1,993 research outputs found
Winners and losers from a commodities-for-manufactures trade boom
A recent boom in commodities-for-manufactures trade between China and other developing countries has led to much concern about the losers from rising import competition in manufacturing, but little attention on the winners from growing Chinese demand for commodities. Using census data for Brazil, we find that local labour markets more affected by Chinese import competition experienced slower growth in manufacturing wages and in-migration rates between 2000 and 2010, and greater rises in local wage inequality. However, in locations benefiting from rising Chinese demand, we observe higher wage growth, lower takeup of cash transfers and positive effects on job quality
Association of Chlamydia pneumoniae with coronary artery disease and its progression is dependent on the modifying effect of mannose-binding lectin
Background— The possible association between coronary artery disease (CAD) and Chlamydia pneumoniae (C pneumoniae) infection is controversial. On the basis of the recent suggestion that mannose-binding lectin (MBL) variant alleles are related to an increased risk of severe atherosclerosis, and on the in vitro interaction of MBL with C pneumoniae, we asked whether MBL might contribute to CAD in conjunction with C pneumoniae.
Methods and Results— Antibodies to C pneumoniae were measured by immunofluorescence and MBL alleles were determined by polymerase chain reaction technique in samples from 210 patients with CAD and 257 healthy subjects from Hungary collected between 1995 and 1996. A higher percentage of patients with CAD were anti-C pneumoniae positive as compared with the control group (P=0.058). However, at logistic regression analysis adjusted to age, sex, and serum lipid levels, this difference was confined only to subjects carrying MBL variant alleles (P=0.035, odds ratio 2.63, [95% CI: 1.07 to 6.45]). In contrast, no significant difference was seen in those homozygous for the normal MBL allele (P=0.412). During a 65±5.8-month follow-up period, major outcomes (new myocardial infarction, and/or bypass operation or cardiovascular death) occurred in 11 C pneumoniae positive and 3 C pneumoniae negative patients. In the C pneumoniae positive group, the odds ratio of development of outcomes was 3.27 (95% CI: 1.10 to 9.71, P=0.033) in the carriers of the MBL variant alleles compared with the homozygous carriers of the normal MBL allele.
Conclusions— These results indicate that infection with C pneumoniae leads mainly to the development and progression of severe CAD in patients with variation in the MBL gene
Dark Energy or Apparent Acceleration Due to a Relativistic Cosmological Model More Complex than FLRW?
We use the Szekeres inhomogeneous relativistic models in order to fit
supernova combined data sets. We show that with a choice of the spatial
curvature function that is guided by current observations, the models fit the
supernova data almost as well as the LCDM model without requiring a dark energy
component. The Szekeres models were originally derived as an exact solution to
Einstein's equations with a general metric that has no symmetries and are
regarded as good candidates to model the true lumpy universe that we observe.
The null geodesics in these models are not radial. The best fit model found is
also consistent with the requirement of spatial flatness at CMB scales. The
first results presented here seem to encourage further investigations of
apparent acceleration using various inhomogeneous models and other constraints
from CMB and large structure need to be explored next.Comment: 6 pages, 1 figure, matches version published in PR
How strong is the evidence for accelerated expansion?
We test the present expansion of the universe using supernova type Ia data
without making any assumptions about the matter and energy content of the
universe or about the parameterization of the deceleration parameter. We assume
the cosmological principle to apply in a strict sense. The result strongly
depends on the data set, the light-curve fitting method and the calibration of
the absolute magnitude used for the test, indicating strong systematic errors.
Nevertheless, in a spatially flat universe there is at least a 5 sigma evidence
for acceleration which drops to 1.8 sigma in an open universe.Comment: 16 pages, 3 figure
Association of Ficolin-3 with Severity and Outcome of Chronic Heart Failure
BACKGROUND: Inflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown. We hypothesized that the main initiator molecules of the lectin complement pathway mannose-binding lectin (MBL), ficolin-2 and ficolin-3 were related to disease severity and outcome in chronic heart failure. METHODS AND RESULTS: MBL, ficolin-2 and ficolin-3 plasma concentrations were determined in two consecutive cohorts comprising 190 patients from Hungary and 183 patients from Norway as well as controls. Disease severity and clinical parameters were determined at baseline, and all-cause mortality was registered after 5-years follow-up. In univariate analysis a low level of ficolin-3, but not that of MBL or ficolin-2, was significantly associated with advanced heart failure (New York Heart Association Class IV, p<0.001 for both cohorts) and showed inverse correlation with B- type natriuretic peptide (BNP) levels (r = -0.609, p<0.001 and r = -0.467, p<0.001, respectively). In multivariable Cox regression analysis, adjusted for age, gender and BNP, decreased plasma ficolin-3 was a significant predictor of mortality (HR 1.368, 95% CI 1.052-6.210; and HR 1.426, 95% CI 1.013-2.008, respectively). Low ficolin-3 levels were associated with increased complement activation product C3a and correspondingly decreased concentrations of complement factor C3. CONCLUSIONS: This study provides evidence for an association of low ficolin-3 levels with advanced heart failure. Concordant results from two cohorts show that low levels of ficolin-3 are associated with advanced heart failure and outcome. The decrease of ficolin-3 was associated with increased complement activation
Dimensions of Dialogue:an Inquiry into the Role of Music and of Words in Creative Nusic Therapy
A Study to Determine the Anticipated Qualifications and Competencies of Audiovisual Specialists in the Community Colleges of the State of Washington
The problem considered in this study is to determine the relationship between the responsibilities and duties of the audiovisual services administrator and the competencies and qualifications necessary to perform those responsibilities and duties satisfactorily and professionally
The changing epidemiology of Burkholderia species infection at an adult cystic fibrosis centre
Cosmological Backreaction from Perturbations
We reformulate the averaged Einstein equations in a form suitable for use
with Newtonian gauge linear perturbation theory and track the size of the
modifications to standard Robertson-Walker evolution on the largest scales as a
function of redshift for both Einstein de-Sitter and Lambda CDM cosmologies. In
both cases the effective energy density arising from linear perturbations is of
the order of 10^-5 the matter density, as would be expected, with an effective
equation of state w ~ -1/19. Employing a modified Halofit code to extend our
results to quasilinear scales, we find that, while larger, the deviations from
Robertson-Walker behaviour remain of the order of 10^-5.Comment: 15 pages, 8 figures; replaced by version accepted by JCA
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