Effect of reduced computer precision on a midcourse navigation and guidance system using optimal filtering and linear prediction

Reduced computer precision effect on midcourse navigation and guidance system using optimal filtering and linear predictio

West Virginia\u27s Reimbursement Statute: The Hidden Costs of Institutionalization

Fate makes our relatives... , The treatment, care and maintenance received by the mentally ill and the mentally retarded in state hospitals do not fall into the traditional category of public welfare. Unlike other programs which assist the disadvantaged, most mental health laws impose a statutory duty on the recipient or his family to reimburse the state for all or part of the maintenance and treatment costs. West Virginia is among the jurisdictions which have adopted such laws. This state has statutory provisions5 which require reimbursement from the patient and designated family members. The amount the patient, or his family, is required to pay depends on the per patient cost at the individual institution. During the first six months of 1982, patients at the various West Virginia hospitals were billed anywhere between $10.94 and$56.00 per day for their care and maintenance. The majority of patients billed made partial or no payments. The money collected for reimbursement, in this state, is placed in a new fund which gives health administrators an incentive for strictly enforcing the reimbursement statute. Recent legislation allows the Department of Health to develop a long range plan for mental health facilities financed by collections from patients. In addition to new emphasis on collection, state institutions are under judicial pressure to provide more adequate and professional custody and treatment as mandated by the legislature. Improvements in physical conditions and professional treatment will indirectly increase the cost of patient care which is ultimately placed on the patient or his family. This note focuses on the rights and responsibilities of the patient and his family under the West Virginia cost reimbursement statute. The analysis includes a brief comparison between the West Virginia scheme and the more detailed Virginia provisions. The note also provides estate and family financial planning suggestions to help the patient and his family cover the institutional costs. While the patient\u27s financial responsibilities will be discussed, the key emphasis of this note is on the family, especially the parents and spouse

Some factors influencing the activity of Azotobacter in soils

May 10, 1937.Includes bibliographical references (pages 71-77)

Identification of presumed pathogenic KRT3 and KRT12 gene mutations associated with Meesmann corneal dystrophy.

PurposeTo report potentially pathogenic mutations in the keratin 3 (KRT3) and keratin 12 (KRT12) genes in two individuals with clinically diagnosed Meesmann corneal dystrophy (MECD).MethodsSlit-lamp examination was performed on the probands and available family members to identify characteristic features of MECD. After informed consent was obtained, saliva samples were obtained as a source of genomic DNA, and screening of KRT3 and KRT12 was performed. Potentially pathogenic variants were screened for in 200 control chromosomes. PolyPhen-2, SIFT, and PANTHER were used to predict the functional impact of identified variants. Short tandem repeat genotyping was performed to confirm paternity.ResultsSlit-lamp examination of the first proband demonstrated bilateral, diffusely distributed, clear epithelial microcysts, consistent with MECD. Screening of KRT3 revealed a heterozygous missense variant in exon 1, c.250C>T (p.(Arg84Trp)), which has a minor allele frequency of 0.0076 and was not identified in 200 control chromosomes. In silico analysis with PolyPhen-2 and PANTHER predicted the variant to be damaging to protein function; however, SIFT analysis predicted tolerance of the variant. The second proband demonstrated bilateral, diffusely distributed epithelial opacities that appeared gray-white on direct illumination and translucent on retroillumination. Neither parent demonstrated corneal opacities. Screening of KRT12 revealed a novel heterozygous insertion/deletion variant in exon 6, c.1288_1293delinsAGCCCT (p.(Arg430_Arg431delinsSerPro)). This variant was not present in either of the proband's parents or in 200 control chromosomes and was predicted to be damaging by PolyPhen-2, PANTHER, and SIFT. Haplotype analysis confirmed paternity of the second proband, indicating that the variant arose de novo.ConclusionsWe present a novel KRT12 mutation, representing the first de novo mutation and the first indel in KRT12 associated with MECD. In addition, we report a variant of uncertain significance in KRT3 in an individual with MECD. Although the potential pathogenicity of this variant is unknown, it is the first variant affecting the head domain of K3 to be reported in an individual with MECD and suggests that disease-causing variants associated with MECD may not be restricted to primary sequence alterations of either the helix-initiation or helix-termination motifs of K3 and K12

Flight test evaluation of a separate surface attitude command control system on a Beech 99 airplane

A joint NASA/university/industry program was conducted to flight evaluate a potentially low cost separate surface implementation of attitude command in a Beech 99 airplane. Saturation of the separate surfaces was the primary cause of many problems during development. Six experienced professional pilots who made simulated instrument flight evaluations experienced improvements in airplane handling qualities in the presence of turbulence and a reduction in pilot workload. For ride quality, quantitative data show that the attitude command control system results in all cases of airplane motion being removed from the uncomfortable ride region

Sensitivity Analysis of Launch Vehicle Debris Risk Model

As part of an analysis of the loss of crew risk associated with an ascent abort system for a manned launch vehicle, a model was developed to predict the impact risk of the debris resulting from an explosion of the launch vehicle on the crew module. The model consisted of a debris catalog describing the number, size and imparted velocity of each piece of debris, a method to compute the trajectories of the debris and a method to calculate the impact risk given the abort trajectory of the crew module. The model provided a point estimate of the strike probability as a function of the debris catalog, the time of abort and the delay time between the abort and destruction of the launch vehicle. A study was conducted to determine the sensitivity of the strike probability to the various model input parameters and to develop a response surface model for use in the sensitivity analysis of the overall ascent abort risk model. The results of the sensitivity analysis and the response surface model are presented in this paper

The Effect of Growth Promoting Implants on Feedlot Performance by Gelbvieh Bulls

The objective of this research was to determine the effect on feedlot performance of implanting various growth promotants in young bulls. Responses to these various implants by bulls were compared to a control group of bulls to determine the differences in feedlot performance. These comparisons provide information to help determine the most effective methods of bull feeding