29 research outputs found
BHPR research: qualitative1. Complex reasoning determines patients' perception of outcome following foot surgery in rheumatoid arhtritis
- Author
- Abernethy Veronica
- Abignano Giuseppina
- Abraham David
- Abraham David
- Abraham David J.
- Abraham Sonya
- Adams Jo
- Adams Jo
- Adshead Rebecca
- Ahmad Yasmeen A.
- Ahmed Tazeen J.
- Ainley Louise
- Al-Allaf Wahab
- Alber Catherine Fouad
- Alhusain Awal Z.
- Ali Fizzah
- Allen Roger
- Alston Claire
- Alton Peter
- Anderson Marina
- Appleton Louise H.
- Ariyo Mercy
- Aronson Diane
- Arthanari S.
- Atteno Mariangela
- Backhouse Michael R.
- Backhouse Michael R.
- Bacon Paul A.
- Bacon Pauline
- Baker Sarah
- Baker Sharon
- Baker Sharon
- Balarajah Sharmili
- Ball Elisabeth
- Baqai Charlotte
- Bari Farhan
- Barton Anne
- Benson Claire
- Berry Jacqueline
- Bertolino Arthur
- Betteridge Zoe
- Beutler Anna
- Beutler Anna
- Beynon Huw
- Bhaduri Mahua
- Birt Linda
- Black Carol M.
- Bombardieri Michele
- Boton-Maggs Ben
- Bourke Brian E.
- Bouças Sofia Barbosa
- Braun Jürgen
- Breslin Anne
- Briggs N.
- Brophy Richard
- Brophy Sinead
- Brown Diane
- Browne Hannah K.
- Bruce Ian
- Bruce Ian
- Brunner Hermine
- Buch Maya H.
- Buckley Christopher
- Bunn Chris
- Bunn Diane
- Burns James
- Cadman Susan
- Campbell Sophie
- Carroll Douglas
- Carroll Douglas
- Castiglione Fabiana
- Cavet Guy
- Chaitow Jeffrey
- Chamberlain Victoria A.
- Chan Marian
- Chard Michael
- Charles Peter
- Charleton Rebecca C.
- Charlton-Menys Valentine
- Chattopadhyay Chandrabhusan
- Chattopadhyay Chandrabhusan
- Chevance Aurelie
- Chighizola Cecilia
- Chowdhary Bhavani
- Choy Ernest
- Choy Ernest H.
- Ciurtin Coziana
- Ciurtin Coziana
- Clayton Ann M.
- Clemence Mark
- Clewes Adrian
- Coghlan Gerry
- Coghlan Gerry
- Cohen Carla J.
- Collins David
- Conaghan Philip
- Conaghan Philip
- Conaghan Philip
- Connor John
- Cook Haley
- Cooksey Roxanne
- Cooney Jennifer K.
- Coop Hazel
- Cope Andrew
- Cornell Patricia
- Cornell Tricia
- Costa Luisa
- Crooks Daniel
- Cuomo Giovanna
- Dabu Bogdan
- Dabu Mihaela
- Dahmen Georg
- Dale Rebecca M.
- Dario Di Minno M. N.
- Davies Helen
- Davies Rebecca
- Davies Ursula
- Dawson Julie
- De Benedetti Fabrizio
- De Lord Denise
- Del Galdo Francesco
- Dennis Michael S.
- Dennis Sean
- Denton Chris
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Derrett-Smith Emma
- Devlin Clare
- Dey Dzifa
- Di Cicco Maria
- Dimofte Ionela
- Dixon William
- Dobarro David
- Dobarro David
- Done John
- Donnelly Simon P.
- Dougados Maxime
- Douiri Abdel
- Drew Sarah
- Duddy Martin
- Dunkley Lisa
- Dunphy Juliet
- Dures Emma
- Durrington Paul
- Dyke Claire
- Dziedzic Krysia
- Edwards Elizabeth A.
- Ehrenstein Michael
- Ellegard Karen
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Ennis Holly
- Epis Oscar
- Espada Graciela
- Evans Rob
- Eyes Brian
- Farewell Daniel
- Farrar Claire
- Ferguson Anna M.
- Filer Andrew
- Fisher Ben
- Flato Berit
- Fleischmann Roy
- Flurey Caroline A.
- Foglia Francesca
- Fonseca Carmen
- Foo Joanne
- France Brisa
- France Brisa
- Freeman Tanya
- Freeston Jane
- Freeston Jane
- Furlong Anita
- Furlong Anita
- Galloway James
- Gathany Tim
- Gaywood Ian C.
- Genovese Mark C.
- George Malal Joby J.
- Giancola Giorgio
- Giles Ian
- Gill Rachel
- Gladman Dafna
- Gladman Dafna
- Gooberman-Hill Rachael
- Goodacre Lynne
- Goodfellow Rhian
- Gordhan Chandrika
- Gorodkin Rachel
- Grainger Andrew
- Greenhalgh Ann
- Greenwood James
- Greenwood Mandy
- Griffith Sian
- Griffiths Ann E.
- Griffiths Bridget
- Grover Bob
- Gsteiger Sandro
- Gullick Nicola J.
- Gullick Nicola J.
- Hadjinicolaou Andreas V.
- Hadjinicolaou Andreas V.
- Hale Elizabeth
- Hale Elizabeth D.
- Hall Frances C.
- Hall Frances C.
- Hall John
- Halls Serena
- Hamilton Jennifer
- Hamilton Jennifer
- Hammond Alison
- Han Chenglong
- Han Chenglong
- Han Chenglong
- Handler Clive
- Handler Clive
- Hands Rebecca
- Haney Doug
- Hanson Mark
- Haq Inam
- Haq Inam
- Hayes Janita
- Haywood Kirstie L.
- Heckaman Michele
- Heckaman Michele
- Helliwell Philip
- Helliwell Philip
- Hensor Elizabeth
- Hensor Elizabeth
- Herrick Ariane L.
- Herrick Ariane L.
- Hewlett Sarah
- Hewlett Sarah
- Heycock Carol
- Hill Ingrid
- Hill Ingrid
- Hislop Kelly
- Ho Pauline
- Hodgson Richard
- Holmes A.
- Horneff Gerd
- Howell Kevin
- Hoyles Rachel
- Hsia Elizabeth
- Hueber Wolfgang
- Hughes Gwenan
- Hughes Lyndsay
- Hughes Rod
- Humby Fran
- Hurley Mike
- Hyrich Kimme
- Hyrich Kimme
- Ibrahim Fowzia
- Iervolino Salvatore
- Ioannou John
- Irvine Elizabeth
- Isaacs Anthony
- Isaacs David
- Isaacs John
- Ishorari Jasmine
- Jack James
- Jenkins Jessica
- Jenkins Suzanne
- Jinks Clare
- Jinks Clare
- Jobanputra Paresh
- John Holly
- Jones Jeremy
- Jones Jeremy G.
- Jones Tadeusz
- Jordan Kelsey
- Jordan Kelvin P.
- Juneja Parmjit
- Kamath Sanjeet
- Karaderi Tugce
- Karaderi Tugce
- Kavanaugh Arthur
- Kavanaugh Arthur
- Keenan Anne-Maree
- Keenan Anne-Maree
- Keidel Sarah
- Keller Majella
- Kelly Clive
- Kelly Clive
- Kelly Stephen
- Kenwright Andrew
- Keystone Edward
- Khan Korsa
- Khan Korsa
- Khan Korsa
- Kiely Patrick D.
- Kiely Patrick D.
- Kingsley Gabrielle H.
- Kingsley Gabrielle H.
- Kirkham Bruce
- Kirkham Bruce W.
- Kirwan John
- Kitas George
- Kitas George D.
- Kitas George D.
- Kitas George D.
- Kraus Alexandra
- Krueger Gerald
- Landewé Robert
- Law Rebecca-Jane
- Law Rebecca-Jane
- Lawson Tom
- Lazarus Mark
- Leandro Maria
- Leask Andrew
- Lemmey Andrew
- Lempp Heidi
- Leone Francesca
- Leung Alexander
- Lille Kate
- Liu Shangxi
- Lloyd Mark
- Lloyd Mark
- Lofrano Mariana
- Lottay Neena
- Lovell Daniel
- Low Audrey
- Lunt Mark
- Lunt Mark
- Lynch Michael
- Ma Margaret H.
- Mack Michael
- Mackay Kirsten
- Maddison Peter
- Maddison Peter
- Maddison Peter J.
- Makadsi Raad
- Malaviya Anshuman P.
- Malaviya Anshuman P.
- Malik Saadia
- Malik Saadia
- Manning Joanne
- Markland David
- Martin James C.
- Martin Keith
- Martini Alberto
- McArthur Margaret
- McHugh Neil
- McHugh Neil
- McInnes Iain
- McInnes Iain
- McInnes Iain
- McKeeman Helen
- McKenna Frank
- McLaughlin Maeve
- McLoughlin YokeMei
- McNeilly Natasha E.
- Mease Philip
- Mease Philip
- Mease Philip
- Mercer Louise
- Mewar Devesh
- Mirjafari Hoda
- Moffat Claire
- Moinzadeh Pia
- Moinzadeh Pia
- Moore Jonathan P.
