Wind-Tunnel Investigation of Shielded Horn Balances and Tabs on a 0.7-Scale Model of XF6F Vertical Tail Surface

Results of subject tests indicate the difficulty of obtaining closely balanced rudder surfaces for most tail assemblies with shielded horns and maintaining a near zero rate-of-change of hinge-moment coefficient without an additional balancing device. A comparison is made between shielded and unshielded horn test results. Pressure distribution and tuft tests of flow over different shaped horns showed higher critical speed for medium-taper nosed horn. The trim tab nose shape had little effect on tab test results

The Care Programme Approach and the end of indefinitely renewable Leave of Absence in Scotland

ObjectiveTo consider the relationship between the restriction of leave of absence (LOA) to 12 months, the introduction of community care orders (CCOs) and the implementation of the Care Programme Approach (CPA).DesignMultiple methods were employed: scrutiny of Mental Welfare Commission for Scotland (MWC) records; questionnaire to consultant psychiatrists and mental health officers (MHOs) regarding attitudes; survey of psychiatrists in respect of outcomes for named patients.SettingScotlandSubjectsTwo hundred and sixty six patients who were affected by the changes introduced by the Mental Health (Patients in the Community) Act 1995.ResultsInformation was available for 195 (73%) patients in relation to CPA. Of these 113 (58%) were included on CPA and for 63/113 (56%) (63/195 (32%)) CPA was considered to have enhanced patient care.Where CPA was considered useful it was because it was seen as bringing people together, enhancing the patient’s role in treatment and managing difficult situations. Negative comments regarding CPA were that it was unnecessary as the patient’s needs were straightforward, it duplicated current practices or it was too bureaucratic.ConclusionsDespite concerns expressed by professionals about the restriction to LOA and the guidance that patients should be on CPA, for only a minority of patients was CPA described as enhancing care. Questions are raised about the low use of CCOs and CPA by psychiatrists for patients who reached the new limits of LOA

The Grizzly, October 26, 1979

J-Board Issues Warning • Graduate Aids NASA In Antimatter Finding • Campus Planning Group Looks At Student Life • Alumnus Honored for Middle East Peace Role • Letters to the Editor • Fashion Show In Wismer • Pianist to Perform at Ursinus Wins International Competition • College Bowl Update • Sports Profile: John Onopchenko • Rooters Lose, Rebound for Win • Videon Top Scorer On Third Team • Bear Pack Win Aided By Frosh • Hockey Aims For Berth • V-Ball Edges Swarthmorehttps://digitalcommons.ursinus.edu/grizzlynews/1025/thumbnail.jp

Effects of increasing the affinity of CarD for RNA polymerase on Mycobacterium tuberculosis growth, rRNA transcription, and virulence

CarD is an essential RNA polymerase (RNAP) interacting protein in Mycobacterium tuberculosis that stimulates formation of RNAP-promoter open complexes. CarD plays a complex role in M. tuberculosis growth and virulence that is not fully understood. Therefore, to gain further insight into the role of CarD in M. tuberculosis growth and virulence, we determined the effect of increasing the affinity of CarD for RNAP. Using site-directed mutagenesis guided by crystal structures of CarD bound to RNAP, we identified amino acid substitutions that increase the affinity of CarD for RNAP. Using these substitutions, we show that increasing the affinity of CarD for RNAP increases the stability of the CarD protein in M. tuberculosis. In addition, we show that increasing the affinity of CarD for RNAP increases the growth rate in M. tuberculosis without affecting 16S rRNA levels. We further show that increasing the affinity of CarD for RNAP reduces M. tuberculosis virulence in a mouse model of infection despite the improved growth rate in vitro. Our findings suggest that the CarD-RNAP interaction protects CarD from proteolytic degradation in M. tuberculosis, establish that growth rate and rRNA levels can be uncoupled in M. tuberculosis and demonstrate that the strength of the CarD-RNAP interaction has been finely tuned to optimize virulence. IMPORTANCE Mycobacterium tuberculosis, the causative agent of tuberculosis, remains a major global health problem. In order to develop new strategies to battle this pathogen, we must gain a better understanding of the molecular processes involved in its survival and pathogenesis. We have previously identified CarD as an essential transcriptional regulator in mycobacteria. In this study, we detail the effects of increasing the affinity of CarD for RNAP on transcriptional regulation, CarD protein stability, and virulence. These studies expand our understanding of the global transcription regulator CarD, provide insight into how CarD activity is regulated, and broaden our understanding of prokaryotic transcription

Soil Resources Area Affects Herbivore Health

Soil productivity effects nutritive quality of food plants, growth of humans and animals, and reproductive health of domestic animals. Game-range surveys sometimes poorly explained variations in wildlife populations, but classification of survey data by major soil types improved effectiveness. Our study evaluates possible health effects of lower condition and reproductive rates for wild populations of Odocoileus virginianus Zimmerman (white-tailed deer) in some physiographic regions of Mississippi. We analyzed condition and reproductive data for 2400 female deer from the Mississippi Department of Wildlife, Fisheries, and Parks herd health evaluations from 1991–1998. We evaluated age, body mass (Mass), kidney mass, kidney fat mass, number of corpora lutea (CL) and fetuses, as well as fetal ages. Region affected kidney fat index (KFI), which is a body condition index, and numbers of fetuses of adults (P ≤ 0.001). Region affected numbers of CL of adults (P ≤ 0.002). Mass and conception date (CD) were affected (P ≤ 0.001) by region which interacted significantly with age for Mass (P ≤ 0.001) and CD (P < 0.04). Soil region appears to be a major factor influencing physical characteristics of female deer

