Khresmoi Professional: Multilingual Semantic Search for Medical Professionals

There is increasing interest in and need for innovative solutions to medical search. In this paper we present the EU funded Khresmoi medical search and access system, currently in year 3 of 4 of development across 12 partners . The Khresmoi system uses a component based architecture housed in the cloud to allow for the development of several innovative applications to support target users medical information needs. The Khresmoi search systems based on this architecture have been designed to support the multilingual and multimod al information needs of three target groups the general public, general practitioners and consultant radiologists. In this paper we focus on the presentation of the systems to support the latter two groups using semantic, multilingual text and image based (including 2D and 3D radiology images) search

Khresmoi: Multimodal Multilingual Medical Information Search

Khresmoi is a European Integrated Project developing a multilingual multimodal search and access system for medical and health information and documents. It addresses the challenges of searching through huge amounts of medical data, including general medical information available on the internet, as well as radiology data in hospital archives. It is developing novel semantic search and visual search techniques for the medical domain. At the MIE Village of the Future, Khresmoi proposes to have two interactive demonstrations of the system under development, as well as an overview oral presentation and potentially some poster presentation

Khresmoi – multilingual semantic search of medical text and images

The Khresmoi project is developing a multilingual multimodal search and access system for medical and health information and documents. This scientific demonstration presents the current state of the Khresmoi integrated system, which includes components for text and image annotation, semantic search, search by image similarity and machine translation. The flexibility in adapting the system to varying requirements for different types of medical information search is demonstrated through two instantiations of the system, one aimed at medical professionals in general and the second aimed at radiologists. The key innovations of the Khresmoi system are the integration of multiple software components in a flexible scalable medical search system, the use of annotation cycles including manual correction to improve semantic search, and the possibility to do large scale visual similarity search on 2D and 3D (CT, MR) medical images

The Somali crisis and the EU : Moving onshore and committing to Somalia

About 90 percent of world trade is conducted via sea transport and up to 50 percent of the world’s container ships pass by the Horn of Africa. In result, Somali piracy attacks costs the global economy some USD 7 billion a year according to the One Earth Future Foundation.The crisis in Somalia has thus become a global problem. In response, the worlds’ powers are trying to contain and defuse it. The United States, China, Russia, NATO and the European Union all patrol the Indian Ocean in one of the largest military operations currently ongoing. Thousands of navy officers on war ships are engaged off the Somali coast aiming to protect container and cargo ships. With this costly undertaking not having much effect on preventing piracy, new strategies are needed.The Global Governance Institute takes a look at the political dynamics in Somalia and recommends to closer integrating shore and offshore-based engagement. It focuses on the European engagement with two running crisis management operations and one launched on 16 July 2012 and to be operational in the autumn. In the medium- to long-term engagement on the ground is needed.Piracy is a symptom of political instability in Somalia, not its cause. The revenue generated by pirates via ransom was about USD 160m in 2011, a fraction of what the international naval operations cost.The new European EUCAP Nestor operation can be a first step in the right direction if it is the first of many steps to much stronger engagement, fostering dialogue and addressing the causes of conflict: poverty and instability within Somalia rather than merely deploying warships to patrol the Somali coast

Forschungsprojekt „Krise und Kontinuität in Bildungsgängen: der Übergang Schule-Hochschule“

Asdonk J, Bornkessel P, Glässing G, et al. Forschungsprojekt „Krise und Kontinuität in Bildungsgängen: der Übergang Schule-Hochschule“. Bericht 2005 – 2010 Band I. 2010:133-150

“Primeval forest relict beetles” of Central Europe : a set of 168 umbrella species for the protection of primeval forest remnants

Identification of forest stands with priority for the conservation of biodiversity is of particular importance in landscapes with a long cultural and agricultural history, such as Central Europe. A group of species with a high indicator value for the naturalness of forest ecosystems are saproxylic insects. Some of these species, especially within the order Coleoptera, have been described as primeval forests relicts. Here, we compiled a list of 168 “primeval forest relict species” of saproxylic beetles based on expert knowledge. These species can serve as focal and umbrella species for forest conservation in Central Europe. They were selected because of their dependence on the continuous presence of primeval forest habitat features, such as over-mature trees, high amounts of dead wood, and dead wood diversity, as well as their absence in managed Central European forests. These primeval forest relict species showed a moderately strong clumping pattern within the phylogeny of beetles, as indicated by phylogenetic signal testing using the D-statistic. When we controlled for phylogenetic relatedness, an ordinal linear model revealed that large body size and preference for dead wood and trees of large diameter are the main characteristics of these species. This list of species can be used to identify forest stands of conservation value throughout Central Europe, to prioritize conservation and to raise public awareness for conservation issues related to primeval forests

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field