- Moore Owen
- Moore Tonia
- Morris Marianne
- Morris Vanessa
- Mudivarthy Surekha
- Muir Lindsay
- Munns Catherine
- Nandagudi Anupama
- Neville Cai
- Neville Cai
- Ng Nora
- Ngcozana Tanaka
- Nguyen Dianne
- Nightingale Peter
- Nihtyanova Svetlana
- Nisar M.
- Nisar Muhammad K.
- Nisar Muhammad K.
- Nordenskiold Ulla
- O'Connor Philip J.
- Ong Bie Nio
- Ong Voon
- Ong Voon
- Ong Voon
- Owen Pat
- Packham Jon
- Pande Ira
- Panthakalam Sathianathan
- Pardeo Manuela
- Parker Louise
- Parker S.
- Partlett Rosamund
- Patel Dipti
- Patterson Chris
- Pauling John
- Pauling John D.
- Pavey Chee
- Pease Colin T.
- Pease Emily E.
- Pellegrini Vincent
- Peluso Rosario
- Penn Henry
- Petford Sharon
- Pitzalis Costantino
- Pointon Jennifer J.
- Pointon Jennifer J.
- Pollard Louise C.
- Pollock Jon
- Pradère Marie-Josèphe
- Price Elizabeth
- Price Shyra
- Puntis Daniel
- Quest Enid
- Quinlan Tim M.
- Rahmeh Fouz
- Rajak Rizwan
- Rajak Rizwan
- Ramanujan Saroja
- Rankin Elizabeth
- Raut-Roy Dominique
- Redmond Anthony
- Redmond Anthony
- Reynolds John A.
- Rhodes Carol
- Rhys-Dillon Ceril
- Rhys-Dillon Ceril
- Richards Pam
- Richards Selwyn
- Richardson Ann
- Robinson Sandra M.
- Rodziewicz Mia
- Rose Katy
- Rosenberg William M.
- Rubbert-Roth Andrea
- Ruddlesden Michael
- Ruddlesden Michael
- Ruperto Nicola
- Russell Bridget
- Ryan Sarah
- Ryan Sarah
- Ryan Sarah
- Rynne Martin
- Sandhu Amrita
- Sandhu Virinderjit
- Sandoo Aamer
- Sandoo Aamer
- Sanyal Kaushik
- Saravanan Vadivelu
- Scali Juan
- Scarpa Raffaele
- Schneider Rayfel
- Schreiber Benjamin E.
- Schreiber Benjamin E.
- Schulze-Koops Hendrik
- Scott David
- Scott David L.
- Scott David L.
- Scott David L.
- Scott David L.
- Sebba Anthony
- Sen Debajit
- Sengupta Raj
- Sengupta Raj
- Shah Preeti
- Shattles Warren
- Shipley Mike
- Shiwen Xu
- Shiwen Xu
- Siebert Stefan
- Sieper Joachim
- Silman Alan
- Singh Animesh
- Smith Angela
- Smith H.
- Smith Jacqueline
- Smith Jacqueline
- Smith Jacqueline P.
- Soh Vicky
- Soscia Ernesto
- Spencer Simon
- Stratton Richard
- Stratton Richard
- Strickland Gemma
- Sykes Rebecca
- Symmons Deborah
- Symmons Deborah
- Taggart Allister
- Tahir Hasan
- Tak Paul P.
- Tandon Neeta
- Tanner Lorraine
- Tarzi Mike
- Taylor Peter
- Taylor Peter
- Tennant Alan
- Terslev Lene
- Thalayasingam Nishanthi
- Thom Jeanette
- Thom Jeanette M.
- Thom Jeanette M.
- Thomas Amanda
- Thomas Amanda
- Thomas Eleri
- Thomas Tasmin
- Thompson Katherine
- Thompson Liz
- Thompson Nicola
- Thwaites Catharine
- Tibble Jeremy
- Toberty Elizabeth
- Toms Tracey
- Toms Tracey E.
- Trehane Anne
- Treharne Gareth J.
- Turner Michael
- Turner-Cobb Julie
- Tyson Sarah
- Vail Andy
- Valentini Gabriele
- van der Heijde Desiree
- van der Heijde Désirée
- Van Vollenhoven Ronald
- van Zanten Jet J. Veldhuijzen
- Verstappen Suzanne M.
- Vinall Karen A.
- Wajed Julekha
- Wakefield Richard J.
- Walker David
- Wallis Dinny
- Wardle Phil
- Warrell Clare
- Warrell Clare E.
- Waterfield Jackie
- Watson Kath
- Watson Liam
- Westlake Sarah L.
- Westlake Sarah L.
- White Catherine
- White Derrick
- Wig Surabhi
- Wilby M. J.
- Wilkinson Kate
- Williams Ann
- Williamson Lyn
- Wilson Jo
- Wilson Oonagh
- Wincup Chris
- Winfield Rachel A.
- Wing Charlotte
- Winter Richard
- Wollenhaupt Jürgen
- Wong Henna
- Woo Patricia
- Wordsworth Bryan P.
- Wordsworth Bryan P.
- Wren Damian
- Wright Gary
- Xu Weichun
- Yau Wing Hoi
- Youll Matthew J.
- Young Adam
- Young Adam
- Zayat Ahmed S.
- Zilberstein Moshe
- Zouita Louisa
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: Foot surgery is common in patients with RA but research into surgical outcomes is limited and conceptually flawed as current outcome measures lack face validity: to date no one has asked patients what is important to them. This study aimed to determine which factors are important to patients when evaluating the success of foot surgery in RA Methods: Semi structured interviews of RA patients who had undergone foot surgery were conducted and transcribed verbatim. Thematic analysis of interviews was conducted to explore issues that were important to patients. Results: 11 RA patients (9 ♂, mean age 59, dis dur = 22yrs, mean of 3 yrs post op) with mixed experiences of foot surgery were interviewed. Patients interpreted outcome in respect to a multitude of factors, frequently positive change in one aspect contrasted with negative opinions about another. Overall, four major themes emerged. Function: Functional ability & participation in valued activities were very important to patients. Walking ability was a key concern but patients interpreted levels of activity in light of other aspects of their disease, reflecting on change in functional ability more than overall level. Positive feelings of improved mobility were often moderated by negative self perception ("I mean, I still walk like a waddling duck”). Appearance: Appearance was important to almost all patients but perhaps the most complex theme of all. Physical appearance, foot shape, and footwear were closely interlinked, yet patients saw these as distinct separate concepts. Patients need to legitimize these feelings was clear and they frequently entered into a defensive repertoire ("it's not cosmetic surgery; it's something that's more important than that, you know?”). Clinician opinion: Surgeons' post operative evaluation of the procedure was very influential. The impact of this appraisal continued to affect patients' lasting impression irrespective of how the outcome compared to their initial goals ("when he'd done it ... he said that hasn't worked as good as he'd wanted to ... but the pain has gone”). Pain: Whilst pain was important to almost all patients, it appeared to be less important than the other themes. Pain was predominately raised when it influenced other themes, such as function; many still felt the need to legitimize their foot pain in order for health professionals to take it seriously ("in the end I went to my GP because it had happened a few times and I went to an orthopaedic surgeon who was quite dismissive of it, it was like what are you complaining about”). Conclusions: Patients interpret the outcome of foot surgery using a multitude of interrelated factors, particularly functional ability, appearance and surgeons' appraisal of the procedure. While pain was often noted, this appeared less important than other factors in the overall outcome of the surgery. Future research into foot surgery should incorporate the complexity of how patients determine their outcome Disclosure statement: All authors have declared no conflicts of interes
Transmission of Yellow Fever Vaccine Virus Through Blood Transfusion and Organ Transplantation in the USA in 2021: Report of an Investigation
- Author
- Ackelsberg Joel
- Ballen Vennus
- Basavaraju Sridhar V.
- Berk Matthew A.
- Bhatnagar Julu
- Brault Aaron C.
- Chiu Charles Y.
- Craig-Shapiro Rebecca
- Dailey Kimberly
- Davis Emily H.
- Dean Amy B.
- Doan Thuy
- Fitzpatrick Kelly A.
- Free Rebecca J.
- Gould Carolyn V.
- Gyure Kymberly A.
- Hadi Azam
- Hughes Holly R.
- Kessler Debra A.
- Kodiyanplakkal Rosy Priya L.
- Kuehnert Matthew J.
- Laven Janeen J.
- Lee Elizabeth
- Lehman Jennifer A.
- Maley Warren R.
- Miller Steve
- Moss Sean
- Muthukumar Thangamani
- Omura Charles
- Panella Amanda
- Pereira Marcus
- Puius Yoram A.
- Raina Amresh
- Reagan-Steiner Sarah
- Ritter Jana M.
- Royer Tricia L.
- Silva-Flannery Luciana
- Soto Raymond A.
- St George Kirsten
- Staples J. Erin
- Trief Danielle
- Velez Jason O.
- Westblade Lars F.
- Wilson Michael R.
- Publication venue
- Jefferson Digital Commons
- Publication date
- 03/08/2023
- Field of study
BACKGROUND: In 2021, four patients who had received solid organ transplants in the USA developed encephalitis beginning 2-6 weeks after transplantation from a common organ donor. We describe an investigation into the cause of encephalitis in these patients.
