804 research outputs found
New Discoveries from the Arecibo 327 MHz Drift Pulsar Survey Radio Transient Search
We present Clusterrank, a new algorithm for identifying dispersed
astrophysical pulses. Such pulses are commonly detected from Galactic pulsars
and rotating radio transients (RRATs), which are neutron stars with sporadic
radio emission. More recently, isolated, highly dispersed pulses dubbed fast
radio bursts (FRBs) have been identified as the potential signature of an
extragalactic cataclysmic radio source distinct from pulsars and RRATs.
Clusterrank helped us discover 14 pulsars and 8 RRATs in data from the Arecibo
327 MHz Drift Pulsar Survey (AO327). The new RRATs have DMs in the range pc cm and periods in the range s. The new
pulsars have DMs in the range pc cm and periods in the
range s, and include two nullers and a mode-switching object.
We estimate an upper limit on the all-sky FRB rate of day for
bursts with a width of 10 ms and flux density mJy. The DMs of all
new discoveries are consistent with a Galactic origin. In comparing statistics
of the new RRATs with sources from the RRATalog, we find that both sets are
drawn from the same period distribution. In contrast, we find that the period
distribution of the new pulsars is different from the period distributions of
canonical pulsars in the ATNF catalog or pulsars found in AO327 data by a
periodicity search. This indicates that Clusterrank is a powerful complement to
periodicity searches and uncovers a subset of the pulsar population that has so
far been underrepresented in survey results and therefore in Galactic pulsar
population models.Comment: 41 pages, 16 figures, 4 tables, accepted by ApJ; added minor
corrections to final ApJ proo
Malaria Immunity in Man and Mosquito: Insights Into Unsolved Mysteries of a Deadly Infectious Disease
Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular Apicomplexa family, the most deadly of which, Plasmodium falciparum, prevails in Africa. Malaria imposes a huge health burden on the world’s most vulnerable populations, claiming the lives of nearly a million children and pregnant women each year in Africa alone. Although there is keen interest in eradicating malaria, we do not yet have the necessary tools to meet this challenge, including an effective malaria vaccine and adequate vector control strategies. Here we review what is known about the mechanisms at play in immune resistance to malaria in both the human and mosquito hosts at each step in the parasite’s complex life cycle with a view towards developing the tools that will contribute to the prevention of disease and death and ultimately the goal of malaria eradication. In so doing we hope to inspire immunologists to participate in defeating this devastating disease
The International Pulsar Timing Array: First Data Release
The highly stable spin of neutron stars can be exploited for a variety of (astro)physical investigations. In particular, arrays of pulsars with rotational periods of the order of milliseconds can be used to detect correlated signals such as those caused by gravitational waves. Three such \u27pulsar timing arrays\u27 (PTAs) have been set up around the world over the past decades and collectively form the \u27International\u27 PTA (IPTA). In this paper, we describe the first joint analysis of the data from the three regional PTAs, i.e. of the first IPTA data set. We describe the available PTA data, the approach presently followed for its combination and suggest improvements for future PTA research. Particular attention is paid to subtle details (such as underestimation of measurement uncertainty and long-period noise) that have often been ignored but which become important in this unprecedentedly large and inhomogeneous data set. We identify and describe in detail several factors that complicate IPTA research and provide recommendations for future pulsar timing efforts. The first IPTA data release presented here (and available on-line) is used to demonstrate the IPTA\u27s potential of improving upon gravitational-wave limit
NEW DISCOVERIES from the ARECIBO 327 MHz DRIFT PULSAR SURVEY RADIO TRANSIENT SEARCH