The Grizzly, December 8, 1978

Campus Entertainment Limited?: Activities Discussed By Task Force • Pi Omega Delta Becomes a Reality; Register Now for Evening Courses; Meistersingers In Televised Concert; Holiday Baskets Distributed By APO • Community And Civilization To Offer Interesting Approach • Bears Crack Garnets • Liberal Education In Our Times • Be Cool Or Bolt • From Beads and Bennies to Bedsheets and Budweiser • Letters to the Editor: Guyana Attitudes - Sig Rho Responds • Touring: Leave The Crowds On The Mountain • le Club Francais s\u27Amuse • The Year In Music • V-Ball Set To Spike Foes • Martha Franklin: For The Love Of Ursinus • Sports Profile: Clayton Ebling • Flying High Downs Slappers • Two No Shows Leave Mermaids Dry • Aquamen Splash To Win • Women Hoopers Drop Twohttps://digitalcommons.ursinus.edu/grizzlynews/1009/thumbnail.jp

The Grizzly, February 16, 1979

Fraternity Pledging Under College Scrutiny • College Bowl: A Positive Note • Middle States, Course Evaluation Approved By Faculty • Men\u27s Campus Council Explores Centralized Mail • Pledging Begins • Basic Assumption • Letters to the Editor: Community reaction • Roving Reporter: Dorm hours and sexual promiscuity • Ursinus News In Brief: William J. Phillips prize awarded • Marcel Marceau Master Of Mime Thrills Academy Audience • Concert Pianist to Perform • Ski Trips Galore Coming This Week • The Sound Of \u2779 • Audio Corner: Equipment Installation • Portrait Of The Professor: Dr. Joyce Henry • Sports Profile: Tim Todd • Bears Miss Playoffs • Free Throw Playoffs • Mermen Down To 2-7https://digitalcommons.ursinus.edu/grizzlynews/1013/thumbnail.jp

The Grizzly, January 26, 1979

Campus Life Committee to Replace SFARC • Quad Fire Brought Quickly Under Control • The Fabulous Greaseband Presents...Rock \u27N\u27 Roll Revue Tonight • Christmas Thefts Hit Women\u27s Dorms • Four-One-Four Proposed • Integrated Dining: An Interesting Proposal • Low Attendance Attracts Attention • Letters to the Editor: No static at all?; Big-name concert • Roving Reporter: Alcohol policy • Ritter Gift • Class Skiing Trips: Coming Up • Billy Joel: Isn\u27t One Elton John Enough? • Grateful Dead Rocks Spectrum • Operatic Forum • Audio Corner: Receivers • Token Tolkien • Financial aid night to be held; Meistersingers on tour; New sports editor; Gift collection received; William J. Phillip prize endowed • USGA Elections Near • Bears Sink Below .500 • Cagers Capture Only One Of Six • Flying Fish • Grapplers Groping • Girl\u27s B-Ballhttps://digitalcommons.ursinus.edu/grizzlynews/1010/thumbnail.jp

Religion and HIV in Tanzania: Influence of Religious Beliefs on HIV stigma, Disclosure, and Treatment Attitudes.

Religion shapes everyday beliefs and activities, but few studies have examined its associations with attitudes about HIV. This exploratory study in Tanzania probed associations between religious beliefs and HIV stigma, disclosure, and attitudes toward antiretroviral (ARV) treatment. A self-administered survey was distributed to a convenience sample of parishioners (n = 438) attending Catholic, Lutheran, and Pentecostal churches in both urban and rural areas. The survey included questions about religious beliefs, opinions about HIV, and knowledge and attitudes about ARVs. Multivariate logistic regression analysis was performed to assess how religion was associated with perceptions about HIV, HIV treatment, and people living with HIV/AIDS. Results indicate that shame-related HIV stigma is strongly associated with religious beliefs such as the belief that HIV is a punishment from God (p < 0.01) or that people living with HIV/AIDS (PLWHA) have not followed the Word of God (p < 0.001). Most participants (84.2%) said that they would disclose their HIV status to their pastor or congregation if they became infected. Although the majority of respondents (80.8%) believed that prayer could cure HIV, almost all (93.7%) said that they would begin ARV treatment if they became HIV-infected. The multivariate analysis found that respondents' hypothetical willingness to begin ARV treatme was not significantly associated with the belief that prayer could cure HIV or with other religious factors. Refusal of ARV treatment was instead correlated with lack of secondary schooling and lack of knowledge about ARVs. The decision to start ARVs hinged primarily on education-level and knowledge about ARVs rather than on religious factors. Research results highlight the influence of religious beliefs on HIV-related stigma and willingness to disclose, and should help to inform HIV-education outreach for religious groups

Intermittent Preventive Treatment to Reduce the Burden of Malaria in Children: New Evidence on Integration and Delivery

James Beeson and colleagues discuss three new studies in PLoS Medicine that provide valuable evidence on how to delivery and integrate intermittent preventive reatment for malaria in children (IPTc)