Heat transfer enhancement with gas-to-gas micro heat exchangers

This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.A characterization of gas-to-gas micro heat exchangers has been performed in terms of pressure drop behavior and heat transfer performance. The gas-to-gas micro heat exchangers differ by partition wall material, partition wall thickness and flow arrangement. The pressure drop behavior has been analyzed due to the pressure losses in different sections of the gas-to-gas micro heat exchangers. Increased pressure losses in front of and behind the micro channels have been detected due to modified geometries in the inlet and outlet distribution chambers. The heat transfer performance has been determined in terms of thermal effectiveness. The comparison among different partition wall materials and partition wall thicknesses showed no significant criteria of the influence of thermal conductivity on the thermal effectiveness. An assessment due to an overall heat exchanger effectiveness has been performed to compare the gas-to-gas micro heat exchangers. For this purpose, the overall exergy loss has been calculated by combination of thermal effectiveness and pressure losses. A strong impact of the exergy loss due to pressure drop has been detected which influences the overall exergy loss of the gas-to-gas micro heat exchangers

Behavioral and Imaging Studies of Infant Artificial Grammar Learning

Artificial grammar learning (AGL) paradigms have proven to be productive and useful to investigate how young infants break into the grammar of their native language(s). The question of when infants first show the ability to learn abstract grammatical rules has been central to theoretical debates about the innate vs. learned nature of grammar. The presence of this ability early in development, that is, before considerable experience with language, has been argued to provide evidence for a biologically endowed ability to acquire language. Artificial grammar learning tasks also allow infant populations to be readily compared with adults and non-human animals. Artificial grammar learning paradigms with infants have been used to investigate a number of linguistic phenomena and learning tasks, from word segmentation to phonotactics and morphosyntax. In this review, we focus on AGL studies testing infants\u2019 ability to learn grammatical/structural properties of language. Specifically, we discuss the results of AGL studies focusing on repetition-based regularities, the categorization of functors, adjacent and non-adjacent dependencies, and word order. We discuss the implications of the results for a general theory of language acquisition, and we outline some of the open questions and challenges

Coulomb-U and magnetic moment collapse in δ\delta-Pu

The around-the-mean-field version of the LDA+U method is applied to investigate electron correlation effects in $\delta$-Pu. It yields a non-magnetic ground state of $\delta-$Pu, and provides a good agreement with experimental equilibrium volume, bulk modulus and explains important features of the photoelectron spectra

Influence of genomic variation in FTO at 16q12.2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk

Breast cancer is a major cause of cancer-related deaths in women. It is known that obesity is one of the risk factors of breast cancer. The subject of our interest was genes: FTO, MC4R and NRXN3–associated with obesity. In this study we have analyzed frequencies of genomic variants in FTO, MC4R and NRXN3 in the group of 134 breast cancer patients. We genotyped two polymorphic sites located in FTO gene (rs993909 and rs9930506), one polymorphic site of MC4R gene (rs17782313) and one polymorphic site of NRXN3 gene (rs10146997). Our hypothesis was that above mentioned SNPs could participate in carcinogenesis. Our research has showed that only rs10146997 was significantly (P = 0.0445) associated with higher risk of breast cancer development (OR = 0.66 (95% CI 0.44–0.99)). Moreover, G allele carriers in rs10146997 of the NRXN3 gene were the youngest patients at onset of breast cancer. On the basis of our research we suggest that further functional may elucidate the role of genomic variation in breast cancer development

The Las Campanas/AAT Rich Cluster Survey III: Spectroscopic Studies of X-ray Bright Galaxy Clusters at z~0.1

[abridged] We present the analysis of the spectroscopic and photometric catalogues of 11 X-ray luminous clusters at z=0.07-0.16 from the Las Campanas / Anglo-Australian Telescope Rich Cluster Survey. Our spectroscopic dataset consists of over 1600 galaxy cluster members, of which two thirds are outside r_200. We assign cluster membership using a detailed mass model and expand on our previous work on the cluster colour-magnitude relation where membership was inferred statistically. We confirm that the modal colours of galaxies on the colour magnitude relation become progressively bluer with increasing radius and decreasing local galaxy density. Interpreted as an age effect, we hypothesize that these trends in galaxy colour should be reflected in mean Hdelta equivalent width. We confirm that passive galaxies in the cluster increase in Hdelta line strength as dHdelta / d r_p = 0.35 +/- 0.06. A variation of star formation rate, as measured by [OII], with increasing local density of the environment is discernible and is shown to be in broad agreement with previous studies from 2dFGRS and SDSS. We find that clusters at z~0.1 are less active than their higher redshift analogues. We also investigate unusual populations of blue and very red nonstarforming galaxies and we suggest that the former are likely to be the progenitors of galaxies which will lie on the colour-magnitude relation, while the colours of the latter possibly reflect dust reddening. The cluster galaxies at large radii consist of both backsplash ones and those that are infalling to the cluster for the first time. We make a comparison to the field population at z~0.1 and examine broad differences between the two populations. Individually, the clusters show significant variation in their galaxy populations which reflects their recent infall histories.Comment: 25 pages, 16 figures. Accepted for publication in MNRA