We present Clusterrank, a new algorithm for identifying dispersed astrophysical pulses. Such pulses are commonly detected from Galactic pulsars and rotating radio transients (RRATs), which are neutron stars with sporadic radio emission. More recently, isolated, highly dispersed pulses dubbed fast radio bursts (FRBs) have been identified as the potential signature of an extragalactic cataclysmic radio source distinct from pulsars and RRATs. Clusterrank helped us discover 14 pulsars and 8 RRATs in data from the Arecibo 327 MHz Drift Pulsar Survey (AO327). The new RRATs have DMs in the range 23.5-86.6 pc cm-3 and periods in the range 0.172-3.901 s. The new pulsars have DMs in the range 23.6-133.3 pc cm-3 and periods in the range 1.249-5.012 s, and include two nullers and a mode-switching object. We estimate an upper limit on the all-sky FRB rate of 105 day-1 for bursts with a width of 10 ms and flux density ≳83 mJy. The DMs of all new discoveries are consistent with a Galactic origin. In comparing statistics of the new RRATs with sources from the RRATalog, we find that both sets are drawn from the same period distribution. In contrast, we find that the period distribution of the new pulsars is different from the period distributions of canonical pulsars in the ATNF catalog or pulsars found in AO327 data by a periodicity search. This indicates that Clusterrank is a powerful complement to periodicity searches and uncovers a subset of the pulsar population that has so far been underrepresented in survey results and therefore in Galactic pulsar population models
New Discoveries From The Arecibo 327 Mhz Drift Pulsar Survey Radio Transient Search
We present Clusterrank, a new algorithm for identifying dispersed astrophysical pulses. Such pulses are commonly detected from Galactic pulsars and rotating radio transients (RRATs), which are neutron stars with sporadic radio emission. More recently, isolated, highly dispersed pulses dubbed fast radio bursts (FRBs) have been identified as the potential signature of an extragalactic cataclysmic radio source distinct from pulsars and RRATs. Clusterrank helped us discover 14 pulsars and 8 RRATs in data from the Arecibo 327 MHz Drift Pulsar Survey (AO327). The new RRATs have DMs in the range 23.5–86.6 pc cm{sup −3} and periods in the range 0.172–3.901 s. The new pulsars have DMs in the range 23.6–133.3 pc cm{sup −3} and periods in the range 1.249–5.012 s, and include two nullers and a mode-switching object. We estimate an upper limit on the all-sky FRB rate of 10{sup 5} day{sup −1} for bursts with a width of 10 ms and flux density ≳83 mJy. The DMs of all new discoveries are consistent with a Galactic origin. In comparing statistics of the new RRATs with sources from the RRATalog, we find that both sets are drawn from the same period distribution. In contrast, we find that the period distribution of the newmore » pulsars is different from the period distributions of canonical pulsars in the ATNF catalog or pulsars found in AO327 data by a periodicity search. This indicates that Clusterrank is a powerful complement to periodicity searches and uncovers a subset of the pulsar population that has so far been underrepresented in survey results and therefore in Galactic pulsar population models.« les
A Deep Targeted Search for Fast Radio Bursts from the Sites of Low-Redshift Short Gamma-Ray Bursts
Some short gamma-ray bursts (SGRBs) are thought to be caused by the mergers
of binary neutron stars which may sometimes produce massive neutron star
remnants capable of producing extragalactic fast radio bursts (FRBs). We
conducted a deep search for FRBs from the sites of six low-redshift SGRBs. We
collected high time- and frequency-resolution data from each of the sites for
10 hours using the 2 GHz receiver of the Green Bank Telescope. Two of the SGRB
sites we targeted were visible with the Arecibo Radio Telescope with which we
conducted an additional 10 hours of 1.4 GHz observations for each. We searched
our data for FRBs using the GPU-optimized dedispersion algorithm
and the machine-learning-based package
(Fast Extragalactic Transient Candidate Hunter). We did not discover any FRBs,
but would have detected any with peak flux densities in excess of 87 mJy at the
Green Bank Telescope or 21 mJy at Arecibo with a signal-to-noise ratio of at
least 10. The isotropic-equivalent energy of any FRBs emitted from these sites
in our bands during our observations must not have exceeded a few times
erg, comparable to some of the lowest energy bursts yet seen from the
first known repeating FRB 121102.Comment: 10 pages, 2 figures, submitted to A
The NANOGrav 11-Year Data Set: Limits on Gravitational Waves from Individual Supermassive Black Hole Binaries
Observations indicate that nearly all galaxies contain supermassive black
holes (SMBHs) at their centers. When galaxies merge, their component black
holes form SMBH binaries (SMBHBs), which emit low-frequency gravitational waves
(GWs) that can be detected by pulsar timing arrays (PTAs). We have searched the
recently-released North American Nanohertz Observatory for Gravitational Waves
(NANOGrav) 11-year data set for GWs from individual SMBHBs in circular orbits.
