Young’s modulus and hardness of multiphase CaZrO3 -MgO ceramics by micro and nanoindentation

The aim of this work is to determine the values of the hardness and elastic modulus of the phases present in CaZrO3-MgO-ZrO2 composites and to analyse their contribution to the composite properties. Two materials previously developed with the same major phases (CaZrO3, MgO and c-ZrO2) present in different volume fractions and grain size have been analysed. The hardness and Young´s modulus of each phase determined by nanoindentation are independent from the specific composite and coincident with nanoindentation values for single phase bulk materials. The contribution of the individual phases to Young´s modulus of the multiphase materials is in agreement with calculations using the nanoindentation values and the Voight upper limit of the “rule of mixtures”. Scale dependence due to microcracking has been observed for microhardness values of the composites and differences between calculations and experimental values are related to this effect.This work was performed in the frame of the CYTEDnetwork HOREF(312RT0453)and was supported by the Spanish Government underprojectMAT2013-48426-C2-1-R.AbílioP.Silvaacknowledges thefinancialsupportofJECSTrustthroughmobilityContract201597 and Instituto de Cerámica y Vidrio–CSIC.info:eu-repo/semantics/publishedVersio

Beneficial effects of karate on the proprioception and coordination of young people with Down syndrome: a two-year follow up

Resumen Objetivos: establecer el impacto de las artes marciales en el desarrollo de habilidades motoras, específicamente sobre la propiocepción, en jóvenes afectados por síndrome de Down. Diseño: en este estudio participan 7 adolescentes en los que se evalúa secuencialmente el control postural antes, durante y después de 2 años de entrenamiento de karate. Se adaptaron tres pruebas (prueba de sentadillas, del flamenco y de velocidad del movimiento del brazo) para realizar un análisis de la propiocepción. Resultados: concluimos que la incorporación del karate en la rutina deportiva de jóvenes afectados por síndrome de Down conlleva una mejora en su equilibrio y coordinación general

19,19'-diacyloxy signature: an atypical level of structural evolution in carotenoid pigments.

En prens

Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non–Small Cell Lung Cancer: A Phase Ib Study

Purpose: Abemaciclib, a dual inhibitor of cyclin-dependent kinases 4 and 6, has demonstrated preclinical activity in non–small cell lung cancer (NSCLC). A multicenter, nonrandomized, open-label phase Ib study was conducted to test safety, MTD, pharmacokinetics, and preliminary antitumor activity of abemaciclib in combination with other therapies for treatment in patients with metastatic NSCLC. Patients and Methods: An initial dose escalation phase was used to determine the MTD of twice-daily oral abemaciclib (150, 200 mg) plus pemetrexed, gemcitabine, or ramucirumab, followed by an expansion phase for each drug combination. Pemetrexed and gemcitabine were administered according to label. The abemaciclib plus ramucirumab study examined two dosing schedules. Results: The three study parts enrolled 86 patients; all received ≥1 dose of combination therapy. Across arms, the most common treatment-emergent adverse events were fatigue, diarrhea, neutropenia, decreased appetite, and nausea. The trial did not identify an abemaciclib MTD for the combination with pemetrexed or gemcitabine but did so for the combination of abemaciclib with days 1 and 8 ramucirumab (8 mg/kg). Plasma sample analysis showed that abemaciclib did not influence the pharmacokinetics of the combination agents and the combination agents did not affect abemaciclib exposure. The disease control rate was 57% for patients treated with abemaciclib–pemetrexed, 25% for abemaciclib–gemcitabine, and 54% for abemaciclib–ramucirumab. Median progression-free survival was 5.55, 1.58, and 4.83 months, respectively. Conclusions: Abemaciclib demonstrated an acceptable safety profile when dosed on a continuous twice-daily schedule in combination with pemetrexed, gemcitabine, or ramucirumab. Abemaciclib exposures remained consistent with those observed in single-agent studies

HABs in coastal upwelling systems: Insights from an exceptional red tide of the toxigenic dinoflagellate Alexandrium minutum

Alexandrium minutum blooms generally occur in semi-enclosed sites such as estuaries, harbours and lagoons, where enhanced stratification, restricted circulation and accumulation of resting cysts in the sediment set suitable habitat conditions for the proliferation of this paralytic shellfish poisoning toxigenic species. In the Galician Rías Baixas (NW Iberian Peninsula), according to weekly time-series between 1994 and 2020, blooms of A. minutum were recurrent in small, shallow estuarine bays inside the Rías de Vigo and Pontevedra, but rarely detected, and if so at low concentrations, out of these environments. However, from May to July 2018 it developed as usual in the small inner bays but then spread over both Rías (Vigo and Pontevedra) causing discoloured waters during one month and prolonged harvesting closures. Meteorological conditions during that period (rains / runoff higher than climatological averages, sustained temperature increment and oscillating wind pattern –i.e., series of upwelling-relaxation cycles), fostered optimal circumstances for the development of that extensive and massive proliferation: strong vertical stratification and the alternation of retention and dispersion processes. Simulations from a particle tracking model portrayed the observed bloom development phases: onset and development inside a small inner bay; transport within the surface layer, from these sites towards the interior parts of the Ría; and dispersion all over the embayment. Seedbeds with high concentrations of resting cysts were detected several months after the bloom, which may have favoured flourishment of A. minutum in the following two years, markedly in 2020. The present work contributes to the general understanding of the dynamics of harmful algal blooms (HABs), from which surveillance indicators of the state of marine ecosystems and their evolution can be derived. We hypothesize that the intensity and frequency of A. minutum proliferations in the Galician Rías could increase under projected climate trends.Postprint2,69

