Tandem Reactions of Dienes Generated by Enyne Metathesis

Thesis advisor: Marc L. SnapperA catalyst of notoriety Decomposes with great variety. Transformations after metathesis Facilitate tandem catalysis. This reaction has a proclivity For new regioselectivity With methanolic modification: Tandem enyne hydrovinylation. From a diene protonation event, Unexpected reaction with solvent, During catalyst optimization: One-pot enyne hydroarylation.Thesis (PhD) — Boston College, 2010.Submitted to: Boston College. Graduate School of Arts and Sciences.Discipline: Chemistry

Social axioms, cultural dimensions and personal autonomy in Romanian educational field

AbstractOur research is dealing with the topic of social axioms in the educational area, examining the way in which different subscales of social axioms and cultural dimensions from Hofstede's model could be related with personal autonomy, measured through self-esteem, locus of control and self-determination. The sample is composed by 522 subjects from Timisoara (253 from lower and higher secondary school and 269 from universities). The teachers from universities have shown significantly higher scores of social cynicism, power-distance, rewards for application and religiosity than the teacher from secondary schools. The similar and contradictory trend could be indentified for the young cohorts of teachers, comparative with the older ones

A Synthetic Loop Replacement Peptide That Blocks Canonical NFâ κB Signaling

Aberrant canonical NFâ κB signaling is implicated in diseases from autoimmune disorders to cancer. A major therapeutic challenge is the need for selective inhibition of the canonical pathway without impacting the many nonâ canonical NFâ κB functions. Here we show that a selective peptideâ based inhibitor of canonical NFâ κB signaling, in which a hydrogen bond in the NBD peptide is synthetically replaced by a nonâ labile bond, shows an about 10â fold increased potency relative to the original inhibitor. Not only is this molecule, NBD2, a powerful tool for dissection of canonical NFâ κB signaling in disease models and healthy tissues, the success of the synthetic loop replacement suggests that the general strategy could be useful for discovering modulators of the many proteinâ protein interactions mediated by such structures.Ein Peptidâ basierter Inhibitor für die kanonische NFâ κBâ Signalisierung, in dem eine Wasserstoffbrücke im NBDâ Peptid synthetisch durch eine nichtlabile Bindung ersetzt wurde, wirkt 10â mal stärker als der Originalinhibitor. Der Erfolg des Peptidschleifenaustauschs legt nahe, dass die Strategie nützlich sein könnte, um Modulatoren für viele durch solche Strukturen vermittelte Proteinâ Proteinâ Wechselwirkungen zu finden.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135091/1/ange201607990-sup-0001-misc_information.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135091/2/ange201607990.pd

Iterative Assembly of Macrocyclic Lactones using Successive Ring Expansion Reactions

Macrocyclic lactones can be prepared from lactams and hydroxyacid derivatives via an efficient 3- or 4-atom iterative ring expansion protocol. The products can also be expanded using amino acid-based linear fragments, meaning that macrocycles with precise sequences of hydroxy- and amino acids can be assembled in high yields by 'growing' them from smaller rings, using a simple procedure in which high dilution is not required. The method should significantly expedite the practical synthesis of diverse nitrogen containing macrolide frameworks

Potential self-inhibitory peptides from multimeric enzymes in kinetoplastid parasites.

<p>Potential self-inhibitory peptides from multimeric enzymes in kinetoplastid parasites.</p

Protein-protein interactions of drug targets involved in redox homeostasis.

<p>(A) TryR dimer from <i>C</i>. <i>fasciculata</i> (PDB: 1FEC) with known inhibitory helix (green cartoon) and predicted inhibitory helix-terminating loop (yellow cartoon) against calculated electrostatic surface. (B) Detail of interface peptide 71-TIRESAGFGWELD containing hot spots Ile-72, Phe-78, Trp-80, and Leu-82 (orange sticks). (C) TXNPx dimer from <i>L</i>. <i>major</i> (PDB: 4K1F) with predicted helix from HippDB (green cartoon) and predicted inhibitory loop (yellow cartoon) against calculated electrostatic surface. (D) Detail of interface peptide 145-NDMPVGR containing hot spots Asn-145, Val-149, and Arg-151 (orange sticks). (E) G6PDH dimer from <i>T</i>. <i>cruzi</i> (PDB: 4E9I) with predicted helix from HippDB (green cartoon), helix-turn predicted by Loopfinder (purple cartoon), and long, beta-sheet-anchored loop (yellow cartoon) matching the homologous region of a known inhibitor of <i>H</i>. <i>sapiens</i> G6PDH. (F) Detail of interface peptide 441-AMYLKLTAKTPGLLNDTHQTEL containing hot spots Met-442, Leu-446, and Leu-462 (orange sticks) clustered in a hydrophobic pocket. Images were rendered using PyMOL v0.99rc6 [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0005720#pntd.0005720.ref042" target="_blank">42</a>].</p

Classes of multi-chain kinetoplastid enzymes with structural data in the PDB.

<p>Classes of multi-chain kinetoplastid enzymes with structural data in the PDB.</p