó el estadígrafo no paramétrico Rangos de Wilcoxon, para comparar medias de grupo relacionado, antes y después. Nivel de significación de 0,05. Entre los principales resultados se determinó existe una diferencia significativa antes y después de aplicar el programa rehabilitación oral con prótesis removibles sobre el estado nutricional del adulto mayor en el Centro de Salud Ermitaño Bajo Lima 2015. p= 0,00. P< 0,05. Así como, en todas las demás dimensiones

Augmentation of CFTR maturation by S -nitrosoglutathione reductase

-nitrosoglutathione (GSNO) reductase regulates novel endogenou

Prenatal Hypoxia–Ischemia Induces Abnormalities in CA3 Microstructure, Potassium Chloride Co-Transporter 2 Expression and Inhibitory Tone

Infants who suffer perinatal brain injury, including those with encephalopathy of prematurity, are prone to chronic neurological deficits, including epilepsy, cognitive impairment, and behavioral problems, such as anxiety, inattention, and poor social interaction. These deficits, especially in combination, pose the greatest hindrance to these children becoming independent adults. Cerebral function depends on adequate development of essential inhibitory neural circuits and the appropriate amount of excitation and inhibition at specific stages of maturation. Early neuronal synaptic responses to γ-amino butyric acid (GABA) are initially excitatory. During the early postnatal period, GABAAR responses switch to inhibitory with the upregulation of potassium-chloride co-transporter KCC2. With extrusion of chloride by KCC2, the Cl− reversal potential shifts and GABA and glycine responses become inhibitory. We hypothesized that prenatal hypoxic–ischemic brain injury chronically impairs the developmental upregulation of KCC2 that is essential for cerebral circuit formation. Following late gestation hypoxia–ischemia (HI), diffusion tensor imaging in juvenile rats shows poor microstructural integrity in the hippocampal CA3 subfield, with reduced fractional anisotropy and elevated radial diffusivity. The loss of microstructure correlates with early reduced KCC2 expression on NeuN-positive pyramidal neurons, and decreased monomeric and oligomeric KCC2 protein expression in the CA3 subfield. Together with decreased inhibitory post-synaptic currents during a critical window of development, we document for the first time that prenatal transient systemic HI in rats impairs hippocampal CA3 inhibitory tone. Failure of timely development of inhibitory tone likely contributes to a lower seizure threshold and impaired cognitive function in children who suffer perinatal brain injury

Hypoxia releases S-nitrosocysteine from carotid body glomus cells—relevance to expression of the hypoxic ventilatory response

We have provided indirect pharmacological evidence that hypoxia may trigger release of the S-nitrosothiol, S-nitroso-L-cysteine (L-CSNO), from primary carotid body glomus cells (PGCs) of rats that then activates chemosensory afferents of the carotid sinus nerve to elicit the hypoxic ventilatory response (HVR). The objective of this study was to provide direct evidence, using our capacitive S-nitrosothiol sensor, that L-CSNO is stored and released from PGCs extracted from male Sprague Dawley rat carotid bodies, and thus further pharmacological evidence for the role of S-nitrosothiols in mediating the HVR. Key findings of this study were that 1) lysates of PGCs contained an S-nitrosothiol with physico-chemical properties similar to L-CSNO rather than S-nitroso-L-glutathione (L-GSNO), 2) exposure of PGCs to a hypoxic challenge caused a significant increase in S-nitrosothiol concentrations in the perfusate to levels approaching 100 fM via mechanisms that required extracellular Ca2+, 3) the dose-dependent increases in minute ventilation elicited by arterial injections of L-CSNO and L-GSNO were likely due to activation of small diameter unmyelinated C-fiber carotid body chemoafferents, 4) L-CSNO, but not L-GSNO, responses were markedly reduced in rats receiving continuous infusion (10 μmol/kg/min, IV) of both S-methyl-L-cysteine (L-SMC) and S-ethyl-L-cysteine (L-SEC), 5) ventilatory responses to hypoxic gas challenge (10% O2, 90% N2) were also due to the activation of small diameter unmyelinated C-fiber carotid body chemoafferents, and 6) the HVR was markedly diminished in rats receiving L-SMC plus L-SEC. This data provides evidence that rat PGCs synthesize an S-nitrosothiol with similar properties to L-CSNO that is released in an extracellular Ca2+-dependent manner by hypoxia

Infrared light elicits endothelium-dependent vasodilation in isolated occipital arteries of the rat via soluble guanylyl cyclase-dependent mechanisms

