Learner interrupted: understanding the stories behind the codes – a qualitative analysis of HE distance-learner withdrawals

Successful retention of students through understanding their motivations and behaviours is a challenge to universities worldwide. Whilst the impact of withdrawals is an issue for all institutions, attrition for distance-learning providers is particularly problematic owing to higher non-completion rates, less physical visibility, and because distance-learners tend to have more complex lives. This paper examines students’ personal stories explaining their decisions to withdraw from university study. It considers 641 written discourses initiated by students as part of their requests to withdraw, covering the challenges they face, and the complex combinations of factors that contribute to their decisions to give up. This qualitative approach was adopted as a necessary complement to the quantitative rush of metrics information that universities now provide on withdrawal figures. Three themes selected are: deferral/withdrawal, time available, and preparedness for study. The paper concludes that complementary qualitative insights both add clarity and detail to institutional understanding and reduces oversimplification of complex decision-making from unidimensional quantitative approaches

Global Ethics and Nanotechnology: A Comparison of the Nanoethics Environments of the EU and China

The following article offers a brief overview of current nanotechnology policy, regulation and ethics in Europe and The People’s Republic of China with the intent of noting (dis)similarities in approach, before focusing on the involvement of the public in science and technology policy (i.e. participatory Technology Assessment). The conclusions of this article are, that (a) in terms of nanosafety as expressed through policy and regulation, China PR and the EU have similar approaches towards, and concerns about, nanotoxicity—the official debate on benefits and risks is not markedly different in the two regions; (b) that there is a similar economic drive behind both regions’ approach to nanodevelopment, the difference being the degree of public concern admitted; and (c) participation in decision-making is fundamentally different in the two regions. Thus in China PR, the focus is on the responsibility of the scientist; in the EU, it is about government accountability to the public. The formulation of a Code of Conduct for scientists in both regions (China PR’s predicted for 2012) reveals both similarity and difference in approach to nanotechnology development. This may change, since individual responsibility alone cannot guide S&T development, and as public participation is increasingly seen globally as integral to governmental decision-making

Growth control of the eukaryote cell: a systems biology study in yeast.

BACKGROUND: Cell growth underlies many key cellular and developmental processes, yet a limited number of studies have been carried out on cell-growth regulation. Comprehensive studies at the transcriptional, proteomic and metabolic levels under defined controlled conditions are currently lacking. RESULTS: Metabolic control analysis is being exploited in a systems biology study of the eukaryotic cell. Using chemostat culture, we have measured the impact of changes in flux (growth rate) on the transcriptome, proteome, endometabolome and exometabolome of the yeast Saccharomyces cerevisiae. Each functional genomic level shows clear growth-rate-associated trends and discriminates between carbon-sufficient and carbon-limited conditions. Genes consistently and significantly upregulated with increasing growth rate are frequently essential and encode evolutionarily conserved proteins of known function that participate in many protein-protein interactions. In contrast, more unknown, and fewer essential, genes are downregulated with increasing growth rate; their protein products rarely interact with one another. A large proportion of yeast genes under positive growth-rate control share orthologs with other eukaryotes, including humans. Significantly, transcription of genes encoding components of the TOR complex (a major controller of eukaryotic cell growth) is not subject to growth-rate regulation. Moreover, integrative studies reveal the extent and importance of post-transcriptional control, patterns of control of metabolic fluxes at the level of enzyme synthesis, and the relevance of specific enzymatic reactions in the control of metabolic fluxes during cell growth. CONCLUSION: This work constitutes a first comprehensive systems biology study on growth-rate control in the eukaryotic cell. The results have direct implications for advanced studies on cell growth, in vivo regulation of metabolic fluxes for comprehensive metabolic engineering, and for the design of genome-scale systems biology models of the eukaryotic cell.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Structure and Stability of an Amorphous Metal

Using molecular dynamics simulations, with a realistic many-body embedded-atom potential, and a novel method to characterize local order, we study the structure of pure nickel during the rapid quench of the liquid and in the resulting glass. In contrast with previous simulations with pair potentials, we find more crystalline order and fewer icosahedra for slower quenching rates, resulting in a glass less stable against crystallization. It is shown that there is not a specific amorphous structure, only the arrest of the transition from liquid to crystal, resulting in small crystalline clusters immersed in an amorphous matrix with the same structure of the liquid.Comment: 4 pages, 4 ps figs., to appear in Phys. Rev. Let

Modelling the orientation of accretion disks in quasars using H-alpha emission

Infrared spectroscopy of the H-alpha emission lines of a sub-sample of 19 high-redshift (0.8 < z < 2.3) Molonglo quasars, selected at 408 MHz, is presented. These emission lines are fitted with composite models of broad and narrow emission, which include combinations of classical broad-line regions of fast-moving gas clouds lying outside the quasar nucleus, and/or a theoretical model of emission from an optically-thick, flattened, rotating accretion disk. All bar one of the nineteen sources are found to have emission consistent with the presence of an optically-emitting accretion disk, with the exception appearing to display complex emission including at least three broad components. Ten of the quasars have strong Bayesian evidence for broad-line emission arising from an accretion disk together with a standard broad-line region, selected in preference to a model with two simple broad lines. Thus the best explanation for the complexity required to fit the broad H-alpha lines in this sample is optical emission from an accretion disk in addition to a region of fast-moving clouds. We derive estimates of the angle between the rotation axis of the accretion disk and the line of sight. A weak correlation is found between the accretion disk angle and the logarithm of the low-frequency radio luminosity. This is direct, albeit tenuous, evidence for the receding torus model. Velocity shifts of the broad H-alpha components are analysed and the results found to be consistent with a two-component model comprising one single-peaked broad line emitted at the same redshift as the narrow lines, and emission from an accretion disk which appears to be preferentially redshifted with respect to the narrow lines for high-redshift sources and blueshifted relative to the narrow lines for low-redshift sources.Comment: The definitive version is available at www.blackwell-synergy.com. 36 pages, 21 figures, 13 tables. Replaced to fix A4/US letter paper size confusio

