Two Cases of Liposarcoma in the Thigh Area

The liposarcoma are not rare in the thigh area. Two patients both men, 56 and 39 years of age were operated within a few months because of giant liposarcoma in the left thigh region. The liposarcoma of these patients was strikingly similar. Upon suspicion of malignancy, resection of the tumor without prior diagnostic biopsy is recommended. The early postoperative period of both patients passed smoothly. The full range of movement was achieved in left hip and knee joints. Operative wounds healed per primam intentionem. Up till now, several months after tumors removal, both patients have no data of local or distant metastases.The liposarcoma are not rare in the thigh area. Two patients both men, 56 and 39 years of age were operated within a few months because of giant liposarcoma in the left thigh region. The liposarcoma of these patients was strikingly similar. Upon suspicion of malignancy, resection of the tumor without prior diagnostic biopsy is recommended. The early postoperative period of both patients passed smoothly. The full range of movement was achieved in left hip and knee joints. Operative wounds healed per primam intentionem. Up till now, several months after tumors removal, both patients have no data of local or distant metastases

Small bowel carcinoma associated with Crohn`s disease: clinical review and case report

Crohn`s disease is a chronic relapsing and remitting inflammation of the bowel involving all its layers. A small bowel adenocarcinoma in Crohn`s disease is a rare entity. The literature about this disease is reviewed. A case report of a 41-year male patient illustrates the significance of the diagnostic and therapeutic procedures

Giant thigh liposarcoma

IntroductionLiposarcoma is a heterogeneous group of adipocyte tumors in which cells differentiate into lipoblasts and lipocytes. Tumor localized in the extremities affects men more often. It rarely occurs before age 20. Diseases such as obesitas, gout, psoriasis, etc. seem to predispose to the development of this type of tumor. Lipomas (liposarcoma) are considered "giant", if they exceed 10 cm in one dimension or weigh at least 1000 grams. The thigh liposarcoma described in this article is the biggest reported in Bulgaria and one of the largest excised in the world practice.AimThe aim of this article is to draw attention to the difficulties associated with the surgical removal of a giant de-differentiated femoral liposarcoma, as well as the late metastases of such tumors.Patients and methodsThe patient presented is a 74-year-old male with a giant thigh liposarcoma weighing 7.65 kg, which has been subjected to an en bloc tumor excision.ResultsUp to now, a year and a half after surgery, no recurrence or metastases have been detected. The functional state of the limb is very good.ConclusionGiant thigh liposarcomas are a real surgical challenge. They are always located near the femoral vesels, engaging muscles and vessels, often growing proximal to lig. inguinale.IntroductionLiposarcoma is a heterogeneous group of adipocyte tumors in which cells differentiate into lipoblasts and lipocytes. Tumor localized in the extremities affects men more often. It rarely occurs before age 20. Diseases such as obesitas, gout, psoriasis, etc. seem to predispose to the development of this type of tumor. Lipomas (liposarcoma) are considered "giant", if they exceed 10 cm in one dimension or weigh at least 1000 grams. The thigh liposarcoma described in this article is the biggest reported in Bulgaria and one of the largest excised in the world practice.Aim The aim of this article is to draw attention to the difficulties associated with the surgical removal of a giant de-differentiated femoral liposarcoma, as well as the late metastases of such tumors.Patients and methods The patient presented is a 74-year-old male with a giant thigh liposarcoma weighing 7.65 kg, which has been subjected to an en bloc tumor excision.Results Up to now, a year and a half after surgery, no recurrence or metastases have been detected. The functional state of the limb is very good.Conclusion Giant thigh liposarcomas are a real surgical challenge. They are always located near the femoral vesels, engaging muscles and vessels, often growing proximal to lig. inguinale

Synovial lipomatosis of the foot - a unique location. Case report

IntroductionSynovial lipomatosis, also called lipoma arborescens, is an extremely rare chronic, benign disease. Less than 100 cases have been reported in the available literature. It is characterized by substitution of the sub-synovial connective tissue with mature fat cells and villous proliferation of the synovium. The etiology in most cases remains unknown, although some authors attribute it to trauma, degenerative changes in the joint, septic arthritis, psoriatic arthritis, chikungunya viral disease, etc. The most common locations of synovial lipomatosis are the knee, shoulder, elbow and bracelet, exceptionally affecting the hip and ankle joints, etc. Locations in the foot region are extremely rare. The patient described in this article has a unique location.AimThe aim of this article is to draw attention to a rare disease, with an even rarer localization.Materials and MethodsThe presented patient is a man at the age of 53 with synovial lipomatosis on the plantar side of the left foot.ResultsUp to this moment, three and a half years after the operation, the patient has no complaints and no recurrence data. The functional condition of the limb is excellent.ConclusionSynovial lipomatosis, especially that located in the foot area, is extremely rare, almost casuistic. However, it should not be excluded from the differential diagnosis

Is DTPA a good competing chelating agent for Th(IV) in human serum and suitable in targeted alpha therapy?

