Cheating and the evolutionary stability of mutualisms

Interspecific mutualisms have been playing a central role in the functioning of all ecosystems since the early history of life. Yet the theory of coevolution of mutualists is virtually nonexistent, by contrast with well-developed coevolutionary theories of competition, predator–prey and host–parasite interactions. This has prevented resolution of a basic puzzle posed by mutualisms: their persistence in spite of apparent evolutionary instability. The selective advantage of 'cheating', that is, reaping mutualistic benefits while providing fewer commodities to the partner species, is commonly believed to erode a mutualistic interaction, leading to its dissolution or reciprocal extinction. However, recent empirical findings indicate that stable associations of mutualists and cheaters have existed over long evolutionary periods. Here, we show that asymmetrical competition within species for the commodities offered by mutualistic partners provides a simple and testable ecological mechanism that can account for the long-term persistence of mutualisms. Cheating, in effect, establishes a background against which better mutualists can display any competitive superiority. This can lead to the coexistence and divergence of mutualist and cheater phenotypes, as well as to the coexistence of ecologically similar, but unrelated mutualists and cheaters

Generalized Cylinders in Semi-Riemannian and Spin Geometry

We use a construction which we call generalized cylinders to give a new proof of the fundamental theorem of hypersurface theory. It has the advantage of being very simple and the result directly extends to semi-Riemannian manifolds and to embeddings into spaces of constant curvature. We also give a new way to identify spinors for different metrics and to derive the variation formula for the Dirac operator. Moreover, we show that generalized Killing spinors for Codazzi tensors are restrictions of parallel spinors. Finally, we study the space of Lorentzian metrics and give a criterion when two Lorentzian metrics on a manifold can be joined in a natural manner by a 1-parameter family of such metrics.Comment: 29 pages, 2 figure

Vanishing Theorems and String Backgrounds

We show various vanishing theorems for the cohomology groups of compact hermitian manifolds for which the Bismut connection has (restricted) holonomy contained in SU(n) and classify all such manifolds of dimension four. In this way we provide necessary conditions for the existence of such structures on hermitian manifolds. Then we apply our results to solutions of the string equations and show that such solutions admit various cohomological restrictions like for example that under certain natural assumptions the plurigenera vanish. We also find that under some assumptions the string equations are equivalent to the condition that a certain vector is parallel with respect to the Bismut connection.Comment: 25 pages, Late

Compact Einstein-Weyl four-dimensional manifolds

We look for four dimensional Einstein-Weyl spaces equipped with a regular Bianchi metric. Using the explicit 4-parameters expression of the distance obtained in a previous work for non-conformally-Einstein Einstein-Weyl structures, we show that only four 1-parameter families of regular metrics exist on orientable manifolds : they are all of Bianchi $IX$ type and conformally K\"ahler ; moreover, in agreement with general results, they have a positive definite conformal scalar curvature. In a Gauduchon's gauge, they are compact and we obtain their topological invariants. Finally, we compare our results to the general analyses of Madsen, Pedersen, Poon and Swann : our simpler parametrisation allows us to correct some of their assertions.Comment: Latex file, 13 pages, an important reference added and a critical discussion of its claims offered, others minor modification

Blowing up generalized Kahler 4-manifolds

We show that the blow-up of a generalized Kahler 4-manifold in a nondegenerate complex point admits a generalized Kahler metric. As with the blow-up of complex surfaces, this metric may be chosen to coincide with the original outside a tubular neighbourhood of the exceptional divisor. To accomplish this, we develop a blow-up operation for bi-Hermitian manifolds.Comment: 16 page

Einstein-Weyl structures and Bianchi metrics

We analyse in a systematic way the (non-)compact four dimensional Einstein-Weyl spaces equipped with a Bianchi metric. We show that Einstein-Weyl structures with a Class A Bianchi metric have a conformal scalar curvature of constant sign on the manifold. Moreover, we prove that most of them are conformally Einstein or conformally K\"ahler ; in the non-exact Einstein-Weyl case with a Bianchi metric of the type $VII_0, VIII$ or $IX$, we show that the distance may be taken in a diagonal form and we obtain its explicit 4-parameters expression. This extends our previous analysis, limited to the diagonal, K\"ahler Bianchi $IX$ case.Comment: Latex file, 12 pages, a minor modification, accepted for publication in Class. Quant. Gra

Small Horizons

All near horizon geometries of supersymmetric black holes in a N=2, D=5 higher-derivative supergravity theory are classified. Depending on the choice of near-horizon data we find that either there are no regular horizons, or horizons exist and the spatial cross-sections of the event horizons are conformal to a squashed or round S^3, S^1 * S^2, or T^3. If the conformal factor is constant then the solutions are maximally supersymmetric. If the conformal factor is not constant, we find that it satisfies a non-linear vortex equation, and the horizon may admit scalar hair.Comment: 21 pages, latex. Typos corrected and reference adde

Relevance of cyclin D1b expression and CCND1 polymorphism in the pathogenesis of multiple myeloma and mantle cell lymphoma

BACKGROUND: The CCND1 gene generates two mRNAs (cyclin D1a and D1b) through an alternative splicing at the site of a common A/G polymorphism. Cyclin D1a and b proteins differ in their C-terminus, a region involved in protein degradation and sub-cellular localization. Recent data have suggested that cyclin D1b could be a nuclear oncogene. The presence of cyclin D1b mRNA and protein has been studied in two hemopathies in which cyclin D1 could be present: multiple myeloma (MM) and mantle cell lymphoma (MCL). The A/G polymorphism of CCND1 has also been verified in a series of patients. METHODS: The expression of cyclin D1 mRNA isoforms has been studied by real-time quantitative PCR; protein isoforms expression, localization and degradation by western blotting. The CCND1 polymorphism was analyzed after sequencing genomic DNA. RESULTS: Cyclin D1 mRNA isoforms a and b were expressed in mantle cell lymphoma (MCL) and multiple myeloma (MM). Cyclin D1b proteins were present in MCL, rarely in MM. Importantly, both protein isoforms localized the nuclear and cytoplasmic compartments. They displayed the same short half-life. Thus, the two properties of cyclin D1b recognized as necessary for its transforming activity are missing in MCL. Moreover, CCND1 polymorphism at the exon/intron boundary had no influence on splicing regulation in MCL cells. CONCLUSION: Our results support the notion that cyclin D1b is not crucial for the pathogenesis of MCL and MM

Twisted characters and holomorphic symmetries

We consider holomorphic twists of arbitrary supersymmetric theories in four dimensions. Working in the BV formalism, we rederive classical results characterizing the holomorphic twist of chiral and vector supermultiplets, computing the twist explicitly as a family over the space of nilpotent supercharges in minimal supersymmetry. The BV formalism allows one to work with or without auxiliary fields, according to preference; for chiral superfields, we show that the result of the twist is an identical BV theory, the holomorphic $\beta\gamma$ system with superpotential, independent of whether or not auxiliary fields are included. We compute the character of local operators in this holomorphic theory, demonstrating agreement of the free local operators with the usual index of free fields. The local operators with superpotential are computed via a spectral sequence, and are shown to agree with functions on a formal mapping space into the derived critical locus of the superpotential. We consider the holomorphic theory on various geometries, including Hopf manifolds and products of arbitrary pairs of Riemann surfaces, and offer some general remarks on dimensional reductions of holomorphic theories along the $(n-1)$-sphere to topological quantum mechanics. We also study an infinite-dimensional enhancement of the flavor symmetry in this example, to a recently-studied central extension of the derived holomorphic functions with values in the original Lie algebra that generalizes the familiar Kac--Moody enhancement in two-dimensional chiral theories