Influencia de las aplicaciones hormonales para el retraso de la recolección en el caqui 'Rojo Brillante' sobre la brotación, desarrollo vegetativo y floración. Técnicas de estímulo

[ES] Tras el retraso de la recolección del caqui promovido por la aplicación de ácido giberélico y sales de calcio, se ha observado un decaimiento generalizado en el vigor del árbol que repercute negativamente en la brotación y floración siguiente y, por consiguiente, en la cosecha. El objetivo de este trabajo es estudiar si este declive en el crecimiento vegetativo puede recuperarse con la aplicación de la hormona y compuestos nitrogenados y cuál es su comportamiento nutricional. Para ello, se ha realizado un seguimiento del crecimiento vegetativo de 5 brotes en cada uno de los 20 árboles, siendo 10 de estos tratados en otoño (30 de septiembre, 24 de octubre y 8 de noviembre) con AG para retrasar la recolección. A una parte de estos árboles se les aplicó adicionalmente en el momento de la brotación (28 de marzo) una mezcla de AG(2.5g) y un compuesto nitrogenado (28% N), y también a otros de los que en otoño habían sido control, y se repitió 35 días después (2 de mayo). Siete árboles se mantuvieron como control. Periódicamente se midió la longitud de los brotes, y se muestrearon yemas, y hojas y flores para analizar la calidad de las yemas mediante microscopía óptica y su contenido nutricional.[EN] Currently, after the persimmon harvesting delay promoted by the gibberellic acid and calcium salts, it has been observed the general decay in the vigor that affects negatively in the next sprouting and flowering and therefore, in the harvesting. The goal of this paper is to study if this decline in the vegetative development could normalize with the hormone application and nitrogenous compounds and which is its nutritional behavior. In order to this, it has been done a vegetative development monitoring of 5 buds in each of the 20 trees, being 10 of these trees treated in autumn(30th September, 24th October and 8th November) with GA to delay the harvest. In the sprouting (28th March), it has been applicated in a part of these trees a mixture of GA(2.5g) and nitrogenous compound (28%N), and also to other trees that were kept as a control in autumn, and this process was repeated again 35 days later (2nd May). Seven trees were kept as a total control. Periodically it was measured the sprout length, and it was sampled the buds, leaves and flowers to analyze the buds quality by means of optic microscopy and their nutritional contents.García Vega, LG. (2017). Influencia de las aplicaciones hormonales para el retraso de la recolección en el caqui 'Rojo Brillante' sobre la brotación, desarrollo vegetativo y floración. Técnicas de estímulo. http://hdl.handle.net/10251/88263.TFG

Costume: a method for building quality models for composite COTS-based software systems

The use of quality models during the selection of Commercial, Off-The-Shelf (COTS) products provides a framework for the description of the domains which the COTS products belong to. Descriptions of COTS products and user quality requirements may be translated into the quality concepts defined in the model, making selection more efficient and reliable. In this paper we propose a method for the construction of quality models for Composite COTS-based Software Systems (CCSS), defined as systems that are composed by several interconnected COTS products. Selection processes carried out when procuring a CCSS require not a single COTS product to be selected but a set of them. As a consequence, instead of a classical quality model, we need a more elaborated one, defined as the composition of those models that belong to the domains of the COTS products that form the CCSS.Peer Reviewe

DesCOTS: a software system for selecting COTS components

Selection of commercial-off-the-shelf software components (COTS components) has a growing importance in software engineering. Unfortunately, selection projects have a high risk of ending up into abandonment or yielding an incorrect selection. The use of some software engineering practices such as the definition of quality models can reduce this risk. We defined a process for COTS components selection based on the use of quality models and we started to apply it in academic and industrial cases. The need of having a tool to support this process arose and, although some tools already exist to partially support the involved activities, none of them was suitable enough. Because of this we developed DesCOTS, a software system that embraces several tools that interact to support the different activities of our process. The system has been designed taking into account not only functional concerns but also nonfunctional aspects such as reusability, interoperability and portability. We present in this paper the different subsystems of DesCOTS and discuss about their applicability.Peer ReviewedPostprint (published version

Reduction of foveal bulges and other anatomical changes in fellow eyes of patients with unilateral idiopathic macular hole without vitreomacular pathologic changes

