Twelve massless flavors and three colors below the conformal window

We report new results for a frequently discussed gauge theory with twelve fermion flavors in the fundamental representation of the SU(3) color gauge group. The model, controversial with respect to its conformality, is important in non-perturbative studies searching for a viable composite Higgs mechanism Beyond the Standard Model (BSM). To resolve the controversy, we subject the model to opposite hypotheses inside and outside of the conformal window. In the first hypothesis we test chiral symmetry breaking ($\chi{\rm SB}$) with its Goldstone spectrum, $F_\pi$, the $\chi{\rm SB}$ condensate, and several composite hadron states as the fermion mass is varied in a limited range with our best effort to control finite volume effects and extrapolation to the massless chiral limit. Supporting results for $\chi{\rm SB}$ from the running coupling based on the force between static sources and some preliminary evidence for the finite temperature transition are also presented. In the second test for the alternate hypothesis we probe conformal behavior driven by a single anomalous mass dimension under the assumption of unbroken chiral symmetry. Our results show a very low level of confidence in the conformal scenario. Staggered lattice fermions with stout-suppressed taste breaking are used throughout the simulations.Comment: 9 pages, 9 figure

Nearly conformal gauge theories in finite volume

We report new results on nearly conformal gauge theories with fermions in the fundamental representation of the SU(3) color gauge group as the number of fermion flavors is varied in the Nf = 4-16 range. To unambiguously identify the chirally broken phase below the conformal window we apply a comprehensive lattice tool set in finite volumes which includes the test of Goldstone pion dynamics, the spectrum of the fermion Dirac operator, and eigenvalue distributions of random matrix theory. We also discuss the theory inside the conformal window and present our first results on the running of the renormalized gauge coupling and the renormalization group beta function. The importance of understanding finite volume zero momentum gauge field dynamics inside the conformal window is illustrated. Staggered lattice fermions are used throughout the calculations.Comment: 9 pages and 7 figure

Can the nearly conformal sextet gauge model hide the Higgs impostor?

New results are reported from large scale lattice simulations of a frequently discussed strongly interacting gauge theory with a fermion flavor doublet in the two-index symmetric (sextet) representation of the SU(3) color gauge group. We find that the chiral condensate and the mass spectrum of the sextet model are consistent with chiral symmetry breaking in the limit of vanishing fermion mass. In contrast, sextet fermion mass deformations of spectral properties are not consistent with leading conformal scaling behavior near the critical surface of a conformal theory. A recent paper could not resolve the conformal fixed point of the gauge coupling from the slowly walking scenario of a very small nearly vanishing \beta-function (DeGrand:2012yq). It is argued that overall consistency with our new results is resolved if the sextet model is close to the conformal window, staying outside with a very small non-vanishing \beta-function. The model would exhibit then the simplest composite Higgs mechanism leaving open the possibility of a light scalar state with quantum numbers of the Higgs impostor. It would emerge as the pseudo-Goldstone dilaton state from spontaneous symmetry breaking of scale invariance. We will argue that even without association with the dilaton, the scalar Higgs-like state can be light very close to the conformal window. A new Higgs project of sextet lattice simulations is outlined to resolve these important questions.Comment: 10 pages, 8 figure

Theoretical Overview: The New Mesons

After commenting on the state of contemporary hadronic physics and spectroscopy, I highlight four areas where the action is: searching for the relevant degrees of freedom, mesons with beauty and charm, chiral symmetry and the D_{sJ} levels, and X(3872) and the lost tribes of charmonium.Comment: 10 pages, uses jpconf.cls; talk at First Meeting of the APS Topical Group on Hadronic Physic

Evolutionary connectionism: algorithmic principles underlying the evolution of biological organisation in evo-devo, evo-eco and evolutionary transitions

The mechanisms of variation, selection and inheritance, on which evolution by natural selection depends, are not fixed over evolutionary time. Current evolutionary biology is increasingly focussed on understanding how the evolution of developmental organisations modifies the distribution of phenotypic variation, the evolution of ecological relationships modifies the selective environment, and the evolution of reproductive relationships modifies the heritability of the evolutionary unit. The major transitions in evolution, in particular, involve radical changes in developmental, ecological and reproductive organisations that instantiate variation, selection and inheritance at a higher level of biological organisation. However, current evolutionary theory is poorly equipped to describe how these organisations change over evolutionary time and especially how that results in adaptive complexes at successive scales of organisation (the key problem is that evolution is self-referential, i.e. the products of evolution change the parameters of the evolutionary process). Here we first reinterpret the central open questions in these domains from a perspective that emphasises the common underlying themes. We then synthesise the findings from a developing body of work that is building a new theoretical approach to these questions by converting well-understood theory and results from models of cognitive learning. Specifically, connectionist models of memory and learning demonstrate how simple incremental mechanisms, adjusting the relationships between individually-simple components, can produce organisations that exhibit complex system-level behaviours and improve the adaptive capabilities of the system. We use the term “evolutionary connectionism” to recognise that, by functionally equivalent processes, natural selection acting on the relationships within and between evolutionary entities can result in organisations that produce complex system-level behaviours in evolutionary systems and modify the adaptive capabilities of natural selection over time. We review the evidence supporting the functional equivalences between the domains of learning and of evolution, and discuss the potential for this to resolve conceptual problems in our understanding of the evolution of developmental, ecological and reproductive organisations and, in particular, the major evolutionary transitions

Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging

Synaptic plasticity processes, which underlie learning and memory formation, require RNA to be translated local to synapses. The synaptic tagging hypothesis has previously been proposed to explain how mRNAs are available at specific activated synapses. However how RNA is regulated, and which transcripts are silenced or processed as part of the tagging process is still unknown. Modification of RNA by N6-methyladenosine (m6A/m) influences the cellular fate of mRNA. Here, by advanced microscopy, we showed that m6A demethylation by the eraser protein ALKBH5 occurs at active synaptic ribosomes and at synapses during short term plasticity. We demonstrated that at activated glutamatergic post-synaptic sites, both the YTHDF1 and YTHDF3 reader and the ALKBH5 eraser proteins increase in co-localisation to m6A-modified RNAs; but only the readers showed high co-localisation to modified RNAs during late-stage plasticity. The YTHDF1 and YTHFDF3 readers also exhibited differential roles during synaptic maturation suggesting that temporal and subcellular abundance may determine specific function. m6A-sequencing of human parahippocampus brain tissue revealed distinct white and grey matter m6A methylome profiles indicating that cellular context is a fundamental factor dictating regulated pathways. However, in both neuronal and glial cell-rich tissue, m6A effector proteins are themselves modified and m6A epitranscriptional and posttranslational modification processes coregulate protein cascades. We hypothesise that the availability m6A effector protein machinery in conjunction with RNA modification, may be important in the formation of condensed synaptic nanodomain assemblies through liquid-liquid phase separation. Our findings support that m6A demethylation by ALKBH5 is an intrinsic component of the synaptic tagging hypothesis and a molecular switch which leads to alterations in the RNA methylome, synaptic dysfunction and potentially reversible disease states

Metallothionein (MT) -I and MT-II Expression Are Induced and Cause Zinc Sequestration in the Liver after Brain Injury

Experiments with transgenic over-expressing, and null mutant mice have determined that metallothionein-I and -II (MT-I/II) are protective after brain injury. MT-I/II is primarily a zinc-binding protein and it is not known how it provides neuroprotection to the injured brain or where MT-I/II acts to have its effects. MT-I/II is often expressed in the liver under stressful conditions but to date, measurement of MT-I/II expression after brain injury has focused primarily on the injured brain itself. In the present study we measured MT-I/II expression in the liver of mice after cryolesion brain injury by quantitative reverse-transcriptase PCR (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) with the UC1MT antibody. Displacement curves constructed using MT-I/II knockout (MT-I/II−/−) mouse tissues were used to validate the ELISA. Hepatic MT-I and MT-II mRNA levels were significantly increased within 24 hours of brain injury but hepatic MT-I/II protein levels were not significantly increased until 3 days post injury (DPI) and were maximal at the end of the experimental period, 7 DPI. Hepatic zinc content was measured by atomic absorption spectroscopy and was found to decrease at 1 and 3 DPI but returned to normal by 7DPI. Zinc in the livers of MT-I/II−/− mice did not show a return to normal at 7 DPI which suggests that after brain injury, MT-I/II is responsible for sequestering elevated levels of zinc to the liver. Conclusion: MT-I/II is up-regulated in the liver after brain injury and modulates the amount of zinc that is sequestered to the liver

The infrared structure of gauge theory amplitudes in the high-energy limit

We develop an approach to the high-energy limit of gauge theories based on the universal properties of their infrared singularities. Our main tool is the dipole formula, a compact ansatz for the all-order infrared singularity structure of scattering amplitudes of massless partons. By taking the high-energy limit, we show that the dipole formula implies Reggeization of infrared-singular contributions to the amplitude, at leading logarithmic accuracy, for the exchange of arbitrary color representations in the cross channel. We observe that the real part of the amplitude Reggeizes also at next-to-leading logarithmic order, and we compute the singular part of the two-loop Regge trajectory, which is universally expressed in terms of the cusp anomalous dimension. Our approach provides tools to study the high-energy limit beyond the boundaries of Regge factorization: thus we show that Reggeization generically breaks down at next-to-next-to-leading logarithmic accuracy, and provide a general expression for the leading Reggeization-breaking operator. Our approach applies to multiparticle amplitudes in multi-Regge kinematics, and it also implies new constraints on possible corrections to the dipole formula, based on the Regge limit