Investigation of liquid metal embrittlement of dual phase steel joints by electro-thermomechanical spot-welding simulation

A 3D electro-thermomechanical model is established in order to investigate liquid metal embrittlement. After calibration to a dual phase steel of the 1000 MPa tensile strength class, it is used to analyse the thermo-mechanical system of an experimental procedure to enforce liquid metal embrittlement during resistance spot welding. In this procedure, a tensile stress level is applied to zinc coated advanced high strength steel samples during welding. Thereby, liquid metal embrittlement formation is enforced, depending on the applied stress level and the selected material. The model is suitable to determine and visualise the corresponding underlying stresses and strains responsible for the occurrence of liquid metal embrittlement. Simulated local stresses and strains show good conformity with experimentally observed surface crack locations

The Ursinus Weekly, January 10, 1949

Ursinus represented at N.S.A. conference • Clash Dance to feature coming weekend events • New openings made by CCC for jobs in U.S. government • Placement service, reprimands, on list of council\u27s duties • President\u27s speech, Secretary Marshall top news of week • Beardwood\u27s events increase with age • Sensation scored by seniors with Club 49 • Student uncovers recipe for national economic prosperity • Dr. Helen Garrett aids Navy plans at U. of Columbia • What has been your most valuable course? • Open discussion of race equality scheduled by Y • Faculty members attain local honors; Dr. McClure given citizenship award • U.S Medical Corps formed for women • Creager starts chaplain\u27s duties • WSGA holding annual contest to choose May pageant script • Flowers and weeds top Kromka\u27s work • Regional assembly marks anniversary of NSA\u27s 2nd year • Conference delegates reach no conclusion • Future graduates given final notices • French lawyer to speak here tonight • Court lassies open season with Albright on Saturday • Natators commence practice with host of new candidates • Bears break even in league contests • Garnet ties Cadets for division honors • PMC edges Jay-Vees in 35-34 thriller; Cubs bow to Fords in overtime, 47-46 • Jaffe and Reice spark Seeders\u27 five in 47-45 triumph over Main Liners • Cadets open league with 72-50 victory in mid-week gamehttps://digitalcommons.ursinus.edu/weekly/1605/thumbnail.jp

Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial

PURPOSE Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit in mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially in pMMR disease. METHODS This phase III, global, double-blind, placebo-controlled trial randomly assigned eligible patients with newly diagnosed advanced or recurrent endometrial cancer 1:1:1 to: carboplatin/paclitaxel plus durvalumab placebo followed by placebo maintenance (control arm); carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib placebo (durvalumab arm); or carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib (durvalumab + olaparib arm). The primary end points were progression-free survival (PFS) in the durvalumab arm versus control and the durvalumab + olaparib arm versus control. RESULTS Seven hundred eighteen patients were randomly assigned. In the intention-to-treat population, statistically significant PFS benefit was observed in the durvalumab (hazard ratio [HR], 0.71 [95% CI, 0.57 to 0.89]; P = .003) and durvalumab + olaparib arms (HR, 0.55 [95% CI, 0.43 to 0.69]; P < .0001) versus control. Prespecified, exploratory subgroup analyses showed PFS benefit in dMMR (HR [durvalumab v control], 0.42 [95% CI, 0.22 to 0.80]; HR [durvalumab + olaparib v control], 0.41 [95% CI, 0.21 to 0.75]) and pMMR subgroups (HR [durvalumab v control], 0.77 [95% CI, 0.60 to 0.97]; HR [durvalumab + olaparib v control] 0.57; [95% CI, 0.44 to 0.73]); and in PD-L1-positive subgroups (HR [durvalumab v control], 0.63 [95% CI, 0.48 to 0.83]; HR [durvalumab + olaparib v control], 0.42 [95% CI, 0.31 to 0.57]). Interim overall survival results (maturity approximately 28%) were supportive of the primary outcomes (durvalumab v control: HR, 0.77 [95% CI, 0.56 to 1.07]; P = .120; durvalumab + olaparib v control: HR, 0.59 [95% CI, 0.42 to 0.83]; P = .003). The safety profiles of the experimental arms were generally consistent with individual agents. CONCLUSION Carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab with or without olaparib demonstrated a statistically significant and clinically meaningful PFS benefit in patients with advanced or recurrent endometrial cancer

Building biosensors for neuropsychopharmacology

Our understanding of the brain’s beautiful and complex machinery is largely driven by our ability to measure the chemical and electrical signals that govern its convoluted circuitry. As such, our knowledge is only as good as the tools we have at our disposal. The study of neurochemistry and neuropharmacology research has largely been driven by the use of microdialysis and electrochemical methods to measure targets of interest in the brain. While these techniques are powerful and have contributed immensely to our conceptualization of brain activity, they are not without their limitations. Briefly, microdialysis suffers from poor temporal resolution and lacks the potential for real-time data delivery, while previous electrochemical methods suffer from debatable specificity and limited generalizability for the detection of many critical targets. In response to these limitations, I have applied electrochemical aptamer-based (E-AB) sensors to the field of in-brain molecular sensing. The modular E-AB platform does not rely on the reactivity of its intended target, is generalizable to the detection of a wide range of analytes and has been shown to support real-time detection of small molecules directly in the living body. By modifying the existing E-AB platform, which has demonstrated success for peripheral measurements in blood, I have developed a novel E-AB sensor platform for making in-brain measurements of small molecules. In-brain E-AB sensing opens a path towards measuring a wide range of targets in the brain. To showcase this, I have applied this platform to model drug transport (using simultaneous measurements in blood and CSF), as well as study neuropsychopharmacology (using simultaneous measurements of a psychoactive drug and on-going behavior). Together these studies lay the foundation for a powerful new tool with which to study neurochemistry and neuropharmacology

