2,589 research outputs found
Night sky brightness at sites from DMSP-OLS satellite measurements
We apply the sky brightness modelling technique introduced and developed by
Roy Garstang to high-resolution DMSP-OLS satellite measurements of upward
artificial light flux and to GTOPO30 digital elevation data in order to predict
the brightness distribution of the night sky at a given site in the primary
astronomical photometric bands for a range of atmospheric aerosol contents.
This method, based on global data and accounting for elevation, Earth curvature
and mountain screening, allows the evaluation of sky glow conditions over the
entire sky for any site in the World, to evaluate its evolution, to disentangle
the contribution of individual sources in the surrounding territory, and to
identify main contributing sources. Sky brightness, naked eye stellar
visibility and telescope limiting magnitude are produced as 3-dimensional
arrays whose axes are the position on the sky and the atmospheric clarity. We
compared our results to available measurements.Comment: 14 pages, 12 figures, accepted for publication in MNRAS, 17 june 200
Design of the primary and secondary Pre-TRMM and TRMM ground truth sites
Results generated over six months are covered in five manuscripts: (1) estimates of rain volume over the Peninsula of Florida during the summer season based upon the Manually Digitized Radar data; (2) the diurnal characteristics of rainfall over Florida and over the near shore waters; (3) convective rainfall as measured over the east coast of central Florida; (4) the spatial and temporal variability of rainfall over Florida; and (5) comparisons between the land based radar and an optical raingage onboard an anchored buoy 50 km offshore
Rigour and Rapport: a qualitative study of parents’ and professionals’ experiences of joint agency infant death investigation
Background: In many countries there are now detailed Child Death Review (CDR) processes following unexpected child deaths. CDR can lead to a fuller understanding of the causes for each child’s death but this potentially intrusive process may increase the distress of bereaved families. In England, a joint agency approach (JAA) is used where police, healthcare and social services investigate sudden child deaths together and a key part of this is the joint home visit (JHV) where specialist police and paediatricians visit the home with the parents to view the scene of death.
This study aimed to learn of bereaved parents’ experiences of JAA investigation following Sudden Unexpected Death in Infancy (SUDI).
Methods: This was a qualitative study of joint agency investigation of SUDI by specialist police, healthcare and social services including case note analysis, parental questionnaires, and in-depth interviews with parents and professionals. Families were recruited at the conclusion of the JAA. Data were analysed using a Framework Approach.
Results: 21/113 eligible families and 26 professionals participated giving theoretical saturation of data. There was an inherent conflict for professionals trying to both investigate deaths thoroughly as well as support families. Bereaved parents appreciated the JAA especially for the information it provided about the cause of death but were frustrated
with long delays waiting to obtain this. Many parents wanted more emotional support to be routinely provided. Most parents found the JHV helpful but a small minority of mothers found this intensely distressing. In comparison to JHVs, when police visited death scenes without paediatricians, information was missed and parents found these visits
more upsetting. There were issues with uniformed non-specialist police traumatising parents by starting criminal investigations and preventing parents from accessing their home or collecting vital possessions.
Conclusions: Overall most parents feel supported by professionals during the JAA; however there is scope for improvement. Paediatricians should ensure that parents are kept updated with the progress of the investigations. Some parents require more emotional support and professionals should assist them in accessing this
A study of a non-deepening tropical disturbance
Data from research vessel, instrumented research aircraft, and Tiros VI and Tiros VII SATELLITES to study nondeepening tropical disturbanc
Parental understanding and self-blame following sudden infant death : a mixed-methods study of bereaved parents' and professionals' experiences
Objectives: Improvements in our understanding of the role of modifiable risk factors for sudden infant death syndrome (SIDS) mean that previous reassurance to parents that these deaths were unpreventable may no longer be appropriate. This study aimed to learn of bereaved parents' and healthcare professionals' experiences of understanding causes of death following detailed sudden unexpected death in infancy (SUDI) investigations. The research questions were: How do bereaved parents understand the cause of death and risk factors identified during detailed investigation following a sudden unexpected infant death? What is the association between bereaved parents' mental health and this understanding? What are healthcare professionals' experiences of sharing such information with families?
Design: This was a mixed-methods study using a Framework Approach.
Setting: Specialist paediatric services.
Participants: Bereaved parents were recruited following detailed multiagency SUDI investigations; 21/113 eligible families and 27 professionals participated giving theoretical saturation of data.
Data collection: We analysed case records from all agencies, interviewed professionals and invited parents to complete the Hospital Anxiety and Depression Scale (HADS) and questionnaires or in-depth interviews.