As we did not find strong evidence for GWs in our data, we placed 95\% upper
limits on the strength of GWs from such sources as a function of GW frequency
and sky location. We placed a sky-averaged upper limit on the GW strain of at nHz. We also developed a
technique to determine the significance of a particular signal in each pulsar
using ``dropout' parameters as a way of identifying spurious signals in
measurements from individual pulsars. We used our upper limits on the GW strain
to place lower limits on the distances to individual SMBHBs. At the
most-sensitive sky location, we ruled out SMBHBs emitting GWs with
nHz within 120 Mpc for , and
within 5.5 Gpc for . We also determined that
there are no SMBHBs with emitting
GWs in the Virgo Cluster. Finally, we estimated the number of potentially
detectable sources given our current strain upper limits based on galaxies in
Two Micron All-Sky Survey (2MASS) and merger rates from the Illustris
cosmological simulation project. Only 34 out of 75,000 realizations of the
local Universe contained a detectable source, from which we concluded it was
unsurprising that we did not detect any individual sources given our current
sensitivity to GWs.Comment: 10 pages, 11 figures. Accepted by Astrophysical Journal. Please send
any comments/questions to S. J. Vigeland ([email protected]
Anopheles Imd Pathway Factors and Effectors in Infection Intensity-Dependent Anti-Plasmodium Action
The Anopheles gambiae immune response against Plasmodium falciparum, an etiological agent of human malaria, has been identified as a source of potential anti-Plasmodium genes and mechanisms to be exploited in efforts to control the malaria transmission cycle. One such mechanism is the Imd pathway, a conserved immune signaling pathway that has potent anti-P. falciparum activity. Silencing the expression of caspar, a negative regulator of the Imd pathway, or over-expressing rel2, an Imd pathway-controlled NFkappaB transcription factor, confers a resistant phenotype on A. gambiae mosquitoes that involves an array of immune effector genes. However, unexplored features of this powerful mechanism that may be essential for the implementation of a malaria control strategy still remain. Using RNA interference to singly or dually silence caspar and other components of the Imd pathway, we have identified genes participating in the anti-Plasmodium signaling module regulated by Caspar, each of which represents a potential target to achieve over-activation of the pathway. We also determined that the Imd pathway is most potent against the parasite's ookinete stage, yet also has reasonable activity against early oocysts and lesser activity against late oocysts. We further demonstrated that caspar silencing alone is sufficient to induce a robust anti-P. falciparum response even in the relative absence of resident gut microbiota. Finally, we established the relevance of the Imd pathway components and regulated effectors TEP1, APL1, and LRIM1 in parasite infection intensity-dependent defense, thereby shedding light on the relevance of laboratory versus natural infection intensity models. Our results highlight the physiological considerations that are integral to a thoughtful implementation of Imd pathway manipulation in A. gambiae as part of an effort to limit the malaria transmission cycle, and they reveal a variety of previously unrecognized nuances in the Imd-directed immune response against P. falciparum
Modeling Algae Self-Replenishment
This paper presents a sunlight-dependent algae growth model. Driven by the circumstances surrounding Lake Chapala, Mexico, this theoretical model is an endeavor to understand the resilient sustainability of algae that threatens the area’s ecosystem. In this paper, free-floating algae (phytoplankton) are treated as two distinct populations according to their location in the body of water: the vibrant sunlit upper region and the stagnate lower region where photosynthesis is not possible. The numerical solution for the model is analyzed and results are discussed in light of previous studies and the state of Lake Chapala
Expression of midkine in the early stage of carcinogenesis in human colorectal cancer
It has been suggested that a heparin-binding growth factor, midkine (MK), plays an important role incarcinogenesis because of its frequent overexpression in various malignant tumours. To clarify whether or not MK contributes to theearly stage of carcinogenesis, we examined the status of MK mRNA in 20 adenomas with moderate- and severe-grade dysplasia, 28carcinomas and 28 corresponding normal tissues, by means of Northern blotting. The MK expression level was significantly moreelevated in adenomas than in normal tissues P< 0.001, unpaired Student's t -test). A difference wasalso observed between carcinomas and the corresponding normal tissues P< 0.04, paired Student's t-test). Moreover, MK immunostaining was positive in the adenomas with moderate- and severe-grade dysplasia and in the carcinomas,but not in mild-grade dysplasia or in normal tissues. These findings were in line with those on Western blotting. In three patientswith both adenomas with moderate- or severe-grade dysplasia and carcinomas, elevated MK expression was observed in the neoplasticlesions. This is the first report of the association of elevated MK expression with the early stage of carcinogenesis in humans. © 1999 Cancer Research Campaig
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