220 research outputs found
Loss of correlation between HIV viral load and CD4+ T-cell counts in HIV/HTLV-1 co-infection in treatment naive Mozambican patients
Seven hundred and four HIV-1/2-positive, antiretroviral therapy (ART) naïve patients were screened for HTLV-1 infection. Antibodies to HTLV-1 were found in 32/704 (4.5%) of the patients. Each co-infected individual was matched with two HIV mono-infected patients according to World Health Organization clinical stage, age +/-5 years and gender. Key clinical and laboratory characteristics were compared between the two groups. Mono-infected and co-infected patients displayed similar clinical characteristics. However, co-infected patients had higher absolute CD4+ T-cell counts (P = 0.001), higher percentage CD4+ T-cell counts (P < 0.001) and higher CD4/CD8 ratios (P < 0.001). Although HIV plasma RNA viral loads were inversely correlated with CD4+ T-cell-counts in mono-infected patients (P < 0.0001), a correlation was not found in co-infected individuals (P = 0.11). Patients with untreated HIV and HTLV-1 co-infection show a dissociation between immunological and HIV virological markers. Current recommendations for initiating ART and chemoprophylaxis against opportunistic infections in resource-poor settings rely on more readily available CD4+ T-cell counts without viral load parameters. These guidelines are not appropriate for co-infected individuals in whom high CD4+ T-cell counts persist despite high HIV viral load states. Thus, for co-infected patients, even in resource-poor settings, HIV viral loads are likely to contribute information crucial for the appropriate timing of ART introduction
On the Complexity of Searching in Trees: Average-case Minimization
We focus on the average-case analysis: A function w : V -> Z+ is given which
defines the likelihood for a node to be the one marked, and we want the
strategy that minimizes the expected number of queries. Prior to this paper,
very little was known about this natural question and the complexity of the
problem had remained so far an open question.
We close this question and prove that the above tree search problem is
NP-complete even for the class of trees with diameter at most 4. This results
in a complete characterization of the complexity of the problem with respect to
the diameter size. In fact, for diameter not larger than 3 the problem can be
shown to be polynomially solvable using a dynamic programming approach.
In addition we prove that the problem is NP-complete even for the class of
trees of maximum degree at most 16. To the best of our knowledge, the only
known result in this direction is that the tree search problem is solvable in
O(|V| log|V|) time for trees with degree at most 2 (paths).
We match the above complexity results with a tight algorithmic analysis. We
first show that a natural greedy algorithm attains a 2-approximation.
Furthermore, for the bounded degree instances, we show that any optimal
strategy (i.e., one that minimizes the expected number of queries) performs at
most O(\Delta(T) (log |V| + log w(T))) queries in the worst case, where w(T) is
the sum of the likelihoods of the nodes of T and \Delta(T) is the maximum
degree of T. We combine this result with a non-trivial exponential time
algorithm to provide an FPTAS for trees with bounded degree
Some combinatorial identities related to commuting varieties and Hilbert schemes
In this article we explore some of the combinatorial consequences of recent results relating the isospectral commuting variety and the Hilbert scheme of points in the plane
Normal Ordering for Deformed Boson Operators and Operator-valued Deformed Stirling Numbers
The normal ordering formulae for powers of the boson number operator
are extended to deformed bosons. It is found that for the `M-type'
deformed bosons, which satisfy , the
extension involves a set of deformed Stirling numbers which replace the
Stirling numbers occurring in the conventional case. On the other hand, the
deformed Stirling numbers which have to be introduced in the case of the
`P-type' deformed bosons, which satisfy , are found to depend on the operator . This distinction
between the two types of deformed bosons is in harmony with earlier
observations made in the context of a study of the extended
Campbell-Baker-Hausdorff formula.Comment: 14 pages, Latex fil
Golden gaskets: variations on the Sierpi\'nski sieve
We consider the iterated function systems (IFSs) that consist of three
general similitudes in the plane with centres at three non-collinear points,
and with a common contraction factor \la\in(0,1).