METHODS: From Nov 7, 2021, to Feb 24, 2022, we conducted a public health investigation involving 15 agencies and medical centres in the USA. We tested various specimens (blood, cerebrospinal fluid, intraocular fluid, serum, and tissues) from the organ donor and recipients by serology, RT-PCR, immunohistochemistry, metagenomic next-generation sequencing, and host gene expression, and conducted a traceback of blood transfusions received by the organ donor.
FINDINGS: We identified one read from yellow fever virus in cerebrospinal fluid from the recipient of a kidney using metagenomic next-generation sequencing. Recent infection with yellow fever virus was confirmed in all four organ recipients by identification of yellow fever virus RNA consistent with the 17D vaccine strain in brain tissue from one recipient and seroconversion after transplantation in three recipients. Two patients recovered and two patients had no neurological recovery and died. 3 days before organ procurement, the organ donor received a blood transfusion from a donor who had received a yellow fever vaccine 6 days before blood donation.
INTERPRETATION: This investigation substantiates the use of metagenomic next-generation sequencing for the broad-based detection of rare or unexpected pathogens. Health-care workers providing vaccinations should inform patients of the need to defer blood donation for at least 2 weeks after receiving a yellow fever vaccine. Despite mitigation strategies and safety interventions, a low risk of transfusion-transmitted infections remains.
FUNDING: US Centers for Disease Control and Prevention (CDC), the Biomedical Advanced Research and Development Authority, and the CDC Epidemiology and Laboratory Capacity Cooperative Agreement for Infectious Diseases
The Science Performance of JWST as Characterized in Commissioning
- Author
- Abell Jim
- Abney Faith
- Abul-Huda Yasin
- Acton D. Scott
- Adams Evan
- Adler David
- Aguilar Jonathan
- Ahmed Nasif
- Alarcon Rafael Ramos
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Marsha
- Altenburg Martin
- Alvarez Jose Lorenzo
- Andersen Greg
- Anderson Harry
- Anderson Sara
- Argyriou Ioannis
- Armstrong Amber
- Arribas Santiago
- Artigau Etienne
- Arvai Amanda
- Atkinson Charles
- Bacon Gregory
- Bair Thomas
- Banks Kimberly
- Barrientes Jaclyn
- Barringer Bruce
- Bartosik Peter
- Bast William
- Baudoz Pierre
- Beatty Thomas
- Bechtold Katie
- Beck Tracy
- Bergeron Eddie
- Bergkoetter Matthew
- Bhatawdekar Rachana
- Birkmann Stephan
- Blazek Ronald
- Blome Claire
- Boccaletti Anthony
- Boeker Torsten
- Boia John
- Bonaventura Nina
- Bond Nicholas
- Bosley Kari
- Boucarut Ray
- Bourque Matthew
- Bouwman Jeroen
- Bower Gary
- Bowers Charles
- Boyer Martha
- Bradley Larry
- Brady Greg
- Braun Hannah
- Breda David
- Bresnahan Pamela
- Bright Stacey
- Britt Christopher
- Bromenschenkel Asa
- Brooks Brian
- Brooks Keira
- Brown Bob
- Brown Matthew
- Brown Patricia
- Bunker Andy
- Burger Matthew
- Bushouse Howard
- Cale Steven
- Cameron Alex
- Cameron Peter
- Canipe Alicia
- Caplinger James
- Caputo Francis
- Cara Mihai
- Carey Larkin
- Carniani Stefano
- Carrasquilla Maria
- Carruthers Margaret
- Case Michael
- Catherine Riggs
- Chance Don
- Chapman George
- Charlot Stéphane
- Charlow Brian
- Chayer Pierre
- Chen Bin
- Cherinka Brian
- Chichester Sarah
- Chilton Zack
- Chonis Taylor
- Clampin Mark
- Clark Charles
- Clark Kerry
- Coe Dan
- Coleman Benee
- Colon Knicole
- Comber Brian
- Comeau Tom
- Connolly Dennis
- Cooper James
- Cooper Rachel
- Coppock Eric
- Correnti Matteo
- Cossou Christophe
- Coulais Alain
- Coyle Laura
- Cracraft Misty
- Curti Mirko
- Cuturic Steven
- Davis Katherine
- Davis Michael
- de Oliveira Catarina Alves
- Dean Bruce
- Del Pino Bruno Rodriguez
- DeLisa Amy
- deMeester Wim
- Dencheva Nadezhda
- Dencheva Nadia
- DePasquale Joseph
- Deschenes Jeremy
- Detre Örs Hunor
- Diaz Rosa
- Dicken Dan
- DiFelice Audrey
- Dillman Matthew
- Dixon William
- Doggett Jesse
- Donaldson Tom
- Douglas Rob
- Doyon René
- DuPrie Kimberly
- Dupuis Jean
- Durning John
- Easmin Nilufar
- Eck Weston
- Edeani Chinwe
- Egami Eiichi
- Ehrenwinkler Ralf
- Eisenhamer Jonathan
- Eisenhower Michael
- Elie Michelle
- Elliott James
- Elliott Kyle
- Ellis Tracy
- Engesser Michael
- Espinoza Nestor
- Etienne Odessa
- Etxaluze Mireya
- Falini Patrick
- Feeney Matthew
- Feinberg Lee
- Ferruit Pierre
- Ferry Malcolm
- Filippazzo Joseph
- Fincham Brian
- Fix Mees
- Flagey Nicolas
- Florian Michael
- Flynn Jim
- Fontanella Erin
- Ford Terrance
- Forshay Peter
- Fox Ori
- Franz David
- Friedman Scott
- Fu Henry
- Fullerton Alexander
- Galkin Sergey
- Galyer Anthony
- Gardner Jonathan
- Gardner Lisa
- Garland Dennis
- Garrett Bruce
- Gasman Danny
- Gaspar Andras
- Gaudreau Daniel
- Gauthier Peter
- Geers Vincent
- Geithner Paul
- Gennaro Mario
- Giardino Giovanna
- Girard Julien
- Giuliano Mark
- Glasse Alistair
- Glassmire Kirk
- Glauser Adrian
- Glazer Stuart
- Godfrey John
- Golimowski David
- Gollnitz David
- Gong Fan
- Gonzaga Shireen
- Gordon Karl
- Gordon Michael
- Goudfrooij Paul
- Greene Thomas
- Greenhouse Matthew
- Grimaldi Stefano
- Groebner Andrew
- Grundy Timothy
- Guillard Pierre
- Gutman Irvin
- Ha Kong Q.
- Haderlein Peter
- Hagedorn Andria
- Hainline Kevin
- Haley Craig
- Hami Maryam
- Hamilton Forrest
- Hammel Heidi
- Hansen Carl
- Harkins Tom
- Harr Michael
- Hart Jessica
- Hart Quyen
- Hartig George
- Hashimoto Ryan
- Haskins Sujee
- Hathaway William
- Havey Keith
- Hayden Brian
- Hecht Karen
- Heller-Boyer Chris
- Henriques Caroline
- Henry Alaina
- Hermann Karl
- Hernandez Scarlin
- Hesman Brigette
- Hicks Brian
- Hilbert Bryan
- Hines Dean
- Hoffman Melissa
- Holfeltz Sherie
- Holler Bryan J.
