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Expression of midkine in the early stage of carcinogenesis in human colorectal cancer
Authors
A Nakagawara
CJ Hughes
+32Β more
D Yang
EP Sandgren
H Muramatsu
H Muramatsu
HC Pitot
J Tsutsui
K Aridome
K Kadomatsu
K Kadomatsu
K Kadomatsu
K Kadomatsu
K Unoki
M Cross
M Michikawa
M Tomomura
M Tomomura
MB Sporn
R Choudhuri
RI Garver Jr
RI Garver Jr
S Nakajima-Iijima
S Tamano
SA Aaronson
T Dawson
T Muramatsu
T Muramatsu
T O'Brien
UK Laemmli
V Nurcombe
VA Aster
W Daughaday
Y Adachi
Publication date
Publisher
Nature Publishing Group
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PubMed
Abstract
It has been suggested that a heparin-binding growth factor, midkine (MK), plays an important role incarcinogenesis because of its frequent overexpression in various malignant tumours. To clarify whether or not MK contributes to theearly stage of carcinogenesis, we examined the status of MK mRNA in 20 adenomas with moderate- and severe-grade dysplasia, 28carcinomas and 28 corresponding normal tissues, by means of Northern blotting. The MK expression level was significantly moreelevated in adenomas than in normal tissues P< 0.001, unpaired Student's t -test). A difference wasalso observed between carcinomas and the corresponding normal tissues P< 0.04, paired Student's t-test). Moreover, MK immunostaining was positive in the adenomas with moderate- and severe-grade dysplasia and in the carcinomas,but not in mild-grade dysplasia or in normal tissues. These findings were in line with those on Western blotting. In three patientswith both adenomas with moderate- or severe-grade dysplasia and carcinomas, elevated MK expression was observed in the neoplasticlesions. This is the first report of the association of elevated MK expression with the early stage of carcinogenesis in humans. Β© 1999 Cancer Research Campaig
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Last time updated on 03/01/2020