267 research outputs found
Characterization of adolescent and pediatric renal cell carcinoma: A report from the Children's Oncology Group study AREN03B2
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111918/1/cncr29368.pd
The Updated Zwicky Catalog (UZC)
The Zwicky Catalog of galaxies (ZC), with m_Zw<=15.5mag, has been the basis
for the Center for Astrophysics (CfA) redshift surveys. To date, analyses of
the ZC and redshift surveys based on it have relied on heterogeneous sets of
galaxy coordinates and redshifts. Here we correct some of the inadequacies of
previous catalogs by providing: (1) coordinates with <~2 arcsec errors for all
of the Nuzc catalog galaxies, (2) homogeneously estimated redshifts for the
majority (98%) of the data taken at the CfA (14,632 spectra), and (3) an
estimate of the remaining "blunder" rate for both the CfA redshifts and for
those compiled from the literature. For the reanalyzed CfA data we include a
calibrated, uniformly determined error and an indication of the presence of
emission lines in each spectrum. We provide redshifts for 7,257 galaxies in the
CfA2 redshift survey not previously published; for another 5,625 CfA redshifts
we list the remeasured or uniformly re-reduced value. Among our new
measurements, Nmul are members of UZC "multiplets" associated with the original
Zwicky catalog position in the coordinate range where the catalog is 98%
complete. These multiplets provide new candidates for examination of tidal
interactions among galaxies. All of the new redshifts correspond to UZC
galaxies with properties recorded in the CfA redshift compilation known as
ZCAT. About 1,000 of our new measurements were motivated either by inadequate
signal-to-noise in the original spectrum or by an ambiguous identification of
the galaxy associated with a ZCAT redshift. The redshift catalog we include
here is ~96% complete to m_Zw<=15.5, and ~98% complete (12,925 galaxies out of
a total of 13,150) for the RA(1950) ranges [20h--4h] and [8h--17h] and
DEC(1950) range [-2.5d--50d]. (abridged)Comment: 34 pp, 7 figs, PASP 1999, 111, 43
Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature
In high-income countries, the overall survival of children with Wilms tumors (WT) is ~90%.
However, overall, 15% of patients experience tumor recurrence. The adverse prognostic factors
currently used for risk stratification (advanced stage, high risk histology, and combined loss of
heterozygosity at 1p and 16q in chemotherapy-naïve WTs) are present in only one third of these cases,
and the significance of these factors is prone to change with advancing knowledge and improved
treatment regimens. Therefore, we present a comprehensive, updated overview of the published
prognostic variables for WT recurrence, ranging from patient-, tumor- and treatment-related characteristics to geographic and socioeconomic factors. Improved first-line treatment regimens based on clinicopathological characteristics and advancing knowledge on copy number variations unveil
the importance of further investigating the significance of biological markers for WT recurrence in
international collaborations
The WiggleZ Dark Energy Survey: the transition to large-scale cosmic homogeneity
We have made the largest-volume measurement to date of the transition to
large-scale homogeneity in the distribution of galaxies. We use the WiggleZ
survey, a spectroscopic survey of over 200,000 blue galaxies in a cosmic volume
of ~1 (Gpc/h)^3. A new method of defining the 'homogeneity scale' is presented,
which is more robust than methods previously used in the literature, and which
can be easily compared between different surveys. Due to the large cosmic depth
of WiggleZ (up to z=1) we are able to make the first measurement of the
transition to homogeneity over a range of cosmic epochs. The mean number of
galaxies N(<r) in spheres of comoving radius r is proportional to r^3 within
1%, or equivalently the fractal dimension of the sample is within 1% of D_2=3,
at radii larger than 71 \pm 8 Mpc/h at z~0.2, 70 \pm 5 Mpc/h at z~0.4, 81 \pm 5
Mpc/h at z~0.6, and 75 \pm 4 Mpc/h at z~0.8. We demonstrate the robustness of
our results against selection function effects, using a LCDM N-body simulation
and a suite of inhomogeneous fractal distributions. The results are in
excellent agreement with both the LCDM N-body simulation and an analytical LCDM
prediction. We can exclude a fractal distribution with fractal dimension below
D_2=2.97 on scales from ~80 Mpc/h up to the largest scales probed by our
measurement, ~300 Mpc/h, at 99.99% confidence.Comment: 21 pages, 16 figures, accepted for publication in MNRA
Latent class analysis of the Child Behavior Checklist Obsessive-Compulsive Scale
The Obsessive-Compulsive Scale (OCS) of the Child Behavior Checklist (CBCL) predicts obsessive-compulsive disorder and is highly heritable. Latent class analysis (LCA) of the OCS was used to identify profiles within this 8-item scale and to examine heritability of those profiles. The LCA was performed on maternal CBCL reports of their 6- to 18-year-old children from 2 US nationally representative samples from 1989 (n = 2475, 50% male) and 1999 (n = 2029, 53% male) and from Dutch twins in the Netherlands Twin Registry at ages 7 (n = 10 194, 49.3% male), 10 (n = 6448, 48.1% male), and 12 (n = 3674, 48.6% male) years. The heritability of the resultant classes was estimated using odds ratios of twin membership across classes. A 4-class solution fitted all samples best. The resulting classes were a "No or Few Symptoms" class, a "Worries and Has to Be Perfect" class, a "Thought Problems" class, and an "OCS" class. Within-class odds ratios were higher than across-class odds ratios and were higher for monozygotic than dizygotic twins. We conclude that LCA identifies an OCS class and that class is highly heritable using across-twin comparisons. © 2009 Elsevier Inc. All rights reserved