Purpose: To compare the foveal characteristics in fellow eyes (FE) of patients with unilateral idiopathic macular hole without vitreomacular pathologic changes with eyes of healthy controls. Methods: Forty-seven FE and 52 eyes of 52 age- and sex-matched healthy controls were studied. Quantitative assessment of the dome-shaped appearance of the hyperreflective lines that represent external limiting membrane (ELM_bulge) and inner outer segment junctions (IS/OS_bulge) were made by optical coherence tomography (OCT) images. Inner retinal complex thickness (IRCT) was quantitatively assessed at 1000 and 2000 µm of the foveal center in nasal and temporal quadrants. Presence of alterations in the inner retinal outer layers and central foveal thickness (CFT) were also analyzed. Results: Significantly lower ELM_bulge (p < 0.0001; Mann-Whitney test) and IS/OS_bulge (p < 0.001; student t test) and higher cases with COST alterations, expressed as a diffuse line (p < 0.006; Chi2 test) were found in FE than control eyes. IRCT were significantly reduced in FE at all the studied locations when comparing to control eyes (p < 0.05; student t test), maintaining anatomical proportionality among locations. Conclusion: FE without pathologic vitreomacular interactions seems to present some central cone alterations that may be related to other causes than vitreomacular traction.Preprin

Reduction of foveal bulges and other anatomical changes in fellow eyes of patients with unilateral idiopathic macular hole without vitreomacular pathologic changes

Purpose: To compare the foveal characteristics in fellow eyes (FE) of patients with unilateral idiopathic macular hole without vitreomacular pathologic changes with eyes of healthy controls. Methods: Forty-seven FE and 52 eyes of 52 age- and sex-matched healthy controls were studied. Quantitative assessment of the dome-shaped appearance of the hyperreflective lines that represent external limiting membrane (ELM_bulge) and inner outer segment junctions (IS/OS_bulge) were made by optical coherence tomography (OCT) images. Inner retinal complex thickness (IRCT) was quantitatively assessed at 1000 and 2000 µm of the foveal center in nasal and temporal quadrants. Presence of alterations in the inner retinal outer layers and central foveal thickness (CFT) were also analyzed. Results: Significantly lower ELM_bulge (p < 0.0001; Mann-Whitney test) and IS/OS_bulge (p < 0.001; student t test) and higher cases with COST alterations, expressed as a diffuse line (p < 0.006; Chi2 test) were found in FE than control eyes. IRCT were significantly reduced in FE at all the studied locations when comparing to control eyes (p < 0.05; student t test), maintaining anatomical proportionality among locations. Conclusion: FE without pathologic vitreomacular interactions seems to present some central cone alterations that may be related to other causes than vitreomacular traction.Preprin

Construcción y reflexión metalingüística de textos orales monogestionados y plurigestionados en el grado de maestro.

El dominio de la competencia comunicativa en los estudiantes del grado de maestro es crucial por ser instrumento de aprendizaje y por el perfil profesional. Se presentan resultados de un estudio piloto cuyo objetivo es la mejora en la construcción de textos orales argumentativos y la reflexión metalingüística. Los resultados indican que los estudiantes aprenden a construir textos monogestionados y plurigestionados y a reflexionar sobre ellos si se introducen estrategias e instrumentos ajustados

Satisfaction with care evaluation in cancer patients. The EORTC assessment system

Este trabajo pretende presentar el área de la evaluación de la Satisfacción con los Cuidados (SC) recibidos por el paciente oncológico. La SC es considerara como una de las variables PRO – patients reported outcomes más importantes. La SC se entiende como un concepto multidimensional en el que se incluyen las diferentes experiencias y procesos asociados con la atención que reciben los pacientes. La evaluación de la SC juega un papel importante en la investigación clínica, en la gestión o en la práctica clínica diaria, y puede ser realizada en varios niveles de la atención sanitaria. El Grupo de Calidad de Vida de la Organización Europea para la Investigación y Tratamiento del Cáncer-EORTC ha desarrollado un sistema de medida formado por un cuestionario general de Calidad de Vida y módulos para diferentes tipos de tumor, tratamientos y otras áreas que lo complementan. Dentro de este grupo hay una línea de investigación dirigida a la creación de cuestionarios de SC. En el presente trabajo presentamos los cuestionarios creados por este grupo EORTC IN-PATSAT32 y OUT-PATSAT35 RT, las validaciones que se han realizado para nuestro país de dichos instrumentos, y otros cuestionarios de medida de SC que han sido empleados en oncología. Además, se hace referencia a aspectos específicos de la medición de SC.The aim of the present work is to introduce to the field of Satisfaction with Care (SC) assessment in cancer patients. SC is considered as one of the most important PRO - patients reported outcomes variables. SC is understood as a multidimensional concept in which the different experiences and processes related to the attention patients receive are included. SC assessment has a key role in clinical research, in administration or in the daily clinical practice, and can be performed in different levels of the health care system. The European Organization for Research and Treatment of Cancer–EORTC-Quality of Life Group has developed an assessment system composed of a general Quality of Life questionnaire and some modules for different treatments, tumors and other areas that complete it. There is a research line within the EORTC Quality of Life Group for developing SC questionnaires. In the present work the SC instruments built by this group EORTC IN-PATSAT32 and OUT-PATSAT35 RT, the validation studies for Spain of these two instruments, and other SC questionnaires that have been used in oncology are presented. Besides, specific aspects of SC assessment are explained