The left and right occipital arteries provide blood supply to afferent cell bodies in the ipsilateral nodose and petrosal ganglia. This supply is free of an effective blood-ganglion barrier, so changes in occipital artery blood flow directly affect the access of circulating factors to the afferent cell bodies. The application of infrared (IR) light to modulate neural and other cell processes has yielded information about basic biological processes within tissues and is gaining traction as a potential therapy for a variety of disease processes. To address whether IR can directly modulate vascular function, we performed wire myography studies to determine the actions of IR on occipital arteries isolated from male Sprague-Dawley rats. Based on our previous research that functionally-important differences exist between occipital artery segments close to their origin at the external carotid artery (ECA) and those closer to the nodose ganglion, the occipital arteries were dissected into two segments, one closer to the ECA and the other closer to the nodose ganglion. Segments were constricted with 5-hydroxytryptamine to a level equal to 50% of the maximal response generated by the application of a high (80 mM) concentration of K+ ions. The direct application of pulsed IR (1,460 nm) for 5 s produced a rapid vasodilation in occipital arteries that was significantly more pronounced in segments closest to the ECA, although the ECA itself was minimally responsive. The vasodilation remained for a substantial time (at least 120 s) after cessation of IR application. The vasodilation during and following cessation of the IR application was markedly diminished in occipital arteries denuded of the endothelium. In addition, the vasodilation elicited by IR in endothelium-intact occipital arteries was substantially reduced in the presence of a selective inhibitor of the nitric oxide-sensitive guanylate cyclase, 1H-[1,2,4]oxadiazolo [4,3-a]quinoxalin-1-one (ODQ). It appears that IR causes endothelium-dependent, nitric-oxide-mediated vasodilation in the occipital arteries of the rat. The ability of IR to generate rapid and sustained vasodilation may provide new therapeutic approaches for restoring or improving blood flow to targeted tissues

L-cysteine ethyl ester prevents and reverses acquired physical dependence on morphine in male Sprague Dawley rats

The molecular mechanisms underlying the acquisition of addiction/dependence on morphine may result from the ability of the opioid to diminish the transport of L-cysteine into neurons via inhibition of excitatory amino acid transporter 3 (EAA3). The objective of this study was to determine whether the co-administration of the cell-penetrant L-thiol ester, L-cysteine ethyl ester (L-CYSee), would reduce physical dependence on morphine in male Sprague Dawley rats. Injection of the opioid-receptor antagonist, naloxone HCl (NLX; 1.5 mg/kg, IP), elicited pronounced withdrawal phenomena in rats which received a subcutaneous depot of morphine (150 mg/kg) for 36 h and were receiving a continuous infusion of saline (20 μL/h, IV) via osmotic minipumps for the same 36 h period. The withdrawal phenomena included wet-dog shakes, jumping, rearing, fore-paw licking, 360° circling, writhing, apneas, cardiovascular (pressor and tachycardia) responses, hypothermia, and body weight loss. NLX elicited substantially reduced withdrawal syndrome in rats that received an infusion of L-CYSee (20.8 μmol/kg/h, IV) for 36 h. NLX precipitated a marked withdrawal syndrome in rats that had received subcutaneous depots of morphine (150 mg/kg) for 48 h) and a co-infusion of vehicle. However, the NLX-precipitated withdrawal signs were markedly reduced in morphine (150 mg/kg for 48 h)-treated rats that began receiving an infusion of L-CYSee (20.8 μmol/kg/h, IV) at 36 h. In similar studies to those described previously, neither L-cysteine nor L-serine ethyl ester (both at 20.8 μmol/kg/h, IV) mimicked the effects of L-CYSee. This study demonstrates that 1) L-CYSee attenuates the development of physical dependence on morphine in male rats and 2) prior administration of L-CYSee reverses morphine dependence, most likely by intracellular actions within the brain. The lack of the effect of L-serine ethyl ester (oxygen atom instead of sulfur atom) strongly implicates thiol biochemistry in the efficacy of L-CYSee. Accordingly, L-CYSee and analogs may be a novel class of therapeutics that ameliorate the development of physical dependence on opioids in humans

Late style and speaking out: J A Symonds's In the Key of Blue

This article examines In the Key of Blue (1893)—an essay collection by John Addington Symonds—as a case study in queer public utterance during the early 1890s. Viewed through the critical lens of late style, as theorised by Edward Said, the evolution of this project, from compilation through to reader reception, reveals Symonds's determination to “speak out” on the subject of homosexuality. Paradoxically, In the Key of Blue was thus a timely and untimely work: it belonged to a brief period of increased visibility and expressiveness when dealing with male same-sex desire, spearheaded by a younger generation of Decadent writers, but it also cut against the grain of nineteenth-century social taboo and legal repression. Symonds's essay collection brought together new and previously unpublished work with examples of his writing for the periodical press. These new combinations, appearing together for the first time, served to facilitate new readings and new inferences, bringing homosexual themes to the fore. This article traces the dialogic structure of In the Key of Blue , its strategies for articulating homosexual desire, and examines the response of reviewers, from the hostile to celebratory