As is well known, for \la=1/2 the invariant set, \S_\la, is a fractal
called the Sierpi\'nski sieve, and for \la<1/2 it is also a fractal. Our goal
is to study \S_\la for this IFS for 1/2<\la<2/3, i.e., when there are
"overlaps" in \S_\la as well as "holes". In this introductory paper we show
that despite the overlaps (i.e., the Open Set Condition breaking down
completely), the attractor can still be a totally self-similar fractal,
although this happens only for a very special family of algebraic \la's
(so-called "multinacci numbers"). We evaluate \dim_H(\S_\la) for these
special values by showing that \S_\la is essentially the attractor for an
infinite IFS which does satisfy the Open Set Condition. We also show that the
set of points in the attractor with a unique ``address'' is self-similar, and
compute its dimension.
For ``non-multinacci'' values of \la we show that if \la is close to 2/3,
then \S_\la has a nonempty interior and that if \la<1/\sqrt{3} then \S_\la$
has zero Lebesgue measure. Finally we discuss higher-dimensional analogues of
the model in question.Comment: 27 pages, 10 figure
Towards a unified theory of Sobolev inequalities
We discuss our work on pointwise inequalities for the gradient which are
connected with the isoperimetric profile associated to a given geometry. We
show how they can be used to unify certain aspects of the theory of Sobolev
inequalities. In particular, we discuss our recent papers on fractional order
inequalities, Coulhon type inequalities, transference and dimensionless
inequalities and our forthcoming work on sharp higher order Sobolev
inequalities that can be obtained by iteration.Comment: 39 pages, made some changes to section 1
Team-based learning (TBL): a community of practice
Background
Rapid changes in medical practice have a large impact on the demands faced by educators in preparing students for future participation in a multifaceted healthcare workforce. Competencies required by today’s medical graduates encompass the ability to effectively collaborate, communicate and problem solve. The learning needs of medical students have also changed over time. Today’s medical students are highly interconnected, enjoying teamwork and collaborative practice, and desire continuous, explicit feedback. They want structured learning activities, with clear expectations, and enjoy a sense of accomplishment on their achievements. The conflation of these issues has seen many medical schools adopt the model of Team-based learning (TBL). Using the conceptual framework of communities of practice, we sought to qualitatively explore students’ and teachers’ experience of TBL in Year 1 of a graduate entry medical program.
Methods
Convenience sampling was used to select 169/350 (48%) Year 1 students who completed three TBL sessions. Each TBL session was facilitated by three senior clinicians. Following participation in the TBLs, students were invited to attend focus groups, and all facilitators (n = 9) were invited to attend interviews. A coding framework was developed to code the entire dataset, using the theoretical lens of communities of practice.
Results
34/169 (20%) of students attended focus groups. Three facilitators (3/9, 33%) were interviewed. Students and facilitators felt the structure and organisation of TBL made students accountable for their learning and team contributions. The combined expertise and clinical experience of facilitators, with immediate feedback helped groups to work both independently and collaboratively. Facilitators found working with their peers in the TBLs to be a rewarding experience.
Conclusions
The community of practice found in the TBL classes, provided an enriching and rewarding learning environment that motivated students to build on their basic knowledge and apply what had been learnt. The interactions of experienced, senior clinicians as facilitators, sharing their expertise within a clinical context, prompted effective student engagement in learning and understanding. Our change in curriculum design and pedagogy will assist in preparing medical students for demands of the increasingly complex healthcare systems in which they will work
Operator renewal theory and mixing rates for dynamical systems with infinite measure
We develop a theory of operator renewal sequences in the context of infinite
ergodic theory. For large classes of dynamical systems preserving an infinite
measure, we determine the asymptotic behaviour of iterates of the
transfer operator. This was previously an intractable problem.
Examples of systems covered by our results include (i) parabolic rational
maps of the complex plane and (ii) (not necessarily Markovian) nonuniformly
expanding interval maps with indifferent fixed points.
In addition, we give a particularly simple proof of pointwise dual ergodicity
(asymptotic behaviour of ) for the class of systems under
consideration.
In certain situations, including Pomeau-Manneville intermittency maps, we
obtain higher order expansions for and rates of mixing. Also, we obtain
error estimates in the associated Dynkin-Lamperti arcsine laws.Comment: Preprint, August 2010. Revised August 2011. After publication, a
minor error was pointed out by Kautzsch et al, arXiv:1404.5857. The updated
version includes minor corrections in Sections 10 and 11, and corresponding
modifications of certain statements in Section 1. All main results are
unaffected. In particular, Sections 2-9 are unchanged from the published
versio
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