CGC/saturation approach: Impact-parameter dependent model in next-to-leading order and combined HERA data

In this paper we confront the next-to-leading order (NLO) CGC/saturation approach of Ref. [1] with the experimental combined HERA data and obtain its parameters. The model includes two features that are in accordance with our theoretical knowledge of deep inelastic scattering. These consist of: $i$) the use of analytical solution for the non-linear Balitsky-Kovchegov (BK) evolution equation and $ii$) the exponential behavior of the saturation momentum on the impact parameter $b$-dependence, characterized by $Q_s$ $\propto\exp( -m b )$ which reproduce the correct behaviour of the scattering amplitude at large $b$ in accord with Froissart theorem. The model results are then compared to data at small-x for the structure function of the proton $F_{2}$, the longitudinal structure function $F_{L}$, the charm structure function $F_2^{c\bar{c}}$, the exclusive vector meson ($J/\psi,\phi,\rho$) production and Deeply Virtual Compton Scattering (DVCS). We obtain a good agreement for the processes in a wide kinematic range of $Q^2$ at small $x$. Our results provide a strong guide for finding an approach, based on Color Glass Condensate/saturation effective theory for high energy QCD, to make reliable predictions from first principles as well as for forthcoming experiments like the Electron-Ion Collider and the LHeC.Comment: 19 pages, 14 figure

Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-βInduced Neuronal Death

Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving an interaction of the phosphatase calcineurin with the transcription factor FOXO3 is a major driver in AD associated pathological inflammation, suggesting a potential new druggable target for this devastating disease. We have now developed decoy molecules to interfere with calcineurin/FOXO3 interactions, and tested them in astrocytes and neuronal co-cultures exposed to amyloid-β (Aβ) toxicity. We observed that interference of calcineurin/FOXO3 interactions exerts a protective action against A-induced neuronal death and favors the production of a set of growth factors that we hypothesize form part of a cytoprotective pathway to resolve inflammation. Furthermore, interference of the A-induced interaction of calcineurin with FOXO3 by decoy compounds significantly decreased amyloid-β protein precursor (AβPP) synthesis, reduced the AβPP amyloidogenic pathway, resulting in lower Alevels, and blocked the expression of pro-inflammatory cytokines TNFα and IL-6 in astrocytes. Collectively, these data indicate that interrupting pro-inflammatory calcineurin/FOXO3 interactions in astrocytes triggered by Aβ accumulation in brain may constitute an effective new therapeutic approach in AD. Future studies with intranasal delivery, or brain barrier permeable decoy compounds, are warranted

Relatos y literatura de viajes en el ámbito hispánico: poética e historia [RESEÑA]

Reseña de Alburquerque García, Luis, coord. Relatos y literatura de viajes en el ámbito his- pánico: poética e historia. Número mono- gráfico de la Revista de literatura 73 (2011). 361 pp. (ISSN: 0034-849X

Dielectric susceptibility of the Coulomb-glass

We derive a microscopic expression for the dielectric susceptibility X of a Coulomb glass, which corresponds to the definition used in classical electrodynamics, the derivative of the polarization with respect to the electric field. The fluctuation–dissipation theorem tells us that is a function of the thermal fluctuations of the dipole moment of the system. We calculate X numerically for three–dimensional Coulomb glasses as a function of temperature and frequency.We acknowledge financial support from the DGES project number PB96-1118, SMWK, and DFG (SFB 393). A great part of this work was performed during A. D.-S.’s visit at the IFW Dresden; A. D.-S. thanks the IFW for its hospitality

Formación en enfermería escolar: Efectividad del taller 'Cine y salud escolar'