Bloom dynamics of an exceptional red tide of the toxigenic dinoflagellate

The toxic dinoflagellate Alexandrium minutum generally proliferates in semi-enclosed sites such as estuaries, harbours and lagoons, where stratification, restricted circulation and accumulation of resting cysts set suitable conditions for its development. In the Galician Rías (NW Iberian Peninsula), its blooms follow also this pattern. They are recurrent in small, shallow estuarine bays inside the Rías, but rarely detected, and if so in minor amount, out of these areas. However, a massive proliferation of A. minutum from June to July 2018 in the Rías Baixas (Vigo and Pontevedra) changed this picture. The bloom initiated in semi-enclosed waters, as previously described for this species, but thereafter spread to the whole embayments where persisted more than one month. It generated a noticeable red tide with disperse patches that became heavily concentrated inside the port of Vigo. During that period shellfish harvesting closures and paralytic shellfish toxins in certain marine invertebrates and fish were reported for the first time in Spain. Meteorological conditions (higher than usual rains/runoff, sustained temperature increment and oscillating wind pattern promoting a series of upwelling-relaxation cycles) fostered optimal circumstances for the outbreak of A. minutum: strong vertical stratification and the alternation of retention and dispersion processes. Simulations from a particle tracking model portrayed the observed bloom development phases: onset, transport within the surface layer towards the interior parts of the Ría of Vigo, and dispersion all over the embayment. High concentrations of resting cysts were detected several months after the bloom, which may have favoured flourish of A. minutum in the following years, markedly in 2020

Supervisión multidistribuida de transportes refrigerados mediante redes de sensores: diagramas de fases, una nueva metodología de análisis

El estudio de la variabilidad de la temperatura en cámaras frigoríficas y contenedores es un problema crítico en la industria alimentaria para el aseguramiento de la calidad de los productos durante el transporte, así como para minimizar las pérdidas. El objetivo de este trabajo es el desarrollo de una nueva metodología de análisis de datos basada en la reconstrucción del espacio de fases de la serie temporal de temperaturas, registradas por una red multidistribuida de sensores inalámbricos autónomos y de bajo coste

Description of the exposure of the most-followed spanish instamom's children to social medias

There is evidence of the risk of overexposure of children on social networks by parents working as influencers. A cross-sectional study of the profiles of the sixteen most-followed Instamoms in Spain was carried out. An analysis of these profiles was performed over a full month (April 2022), three times a week, to describe the representation of influencers’ children in the posts shared by them, as well as their role in the Instamoms’ marketing. A total of 192 evaluations of the profiles were performed in the study period. The average number of children exposed by an Instamom was three, generally preschoolers and schoolchildren. The children appear in a context of the family home and accompanied by their mother. The type of advertising that accompanies the appearance of underage children is usually women or children’s clothing, but also food products, leisure, etc. Appearance of children in the posts had a statistically significant influence on followers measured by the number of likes. Results provided the identification of two Instamom clusters with differentiated behaviors in relation to appearance of children in posts. It is important to involve Social Pediatrics in the protection of the privacy and interests of children given the increase in sharenting. The authors believe that there are concerns about their explicit consent to public exposure from early childhood and about the medium and long-term effect that this may have on their future well-being

Estudio de la madurez y fecundidad de Coryphaena hippurus, en el mar de Alborán - Mediterráneo occidental

La llampuga Coryphaena hippurus (Linnaeus, 1758) también conocida como dorado o lirio es una especie epipelágica migratoria ampliamente distribuida en aguas tropicales y subtropicales. Esta especie es de gran interés tanto para las pesquerías comerciales como para las deportivas en múltiples países a nivel mundial. Las llampugas son reproductores parciales con periodos de puesta que se extienden durante varios meses en aguas cálidas preferentemente de 21-30ºC. En este trabajo se emplearon ejemplares capturados por la pesca deportiva en campeonatos de pesca de altura celebrados en aguas del Mediterráneo, concretamente en el mar de Alborán, durante nueve años (2011-2019) en los meses de agosto y septiembre. El análisis del sex ratio de 70 individuos (57 – 114 cm) mostró una mayor proporción de hembras que de machos (2:1). Un total de 45 ovarios fueron clasificados macroscópicamente, de los cuales 30 fueron examinados histológicamente. Las estimas de la fecundidad por tandas de 10 hembras (58 – 101 cm) varío entre 104179 y 1231207 ovocitos hidratados con una media de 686495 ± 409088 ovocitos hidratados. El análisis del índice gonadosomático y el examen de las gónadas (macroscópico y microscópico) ponen de manifiesto que el mar de Alborán es una zona de puesta para la llampuga

Equity, barriers and cancer disparities: study of the Spanish Society of Medical Oncology on the access to oncologic drugs in the Spanish Regions

[Purpose] The Spanish Society of Medical Oncology (SEOM) has conducted a study on the access to oncologic drugs across the 17 Spanish Regions with the aim of identifying potential heterogeneities and making proposals for eliminating the barriers identified at the different levels.[Methods] An Expert Panel made up of medical oncologists designed a survey on certain indications approved for 11 drugs in the approach of breast cancer, melanoma, lung cancer, prostate cancer and support treatment. This survey was sent to 144 National Health System (NHS) hospitals. [Results] 77 hospitals answered the survey. The information modules analysed were: scope of the Commission that establishes binding decisions related to drug access; conditions, stages and periods of drug application, approval and administration processes; barriers to accessing drugs. [Conclusions] The study shows variability in drug access. The SEOM makes proposals addressed to reducing the differences identified and homogenizing drug access conditions.This study was funded by SEOM