The Kinematics of Intracluster Planetary Nebulae and the On-Going Subcluster Merger in the Coma Cluster Core

The Coma cluster is the richest and most compact of the nearby clusters, yet there is growing evidence that its formation is still on-going. With a new multi-slit imaging spectroscopy technique pioneered at the 8.2 m Subaru telescope and FOCAS, we have detected and measured the line-of-sight velocities of 37 intracluster planetary nebulae associated with the diffuse stellar population of stars in the Coma cluster core, at 100 Mpc distance. We detect clear velocity substructures within a 6 arcmin diameter field. A substructure is present at ~5000 km/s, probably from in-fall of a galaxy group, while the main intracluster stellar component is centered around ~6500 km/s, ~700 km/s offset from the nearby cD galaxy NGC 4874. The kinematics and morphology of the intracluster stars show that the cluster core is in a highly dynamically evolving state. In combination with galaxy redshift and X-ray data this argues strongly that the cluster is currently in the midst of a subcluster merger, where the NGC 4874 subcluster core may still be self-bound, while the NGC 4889 subcluster core has probably dissolved. The NGC 4889 subcluster is likely to have fallen into Coma from the eastern A2199 filament, in a direction nearly in the plane of the sky, meeting the NGC 4874 subcluster arriving from the west. The two inner subcluster cores are presently beyond their first and second close passage, during which the elongated distribution of diffuse light has been created. We predict the kinematic signature expected in this scenario, and argue that the extended western X-ray arc recently discovered traces the arc shock generated by the collision between the two subcluster gas halos. Any preexisting cooling core region would have been heated by the subcluster collision.Comment: Astronomy & Astrophysics, in press, 9 pages, 5 figure

Galaxy-Mass Correlations on 10 Mpc Scales in the Deep Lens Survey

We examine the projected correlation of galaxies with mass from small scales (<few hundred kpc) where individual dark matter halos dominate, out to 15 Mpc where correlated large-scale structure dominates. We investigate these profiles as a function of galaxy luminosity and redshift. Selecting 0.8 million galaxies in the Deep Lens Survey, we use photometric redshifts and stacked weak gravitational lensing shear tomography out to radial scales of 1 degree from the centers of foreground galaxies. We detect correlated mass density from multiple halos and large-scale structure at radii larger than the virial radius, and find the first observational evidence for growth in the galaxy-mass correlation on 10 Mpc scales with decreasing redshift and fixed range of luminosity. For a fixed range of redshift, we find a scaling of projected halo mass with rest-frame luminosity similar to previous studies at lower redshift. We control systematic errors in shape measurement and photometric redshift, enforce volume completeness through absolute magnitude cuts, and explore residual sample selection effects via simulations.Comment: 13 pages, 9 figures, re-submitted to ApJ after addressing referee comment

Are Child and Adolescent Responses to Placebo Higher in Major Depression than in Anxiety Disorders? A Systematic Review of Placebo-Controlled Trials

BACKGROUND: In a previous report, we hypothesized that responses to placebo were high in child and adolescent depression because of specific psychopathological factors associated with youth major depression. The purpose of this study was to compare the placebo response rates in pharmacological trials for major depressive disorder (MDD), obsessive compulsive disorder (OCD) and other anxiety disorders (AD-non-OCD). METHODOLOGY AND PRINCIPAL FINDINGS: We reviewed the literature relevant to the use of psychotropic medication in children and adolescents with internalized disorders, restricting our review to double-blind studies including a placebo arm. Placebo response rates were pooled and compared according to diagnosis (MDD vs. OCD vs. AD-non-OCD), age (adolescent vs. child), and date of publication. From 1972 to 2007, we found 23 trials that evaluated the efficacy of psychotropic medication (mainly non-tricyclic antidepressants) involving youth with MDD, 7 pertaining to youth with OCD, and 10 pertaining to youth with other anxiety disorders (N = 2533 patients in placebo arms). As hypothesized, the placebo response rate was significantly higher in studies on MDD, than in those examining OCD and AD-non-OCD (49.6% [range: 17-90%] vs. 31% [range: 4-41%] vs. 39.6% [range: 9-53], respectively, ANOVA F = 7.1, p = 0.002). Children showed a higher stable placebo response within all three diagnoses than adolescents, though this difference was not significant. Finally, no significant effects were found with respect to the year of publication. CONCLUSION: MDD in children and adolescents appears to be more responsive to placebo than other internalized conditions, which highlights differential psychopathology

Spatial variations of the optical galaxy luminosity functions and red sequences in the Coma cluster: clues to its assembly history

Clusters of galaxies are believed to be at the intersections of cosmological filaments and to grow by accreting matter from these filaments. Such continuous infall has major consequences not only on clusters but also on the physics of cluster galaxies. Faint galaxies are particularly interesting as they are very sensitive to environmental effects, and may have a different behaviour from that of bright galaxies. The aim of this paper is to sample the Coma cluster building history, based on the analysis of galaxy luminosity functions and red sequences in the Color Magnitude Relation down to faint magnitudes, which are privileged tools for this purpose. The present analysis is based on deep (R~24), wide (~0.5 deg2) multiband (BVRI Vega system) images of the Coma cluster obtained with the CFH12K camera at the CFHT. We have derived LFs and CMRs in twenty 10x10 arcmin2 regions and in larger regions. In all photometric bands, we found steeply rising LFs in the north-northeast half of the cluster (due to early type galaxies at bright magnitudes and due to late type galaxies at the faint end), and much flatter LFs in the south-southwest region. Although the fine behaviour of the CMR RS is different in these two regions, a good agreement is found in general between the RS computed for faint and for bright galaxies. All these results can be interpreted consistently in the framework of the building up process previously proposed. The Northern Coma area is a relatively quiescent region while the southern area experiences several infalls.Comment: To be published in A&A, several figures in jpg format, full resolution figures and paper available at http://cencosw.oamp.fr/ under the Coma page. The lacking figures are available at the same adress. Updated CFHT acknowledgements and aa forma

