Institutional features of wage bargaining in 23 European countries, the US and Japan.

This paper presents information on wage bargaining institutions, collected using a standardised questionnaire. Our data provide information from 1995 and 2006, for four sectors of activity and the aggregate economy, considering 23 European countries, plus the US and Japan. Main findings include a high degree of regulation in wage setting in most countries. Although union membership is low in many countries, union coverage is high and almost all countries also have some form of national minimum wage. Most countries negotiate wages on several levels, the sectoral level still being the most dominant, with an increasingly important role for bargaining at the firm level. The average length of collective bargaining agreements is found to lie between one and three years. Most agreements are strongly driven by developments in prices and eleven countries have some form of indexation mechanism which affects wages. Cluster analysis identifies three country groupings of wage-setting institutions.Wage Bargaining ; Institutions ; Indexation ; Trade Union Membership, Cluster Analysis

Three-dimensional Maxwell-Bloch calculation of the temporal profile of a seeded soft x-ray laser pulse

International audienceWe present three-dimensional modeling of amplification of a high-order harmonic seed by a soft x-ray laser plasma. The time-dependent evolution of the x-ray signal is determined from a fully dynamic Maxwell-Bloch calculation. At high seed intensities , a simplified one-dimensional calculation leads to strong Rabi-like temporal oscillations of the output signal. However, such oscillations have not been observed experimentally. Our three-dimensional calculations demonstrate that this is due to spatial non-uniformities in the plasma gain that cause the Rabi oscillations to dampen dramatically. Large amplitude Rabi-like oscillations are expected to appear only in long and uniform plasma. Such targets require optimized guiding techniques

Internal frequency conversion extreme ultraviolet interferometer using mutual coherence properties of two high-order-harmonic sources

International audienceWe report on an innovative two-dimensional imaging extreme ultraviolet (XUV) interferometer operating at 32 nm based on the mutual coherence of two laser high order harmonics (HOH) sources, separately generated in gas. We give the first evidence that the two mutually coherent HOH sources can be produced in two independent spatially separated gas jets, allowing for probing centimeter-sized objects. A magnification factor of 10 leads to a micron resolution associated with a subpicosecond temporal resolution. Single shot interferograms with a fringe visibility better than 30% are routinely produced. As a test of the XUV interferometer, we measure a maximum electronic density of 3×10^20 cm^−3 1.1 ns after the creation of a plasma on aluminum target

A TGFβ-ECM-Integrin signalling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease

: The formation of multiple cysts in the liver occurs in a number of isolated monogenic diseases or multisystemic syndromes, during which bile ducts develop into fluid-filled biliary cysts. For patients with polycystic liver disease (PCLD), nonsurgical treatments are limited, and managing life-long abdominal swelling, pain, and increasing risk of cyst rupture and infection is common. We demonstrate here that loss of the primary cilium on postnatal biliary epithelial cells (via the deletion of the cilia gene Wdr35) drives ongoing pathological remodeling of the biliary tree, resulting in progressive cyst formation and growth. The development of cystic tissue requires the activation of transforming growth factor-β (TGFβ) signaling, which promotes the expression of a procystic, fibronectin-rich extracellular matrix and which itself is perceived by a changing profile of integrin receptors on the cystic epithelium. This signaling axis is conserved in liver cysts from patients with either autosomal dominant polycystic kidney disease or autosomal dominant polycystic liver disease, indicating that there are common cellular mechanisms for liver cyst growth regardless of the underlying genetic cause. Cyst number and size can be reduced by inhibiting TGFβ signaling or integrin signaling in vivo. We suggest that our findings represent a therapeutic route for patients with polycystic liver disease, most of whom would not be amenable to surgery

Small-scale structure of the galactic cirrus emission

We examined the Fourier power spectrum characteristics of cirrus structures in 13 sky fields with faint to bright cirrus emission observed with ISOPHOT in the 90--200µm wavelength range in order to study variations of the spectral index $\alpha$. We found that $\alpha$ varies from field to field with --5.3 $\le$ $\alpha$ $\le$ --2.1. It depends on the absolute surface brightness and on the hydrogen column density. We also found different spectral indices for the same sky region at different wavelengths. Longer wavelength measurements show steeper power spectra. This can be explained by the presence of dust at various temperatures, in particular of a cold extended component. For the faintest areas of the far-infrared sky we derive a wavelength independent spectral index of $\alpha$ = --2.3$\pm$0.6 for the cirrus power spectrum. The application of the correct spectral index is a precondition for the proper disentanglement of the cirrus foreground component of the Cosmic Far-Infrared Background and its fluctuations.Comment: 10 pages; 7 figures; Astronomy & Astrophysics, accepte

First Detection of Polarization of the Submillimetre Diffuse Galactic Dust Emission by Archeops

We present the first determination of the Galactic polarized emission at 353 GHz by Archeops. The data were taken during the Arctic night of February 7, 2002 after the balloon--borne instrument was launched by CNES from the Swedish Esrange base near Kiruna. In addition to the 143 GHz and 217 GHz frequency bands dedicated to CMB studies, Archeops had one 545 GHz and six 353 GHz bolometers mounted in three polarization sensitive pairs that were used for Galactic foreground studies. We present maps of the I, Q, U Stokes parameters over 17% of the sky and with a 13 arcmin resolution at 353 GHz (850 microns). They show a significant Galactic large scale polarized emission coherent on the longitude ranges [100, 120] and [180, 200] deg. with a degree of polarization at the level of 4-5%, in agreement with expectations from starlight polarization measurements. Some regions in the Galactic plane (Gem OB1, Cassiopeia) show an even stronger degree of polarization in the range 10-20%. Those findings provide strong evidence for a powerful grain alignment mechanism throughout the interstellar medium and a coherent magnetic field coplanar to the Galactic plane. This magnetic field pervades even some dense clouds. Extrapolated to high Galactic latitude, these results indicate that interstellar dust polarized emission is the major foreground for PLANCK-HFI CMB polarization measurement.Comment: Submitted to Astron. & Astrophys., 14 pages, 12 Fig., 2 Table