The impact of iron sulfide on lead recovery at the giant Navan Zn-Pb orebody, Ireland

It has been proposed that blending of Navan Conglomerate Group Ore (CGO) with Pale Beds Ore (PBO), the latter which floats well in isolation, results in sub-optimal Pb recovery with increased abundance of pyrite reporting to the concentrate and increased abundance of galena reporting to the tails. QEMSCAN data indicate that poor liberation of galena particles is not the primary cause of sub-optimal recovery of galena. Rather, principal component analysis (PCA) of time of flight secondary ion mass spectrometry (ToF-SIMS) reveals that chemically altered surface species interfere with the selectivity and recovery of froth flotation indicating that there is some poisoning of galena mineral surfaces particularly with Fe-containing species possibly leading to loss of recovery. Analysis of the Pb-circuit cleaner tails indicates Pb-species association with sphalerite surfaces, as was observed for the flotation feed and rougher tails but with insufficient induced hydrophobicity by Pb–collector interaction for flotation. A small population of relatively clean galena surfaces is also observed which may result from low bubble–particle collision efficiency or insufficient liberation. Fine-grained framboidal pyrite is the main diluting phase in the cleaner concentrate and is likely present due to entrainment. The presence of framboidal pyrite in CGO is of particular significance as its large surface area increases the rate of galvanic interaction with other metal sulfide minerals. We propose that increased abundance of refractory framboidal pyrite in CGO is the critical factor affecting the performance of the Navan Pb flotation circuit rather than purely high pyrite abundance.Irish Research CouncilBoliden Tara Mines Ltd Enterprise Partnership Scheme PhD scholarshi

Model for the Evaluation of Technical Risk of Non-Compliance in the Construction Works of the Cyclovia in the Circumvallation Avenue of San Andres Island

Este proyecto consiste desarrollar un modelo que permita evaluar el riesgo técnico existente respecto al incumplimiento en la ejecución de la obra para la ciclovía en la avenida circunvalación de la Isla de San Andrés, encontrando la probabilidad de terminación a tiempo y dentro del presupuesto estimado inicialmente en la formulación del proyecto de ingeniería.This project consists in developing a model that allows to evaluate the existing technical risk regarding the non-compliance in the execution of the work for the bikeway in the circumvallation avenue of San Andres Island, finding the probability of termination on time and within the budget initially estimated in the formulation of the engineering project

Persistent effect of withdrawal from intravenous methamphetamine self-administration on brain activation and behavioral economic indices involving an effort cost

Exposure to drugs of abuse produces maladaptive changes in cost-benefit decision-making, including the evaluation of time and risk. Studies probing the effects of drug exposure on such evaluations have primarily used experimenter-administered drug regimens. Similarly, while much is known about the neural bases of effort, there have been relatively fewer investigations of the effects of drug experience on effort-based choices. We recently reported that experimenter-administered methamphetamine (meth) resulted in steeper discounting of effort for food rewards in rats, when assessed in protracted withdrawal. Here, we studied rats that underwent withdrawal from weeks of meth intravenous self-administration that later could freely select between a high effort, preferred option (progressive ratio lever pressing for sucrose pellets) versus a low effort, less preferred option (freely-available lab chow). We found decreased effort for the preferred reward and changes in a behavioral economic index demonstrating an increased sensitivity to effort in meth-experienced rats. Critically, the decreased effort for the preferred option was only present in the context of a competing option, not when it was the only option. We also confirmed rats preferred sucrose pellets over chow when both were freely available. These long-lasting changes were accompanied by decreased c-Fos activation in ventral striatum and basolateral amygdala, regions known to be important in effort-based choices. Taken together with our previous observations, these results suggest a robust and enduring effect of meth on value-based decision-making, and point to the underlying neural mechanisms that support the evaluation of an effort cost

Características de personalidad en presuntos agresores sexuales de menores de edad derivados al ministerio público, Arequipa

El objetivo de la presente investigación fue identificar las características de personalidad psicopatológica de presuntos agresores sexuales de menores de edad del Ministerio Publico, en el departamento de Arequipa. En la investigación se empleó un diseño descriptivo- comparativo de corte transversal. El tipo de muestreo fue no probabilístico, la muestra estuvo conformada por 93 presuntos agresores sexuales del sexo masculino y entre 17 a 72 años de la ciudad de Arequipa. Se aplicó una ficha de datos sociodemográficos y el test de personalidad MINIMULT. Cuya validez y confiabilidad fue de α=.84. Los resultados mostraron que los presuntos agresores sexuales de menores presentaron características psicopatológicas de personalidad, en las escalas clínicas de Desviación psicopática (36.6%), Esquizofrenia (36.6%), e Hipocondría (38.7%). Considerando como característica psicopatológica a todos aquellos que se encontraron en el nivel moderado y marcado. Lo que nos indicaría que existe un porcentaje importante de presuntos agresores con características de personalidad psicopatológicas, sin embargo, este porcentaje no fue representativo de la muestra, por lo que no existe un perfil específico de personalidad psicopatológica en los presuntos agresores sexuales de menores