- Hoppa Jennifer
- Hott Kyle
- Howard Joseph
- Howard Rick
- Hunter Alexander
- Hunter David
- Hurst Brendan
- Husemann Bernd
- Hustak Leah
- Ignat Luminita Ilinca
- Illingworth Garth
- Irish Sandra
- Jackson Wallace
- Jahromi Amir
- Jakobsen Peter
- James Bryan
- James LeAndrea
- Januszewski William
- Jenkins Ann
- Jirdeh Hussein
- Johnson Phillip
- Johnson Timothy
- Jones Danny
- Jones Olivia
- Jones Ron
- Jones Vicki
- Jordan Ian
- Jordan Margaret
- Jurczyk Sarah
- Jurling Alden
- Kaleida Catherine
- Kalmanson Phillip
- Kammerer Jens
- Kang Huijo
- Kao Shaw-Hong
- Karakla Diane
- Kavanagh Patrick
- Kelly Doug
- Kendrew Sarah
- Kennedy Herbert
- Kenny Deborah
- Keski-kuha Ritva
- Keyes Charles
- Kidwell Richard
- Kimble Randy
- Kinzel Wayne
- Kirk Jeff
- Kirkpatrick Mark
- Kirshenblat Danielle
- Klaassen Pamela
- Knapp Bryan
- Knight J. Scott
- Knollenberg Perry
- Koehler Robert
- Koekemoer Anton
- Kovacs Aiden
- Kulp Trey
- Kumari Nimisha
- Kyprianou Mark
- La Massa Stephanie
- Labador Aurora
- Lagage Pierre-Olivier
- Lajoie Charles-Phillipe
- Lallo Matt
- Lallo Matthew
- Lam May
- Lamb Tracy
- Lambros Scott
- Lampenfield Richard
- Langston James
- Larson Kirsten
- Law David
- Lawrence Jon
- Lee David
- Leisenring Jarron
- Lepo Kelly
- Leveille Michael
- Levenson Nancy
- Levine Marie
- Levy Zena
- Lewis Dan
- Lewis Hannah
- Libralato Mattia
- Lightsey Paul
- Link Miranda
- Liu Lily
- Lo Amy
- Lockwood Alexandra
- Logue Ryan
- Long Chris
- Long Douglas
- Loomis Charles
- Lopez-Caniego Marcos
- Love-Pruitt Jennifer
- Lucy Adrian
- Luetzgendorf Nora
- Maghami Peiman
- Maiolino Roberto
- Major Melissa
- Malla Sunita
- Malumuth Eliot
- Manjavacas Elena
- Mannfolk Crystal
- Marin Macarena Garcia
- Marquez Javier Alvarez
- Marrione Amanda
- Marston Anthony
- Martel André
- Maschmann Marc
- Masci Gregory
- Masciarelli Michaela
- Maszkiewicz Michael
- Mather John
- McElwain Michael
- McKenzie Kenny
- McLean Brian
- McMaster Matthew
- Melbourne Katie
- Meléndez Marcio
- Menzel Michael
- Merz Kaiya
- Meyett Michele
- Meza Luis
- Milam Stefanie
- Miskey Cherie
- Misselt Karl
- Moller Christopher
- Morrison Jane
- Morse Ernie
- Moseley Harvey
- Mosier Gary
- Mountain Matt
- Mueckay Julio
- Mueller Michael
- Mullally Susan
- Murphy Jess
- Murray Claire
- Murray Katherine
- Mustelier David
- Muzerolle James
- Mycroft Matthew
- Myers Richard
- Myrick Kaila
- Nanavati Shashvat
- Nance Elizabeth
- Nayak Omnarayani
- Naylor Bret
- Neff Susan
- Neira Irma Quispe
- Nelan Edmund
- Nickson Bryony
- Nielson Alethea
- Nieto-Santisteban Maria
- Nikolov Nikolay
- Noriega-Crespo Alberto
- O'Shaughnessy Brian
- O'Sullivan Brian
- Ochs William
- Ogle Patrick
- Oleszczuk Brenda
- Olmsted Joseph
- Ortega Alvaro Labiano
- Osborne Shannon
- Ottens Richard
- Owens Beverly
- Pacifici Camilla
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- Williams Christina
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- Willott Chris
- Willoughby Scott
- Wilson Andrew
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- Wislowski Emily
- Wolf Erin
- Wolfe David
- Wolff Schuyler
- Workman Bill
- Wright Gillian
- Wright Ray
- Wu Carl
- Wu Rai
- Wymer Kristen
- Yates Kayla
- Yeager Christopher
- Yeates Jared
- Yerger Ethan
- Yoon Jinmi
- Young Alice
- Yu Susan
- Zak Dean
- Zeidler Peter
- Zhou Julia
- Zielinski Thomas
- Zincke Cristian
- Zonak Stephanie
- Publication venue
- 'IOP Publishing'
- Publication date
- 10/04/2023
- Field of study
This paper characterizes the actual science performance of the James Webb
Space Telescope (JWST), as determined from the six month commissioning period.
We summarize the performance of the spacecraft, telescope, science instruments,
and ground system, with an emphasis on differences from pre-launch
expectations. Commissioning has made clear that JWST is fully capable of
achieving the discoveries for which it was built. Moreover, almost across the
board, the science performance of JWST is better than expected; in most cases,
JWST will go deeper faster than expected. The telescope and instrument suite
have demonstrated the sensitivity, stability, image quality, and spectral range
that are necessary to transform our understanding of the cosmos through
observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures;
https://iopscience.iop.org/article/10.1088/1538-3873/acb29
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
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- Caryl David
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- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
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- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
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- Dagmar Bartaskova
- Dale Crawford Allison
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- Dana Cosma
- Daniel Coyne
- Daniel Hiser
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- Daniel Panarotto
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- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
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- Edwards R.
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- Elizabeth Barranco
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- Eloisa Tellez Chavez
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- Emil Martinka
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- Heerspink H. J. L.
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- Jardine M. J.
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- Javier Narvarte
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- Jean Carlo Tibes Hachmann
- Jean Welsh
- Jean-Pierre Fauvel
- Jeevren Reddy
- Jeffrey Kropp
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- Jiao Sun
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- José Vicente Sanchez Polo
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- Juan Villagordoa Mesa
- JungEun Lee
- Kamal Abouglila
- Karel Peterka
- Karina Hufert
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- Kazunori Koyama
- Kazuyuki Mizuyama
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- Kenneth Liss
- Kenneth W Mahaffey
- Khalid Abdul Kadir
- Khurram Wadud
- Kim Travis
- Kiril Hristozov
- Kook-Hwan Oh
- Krisztian Kiss
- Kun Ho Yoon
- Lachezar Lozanov
- Lajos Major
- Lalaine Delos Santos
- Landman Lombard
- Larisha Pillay-Ramaya
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- Larysa Pererva
- Laszlo Deak
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- Sandra Berenice Saaveddra Sanchez
- Sanjeev Rastogi
- Sara Jaffer
- Sarah Olelewe
- Satoshi Ota
- Satu Pesickova
- Scott Kasner
- Secundino Cigarran Guldris
- Senan Sultan
- Serge Cournoyer
- Sergei Nedogoda
- Sergey Vorobyev
- Sergio Saul Irizar Santana
- Shahabul Arfeen
- Shahnaz Shahinfar
- Shang-Jyh Hwang
- Shelley Williams
- Shenaz Ramtoola
- Shenglian Gan
- Sherry Sussman
- Shizuo Kajiyama
- Shozo Miyauchi
- Silvia Ines Orio
- Silvia Nicolai
- Simon Davies
- Simon Roger
- Simon Young
- Sin Gon Kim
- Singhan Krishnan
- Sini George
- Slobodan Antic
- Sohan Dua
- Sonia Hermida
- Soo Kun Lim
- Sophie Borot
- Souhila Ounadjela
- Sreedhar Mandayam
- Srikanth Bellary
- Stanislav Zemek
- Stanislaw Mazur
- Stefan Dimitrov
- Stephan Maxeiner
- Stephen Grubb
- Stephen Smith
- Steven Fishbane
- Stuart Handelsman
- Suely Keiko Kohara
- Sun Kim
- Sun-Hee Park
- Sunil Sheth
- Susumu Kashine
- Svetlana Goykhman
- Svitlana D Bilyk
- Swee Win Lam
- Sylvia Rosas
- Sylvia Shaw
- Szilard Vasas
- Sérgio Alberto Cunha Vêncio
- Sérgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
- Tetyana Pertseva
- Tiago Schuch
- Timothy Hall
- Tom Christensen
- Tom Greene
- Tomas Drasnar
- Tomas Smith Casabella
- Tonatiu Diaz Escalante
- Toshihiko Yanase
- Toshio Kawada
- Vadym Vizir
- Vanassa Ratnasingam
- Venessa Tsang
- Venkata Behara
- Vera Klokocnikova
- Vera Krane
- Veronica Anghel
- Veselka Genadieva
- Vesna Popovic-Radinovic
- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
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- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
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- Heitmann Katja
- Helfenbein Keven
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- Hellsten Uffe
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- Hepa Victor
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- Hewitt Stephen
- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
- Holden Jane
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- Holmes Sarah
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- Holtzer Caleb
- Homsi Deana K.
- Homsi Farah J.
- Honan Tracy
- Hood Leroy
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- Idlebird Devincent G.
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- Ishibashi Akiko
- Ishikawa Sabine K.
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- Nakato Eriko
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- Nandkeshwar Richard
- Nankervis Colin E.
- Naranjo Cleo M.
- Nash William
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- Nwokenkwo Stanley
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- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
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- Olson Maynard V.
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- Patel Ritesh
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- Paul Shelia
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- Pennacchio Len A.
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- Perez Lesette M.
