163 research outputs found
A Qualitative Evidence Synthesis Protocol
Nursing Bedside Handover (NBH) is acknowledged as a nursing practice implemented at the patientâs bedside to improve communication safety during the shift change, but it is vulnerable due to inconsistent application among nurses. This synthesis of qualitative evidence aims to review and synthesize the perceptions and experiences of nurses regarding the factors that, in their perspective, influence NBH practice. We will follow the thematic synthesis methodology of Thomas and Harden and the Enhancing Transparency in Reporting the Synthesis of Qualitative Research (ENTREQ) Statement guidelines. A search will be conducted through the databases of MEDLINE, CINAHL, Web of Science, and Scopus, and we will follow the three-step search process to identify primary studies with qualitative or mixed-method research designs and projects of quality improvement. The screening and selection of the studies will be carried out by two independent reviewers. We will use the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) to report the screening, search, and selection of studies. To assess its methodological quality, two reviewers will independently use the CASM Tool. The extracted data will be reviewed, categorized, and summarized in tabular and narrative formats. The findings obtained will allow us to inform future research and change management led by nurse managers.info:eu-repo/semantics/publishedVersio
Qualidade do ambiente de prĂĄtica de enfermagem em contexto hospitalar
info:eu-repo/semantics/publishedVersio
Ambiente de prĂĄtica de enfermagem em contexto hospitalar
info:eu-repo/semantics/publishedVersio
Biopolymer-based membranes associated with osteogenic growth peptide for guided bone regeneration
Barrier membranes for guided bone regeneration (GBR) mainly promote mechanical maintenance of bone defect space and induce
osteopromotion. Additionally, biopolymer-based membranes may provide greater bioactivity and biocompatibility due to their similarity to
extracellular matrix (ECM).In this study, biopolymers-based membranes from bacterial cellulose (BC) and collagen (COL) associated with
osteogenic growth peptide (OGP(10â14)) were evaluated to determine in vitro osteoinductive potential in early osteogenesis; moreover, histological
study was performed to evaluate the BCâCOL OGP(10â14) membranes on bone healing after GBR in noncritical defects in rat femur. The results
showed that the BCâCOL and BCâCOL OGP(10â14) membranes promoted cell proliferation and alkaline phosphatase activity in osteoblastic cell
cultures. However, ECMmineralization was similar between cultures grown on BC OGP(10â14) and BCâCOL OGP(10â14) membranes. In vivo
results showed that all the membranes tested, including the peptide-free BC membrane, promoted better bone regeneration than control group.
Furthermore, the BCâCOL OGP(10â14) membranes induced higher radiographic density in the repaired bone than the other groups at 1, 4 and 16
weeks. Histomorpho-metric analyses revealed that the BCâCOL OGP(10â14) induced higher percentage of bone tissue in the repaired area at 2 and 4
weeks than others membranes. In general, these biopolymer-based membranes might be potential candidates for bone regeneration applications
LSST Science Book, Version 2.0
A survey that can cover the sky in optical bands over wide fields to faint
magnitudes with a fast cadence will enable many of the exciting science
opportunities of the next decade. The Large Synoptic Survey Telescope (LSST)
will have an effective aperture of 6.7 meters and an imaging camera with field
of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over
20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with
fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a
total point-source depth of r~27.5. The LSST Science Book describes the basic
parameters of the LSST hardware, software, and observing plans. The book
discusses educational and outreach opportunities, then goes on to describe a
broad range of science that LSST will revolutionize: mapping the inner and
outer Solar System, stellar populations in the Milky Way and nearby galaxies,
the structure of the Milky Way disk and halo and other objects in the Local
Volume, transient and variable objects both at low and high redshift, and the
properties of normal and active galaxies at low and high redshift. It then
turns to far-field cosmological topics, exploring properties of supernovae to
z~1, strong and weak lensing, the large-scale distribution of galaxies and
baryon oscillations, and how these different probes may be combined to
constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at
http://www.lsst.org/lsst/sciboo
lincRNAs act in the circuitry controlling pluripotency and differentiation
Although thousands of large intergenic non-coding RNAs (lincRNAs) have been identified in mammals, few have been functionally characterized, leading to debate about their biological role. To address this, we performed loss-of-function studies on most lincRNAs expressed in mouse embryonic stem (ES) cells and characterized the effects on gene expression. Here we show that knockdown of lincRNAs has major consequences on gene expression patterns, comparable to knockdown of well-known ES cell regulators. Notably, lincRNAs primarily affect gene expression in trans. Knockdown of dozens of lincRNAs causes either exit from the pluripotent state or upregulation of lineage commitment programs. We integrate lincRNAs into the molecular circuitry of ES cells and show that lincRNA genes are regulated by key transcription factors and that lincRNA transcripts bind to multiple chromatin regulatory proteins to affect shared gene expression programs. Together, the results demonstrate that lincRNAs have key roles in the circuitry controlling ES cell state.Broad InstituteHarvard UniversityNational Human Genome Research Institute (U.S.)Merkin Family Foundation for Stem Cell Researc
CfA3: 185 Type Ia Supernova Light Curves from the CfA
We present multi-band photometry of 185 type-Ia supernovae (SN Ia), with over
11500 observations. These were acquired between 2001 and 2008 at the F. L.
Whipple Observatory of the Harvard-Smithsonian Center for Astrophysics (CfA).
This sample contains the largest number of homogeneously-observed and reduced
nearby SN Ia (z < 0.08) published to date. It more than doubles the nearby
sample, bringing SN Ia cosmology to the point where systematic uncertainties
dominate. Our natural system photometry has a precision of 0.02 mag or better
in BVRIr'i' and roughly 0.04 mag in U for points brighter than 17.5 mag. We
also estimate a systematic uncertainty of 0.03 mag in our SN Ia standard system
BVRIr'i' photometry and 0.07 mag for U. Comparisons of our standard system
photometry with published SN Ia light curves and comparison stars, where
available for the same SN, reveal agreement at the level of a few hundredths
mag in most cases. We find that 1991bg-like SN Ia are sufficiently distinct
from other SN Ia in their color and light-curve-shape/luminosity relation that
they should be treated separately in light-curve/distance fitter training
samples. The CfA3 sample will contribute to the development of better
light-curve/distance fitters, particularly in the few dozen cases where
near-infrared photometry has been obtained and, together, can help disentangle
host-galaxy reddening from intrinsic supernova color, reducing the systematic
uncertainty in SN Ia distances due to dust.Comment: Accepted to the Astrophysical Journal. Minor changes from last
version. Light curves, comparison star photometry, and passband tables are
available at http://www.cfa.harvard.edu/supernova/CfA3
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