Objetivo. Este estudio pretende evaluar la efectividad del taller 'Cine y salud escolar', que trata la utilización de películas como recurso para reforzar los temas de salud que abordan las enfermeras escolares que han cursado el Máster de Enfer-mería Escolar. Materiales y métodos. Se empleó un diseño cuasiexperimental con pretest y postest y en el cual la intervención fue la realización del taller 'Cine y salud escolar'. Las variables estudiadas se referían al conocimiento de los recursos necesarios para preparar un tema de salud con el apoyo de secuencias cinematográficas; además, se analizaron los hábitos de las participantes respecto a su consumo de cine comercial. Resultados. Se obtuvieron 112 respuestas. En cuanto a la efectividad del taller se observa que en todas las preguntas el número de respuestas correctas es superior en el postest respecto al pretest. El 56,25% (n = 63) de encuestadas reconoce el uso de películas durante la carrera de enfermería. Se mencionan 37 títulos con contenidos sobre salud, con una media de 1,53 películas vistas en el último mes. Se vieron 5,11 películas en casa por cada una vista en salas de cine. Conclusiones. En el postest respecto al pretest, se observa un incremento de respuestas correctas en todos los ítems y también una disminución de las respuestas 'no sabe', lo que confirmaría la efectividad del taller

1-Octanol/water partition coefficients of n-alkanes from molecular simulations of absolute solvation free energies

The 1-octanol/water partition coefficient is an important thermodynamic variable usually employed to understand and quantify the partitioning of solutes between aqueous and organic phases. It finds widespread use in many empirical correlations to evaluate the environmental fate of pollutants as well as in the design of pharmaceuticals. The experimental evaluation of 1-octanol/water partition coefficients is an expensive and time-consuming procedure, and thus, theoretical estimation methods are needed, particularly when a physical sample of the solute may not yet be available, such as in pharmaceutical screening. 1-Octanol/water partition coefficients can be obtained from Gibbs free energies of solvation of the solute in both the aqueous and the octanol phases. The accurate evaluation of free energy differences remains today a challenging problem in computational chemistry. In order to study the absolute solvation Gibbs free energies in 1-octanol, a solvent that can mimic many properties of important biological systems, free energy calculations for n-alkanes in the range C-1-C-8 were performed using molecular simulation techniques, following the thermodynamic integration approach. In the first part of this paper, we test different force fields by evaluating their performance in reproducing pure 1-octanol properties. It is concluded that all-atom force fields can provide good accuracy but at the cost of a higher computational time compared to that of the united-atom force fields. Recent versions of united-atom force fields, such as Gromos and TraPPE, provide satisfactory results and are, thus, useful alternatives to the more expensive all-atom models. In the second part of the paper, the Gibbs free energy of solvation in 1-octanol is calculated for several n-alkanes using three force fields to describe the solutes, namely Gromos, TraPPE, and OPLS-AA. Generally, the results obtained are in excellent agreement with the available experimental data and are of similar accuracy to commonly used QSPR models. Moreover, we have estimated the Gibbs free energy of hydration for the different compounds with the three force fields, reaching average deviations from experimental data of less than 0.2 kcal/mol for the case of the Gromos force field. Finally, we systematically compare different strategies to obtain the 1-octanol/water partition coefficient from the simulations. It is shown that a fully predictive method combining the Gromos force field in the aqueous phase and the OPLS-AA/TraPPE force field for the organic phase can give excellent predictions for n-alkanes up to C-8 with an absolute average deviation of 0.1 log P units to the experimental data

Invasive species and habitat degradation in Iberian streams: An analysis of their role in freshwater fish diversity loss

Mediterranean endemic freshwater fish are among the most threatened biota in the world. Distinguishing the role of different extinction drivers and their potential interactions is crucial for achieving conservation goals. While some authors argue that invasive species are a main driver of native species declines, others see their proliferation as a co-occurring process to biodiversity loss driven by habitat degradation. It is difficult to discern between the two potential causes given that few invaded ecosystems are free from habitat degradation, and that both factors may interact in different ways. Here we analyze the relative importance of habitat degradation and invasive species in the decline of native fish assemblages in the Guadiana River basin (southwestern Iberian Peninsula) using an information theoretic approach to evaluate interaction pathways between invasive species and habitat degradation (structural equation modeling, SEM). We also tested the possible changes in the functional relationships between invasive and native species, measured as the per capita effect of invasive species, using ANCOVA. We found that the abundance of invasive species was the best single predictor of natives' decline and had the highest Akaike weight among the set of predictor variables examined. Habitat degradation neither played an active role nor influenced the per capita effect of invasive species on natives. Our analyses indicated that downstream reaches and areas close to reservoirs had the most invaded fish assemblages, independently of their habitat degradation status. The proliferation of invasive species poses a strong threat to the persistence of native assemblages in highly fluctuating environments. Therefore, conservation efforts to reduce native freshwater fish diversity loss in Mediterranean rivers should focus on mitigating the effect of invasive species and preventing future invasions