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- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
- Ananthapadmanabhan Shravankrishna
- Anderson Paul
- Andrew Paul Chimezie
- Andriani Adelaide
- Anestiadou Elissavet
- Angelis Fragkiskos
- Angeslis Fragkiskos
- Aqeel Syed Talha Bin
- Aral Canan
- Arebi Jaber
- Arnaoutoglou Eleni
- Arslangilay Mert
- Arvanitaki Alexandra
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- Ashour Amira
- Ashraf Hamza
- Ashur Abir Ben
- Asjad Imran
- Askar Aamal
- Askin Abdullah Emre
- Aslam Muhammad Nadeem
- Aslan Merve
- Aslangilay Mert
- Astal Mohammed
- Asudo Felicia
- Atadag Yildiz Buyukdereli
- Atef Dina
- Athamneh Tayseer
- Athanasiadis Apostolos
- Ather M Hammad
- Atherton Kristy
- Atia Ahmed
- Atici Semra Demirli
- Atilhan Ridvan
- Atim Terkaa
- Atiq Tabish
- Atta Raneem
- Attia Mohamed
- Attiya Omar
- Awad Hasan
- Awadallah Safaa
- Awoyinka Babatunde
- Ayasrah Salem
- Aydin Cemil
- Aydoğdu Erhan Onur
- Ayogu Emeka
- Ayoub Kerillos
- Ayyad Alaa
- Azboy Ibrahim
- Azer Armia
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- Babalola Olakunle
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- Babiker Afra
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- Bakeer Hibah Bileid
- Bakeer Mohammed
- Balciscueta Zutoia
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- Barbaro Antonio
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- Barker Sally
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- Bolton Damien
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- Bowman Sarah
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- Bresadola Vittorio
- Brewster Dani
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- Burruso Luca
- Busaidi Ibrahim S Al
- Bushaala Hassan
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- Butyrskii Aleksandr
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- Cakcak Ibrahim Ethem
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- Changati Varun
- Chao Phoebe
- Chau Michelle
- Chau Michelle
- Chauhan Karanjeet
- Chawla Tabish
- Chen Andrew
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- Shanahan James
- Shang Mengge
- Shannaq Rabab
- Shaqran Osama Al
- Sharma Sonakshi
- Sharp James
- Shaw Haylee
- Shaw Henry
- Shehab Ali Fahmy
- Shehahda Sireen
- Shehata Mena
- Shen Yijia
- Sherif Yara
- Sheriff Arfaan
- Shetwan Sundes
- Shipa Ahmed
- Shiru Mariam Motunrayo
- Shrestha Pallavi
- Shuaibu Ibrahim Shaphat
- Shui Amanda
- Sibic Osman
- Sierra Oscar Alonso Verduzco
- Silem Yousra Othman Reham
- Silva Yannick De
- Silverii Julia
- Simiona Levi
- Simonetti Marta
- Singer David
- Singh Abhinav
- Singh Gopal
- Singh Jasraaj
- Singh Madhavi
- Singh Ramnik
- Singh Surya
- Singh Surya
- Singhal Megan
- Sinha Akansha
- Siribaddana Venesa
- Sivakumar Gananadha
- Sivakumar Seiyon
- Sivasuthan Goutham
- Sivrikaya Ramazan Kemal
- Skalidou Smaragda
- Skoufias Spyridon
- Slavec Mark
- Smadi Rayyan
- Smith Corinne
- Smith Nicolas
- Smith Quintin
- Smitham Peter
- Snider Ruth
- Sobhy George
- Soek Jenny
- Sofian Ahmad Anuar
- Soh Isabel
- Soh Jien Yen
- Soh Qi Rui
- Soh Rachel TingQian
- Sok Rumnea
- Sokmen Selman
- Solagbade Remi Sanyaolu
- Solanki Krisha
- Solar Caitlin Del
- Soliman Keroles
- Soliman Mahmoud Ayman
- Soliman Nisha Bianca
- Soliman Randa
- Soltan Hatem
- Songden Zumnan
- Soni Akshay
- Soula Enas
- Soytas Mustafa
- Sriranjan Roshni
- Sritharan Mithra
- Srivastava Shambhavi
- Standish Lucy
- Stavratis Fotios
- Stevens Sean
- Stewart Peter
- Stokes Andrew
- Struthers Jamie
- Studd Rod
- Sulaiman Bilal
- Suleiman Khadijah Richifa
- Suliman Hozifa Mohamed Abdalla
- Suliman Merna Ezz
- Sun Kexin
- Sun Phoebe
- Sun Selena
- Sung Nakjun
- Surkitt Amy
- Suttor Sean
- Swalem Aisha
- Swan Daniel
- Swansson Will
- Sweetapple Amie
- Syed Saifulla
- Syllaios Athanasios
- Symeonidis Savvas
- Şen Eminenur
- Şenödeyici Eylül
- Tabak Elif Zeynep
- Taha Hala Abdelhalim Mohamed
- Taha Ibrahim
- Taha Omima
- Tahir Farah
- Tahir Izza
- Taingson Mathew Chum
- Talaat Omnia
- Talavera Elena
- Taman Mohamed
- Tan Kevin
- Tan Sarah
- Tan Sarah
- Tan Suqi
- Tan Wen Po Jonathan
- Tandogan Yusuf Iskender
- Tang Howard
- Tang Patrick
- Tang-Ieam Pattarapan
- Tao Steve
- Tarek Yousef
- Tariq
- Tarmidi Jazmina
- Tasi Zoya
- Taşcı Muhammed Enes
- Taufiq Maliha
- Tay Kai Yun Jodene
- Taylor Emily
- Taylor Isobel
- Teema Eman
- Telci Hatice
- Temerik Abdallah Rashad
- Teng Cherilyn
- Tepe Mustafa Deniz
- Tepe Mustafa Deniz
- Terrosu Giovanni
- Theophilus Mary
- Thompson Nasya
- Thornton-Hume David
- Tiffany Lea
- Ting Clarissa
- Tiras Hale Nur
- Titan Ashley
- Toft Alexandra
- Traina Francesco
- Tran Anthony
- Tran Quang
- Tran Tam
- Tran Will
- Trotta Georgina
- Tsakiridis Ioannis
- Tsakiridis Nikolaos
- Tsourouflis Gerasimos
- Tsui Sonia Ching Ting
- Tu Hien
- Tun Than
- Tung Melody
- Tuzuner Filiz
- Tynan Dominic
- Ugool Mahmoud
- Uğurlu Mustafa Ümit
- Ukrani Ronika Devi
- Ukwuoma Ohia Ernest
- Ulkucu Attila
- Uludag Server Sezgin
- Ulusahin Mehmet
- umar Abubakar
- Umar Gabi Ibrahim
- Uprak Tevfik Kıvılcım
- Ureña Violeta
- Usman Liman Haruna
- Uyanık Mustafa Safa
- Uzair Ahmad
- Uzel Kadir
- Vadioaloo Dinesh Kumar
- Valaroutsou Olga Maria
- Valverde-Vazquez Rocio
- Vance Lucille
- Vanguardia Kristina
- Vanguardia Maria Kristina
- Vanzuylekom Katie
- Varesano Marco
- Varghese Chris
- Varghese Chris
- Velenciuc Natalia
- Vermeulen Wikus
- Vidanagama Sasini
- Vimalan Vineeth
- Virani Sehar Salim
- Vollenhoven Beverley
- Vong Crystal
- Vrakopoulou Gavriella Zoi
- Vu Jennifer
- Vu Jennifer
- Waaka Nicholas
- Wadhwa Sanya
- Wagaarachchi Prabhath
- Waheed Ayesha Akbar
- Waldin Lucy
- Walsh Eamon
- Walters Chris
- Wang Bill
- Wang Christine
- Wang Erica
- Wang Grace
- Wang Katie
- Wang Nicole Qiwen
- Wang Pengnan
- Wang Qiwen
- Wang Shelley
- Wang Yantong
- Wang Zixuan
- Waqar Usama
- Waraich Abdullah
- Ward Jack
- Wardeh Salah Abu
- Wasim Tayyiba
- Watson David
- Watson David
- Wedatalla Mansour
- Weeda Lewis
- Wells Cameron
- Wells Cameron
- Wells Cameron
- Wells Oliver
- Werenski Hope
- Wijayaratne Rivindu
- Wijetunga Asanka
- Williams Brittany
- Williams Peter
- Wilson Thomas
- Windsor John
- Windsor John
- Winthrop Lily
- Withanage Indrajith
- Wong James
- Wong Jason
- Wong Kenneth
- Wong King Ho
- Wong Patrick
- Wong Samantha
- Woodbridge Christian
- Wright Deborah
- Wright Deborah
- Wright Deborah
- Wu Alan
- Wu Alan
- Wu Chun-Yen
- Wu Hongyi
- Wycliff Daniel
- Xiao Haotian
- Xie Maria
- Xu Cindy
- Xu William
- Xu William
- Xu William
- Yaghmour Jamal
- Yahya Bilal Shuaibu
- Yahya Rawad
- Yang Wah
- Yao Michelle
- Yao Sunny
- Yao Sunny
- Yasar Meltem
- Yasir Ruaa
- Yassin Mohamed
- Yavuz Dogancan
- Yavuz Ikranur
- Yaytokgil Muhammet
- Yazgan Yasemin
- Yee Su-Ann
- Yeung Justin
- Yeung Kar Long
- Yew Anthea
- Yi Kevin
- Yiannakopoulos Christos
- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
- Young Simon
- Young Stevie
- Younus Khadijah
- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer - a multicentre observational study
- Author
- Abdullah Nasreen
- Abroaf Ahmed
- Acher Peter
- Adams Robert
- Adasonla Kelvin
- Adimonye Anthony
- Adwin Zainal
- Ager Michael
- Agrawal Sachin
- Ahmad Adnan
- Ahmed Hashim
- Akaln Mustafa Kaan
- Al?Ibraheem Nihad
- Aldiwani Mohammed
- Almpanis Stephanos
- Alonso Cristina Plaza
- Andres Rosado Mario
- Aning Jonathan
- Antón-Juanilla Marta
- Appanna Timson
- Assmus Mark A.
- Austin Tomas
- Ayres Ben
- Bagley Joseph
- Balderas Olga
- Barcelos André
- Bardet Florian
- Barratt Rachel
- Bass Edward
- Bdesha Amar
- Beder Daniel
- Bedi Nishant
- Bele Uros
- Benitez Cayo Augusto Estigarribia
- Bennett Adam
- Bhatt Nikita
- Bi Hai
- Black Peter C
- Blick Chris
- Boltri Matteo
- Bonnin Thierry
- Boxall Nicholas E.
- Brittain James
- Brophy Tom
- Brown Christian
- Brown Kevin
- Browne Clíodhna
- Bullock Nicholas
- Burden Helena
- Burnhope Tara
- Cadena Iván Revelo
- Campain Nicholas
- Capoun Otakar
- Carrion Diego M
- Castillo Elba Canelon
- Catto James
- Cebola Ana
- Chahal Rohit
- Challacombe Ben
- Chan Luke
- Chau Edwin
- Chaudry Aasem
- Chin Yew Fung
- Chippagiri Arvinda
- Chlosta Piotr L
- Chu Timothy Shun Man
- Chuchu Naomi
- Cimarra Fernando
- Claps Francesco
- Clark Jennifer
- Clarke Holly
- Clarke Holly
- Clarke Laurence
- Cohen Daniel
- Cooper Meghan
- Cormier Luc
- Cortes Victor Parejo
- Courcier Jean
- Crawford-Smith Hugh
- Crespo-Atín Víctor
- Crockett Matthew
- Crockett Matthew
- Cruz Ricardo
- Czech Anna K
- Cózar-Olmo Jose Manuel
- Das Arighno
- Davenport Kim
- David Rotimi
- Day Elizabeth
- Deeks Jon
- Deem Samuel
- Dell'Atti Lucio
- Derbyshire Laura
- Desai Ankit
- Desouky Elsayed
- Dhanasekaran Ananda Kumar
- Dhera Karishma
- Dinneen Eoin
- Dowling Catherine
- Downey Alison P.
- Drake Tamsin
- During Vinnie
- Ebur Andrea
- Edison Eric
- Ellis Ricky
- Ellul Tom
- Emberton Mark
- Erotocritou Paul
- Esler Rachel
- Fen Koo Hui
- Feneley Mark
- Fiala Vojtech
- Figueiredo Arnaldo
- Filtekin Yigit
- Forster Luke
- Frankel Jason
- Freire Maria José
- Gadiyar Neha
- Gaines Emily
- Gallagher Kevin M.
- Gallego Maria Camacho
- Gallegos Christopher
- Galosi Andrea B
- Gao Chuanyu
- García de Jalón Ángel
- Garg Tullika
- Gauhar Vineet
- Gillams Kathryn
- Gillams Kathryn
- Glaser Zachary A
- Gnanapragasam Vincent
- Goldsmith Louise
- Gontero Paolo
- Goonewardene Sanchia
- Gordon Daniel
- Gordon Danny
- Green James
- Gresty Helena
- Grigorakis Alkiviadis
- Gronostaj Katarzyna
- Gómez Rivas Juan
- Hale Nathan
- Hamid Syed Sami
- Haroon Usman
- Hawkins Rosalyn
- Hawlina Simon
- He Ming
- Hellawell Giles
- Hernandez Juan
- Hernando Jamie Borrego
- Herranz-Yagüe José Antonio
- Hessell Robert
- Higgs Claire
- Ho Cherrie Wing Yin
- Hobbs Catherine
- Hori Satoshi
- Horie Shigeo
- Houlton Kathleen
- Hrouda David
- Hsu Ray
- Iacovou John
- Ibrahim Ibrahim
- Ibrahim Youssed
- Inder Shakeel Mohammud
- Irani Jacques
- Jain Sunjay
- Jarimba Roberto
- Jefferies Matthew
- Jelski Joseph
- Jones Jennifer
- Joniau Steven
- Kalsi Jas
- Karsza Dávid
- Kasivisvanathan Veeru
- Kata Slawomir Grzegorz
- Kelly John
- Khadhouri Sinan
- Khalid Raihan
- Khan Shahid
- Khawaja Faizan
- Kilic Enes
- Kitamura Kosuke
- Knight Allen
- Kocher Neil
- Kond?a Andra?
- Kouli Omar
- Kovács Gábor
- Kulkarni Meghana
- Kum Francesca
- Kumar Vivek
- Kumaradeevan Jeevan
- Kynaston Howard
- La Montagna Giuseppe
- Lai Billy
- Lal Asim A
- Lam Chon Meng
- Lam Gitte
- Lam Wayne
- Lau David H. W.
- Lau David Hua Wu
- Leask Jamie
- Lebacle Cédric
- Lee Taeweon
- Lee Taeweon
- Lehman Kathleen
- Leminski Artur
- Lenart Gordan
- Li Mo
- Liew Matthew
- Lillaz Beatrice
- Lloyd Aimee
- Lobo Niyati
- Lopes Sofia Pinheiro
- Lyons Hannah
- Ma Lulin
- MacKay Alison
- MacKenzie Kenneth R.
- MacLennan Graeme
- MacLennan Graeme
- Mahmalji Wasim
- Mains Edward
- Mainwaring Anna
- Mak David
- Mallett Susan
- Manecksha Rustom P
- Mangat Reshma
- Manjavacas Pablo Oteo
- Mannas Miles P.
- Marathe Shekhar
- Marchiñena Patricio Garcia
- Mariappan Paramananthan
- Marra Giancarlo
- Martin-Way David
- Martinez Levin
- Martinez-Piñeiro Luis
- Matanhelia Mudit
- Maw Jonny
- Mazzoli Simone
- McCann Conor
- McConkey Robert
- McGrath John S.
- McKay Alastair
- Meeks Joshua
- Minervini Andrea
- Mistry Kiki
- Moore Madeline
- Moore Sacha
- Morris Steve
- Morton Lawrie
- Mostafid Hugh
- Mount Chloe
- Muilwijk Tim
- Mukhtar Bashir
- Murtagh Kevin
- Nagle Amy
- Nambiar Arjun
- Nellensteijn Brechtje
- Ng ChiFai
- Nielsen Matthew
- Nikles Sven
- Nkwam Nkwam
- Nolazco Jose Ignacio
- Norris Joseph
- Nyanhongo Donald
- O'Meara Sorcha
- O'Rourke John
- Olivier Jonathan
- Olivier Jonathan
- Omran Breish Mohamed
- Oo Aye Moh Moh
- Oomen Robert J.A.
- Osei?Bonsu Peter K
- Otaola-Arca Hugo
- Ouzaid Idir
- Palagonia Erika
- Papworth Emma
- Paramore Louise
- Parker Sidney
- Parson Sian
- Pasha Muhammad
- Patel Dhruv
- Patel Trushar
- Pavan Nicola
- Peters Francesca
- Phan Yih Chyn
- Pira Matea
- Pita Hernado Rios
- Pizzuto Giuseppe
- Planelles Paula
- Plo Teresa Cabañuz
- Poves Victoria Capapé
- Puche-Sanz Ignacio
- Qin Zijian
- Rai Sonpreet
- Raman Jay D
- Ramos Sónia
- Randhawa Karen
- Raveenthiran Sheliyan
- Rico Luis
- Rintoul-Hoad Sophie
- Ristau Benjamin
- Ritchie Robert
- Rivero Marta Viridiana Muñoz
- Rowe Tracey
- Russell Andrew
- Sahibzada Iqbal
- Sangaralingam Shanthi
- Schneider Alexandre
- Schreiter Brielle
- Selph John P
- Sengupta Shomik
- Serag Hosam
- Shah Taimur T.
- Sharma Abhishek
- Sherwood Benedict
- Shrotri Nitin
- Silva Alberto
- Simmons Lucy
- Simpson Helen
- Smith Peter
- Smrkolj Toma
- Stamirowski Remigiusz
- Sukhu Troy
- Suliman Ahmed M
- Suthaharan Denula
- Swami Satchi Kuchibhotla
- Sweeney Paul
- Takwoingi Yemisi
- Tallè Matteo
- Tanasescu George
- Tanasescu Geroge
- Tarin Mohamed
- Tasso Giovanni
- Teoh Jeremy YuenChun
- Testa Joseph
- Thangasamy Isaac
- Tinay Ilker
- Toma Tarq
- Tomakovi Igor
- Toniolo Jason
- Trail Matthew
- Trombetta Carlo
- Turner Stacey
- Tweedle James
- Udzik Jakub
- Ul Ain Qurrat
- Uzan Audrey
- Uçar Taha
- Uçar Taha
- Venturini Stefano
- Villers Arnauld
- Voulgaris Athanasios M
- Vásquez Juan Luis
- Warren Hannah
- Webb Andrew
- Wilby Daniel
- Willemse Peter-Paul Michiel
- Williams Simon
- Wollin Tim
- Wong Albert
- Xylinas Evanguelos
- Y?ld?r?m As?f
- Yan Shahzad Sylvia
- Younis Ayman
- Yuruk Emrah
- Zainuddin Zulkifli
- Zelhof Bachar
- Zimmermann Eleanor F.
- Zotter Zsuzsanna
- Çakurlu Turhan
- Özgür Günal
- Østergren Peter
- Publication venue
- 'Wiley'
- Publication date
- 31/10/2021
- Field of study
Objective
To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer [UTUC] and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation.
Patients and Methods
This was an international multicentre prospective observational study. We included patients aged ≥16 years, referred to secondary care with suspected urinary tract cancer. Patients with a known or previous urological malignancy were excluded. We estimated the prevalence of bladder cancer, UTUC, renal cancer and prostate cancer; stratified by age, type of haematuria, sex, and smoking. We used a multivariable mixed-effects logistic regression to adjust cancer prevalence for age, type of haematuria, sex, smoking, hospitals, and countries.