Results of Treatment for Patients With Multicentric or Bilaterally Predisposed Unilateral Wilms Tumor (AREN0534): A report from the Children’s Oncology Group
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156248/2/cncr32958_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156248/1/cncr32958.pd
DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma
The pathogenesis of cystic nephroma of the kidney has interested pathologists for over 50 years. Emerging from its initial designation as a type of unilateral multilocular cyst, cystic nephroma has been considered as either a developmental abnormality or a neoplasm or both. Many have viewed cystic nephroma as the benign end of the pathologic spectrum with cystic partially differentiated nephroblastoma and Wilms tumor, whereas others have considered it a mixed epithelial and stromal tumor. We hypothesize that cystic nephroma, like the pleuropulmonary blastoma in the lung, represents a spectrum of abnormal renal organogenesis with risk for malignant transformation. Here we studied DICER1 mutations in a cohort of 20 cystic nephromas and 6 cystic partially differentiated nephroblastomas, selected independently of a familial association with pleuropulmonary blastoma and describe four cases of sarcoma arising in cystic nephroma, which have a similarity to the solid areas of type II or III pleuropulmonary blastoma. The genetic analyses presented here confirm that DICER1 mutations are the major genetic event in the development of cystic nephroma. Further, cystic nephroma and pleuropulmonary blastoma have similar DICER1 loss of function and ‘hotspot' missense mutation rates, which involve specific amino acids in the RNase IIIb domain. We propose an alternative pathway with the genetic pathogenesis of cystic nephroma and DICER1-renal sarcoma paralleling that of type I to type II/III malignant progression of pleuropulmonary blastoma
Genetic and Epigenetic Features of Bilateral Wilms Tumor Predisposition in Patients From the Children’s Oncology Group AREN18B5-Q
Developing synchronous bilateral Wilms tumor suggests an underlying (epi)genetic predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or genome sequencing (n = 85 tumors from 61 patients with matched germline blood DNA), RNA-seq (n = 99 tumors), and DNA methylation analysis (n = 61 peripheral blood, n = 29 non-diseased kidney, n = 99 tumors). We determine the predominant events for bilateral Wilms tumor predisposition: 1)pre-zygotic germline genetic variants readily detectable in blood DNA [WT1 (14.8%), NYNRIN (6.6%), TRIM28 (5%), and BRCA-related genes (5%)] or 2)post-zygotic epigenetic hypermethylation at 11p15.5 H19/ICR1 that may require analysis of multiple tissue types for diagnosis. Of 99 total tumor specimens, 16 (16.1%) have 11p15.5 normal retention of imprinting, 25 (25.2%) have 11p15.5 copy neutral loss of heterozygosity, and 58 (58.6%) have 11p15.5 H19/ICR1 epigenetic hypermethylation (loss of imprinting). Here, we ascertain the epigenetic and genetic modes of bilateral Wilms tumor predisposition
Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation
Background: Cdc42 and Rac1, members of the Rho family of small GTPases, play critical roles in actin cytoskeleton regulation. We have shown previously that Rac1 is involved in regulation of platelet secretion and aggregation. However, the role of Cdc42 in platelet activation remains controversial. This study was undertaken to better understand the role of Cdc42 in platelet activation. Methodology/Principal Findings: We utilized the Mx-cre;Cdc42 lox/lox inducible mice with transient Cdc42 deletion to investigate the involvement of Cdc42 in platelet function. The Cdc42-deficient mice exhibited a significantly reduced platelet count than the matching Cdc42 +/+ mice. Platelets isolated from Cdc42 2/2, as compared to Cdc42 +/+, mice exhibited (a) diminished phosphorylation of PAK1/2, an effector molecule of Cdc42, (b) inhibition of filopodia formation on immobilized CRP or fibrinogen, (c) inhibition of CRP- or thrombin-induced secretion of ATP and release of P-selectin, (d) inhibition of CRP, collagen or thrombin induced platelet aggregation, and (e) minimal phosphorylation of Akt upon stimulation with CRP or thrombin. The bleeding times were significantly prolonged in Cdc42 2/2 mice compared with Cdc42 +/+ mice. Conclusion/Significance: Our data demonstrate that Cdc42 is required for platelet filopodia formation, secretion an
A quantitative assessment of uncertainties affecting estimates of global mean OH derived from methyl chloroform observations
We estimated the global abundance of OH by interpreting observations of methyl chloroform (MCF) from two networks using an inverse technique and a 3-D chemical transport model driven by assimilated meteorology. Our inversion approach optimized both the emissions of MCF and the abundance of OH. Because of an a priori overestimate of the latitudinal gradient by the model in the standard setup, the inversion lowers global emissions and the global sink due to OH. Optimized emissions are about 10 % lower than published inventories on average between 1988 and 1994, and the decrease in the sink suggested by the inversion implies an average lifetime for MCF (with respect to tropospheric OH) of about 6.9 years, 11-21 % longer than the 5.7-6.2 years reported in previous studies. Our results are driven by the need to match the observed latitudinal gradient of MCF while balancing the MCF budget. We find that these results depend on the a priori constraint placed on MCF emissions, the rate of interhemispheric mixing in the model, the interhemispheric distribution of OH assumed, and the model simulation of pollution events. Since these factors are highly uncertain, we believe that the level of understanding on global lifetimes of pollutants removed by OH is lower than might be implied by the narrow range of estimates for MCF lifetime in the literature. 2
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