A proposal for multi-tens of GW fully coherent femtosecond soft X-ray lasers

X-ray free-electron lasers1,2 delivering up to 131013 coherent photons in femtosecond pulses are bringing about a revolution in X-ray science3?5. However, some plasma-based soft X-ray lasers6 are attractive because they spontaneously emit an even higher number of photons (131015), but these are emitted in incoherent and long (hundreds of picoseconds) pulses7 as a consequence of the amplification of stochastic incoherent self-emission. Previous experimental attempts to seed such amplifiers with coherent femtosecond soft X-rays resulted in as yet unexplained weak amplification of the seed and strong amplification of incoherent spontaneous emission8. Using a time-dependent Maxwell?Bloch model describing the amplification of both coherent and incoherent soft X-rays in plasma, we explain the observed inefficiency and propose a new amplification scheme based on the seeding of stretched high harmonics using a transposition of chirped pulse amplification to soft X-rays. This scheme is able to deliver 531014 fully coherent soft X-ray photons in 200 fs pulses and with a peak power of 20 GW

Dose-Specific Adverse Drug Reaction Identification in Electronic Patient Records: Temporal Data Mining in an Inpatient Psychiatric Population

BACKGROUND: Data collected for medical, filing and administrative purposes in electronic patient records (EPRs) represent a rich source of individualised clinical data, which has great potential for improved detection of patients experiencing adverse drug reactions (ADRs), across all approved drugs and across all indication areas. OBJECTIVES: The aim of this study was to take advantage of techniques for temporal data mining of EPRs in order to detect ADRs in a patient- and dose-specific manner. METHODS: We used a psychiatric hospital’s EPR system to investigate undesired drug effects. Within one workflow the method identified patient-specific adverse events (AEs) and links these to specific drugs and dosages in a temporal manner, based on integration of text mining results and structured data. The structured data contained precise information on drug identity, dosage and strength. RESULTS: When applying the method to the 3,394 patients in the cohort, we identified AEs linked with a drug in 2,402 patients (70.8 %). Of the 43,528 patient-specific drug substances prescribed, 14,736 (33.9 %) were linked with AEs. From these links we identified multiple ADRs (p < 0.05) and found them to occur at similar frequencies, as stated by the manufacturer and in the literature. We showed that drugs displaying similar ADR profiles share targets, and we compared submitted spontaneous AE reports with our findings. For nine of the ten most prescribed antipsychotics in the patient population, larger doses were prescribed to sedated patients than non-sedated patients; five patients exhibited a significant difference (p < 0.05). Finally, we present two cases (p < 0.05) identified by the workflow. The method identified the potentially fatal AE QT prolongation caused by methadone, and a non-described likely ADR between levomepromazine and nightmares found among the hundreds of identified novel links between drugs and AEs (p < 0.05). CONCLUSIONS: The developed method can be used to extract dose-dependent ADR information from already collected EPR data. Large-scale AE extraction from EPRs may complement or even replace current drug safety monitoring methods in the future, reducing or eliminating manual reporting and enabling much faster ADR detection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40264-014-0145-z) contains supplementary material, which is available to authorised users

Temperature and polarization angular power spectra of Galactic dust radiation at 353 GHz as measured by Archeops

We present the first measurement of temperature and polarization angular power spectra of the diffuse emission of Galactic dust at 353 GHz as seen by Archeops on 20% of the sky. The temperature angular power spectrum is compatible with that provided by the extrapolation to 353 GHz of IRAS and DIRBE maps using \cite{fds} model number 8. For Galactic latitudes $|b| \geq 5$ deg we report a 4 sigma detection of large scale ($3\leq \ell \leq 8$) temperature-polarization cross-correlation $(\ell+1)C_\ell^{TE}/2\pi = 76\pm 21 \mu\rm{K_{RJ}}^2$ and set upper limits to the $E$ and $B$ modes at $11 \mu\rm{K_{RJ}}^2$. For Galactic latitudes $|b| \geq 10$ deg, on the same angular scales, we report a 2 sigma detection of temperature-polarization cross-correlation $(\ell+1)C_\ell^{TE}/2\pi = 24\pm 13 \mu\rm{K_{RJ}}^2$. These results are then extrapolated to 100 GHz to estimate the contamination in CMB measurements by polarized diffuse Galactic dust emission. The $TE$ signal is then $1.7\pm0.5$ and $0.5\pm0.3 \mu\rm{K^2_{CMB}}$ for $|b| \geq 5$ and 10 deg. respectively. The upper limit on $E$ and $B$ becomes $0.2 \mu\rm{K^2_{CMB}} (2\sigma)$. If polarized dust emission at higher Galactic latitude cuts is similar to the one we report here, then dust polarized radiation will be a major foreground for determining the polarization power spectra of the CMB at high frequencies above 100 GHz.Comment: 11 pages, 8 figures, submitted to A