Results
Of the 11 059 patients assessed for eligibility, 10 896 were included from 110 hospitals across 26 countries. The overall adjusted cancer prevalence (n = 2257) was 28.2% (95% confidence interval [CI] 22.3–34.1), bladder cancer (n = 1951) 24.7% (95% CI 19.1–30.2), UTUC (n = 128) 1.14% (95% CI 0.77–1.52), renal cancer (n = 107) 1.05% (95% CI 0.80–1.29), and prostate cancer (n = 124) 1.75% (95% CI 1.32–2.18). The odds ratios for patient risk markers in the model for all cancers were: age 1.04 (95% CI 1.03–1.05; P < 0.001), visible haematuria 3.47 (95% CI 2.90–4.15; P < 0.001), male sex 1.30 (95% CI 1.14–1.50; P < 0.001), and smoking 2.70 (95% CI 2.30–3.18; P < 0.001).
Conclusions
A better understanding of cancer prevalence across an international population is required to inform clinical guidelines. We are the first to report urinary tract cancer prevalence across an international population in patients referred to secondary care, adjusted for patient risk markers and geographical variation. Bladder cancer was the most prevalent disease. Visible haematuria was the strongest predictor for urinary tract cancer
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.
- Author
- Aban Marites
- Abayomi Fatola
- Abeyskera Kushala
- Aboagye Jeremy
- Adam Matthew
- Adams Kirsty
- Adamson James
- Adelaja Yemi A.
- Adlou Syed
- Ahmed Khatija
- Akhalwaya Saajida
- Akhalwaya Yasmeen
- Alcock Andrew
- Aley Parvinder K.
- Ali Aabidah
- Allen Elizabeth R.
- Allen Lauren
- Almeida Thamires C. D. S. C
- Alves Mariana P.S.
- Amorim Fabio
- Andritsou Foteini
- Angus Brian
- Anslow Rachel
- Appleby Matthew
- Arbe-Barnes Edward H.
- Ariaans Mark P.
- Arns Beatriz
- Arruda Laiana
- Awedetan Gbadebo
- Azi Lorena
- Azi Paula
- Babbage Gavin
- Bailey Catherine
- Baillie Vicky L.
- Baker Kenneth F.
- Baker Megan
- Baker Natalie
- Baker Philip
- Baldwin Lisa
- Baleanu Ioana
- Bandeira Danieli
- Bara Anna
- Barbosa Marcella A.S.
- Barker Debbie
- Barlow Gavin D.
- Barnabas Shaun L.
- Barnes Eleanor
- Barr Andrew S.
- Barrett Jessica
- Barrett Jordan R.
- Bates Louise
- Batten Alexander
- Beadon Kirsten
- Beales Emily
- Beckley Rebecca
- Belij-Rammerstorfer Sandra
- Bell Jonathan
- Bellamy Duncan
- Bellei Nancy
- Belton Sue
- Berg Adam
- Bermejo Laura
- Berrie Eleanor
- Berry Lisa
- Berzenyi Daniella
- Beveridge Amy
- Bewley Kevin R.
- Bexhell Helen
- Bhikha Sutika
- Bhorat Asad E.
- Bhorat Qasim E.
- Bhorat Zaheda E.
- Bibi Sagida
- Bijker Else
- Birch Geeta
- Birch Sarah
- Bird Adam
- Bird Olivia
- Bisnauthsing Karen
- Bittaye Mustapha
- Blackstone Katherine
- Blackwell Luke
- Bletchly Heather
- Blundell Caitlin L.
- Blundell Susannah R.
- Bodalia Pritesh
- Boettger Bruno C.
- Bolam Emma
- Boland Elena
- Bormans Daan
- Borthwick Nicola
- Bowring Francesca
- Boyd Amy
- Bradley Penny
- Brenner Tanja
- Briner Carmen
- Brown Claire
- Brown Phillip
- Brown-O'Sullivan Charlie
- Bruce Scott
- Brunt Emily
- Buchan Ruaridh
- Budd William
- Bulbulia Yusuf A.
- Bull Melanie
- Burbage Jamie
- Burhan Hassan
- Burn Aileen
- Buttigieg Karen R.
- Byard Nicholas
- Cabera Puig Ingrid
- Calderon Gloria
- Calvert Anna
- Camara Susana
- Cao Michelangelo
- Cappuccini Federica
- Cardoso João R.
- Carr Melanie
- Carroll Miles W.
- Carson-Stevens Andrew
- Carvalho José A.M.
- Carvalho Yasmin de M.
- Casey Helen R.
- Cashen Paul
- Castro Lucia Carratala
- Castro Thais
- Cathie Katrina
- Cavey Ana
- Cerbino-Neto José
- Chadwick Jim
- Chapman David
- Charlton Sue
- Chelysheva Irina
- Chester Oliver
- Chita Sunder
- Cho Jee-Sun
- Cicconi Paola
- Cifuentes Liliana
- Clark Elizabeth
- Clark Matthew
- Clarke Andrea
- Clemens Sue Ann Costa
- Clutterbuck Elizabeth A.
- Colin-Jones Rachel
- Collins Andrea M.
- Collins Sarah L.K.
- Conlon Christopher P.
- Connarty Sean
- Coombes Naomi
- Cooper Cushla
- Cooper Rachel
- Cornelissen Lynne
- Corrah Tumena
- Cosgrove Catherine
- Cox Tony
- Crocker Wendy E.M.
- Crosbie Sarah
- Cullen Dan
- Cullen Lorraine
- Cunha Debora R.M.F.
- Cunningham Christina
- Cuthbertson Fiona C.
- Cutland Clare L.
- Da Guarda Suzete N. Farias
- da Silva Moraes Antonio Carlos
- da Silva Larissa P.
- Damratoski Brad E.
- Danos Zsofia
- Dantas Maria T.D.C.
- Darroch Paula
- Darton Thomas C.
- Datoo Mehreen S.
- Datta Chandrabali
- Davids Malika
- Davies Hannah
- Davies Sarah L.
- Davis Elizabeth
- Davis John
- Davis Judith
- De Jager Jeanne
- De Nobrega Maristela M.D.
- De Oliveira Kalid Lis Moreno
- Dearlove David
- Demissie Tesfaye
- Desai Amisha
- Dheda Keertan
- Di Marco Stefania
- Di Maso Claudio
- Dinelli Maria I.S.
- Dinesh Tanya
- Docksey Claire
- Dold Christina
- Dong Tao
- Donnellan Francesca R.
- Dos Santos Erika Pachecho
- Dos Santos Tannyth
- dos Santos Thainá G.
- Douglas Alexander D.
- Douglas Naomi
- Downing Charlotte
- Drake Jonathan
- Drake-Brockman Rachael
- Driver Kimberley
- Drury Ruth
- Du Plessis Joan
- Dunachie Susanna J.
- Duncan Christopher J. A.
- Durham Benjamin S.
- Dutra Lidiana
- Easom Nicholas J.W.
- Edwards Mandy
- Edwards Nick J.
- El Muhanna Omar M.
- Elias Sean C.
- Elmore Mike
- Emary Katherine R. W.
- English Marcus
- Esmail Alisgair
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- Farooq Mutjaba
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- Felle Sally
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- Fudge Sabrina
- Furze Julie
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- Galian-Rubio Pablo
- Galiza Eva
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- Gilbert Sarah C
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- Greffrath Johann
- Groenewald Marisa M.
- Grossi Leonardo
- Gupta Gaurav
- Hackett Mark
- Hallis Bassam
- Hamaluba Mainga
- Hamilton Elizabeth
- Hammersley Daniel
- Hanrath Aidan T.
- Hanumunthadu Brama
- Harris Clair
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- Hassan Shadin
- Haughney John
- Hawkins Sophia
- Hay Jodie
- Head Ian
- Heath Paul T.
- Henry John
- Hermosin Herrera Macarena
- Hettle David B.
- Hill Adrian V. S.
- Hill Catherine
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- Ikram Sabina
- Ishwarbhai Alka
- Ivan Monica
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- Izu Alane
- Jackson Frederic
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- Jaumdally Shameem
- Jeffers Helen
- Jenkin Daniel
- Jesudason Natasha
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- Jones Christopher
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- Jorge Marianna Rocha
- Jose Aylin
- Joshi Amar
- Júnior Eduardo A.M.S.
- Kadziola Joanne
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- Lazarus Erica M.
- Lazarus Rajeka
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- Libri Vincenzo
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- Lipworth Samuel
- Liu Shuchang
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- Lloyd Adam
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- Loew Lisa
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- MacGregor Gordon
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- Mainwaring David O.
- Makambwa Edson
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- McInroy Lorna
- McIntyre Zoe
- McLenaghan Daniela
- McRobert Nicky
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- Naker Kush
- Nana Anusha
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- Novaes Gabrielle
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- Taylor Iona Jennifer
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- Themistocleous Andreas
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- Williams Paul
- Williams Rachel L.