Results: Nearly all bereaved parents were able to understand the cause of death and several SIDS parents had a good understanding of the relevant modifiable risk factors even when these related directly to their actions. Paediatricians worried that discussing risk factors with parents would result in parental self-blame and some deliberately avoided these discussions. Over half the families did not mention blame or blamed no one. The cause of death of the infants of these families varied. 3/21 mothers expressed overwhelming feelings of self-blame and had clinically significant scores on HADS.
Conclusions: Bereaved parents want detailed information about their child’s death. Our study suggests parents want health professionals to explain the role of risk factors in SIDS. We found no evidence that sharing this information is a direct cause of parental self-blame
An evidence-based guide to the investigation of sudden unexpected death in infancy
Purpose:
Many countries now have detailed investigations following sudden unexpected death in infancy (SUDI) but there is no clear evidence as to the most effective way to investigate SUDI. This systematic literature review addresses the following questions: What are the current models of practice for investigating SUDI? What is the evidence to support these investigative models? What are the key factors for effective SUDI investigation?
Methods:
This was a systematic review of papers from Europe, North America, and Australasia, detailing models of SUDI investigation or the outcomes of SUDI investigations.
Results:
The review includes data detailing four different models of investigation: police-led, coroner or medical examiner-led, healthcare-led or joint agency approach models. There were 18 different publications providing evidence of effectiveness of these models. All models, with the exception of police-led models, have the potential to reach best practice standards for SUDI investigation. Key factors identified for effective SUDI investigation include the need for mandatory investigation, strong leadership, integration with coronial services, and for investigations to be provided by specialist professionals.
Conclusion:
Detailed SUDI investigation should lead to greater understanding of why infants die and should help prevent future deaths. The challenge is now to ensure that local SUDI investigative practices are as effective as possible
Amphioxus SYCP1 : a case of retrogene replacement and co-option of regulatory elements adjacent to the ParaHox cluster
MGG was supported by the University of St Andrews School of Biology Biotechnology and Biological Sciences Research Council DTG and the Wellcome Trust ISSF. Work in the authors’ laboratory is also supported by the Leverhulme Trust.Retrogenes are formed when an mRNA is reverse transcribed and re-inserted into the genome in a location unrelated to the original locus. If this retrocopy inserts into a transcriptionally favourable locus and is able to carry out its original function, it can, in rare cases, lead to retrogene replacement. This involves the original, often multi-exonic, parental copy being lost whilst the newer single-exon retrogene copy ‘replaces’ the role of the ancestral parent gene. One example of this is amphioxus SYCP1, a gene that encodes a protein used in synaptonemal complex formation during meiosis, and which offers the opportunity to examine how a retrogene evolves after the retrogene replacement event. SYCP1 genes exist as large multi-exonic genes in most animals. AmphiSYCP1, however, contains a single coding exon of ~3200bp and has inserted next to the ParaHox cluster of amphioxus, whilst the multi-exonic ancestral parental copy has been lost. Here, we show that AmphiSYCP1 has not only replaced its parental copy, but has evolved additional regulatory function by co- opting a bidirectional promoter from the nearby AmphiCHIC gene. AmphiSYCP1 has also evolved a de novo, multi-exonic 5’untranslated region that displays distinct regulatory states, in the form of two different isoforms, and has evolved novel expression patterns during amphioxus embryogenesis in addition to its ancestral role in meiosis. Absence of ParaHox-like expression of AmphiSYCP1, despite its proximity to the ParaHox cluster, also suggests this gene is not influenced by any potential pan-cluster regulatory mechanisms, which are seemingly restricted to only the ParaHox genes themselves.Publisher PDFPeer reviewe
Hyperfine quenching of the metastable states in divalent atoms
Hyperfine quenching rates of the lowest-energy metastable and
states of Mg, Ca, Sr, and Yb atoms are computed. The calculations are carried
out using ab initio relativistic many-body methods. The computed lifetimes may
be useful for designing novel ultra-precise optical clocks and trapping
experiments with the fermionic isotopes. The resulting natural widths of
the clock transition are 0.44 mHz for Mg, 2.2 mHz for
Ca, 7.6 mHz for Sr, 43.5 mHz for Yb, and 38.5 mHz for
Yb. Compared to the bosonic isotopes, the lifetime of the states
in fermionic isotopes is noticeably shortened by the hyperfine quenching but
still remains long enough for trapping experiments.Comment: 10 pages, 1 figure, submitted to Phys. Rev.
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