The interaction between thorium and human serum components was studied using difference ultraviolet spectroscopy (DUS), ultrafiltration and high–pressure–anion exchange chromatography (HPAEC) with external inductively coupled plasma mass spectrometry (ICP–MS) analysis. Experimental data are compared with modelling results based on the law of mass action. Transferrin interacts strongly with Th(IV), forming a ternary complex including two synergistic carbonate anions. This complex governs Th(IV) speciation under blood serum conditions. Considering the generally used Langmuir-type model, values of 1033.5 and 1032.5 were obtained for strong and weak sites, respectively. We showed that trace amounts of diethylene triamine pentaacetic acid (DTPA) cannot complex Th(IV) in the blood serum at equilibrium. Unexpectedly this effect is not related to the competition with HSTf but is due to the strong competition with major divalent metal ions for DTPA. However, Th-DTPA complex was shown to be stable for a few hours when it is formed before addition in the biological medium; this is related to the high kinetic stability of the complex. This makes DTPA a potential chelating agent for carrying Th-226 in the body for targeted alpha therapy applications.JRC.E.5-Nuclear chemistr

Neurofibromatosis (case reports)

Introduction: Neurofibromatosis includes a group of genetic diseases that cause tumors affecting nerve tissue. They are primarily benign, but in certain cases (3–5%) may undergo malignant transformation. Both the central and peripheral nervous systems can be affected. This results in their extremely diverse clinical manifestation—from mild cases to dramatic conditions. Three types of the disease have been described—neurofibromatosis type 1 (NF1), type 2 (NF2), and type 3—schwannomatosis.Aim: The aim of this article is to pay attention to a rare disease with a variety of symptoms and course, which due to its progressive course in some patients can lead to severe functional deficits and even amputation.Materials and Methods: Two patients are presented: a 4-year-old girl with a newly discovered disease with spinal localization, as well as a 53-year-old woman who underwent repeated surgery for newly emerging tumor formations in the area of the right forearm and arm.Results: Six years after the removal of the tumor from the spinal area, the child has no complaints, no evidence of local recurrence or involvement of other organs. Three years after the operation, the patient with localization of the tumor in the upper limb has significantly improved blood supply and functional condition of the arm.Conclusion: Neurofibromatosis is a disease with a variety of clinical manifestations. Limb surgeries should be planned and performed with extreme care and individual approach due to the high risk of additional vascular damage as well as potential malignant transformation.Introduction: Neurofibromatosis includes a group of genetic diseases that cause tumors affecting nerve tissue. They are primarily benign, but in certain cases (3–5%) may undergo malignant transformation. Both the central and peripheral nervous systems can be affected. This results in their extremely diverse clinical manifestation—from mild cases to dramatic conditions. Three types of the disease have been described—neurofibromatosis type 1 (NF1), type 2 (NF2), and type 3—schwannomatosis.Aim: The aim of this article is to pay attention to a rare disease with a variety of symptoms and course, which due to its progressive course in some patients can lead to severe functional deficits and even amputation.Materials and Methods: Two patients are presented: a 4-year-old girl with a newly discovered disease with spinal localization, as well as a 53-year-old woman who underwent repeated surgery for newly emerging tumor formations in the area of the right forearm and arm.Results: Six years after the removal of the tumor from the spinal area, the child has no complaints, no evidence of local recurrence or involvement of other organs. Three years after the operation, the patient with localization of the tumor in the upper limb has significantly improved blood supply and functional condition of the arm.Conclusion: Neurofibromatosis is a disease with a variety of clinical manifestations. Limb surgeries should be planned and performed with extreme care and individual approach due to the high risk of additional vascular damage as well as potential malignant transformation

Combination Chemotherapy for Influenza

The emergence of pandemic H1N1 influenza viruses in April 2009 and the continuous evolution of highly pathogenic H5N1 influenza viruses underscore the urgency of novel approaches to chemotherapy for human influenza infection. Anti-influenza drugs are currently limited to the neuraminidase inhibitors (oseltamivir and zanamivir) and to M2 ion channel blockers (amantadine and rimantadine), although resistance to the latter class develops rapidly. Potential targets for the development of new anti-influenza agents include the viral polymerase (and endonuclease), the hemagglutinin, and the non-structural protein NS1. The limitations of monotherapy and the emergence of drug-resistant variants make combination chemotherapy the logical therapeutic option. Here we review the experimental data on combination chemotherapy with currently available agents and the development of new agents and therapy targets