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- Woodyer Mark
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- Wright Danny
- Wroblewska Marzena
- Yao Andy
- Zimmer Rafael
- Zizi Dalila
- Zuidewind Peter
- Publication venue
- 'Elsevier BV'
- Publication date
- 03/12/2020
- Field of study
BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
- Author
- Aban Marites
- Abayomi Fatola
- Abeyskera Kushala
- Aboagye Jeremy
- Adam Matthew
- Adams Kirsty
- Adamson James
- Adelaja Yemi A.
- Adlou Syed
- Ahmed Khatija
- Akhalwaya Saajida
- Akhalwaya Yasmeen
- Alcock Andrew
- Aley Parvinder K.
- Ali Aabidah
- Allen Elizabeth R.
- Allen Lauren
- Almeida Thamires C. D. S. C
- Alves Mariana P.S.
- Amorim Fabio
- Andritsou Foteini
- Angus Brian
- Anslow Rachel
- Appleby Matthew
- Arbe-Barnes Edward H.
- Ariaans Mark P.
- Arns Beatriz
- Arruda Laiana
- Awedetan Gbadebo
- Azi Lorena
- Azi Paula
- Babbage Gavin
- Bailey Catherine
- Baillie Vicky L.
- Baker Kenneth F.
- Baker Megan
- Baker Natalie
- Baker Philip
- Baldwin Lisa
- Baleanu Ioana
- Bandeira Danieli
- Bara Anna
- Barbosa Marcella A.S.
- Barker Debbie
- Barlow Gavin D.
- Barnabas Shaun L.
- Barnes Eleanor
- Barr Andrew S.
- Barrett Jessica
- Barrett Jordan R.
- Bates Louise
- Batten Alexander
- Beadon Kirsten
- Beales Emily
- Beckley Rebecca
- Belij-Rammerstorfer Sandra
- Bell Jonathan
- Bellamy Duncan
- Bellei Nancy
- Belton Sue
- Berg Adam
- Bermejo Laura
- Berrie Eleanor
- Berry Lisa
- Berzenyi Daniella
- Beveridge Amy
- Bewley Kevin R.
- Bexhell Helen
- Bhikha Sutika
- Bhorat Asad E.
- Bhorat Qasim E.
- Bhorat Zaheda E.
- Bibi Sagida
- Bijker Else
- Birch Geeta
- Birch Sarah
- Bird Adam
- Bird Olivia
- Bisnauthsing Karen
- Bittaye Mustapha
- Blackstone Katherine
- Blackwell Luke
- Bletchly Heather
- Blundell Caitlin L.
- Blundell Susannah R.
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- Bowring Francesca
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- Bradley Penny
- Brenner Tanja
- Briner Carmen
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- Brown Phillip
- Brown-O'Sullivan Charlie
- Bruce Scott
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- Buchan Ruaridh
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- Bulbulia Yusuf A.
- Bull Melanie
- Burbage Jamie
- Burhan Hassan
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- Buttigieg Karen R.
- Byard Nicholas
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- Cappuccini Federica
- Cardoso João R.
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- Carroll Miles W.
- Carson-Stevens Andrew
- Carvalho José A.M.
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- Casey Helen R.
- Cashen Paul
- Castro Lucia Carratala
- Castro Thais
- Cathie Katrina
- Cavey Ana
- Cerbino-Neto José
- Chadwick Jim
- Chapman David
- Charlton Sue
- Chelysheva Irina
- Chester Oliver
- Chita Sunder
- Cho Jee-Sun
- Cicconi Paola
- Cifuentes Liliana
- Clark Elizabeth
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- Clemens Sue Ann Costa
- Clutterbuck Elizabeth A.
- Colin-Jones Rachel
- Collins Andrea M.
- Collins Sarah L.K.
- Conlon Christopher P.
- Connarty Sean
- Coombes Naomi
- Cooper Cushla
- Cooper Rachel
- Cornelissen Lynne
- Corrah Tumena
- Cosgrove Catherine
- Cox Tony
- Crocker Wendy E.M.
- Crosbie Sarah
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- Cunha Debora R.M.F.
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- Danos Zsofia
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- Desai Amisha
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- Essack Yakub Moosa
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- Fairlie Lee
- Farmer Eoghan
- Farooq Mutjaba
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- Farrugia Leonard
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- Faust Saul N.
- Fedosyuk Sofiya
- Felle Sally
- Feng Shuo
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- Gilbert Sarah C
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- Harris Clair
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- Howe Elizabeth
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- Humphreys Jonathan
- Humphries Holly E.
- Hurley Katrina
- Huson Claire
- Hyamns Catherine
- Hyder-Wright Angela
- Ikram Sabina
- Ishwarbhai Alka
- Ivan Monica
- Iveson Poppy
- Iyer Vidyashankara
- Izu Alane
- Jackson Frederic
- Jackson Susan
- Jaumdally Shameem
- Jeffers Helen
- Jenkin Daniel
- Jesudason Natasha
- Joe Carina C. D.
- Jones Bryony
- Jones Christopher
- Jones Elizabeth
- Jones Kathryn
- Jorge Marianna Rocha
- Jose Aylin
- Joshi Amar
- Júnior Eduardo A.M.S.
- Kadziola Joanne
- Kailath Reshma
- Kana Faeeza
- Karampatsas Konstantinos
- Kasanyinga Mwila
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- Kelly Dearbhla M.
- Kelly Debbie
- Kelly Elizabeth J.
- Kelly Sarah
- Kerr David
- Kerridge Simon
- Kfouri Renato de Ávila
- Khan Liaquat
- Khozoee Baktash
- Kidd Sarah
- Killen Annabel
- Kinch Jasmin
- Kinch Patrick
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- Kingham Lucy
- Klenerman Paul
- Knapper Francesca
- Knight Julian C.
- Knott Daniel
- Koen Anthonet
- Koleva Stanislava
- Kwatra Gaurav
- Lambe Teresa
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- Larwood Jessica P.J.
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- Lawrie Alison M.
- Lazarus Erica M.
- Lazarus Rajeka
- Leach Amanda
- Lees Emily A.
- Lelliott Alice
- Lemm Nana-Marie
- Lessa Alvaro
- Leung Stephanie
- Li Yuanyuan
- Lias Amelia M.
- Liatsikos Kostas
- Libri Vincenzo
- Lillie Patrick J.
- Linder Aline
- Lipworth Samuel
- Liu Shuchang
- Liu Xinxue
- Lloyd Adam
- Lloyd Stephanie
- Loew Lisa
- Lopez Ramon Raquel
- Lora Leandro
- Lowthorpe Vicki
- Luz Kleber
- MacDonald Jonathan C.
- MacGregor Gordon
- Madhavan Meera
- Madhi Shabir A.
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- Makambwa Edson
- Makinson Rebecca
- Malahleha Mookho
- Malamatsho Ross
- Mallett Garry
- Mallory Raburn
- Mansatta Kushal
- Maoko Takalani
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- Mathew Moncy
- Matlebjane Hosea
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- Mazur Olga
- Mazzella Andrea
- McCaughan Hugh
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- McGlashan Joanna
- McGregor Alastair
- McInroy Lorna
- McIntyre Zoe
- McLenaghan Daniela
- McRobert Nicky
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- Mendonça Renata N.Á.
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- Mpelembue Mushiya
- Msomi Sibekezelo
- Mugodi Yvonne
- Mujadidi Yama F.
- Mukhopadhyay Ekta
- Muller Jilly
- Munro Alasdair
- Munro Claire
- Murphy Sarah
- Mweu Philomena
- Myasaki Celia Hatsuko
- Naik Gurudutt
- Naker Kush
- Nana Anusha
- Nastouli Eleni
- Nazir Abida
- Ndlovu Bongani
- Neffa Fabio
- Njenga Cecilia
- Noal Helena
- Novaes Gabrielle
- Noé Andrés
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- O'Brien Katie
- O'Connor Daniel
- O'Reilly Paula
- O'Reilly Peter J.
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- Oguti Blanche
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- Pennington Anna
- Peralta Alvarez Marco Polo
- Perring James
- Perry Nicola
- Perumal Rubeshan
- Petkar Sahir
- Philip Tricia
- Phillips Daniel J.
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- Phohu Mary Kgomotso
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- Thompson Fawziyah
- Thompson Kevin
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- Thornton-Jones Viv
- Tighe Patrick J.
- Tinoco Lygia Accioly
- Tiongson Gerlynn
- Tladinyane Bonolo
- Tomasicchio Michele
- Tomic Adriana
- Tonks Susan
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- Tran Nguyen
- Tree Julia
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- Truby Adam
- Tsheko Betty Lebogang
- Turabi Aadil
- Turner Cheryl
- Turner David P. J.
- Turner Richard
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- Ulaszewska Marta
- Underwood Benjamin R.
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- Verheul Marije
- Vichos Iason
- Vieira Taiane
- Villafana Tonya L.
- Voysey Merryn
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- White Rachel
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- Williams Paul
- Williams Rachel L.
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- Wroblewska Marzena
- Yao Andy
- Zimmer Rafael
- Zizi Dalila
- Zuidewind Peter
- Publication venue
- 'Elsevier BV'
- Publication date
- 09/01/2021
- Field of study
Background
A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials.
Methods
This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674.
Findings
Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation.
Interpretation
ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials
Six-step management of hypertension in patients with rheumatoid arthritis
- Author
- Publication venue
- 'Future Medicine Ltd'
- Publication date
- Field of study