PEDRo: A database for storing, searching and disseminating experimental proteomics data

Abstract Background Proteomics is rapidly evolving into a high-throughput technology, in which substantial and systematic studies are conducted on samples from a wide range of physiological, developmental, or pathological conditions. Reference maps from 2D gels are widely circulated. However, there is, as yet, no formally accepted standard representation to support the sharing of proteomics data, and little systematic dissemination of comprehensive proteomic data sets. Results This paper describes the design, implementation and use of a Proteome Experimental Data Repository (PEDRo), which makes comprehensive proteomics data sets available for browsing, searching and downloading. It is also serves to extend the debate on the level of detail at which proteomics data should be captured, the sorts of facilities that should be provided by proteome data management systems, and the techniques by which such facilities can be made available. Conclusions The PEDRo database provides access to a collection of comprehensive descriptions of experimental data sets in proteomics. Not only are these data sets interesting in and of themselves, they also provide a useful early validation of the PEDRo data model, which has served as a starting point for the ongoing standardisation activity through the Proteome Standards Initiative of the Human Proteome Organisation

The Neurotropic Parasite Toxoplasma Gondii Increases Dopamine Metabolism

The highly prevalent parasite Toxoplasma gondii manipulates its host's behavior. In infected rodents, the behavioral changes increase the likelihood that the parasite will be transmitted back to its definitive cat host, an essential step in completion of the parasite's life cycle. The mechanism(s) responsible for behavioral changes in the host is unknown but two lines of published evidence suggest that the parasite alters neurotransmitter signal transduction: the disruption of the parasite-induced behavioral changes with medications used to treat psychiatric disease (specifically dopamine antagonists) and identification of a tyrosine hydroxylase encoded in the parasite genome. In this study, infection of mammalian dopaminergic cells with T. gondii enhanced the levels of K+-induced release of dopamine several-fold, with a direct correlation between the number of infected cells and the quantity of dopamine released. Immunostaining brain sections of infected mice with dopamine antibody showed intense staining of encysted parasites. Based on these analyses, T. gondii orchestrates a significant increase in dopamine metabolism in neural cells. Tyrosine hydroxylase, the rate-limiting enzyme for dopamine synthesis, was also found in intracellular tissue cysts in brain tissue with antibodies specific for the parasite-encoded tyrosine hydroxylase. These observations provide a mechanism for parasite-induced behavioral changes. The observed effects on dopamine metabolism could also be relevant in interpreting reports of psychobehavioral changes in toxoplasmosis-infected humans

Measurements of electron-proton elastic cross sections for 0.4<Q2<5.5(GeV/c)20.4 < Q^2 < 5.5 (GeV/c)^2

We report on precision measurements of the elastic cross section for electron-proton scattering performed in Hall C at Jefferson Lab. The measurements were made at 28 unique kinematic settings covering a range in momentum transfer of 0.4 $<$ $Q^2$ $<$ 5.5 $(\rm GeV/c)^2$. These measurements represent a significant contribution to the world's cross section data set in the $Q^2$ range where a large discrepancy currently exists between the ratio of electric to magnetic proton form factors extracted from previous cross section measurements and that recently measured via polarization transfer in Hall A at Jefferson Lab.Comment: 17 pages, 18 figures; text added, some figures replace

Modeling optical and UV polarization of AGNs I. Imprints of individual scattering regions

[abridged] We investigate the effects of various AGN scattering region geometries on the polarized flux. We introduce a new, publicly available Monte Carlo radiative transfer code, Stokes, which models polarization induced by scattering off free electrons and dust grains. We find that the shape of the funnel of the dusty torus has a significant impact on the polarization efficiency. A compact torus with a steep inner surface scatters more light toward type-2 viewing angles than a large torus of the same half-opening angle, theta0. For theta0 < 53 deg, the scattered light is polarized perpendicularly to the symmetry axis, whilst for theta0 > 60 deg it is polarized parallel to the symmetry axis. In between these intervals the orientation of the polarization depends on the viewing angle. The degree of polarization ranges between 0% and 20% and is wavelength-independent for a large range of theta0. Observed wavelength-independent optical and near-UV polarization thus does not necessarily imply electron scattering. For polar dust, scattering spectra are reddened for type-1 viewing angles, and made bluer for type-2 viewing angles. Polar electron-scattering cones are very efficient polarizers at type-2 viewing angles, whilst the polarized flux of the torus is weak. We predict that the net polarization of Seyfert-2 galaxies decreases with luminosity, and conclude that the degree of polarization should be correlated with the relative strength of the thermal IR flux. We find that a flattened, equatorial, electron-scattering disk, of relatively low optical depth, reproduces type-1 polarization. This is insensitive to the exact geometry, but the observed polarization requires a limited range of optical depth.Comment: 19 pages, 20 figures, accepted by Astronomy & Astrophysics. The computer code STOKES described here can be downloaded from http://www.stokes-program.info