Fatness-Associated FTO Gene Variant Increases Mortality Independent of Fatness – in Cohorts of Danish Men

The A-allele of the single nucleotide polymorphism (SNP), rs9939609, in the FTO gene is associated with increased fatness. We hypothesized that the SNP is associated with morbidity and mortality through the effect on fatness.In a population of 362,200 Danish young men, examined for military service between 1943 and 1977, all obese (BMI>or=31.0 kg/m(2)) and a random 1% sample of the others were identified. In 1992-94, at an average age of 46 years, 752 of the obese and 876 of the others were re-examined, including measurements of weight, fat mass, height, and waist circumference, and DNA sampling. Hospitalization and death occurring during the following median 13.5 years were ascertained by linkage to national registers. Cox regression analyses were performed using a dominant effect model (TT vs. TA or AA). In total 205 men died. Mortality was 42% lower (p = 0.001) with the TT genotype than in A-allele carriers. This phenomenon was observed in both the obese and the randomly sampled cohort when analysed separately. Adjustment for fatness covariates attenuated the association only slightly. Exploratory analyses of cause-specific mortality and morbidity prior to death suggested a general protective effect of the TT genotype, whereas there were only weak associations with disease incidence, except for diseases of the nervous system.Independent of fatness, the A-allele of the FTO SNP appears to increase mortality of a magnitude similar to smoking, but without a particular underlying disease pattern barring an increase in the risk of diseases of the nervous system

FTO Gene Associated Fatness in Relation to Body Fat Distribution and Metabolic Traits throughout a Broad Range of Fatness

A common single nucleotide polymorphism (SNP) of FTO (rs9939609, T/A) is associated with total body fatness. We investigated the association of this SNP with abdominal and peripheral fatness and obesity-related metabolic traits in middle-aged men through a broad range of fatness present already in adolescence.Obese young Danish men (n = 753, BMI > or = 31.0 kg/m(2)) and a randomly selected group (n = 879) from the same population were examined in three surveys (mean age 35, 46 and 49 years, respectively). The traits included anthropometrics, body composition, oral glucose tolerance test, blood lipids, blood pressure, fibrinogen and aspartate aminotransferase. Logistic regression analysis was used to assess the age-adjusted association between the phenotypes and the odds ratios for the FTO rs9939609 (TT and TA genotype versus the AA genotype), for anthropometrics and body composition estimated per unit z-score. BMI was strongly associated with the AA genotype in all three surveys: OR = 1.17, p = 1.1*10(-6), OR = 1.20, p = 1.7*10(-7), OR = 1.17, p = 3.4*10(-3), respectively. Fat body mass index was also associated with the AA genotype (OR = 1.21, p = 4.6*10(-7) and OR = 1.21, p = 1.0*10(-3)). Increased abdominal fatness was associated with the AA genotype when measured as waist circumference (OR = 1.21, p = 2.2*10(-6) and OR = 1.19, p = 5.9*10(-3)), sagittal abdominal diameter (OR = 1.17, p = 1.3*10(-4) and OR = 1.18, p = 0.011) and intra-abdominal adipose tissue (OR = 1.21, p = 0.005). Increased peripheral fatness measured as hip circumference (OR = 1.19, p = 1.3*10(-5) and OR = 1.18, p = 0.004) and lower body fat mass (OR = 1.26, p = 0.002) was associated with the AA genotype. The AA genotype was significantly associated with decreased Stumvoll insulin sensitivity index (OR = 0.93, p = 0.02) and with decreased non-fasting plasma HDL-cholesterol (OR = 0.57, p = 0.037), but not with any other of the metabolic traits. However, all significant results for both body fat distribution and metabolic traits were explained by a mediating effect of total fat mass.The association of the examined FTO SNP to general fatness throughout the range of fatness was confirmed, and this association explains the relation between the SNP and body fat distribution and decreased insulin sensitivity and HDL-cholesterol. The SNP was not significantly associated with other metabolic traits suggesting that they are not derived from the general accumulation of body fat