Effects of Atorvastatin on Vitamin D Levels in Patients With Acute Ischemic Heart Disease

Producción CientíficaVitamin D deficiency is a risk factor for osteoporosis and other chronic diseases, including type 1 diabetes, hypertension, metabolic syndrome, and ischemic heart disease. Cholesterol and vitamin D share the 7-dehydrocolesterol metabolic pathway. This study evaluated the possible effect of atorvastatin on vitamin D levels in patients with acute ischemic heart disease. Eighty-three patients (52 men and 31 women) with an acute coronary syndrome (75 with acute myocardial infarction and 8 with unstable angina) were included. After diagnosis, patients received atorvastatin as secondary prevention. Serum vitamin D was measured by high-performance liquid chromatography at baseline and at 12 months. Atorvastatin treatment produced a statistically significant decrease in cholesterol and triglyceride levels and an increase in vitamin D levels (41 19 vs 47 19 nmol/L, p 0.003). Vitamin D deficiency was decreased by 75% to 57% at 12 months. In conclusion, atorvastatin increases vitamin D levels. This increase could explain some of the beneficial effects of atorvastatin at the cardiovascular level that are unrelated to cholesterol levels

Vitamin D Levels and Lipid Response to Atorvastatin

Adequate vitamin D levels are necessary for good vascular health. 1,25-dihydroxycholecalciferol activates CYP3A4, an enzyme of the cytochrome P450 system, which metabolizes atorvastatin to its main metabolites. The objective of this study was to evaluate the response of cholesterol and triglycerides to atorvastatin according to vitamin D levels. Sixty-three patients with acute myocardial infarction treated with low and high doses of atorvastatin were included. Levels of total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol were measured at baseline and at 12 months of follow-up. Baseline levels of 25-hydroxyvitamin D (25-OHD) were classified as deficient (<30 nmol/L), insufficient (30–50 nmol/L), and normal (>50 nmol/L). In patients with 25-OHD <30 nmol/L, there were no significant changes in levels of total cholesterol (173 ± 47 mg/dL versus 164 ± 51 mg/dL), triglycerides (151 ± 49 mg/dL versus 177 ± 94 mg/dL), and LDL cholesterol (111 ± 48 mg/dL versus 92 45 ± mg/dL); whereas patients with insufficient (30–50 nmol/L) and normal vitamin D (>50 nmol/L) had a good response to atorvastatin. We suggest that vitamin D concentrations >30 nmol/L may be required for atorvastatin to reduce lipid levels in patients with acute myocardial infarction

Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression.

gma σ1 and σ2 receptors are targets of cocaine. Despite sharing a similar name, the two receptors are structurally unrelated and their physiological role is unknown. Cocaine increases the level of dopamine, a key neurotransmitter in CNS motor control and reward areas. While the drug also affects dopaminergic signaling by allosteric modulations exerted by σ1R interacting with dopamine D1 and D2 receptors, the potential regulation of dopaminergic transmission by σ2R is also unknown. We here demonstrate that σ2R may form heteroreceptor complexes with D1 but not with D2 receptors. Remarkably σ1, σ2, and D1 receptors may form heterotrimers with particular signaling properties. Determination of cAMP levels, MAP kinase activation and label-free assays demonstrate allosteric interactions within the trimer. Importantly, the presence of σ2R induces bias in signal transduction as σ2R ligands increase cAMP signaling whereas reduce MAP kinase activation. These effects, which are opposite to those exerted via σ1R, suggest that the D1 receptor-mediated signaling depends on the degree of trimer formation and the differential balance of sigma receptor and heteroreceptor expression in acute versus chronic cocaine consumption. Although the physiological role is unknown, the heteroreceptor complex formed by σ1, σ2, and D1 receptors arise as relevant to convey the cocaine actions on motor control and reward circuits and as a key factor in acquisition of the addictive habit. KEYWORDS: ERK1/2 phosphorylation; acute; addiction; cAMP; chronic; dopamine D1 and D2 receptors; label-free; signalin