A re-introduction of environmental mite allergen control strategies for asthma treatment and the debate on their effectiveness

Asthma affects three hundred million people worldwide. The effectiveness of house dust mite allergen control for asthma treatment is debatable. One aspect that has been little discussed in existing meta‐analyses is the possible role of environmental strategies. Here, we re‐introduce the previously defined strategies for mite allergen control and discuss their importance to the debate on clinical effectiveness. The strategy of concurrent bedroom interventions is related to the combined use of a priori defined interventions, while the strategy of exposure‐based control relates to the treatment of relevant textiles after assessing exposure. The air purification strategy aims to purify the human breathing zone of airborne allergens. In Western European patient practice, the use of these strategies differs. A post hoc study of the dominant Cochrane review by Gøtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187) appears to indicate that a majority of the underlying trials reported on the strategy of concurrent bedroom interventions, which were mainly executed in a minimal manner. Some trials have reported on the air purification strategy and may potentially alter the debate on effectiveness. No trial has reported on the strategy of exposure‐based control. We therefore hypothesize that the absence of evidence for the effectiveness of mite allergen control for asthma treatment applies to the strategy of concurrent bedroom interventions. The evidence‐based effectiveness of the exposure‐based control strategy appears to be undetermined. The results of our post hoc re‐analysis urge that future meta‐analyses of mite allergen control should a priori define the environmental strategy under study. Future trials of mite allergen control are warranted to test the exposure‐based strategy as well as the sparsely tested strategy of air purification

Hypersensitivity to Pollen of Olea Europea in Patients with Pollen Allergy in Zadar Country, Croatia

Preosjetljivost na pelud masline važan je uzrok peludnih alergija u mediteranskim zemljama. Cilj ovoga rada bio je utvrditi učestalost preosjetljivosti na pelud masline među bolesnicima s peludnom alergijom u Zadru i Zadarskoj županiji. Dobivene rezultate usporedili smo s ranijim ispitivanjem preosjetljivosti na pelud masline u Dalmaciji. Ukupno je obrađen 671 ispitanik s preosjetljivosti na peludne alergene. Od toga broja 61 % ispitanika bilo je muškog spola, a 39 % je bilo ženskog spola. Od ukupno ispitanih 53.5 % činila su djeca u dobi od 4 do 14 godina, a preostalih 46.5 % bili su odrasli u dobi od 15 do 59 godina života. Svim ispitanicima uzeta je detaljna obiteljska i osobna anamneza, napravljen klinički pregled te učinjeno kožno prick-testiranje i enzimatsko-imunološki UniCAP-test za određivanje specifi čnih IgE-protutijela. Statistička obrada podataka učinjena je χ2-testom. Preosjetljivost na pelud masline dokazana je u 8.8 % bolesnika s peludnom alergijom. Najveći broj bolesnika s preosjetljivosti na pelud masline boluje od alergijskog rinitisa, 58 % bolesnika. Postoji statistički značajna razlika u broju bolesnika između dvije ispitivane sredine, gradske i seoske. Samo 3 % bolesnika stanovnici su otoka. Preosjetljivost na pelud masline u našem ispitivanju najniža je u odnosu na ispitivanja provedena u drugim mediteranskim zemljama. Najčešće se očituje kliničkom slikom alergijskog rinitisa, a statistički je značajno češća u gradskoj sredini. Usporedba preosjetljivosti na pelud masline tijekom dvaju ispitivanih razdoblja u našoj zemlji nije pokazala porast broja bolesnika s preosjetljivosti na pelud masline.Olive pollen is one of the most common respiratory allergens in the Mediterranean countries. The aim of this study was to establish the frequency of hypersensitivity to the pollen of Olea europea in pollen allergic patients in the County of Zadar. The study included 671 patients with pollen allergy; 61 % were male and 39 % female. 53.5 % were children aged from 4 to 14 years and 46.5 % adolescents and adults from 15 to 59 years. We took their case history, clinically examined them, and tested using the skin prick test and enzymo-immunologic UniCAP test for specifi c IgE antibodies. For statistical analysis we used the chi-square test. Hypersensitivity to Olea europea pollen was confi rmed in 8.8 % patients with pollen allergy. Among them, the most prevalent symptom was rhinitis (58 %). Most hypersensitive patients were urban residents. Only 3 % patients lived on an island. Judging by available data, our fi ndings show the lowest hypersensitivity to olive pollen in the Mediterranean. A comparison with our two earlier studies did not show any fl uctuation in this kind of hypersensitivity

Evidence-based Kernels: Fundamental Units of Behavioral Influence

This paper describes evidence-based kernels, fundamental units of behavioral influence that appear to underlie effective prevention and treatment for children, adults, and families. A kernel is a behavior–influence procedure shown through experimental analysis to affect a specific behavior and that is indivisible in the sense that removing any of its components would render it inert. Existing evidence shows that a variety of kernels can influence behavior in context, and some evidence suggests that frequent use or sufficient use of some kernels may produce longer lasting behavioral shifts. The analysis of kernels could contribute to an empirically based theory of behavioral influence, augment existing prevention or treatment efforts, facilitate the dissemination of effective prevention and treatment practices, clarify the active ingredients in existing interventions, and contribute to efficiently developing interventions that are more effective. Kernels involve one or more of the following mechanisms of behavior influence: reinforcement, altering antecedents, changing verbal relational responding, or changing physiological states directly. The paper describes 52 of these kernels, and details practical, theoretical, and research implications, including calling for a national database of kernels that influence human behavior