Routing Topologies of Wireless Sensor Networks for Health Monitoring of a Cultural Heritage Site

This paper provides a performance evaluation of tree and mesh routing topologies of wireless sensor networks (WSNs) in a cultural heritage site. The historical site selected was San Juan Bautista church in Talamanca de Jarama (Madrid, Spain). We report the preliminary analysis required to study the effects of heating in this historical location using WSNs to monitor the temperature and humidity conditions during periods of weeks. To test which routing topology was better for this kind of application, the WSNs were first deployed on the upper floor of the CAEND institute in Arganda del Rey simulating the church deployment, but in the former scenario there was no direct line of sight between the WSN elements. Two parameters were selected to evaluate the performance of the routing topologies of WSNs: the percentage of received messages and the lifetime of the wireless sensor network. To analyze in more detail which topology gave the best performance, other communication parameters were also measured. The tree topology used was the collection tree protocol and the mesh topology was the XMESH provided by MEMSIC (Andover, MA, USA). For the scenarios presented in this paper, it can be concluded that the tree topology lost fewer messages than the mesh topology.The Spanish Ministry of Economy and Competitiveness supported this research under grant numbers BIA2009-14395-C04-01 and TEC2012-38402-C04-03. The present study was also funded under project CGL2010-19554. S. Aparicio benefited from funding provided by the Spanish National Research Council (CSIC) through its Post-graduate Studies Council’s post-doctoral specialisation programme (JAE-Doc). Researcher Martínez-Garrido’s was supported by an International Programme for Recruiting Talent (PICATA) predoctoral fellowship awarded by the Moncloa Campus of International Excellence (UPM-UCM, CSIC). J. Ranz benefited from a FPI grant BES-2010-038826 of the Ministry of Education, Culture and Sports. We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI

Association between chronic irritability and depressive symptoms in children and adolescents.

Association between chronic irritability and depressive symptoms in children and adolescents. Busto-Garrido, M.; Gutierrez-Castillo, D; Navas- Gonzalez, JR; Gutierrez-Bedmar, M; Gutierrez-Casares, JR; Martin-Lunar, MT; Rodríguez-Rosado, A; Pena-Andreu, JM. European Psychiatry 415(2017) 5221.Chronic irritability is the most frequently reported symptom in child and adolescent depression. The association of both has been linked with high rates of chronicity, comorbility and impairment. Objectives To study the association between chronic irritability and depressive symptoms in children and adolescents. Methods We have studied 857 participants recruited from the only Child and Adolescent Mental Health Clinic in a catchment area of 122968 people under 18 (2004-2010). A sample of 677 participants (57 controls and 620 patients) was included to carry out a cross-sectional study. Chronic irritability was measured by a Visual Analog Scale (VAS irritability) -scored from 0 to 10-, and depressive symptoms by the Children's Depression Inventory (CDI). The participants were categorized into controls and patients, and according to their chronic irritability (≤4 [I],5 [II] and ≥6 [III]). The mean of CDI score was calculated for each of the groups, adjusted by sex and age, and analyzed by ANCOVA. Results The following means were obtained from the controls: 13,71 (group I), 9,82 (group II) and 17,45 (group III). Regarding to the patients: 13,92 (group I), 11,54 (group II) and 15,64 (group III). A quadratic association (p <0,0015) was found between VAS irritability score and CDI score. Conclussions There is not a lineal association between chronic irritability and depressive symptoms in children and adolescent. High rates of depressive symptoms were associated both with high and low rates of irritability. Several questions remain unexplained about the status of irritability in psychiatry as Stringaris group has been pointed out. Disclosure statement I have no potential conflict of interest to discloseUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech