43 research outputs found
Regla del Clero
Incluye: "Preparacion proxima para la muerte ... / Simon Salamo y Melchor Gelabet ...", con port. y pag. propias.Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2014Sign.: [calderon]4, A-Z4, 2a-2Z4, 3A-3O
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.
Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs).
Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001).
Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio
Praeparatio proxima ad mortem : ad usum clericorum populo etiam perutilis : compendiosae Regula Cleri nuper editae addita ...
Sign.: A-F, GPort. con viñeta xi
Regula cleri ex sacris litteris SS.PP. monimentis ecclesiasticisque sanctionibus excerpta
Sign.: *, A-Z, 2A-2E, 2F<4
Regla de vida muy útil para los pobres y para el pueblo menos instruido : muy saludable a los ricos, y a las personas doctas
La Viuda de Aguasvivas ejerce en 1798Sign.: []\p6\s, A-X\p8\sAnte
Praeparatio proxima ad mortem ad usum clericorum, populo etiam perutilis ...
Sign.: A-H, I<4
El Grano de Arena : revista católica consagrada al corazón de Jesús: Año XIII Número 1109 - 1908 marzo 24
Sign.: A-2D\p8\s, 2E\p2\sPort. con viñeta xilTexto con reclamo
Praeparatio proxima ad mortem : ad usum clericorum populo etiam perutilis : compendiosae Regula Cleri nuper editae addita ...
Sign.: A-F, GPort. con viñet
Regula cleri ex Sacris Litteris Sanctorum Patrum : monimentis ecclesiasticisque sanctionibus excerpta
Sign.: A-Q, RErro da páx. da 208 pasa a 21
Regula cleri ex sacris litteris SS.PP. : monimentis ecclesiasticisque sanctionibus excerpta
Sign.: [], A-Z, 2A-2E<8