443 research outputs found
Investigation of shock-boundary-layer interaction on the spike of a conical-spike nose inlet
Measurements were made of the height of the shock-induced boundary-layer thickening and separation over a Mach number range of 1.6 to 2.0. The behavior of the interaction depended on longitudinal spike position as well as on cone surface Mach number. The cone position affected the interaction by changing the rate of subsonic diffusion and thereby changing the pressure aft of the terminal shock. When the pressure rise due to the interaction exceeded about 1.9, the boundary layer was separated
New Use for a Corn By-product
Iowa farmers can expect satisfactory results when Iowa-produced hydrol is fed to dairy cows
1936: Abilene Christian College Bible Lectures - Full Text
Delivered in the auditorium of Abilene Christian College, Abilene, Texas, February 193
A very brief description of LOFAR - the Low Frequency Array
LOFAR (Low Frequency Array) is an innovative radio telescope optimized for
the frequency range 30-240 MHz. The telescope is realized as a phased aperture
array without any moving parts. Digital beam forming allows the telescope to
point to any part of the sky within a second. Transient buffering makes
retrospective imaging of explosive short-term events possible. The scientific
focus of LOFAR will initially be on four key science projects (KSPs): 1)
detection of the formation of the very first stars and galaxies in the universe
during the so-called epoch of reionization by measuring the power spectrum of
the neutral hydrogen 21-cm line (Shaver et al. 1999) on the ~5' scale; 2)
low-frequency surveys of the sky with of order expected new sources; 3)
all-sky monitoring and detection of transient radio sources such as gamma-ray
bursts, x-ray binaries, and exo-planets (Farrell et al. 2004); and 4) radio
detection of ultra-high energy cosmic rays and neutrinos (Falcke & Gorham 2003)
allowing for the first time access to particles beyond 10^21 eV (Scholten et
al. 2006). Apart from the KSPs open access for smaller projects is also
planned. Here we give a brief description of the telescope.Comment: 2 pages, IAU GA 2006, Highlights of Astronomy, Volume 14, K.A. van
der Hucht, e
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances
Twin and family studies indicate that the timing of primary tooth eruption is highly heritable, with estimates typically exceeding 80%. To identify variants involved in primary tooth eruption we performed a population based genome-wide association study of ‘age at first tooth’ and ‘number of teeth’ using 5998 and 6609 individuals respectively from the Avon Longitudinal Study of Parents and Children (ALSPAC) and 5403 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966). We tested 2,446,724 SNPs imputed in both studies. Analyses were controlled for the effect of gestational age, sex and age of measurement. Results from the two studies were combined using fixed effects inverse variance meta-analysis. We identified a total of fifteen independent loci, with ten loci reaching genome-wide significance (p<5x10−8) for ‘age at first tooth’ and eleven loci for ‘number of teeth’. Together these associations explain 6.06% of the variation in ‘age of first tooth’ and 4.76% of the variation in ‘number of teeth’. The identified loci included eight previously unidentified loci, some containing genes known to play a role in tooth and other developmental pathways, including a SNP in the protein-coding region of BMP4 (rs17563, P= 9.080x10−17). Three of these loci, containing the genes HMGA2, AJUBA and ADK, also showed evidence of association with craniofacial distances, particularly those indexing facial width. Our results suggest that the genome-wide association approach is a powerful strategy for detecting variants involved in tooth eruption, and potentially craniofacial growth and more generally organ development
1958: Abilene Christian College Bible Lectures - Full Text
“GOD”
Being the
Abilene Christian College Annual
Bible Lectures
1958
Price: $3.00
Published by
FIRM FOUNDATION PUBLISHING HOUSE
Box 77 Austin, Texa
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts
Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing
molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin
- …