Strain Accomodation in the Footwall of the Rubys Inn Thrust Fault, Hillsdale Canyon, Southern Utah

The Rubys Inn thrust fault in southern Utah has produced several styles of deformation in its footwall. This project describes four exceptionally well exposed examples of strain accommodation, including a mountain-scale, ductile footwall drag fold, cataclastic flexural slip between bedding surfaces of differing competencies, plastically deformed petrified wood within the zone of flexural slip, and cataclastic shear expressed as deformation bands. Such examples show how various lithologies can be deformed into a wide array of structures during a single deformation event. Furthermore, some of these structures result in changes in permeability, which are important for those interested in subsurface fluid flow

The Profumo affair in popular culture: The Keeler Affair (1963) and ‘the commercial exploitation of a public scandal’

This article demonstrates that the Profumo affair, which obsessed Britain for large parts of 1963, was not simply a political scandal, but was also an important cultural event. Focussing on the production of The Keeler Affair, a feature film that figured prominently in contemporary coverage of the scandal but which has been largely overlooked since, the article shows that this film emerged from a situation in which cultural entrepreneurs, many of them associated with the satire boom, sought to exploit the scandal for financial gain. Many Profumo-related cultural products found an audience, and thus formed an integral part of, and helped to shape public attitudes towards, the Profumo affair. However, these products did not go uncontested, and resistance to them, and especially to the idea that Keeler might benefit materially from her role in the scandal, speak to concerns about cultural mediations of sex, politics and humour in early-1960s Britain

Probabilistic seismic hazard assessment for a new-build nuclear power plant site in the UK

A probabilistic seismic hazard analysis (PSHA) has been conducted as part of the Safety Case justification for a new-build nuclear power plant in the UK. The study followed a cost-efficient methodology developed by CH2M and associates for safety-significant infrastructure where high-level regulatory assurance is required. Historical seismicity was re-evaluated from original sources. The seismicity model considered fourteen seismic sources which, when combined, formed six alternative seismic source models. Separate models for the median ground-motion and aleatory variability were considered. The median ground-motion model comprised a suite of ground-motion equations adjusted to the site-specific conditions using VS-kappa factors. A partially non-ergodic sigma model was adopted with separate components for the inter-event variability, and single-station intra-event variability, adjusted by a partially ergodic site-to-site variability term. Site response analysis was performed using equivalent-linear random vibration theory with explicit incorporation of the variability in the ground properties using Monte Carlo simulations. The final PSHA results were obtained by convolution of the hazard at the reference rock horizon with the site amplification factors. The overall epistemic uncertainty captured by the logic tree was assessed and compared against results from earlier PSHA studies for the same site

A streamlined approach for the seismic hazard assessment of a new nuclear power plant in the UK

This article presents a streamlined approach to seismic hazard assessment aimed at providing regulatory assurance, whilst acknowledging commercial and program constraints associated with the development of safety–critical facilities. The approach was developed based on international best practice and followed the spirit of the Senior Seismic Hazard Analysis Committee (SSHAC) Level 2 requirements, while incorporating the key features of the SSHAC Level 3 process aimed at achieving regulatory assurance, but with a more flexible implementation. It has also benefited from experience gained by others regarding the implementation of the SSHAC process in projects in the USA, Switzerland and South Africa. The approach has been successfully applied as part of the Safety Case for the new-build nuclear power plant at Hinkley Point, UK. The proposed approach can be considered as a cost-effective solution for the seismic hazard evaluation of safety-significant facilities where a high level of regulatory assurance is required

Autonomous vehicle interactions in the urban street environment: A research agenda

© ICE Publishing 2018. All rights reserved. The Venturer project is trialling an autonomous vehicle (AV) in the context of use on urban roads. This paper summarises a literature review undertaken to assist in developing a research agenda for the trialling. The first contribution of the paper is a framework of four use scenarios for AVs as follows: (1) fully segregated AV network, (2) motorway or expressway network, (3) typical urban network, (4) shared space. The paper then focuses on a review of the social interactions in the street environment and discusses issues concerning human behaviour in relation to autonomy. The second contribution of the paper is a set of research questions for AV trialling in relation to other road users, including, pedestrians and cyclists, which have emerged from the literature review.

Small-scale, semi-automated purification of eukaryotic proteins for structure determination

A simple approach that allows cost-effective automated purification of recombinant proteins in levels sufficient for functional characterization or structural studies is described. Studies with four human stem cell proteins, an engineered version of green fluorescent protein, and other proteins are included. The method combines an expression vector (pVP62K) that provides in vivo cleavage of an initial fusion protein, a factorial designed auto-induction medium that improves the performance of small-scale production, and rapid, automated metal affinity purification of His8-tagged proteins. For initial small-scale production screening, single colony transformants were grown overnight in 0.4 ml of auto-induction medium, produced proteins were purified using the Promega Maxwell 16, and purification results were analyzed by Caliper LC90 capillary electrophoresis. The yield of purified [U-15N]-His8-Tcl-1 was 7.5 μg/ml of culture medium, of purified [U-15N]-His8-GFP was 68 μg/ml, and of purified selenomethione-labeled AIA–GFP (His8 removed by treatment with TEV protease) was 172 μg/ml. The yield information obtained from a successful automated purification from 0.4 ml was used to inform the decision to scale-up for a second meso-scale (10–50 ml) cell growth and automated purification. 1H–15N NMR HSQC spectra of His8-Tcl-1 and of His8-GFP prepared from 50 ml cultures showed excellent chemical shift dispersion, consistent with well folded states in solution suitable for structure determination. Moreover, AIA–GFP obtained by proteolytic removal of the His8 tag was subjected to crystallization screening, and yielded crystals under several conditions. Single crystals were subsequently produced and optimized by the hanging drop method. The structure was solved by molecular replacement at a resolution of 1.7 Å. This approach provides an efficient way to carry out several key target screening steps that are essential for successful operation of proteomics pipelines with eukaryotic proteins: examination of total expression, determination of proteolysis of fusion tags, quantification of the yield of purified protein, and suitability for structure determination

Exposing Politicians’ Peccadilloes in Comparative Context: Explaining the Frequency of Political Sex Scandals in Eight Democracies Using Fuzzy Set Qualitative Comparative Analysis

This article was published in the journal Political Communication [© Taylor & Francis Group]. The definitive version is available at: http://dx.doi.org/10.1080/10584609.2012.737434Political sex scandals are largely absent in some democracies but proliferate in others. However, there have so far been few if any comprehensive attempts to document the actual number of sex scandals that have occurred and to explain their presence (and, indeed, absence), and the one study that has (Barker's 1994 study) ended in the early 1990s and had numerous problems in relation to defining and documenting such scandals. Based on extensive research, this article documents the number of sex scandals in eight advanced industrial democracies and tries to explain their occurrence using Charles Ragin's fuzzy set qualitative comparative analysis. The article has three goals: to determine the number of sex scandals in different democracies, explain why this might be, and demonstrate the utility of fuzzy set qualitative case analysis for small- and medium-N comparative research