71 research outputs found
‘20 tins of Stella for a fiver’: The making of class through Labour and Coalition government alcohol policy
- Author
- Ayto J
- Bakhtin M
- Bauman Z
- Bauman Z
- BBC
- Bourdieu P
- Bourdieu P
- Bourdieu P
- Bourdieu P
- Cabinet Office
- Carey J
- Chick J
- Crompton R
- DCSF
- Department of Health
- Easton S
- Featherstone M
- Garland D
- Hadfield P
- Harrison B
- HM Government
- HM Government
- Hobbs D
- MacAndrew C
- McRobbie A
- ODPM
- Skeggs B
- Stallybrass P
- Thaler RH
- Thompson EP
- Tjønneland A
- Williams R
- Winlow S
- Publication venue
- 'SAGE Publications'
- Publication date
- 01/10/2014
- Field of study
Alcohol use in the UK has been a key concern to both the Labour and Coalition governments, and commands considerable attention in the media and academic discussions. This article analyses how recent government policy discussions have defined particular forms of drinking as problematic, and how these definitions and associated policy initiatives can be seen as part of a wider symbolic economy through which people come to be valued differently, incorporating ideas of economic, cultural and social capital. Therefore, I argue that government policies and discussions of drinking are a key way in which class is constituted in contemporary Britain
A Multi-Proxy Assessment of the Impact of Environmental Instability on Late Holocene (4500-3800 BP) Native American Villages of the Georgia Coast
- Author
- Publication venue
- UKnowledge
- Publication date
- 02/03/2022
- Field of study
Circular shell rings along the South Atlantic Coast of North America are the remnants of some of the earliest villages that emerged during the Late Archaic (5000-3000 BP). Many of these villages, however, were abandoned during the Terminal Late Archaic (ca 3800-3000 BP). We combine Bayesian chronological modeling with mollusk shell geochemistry and oyster paleobiology to understand the nature and timing of environmental change associated with the emergence and abandonment of circular shell ring villages on Sapelo Island, Georgia. Our Bayesian models indicate that Native Americans occupied the three Sapelo shell rings at varying times with some generational overlap. By the end of the complex\u27s occupation, only Ring III was occupied before abandonment ca. 3845 BP. Ring III also consists of statistically smaller oysters harvested from less saline estuaries compared to earlier occupations. Integrating shell biochemical and paleobiological data with recent tree ring analyses shows a clear pattern of environmental fluctuations throughout the period in which the rings were occupied. We argue that as the environment became unstable around 4300 BP, aggregation at villages provided a way to effectively manage fisheries that are highly sensitive to environmental change. However, with the eventual collapse of oyster fisheries and subsequent rebound in environmental conditions ca. post-3800 BP, people dispersed from shell rings, and shifted to non-marine subsistence economies and other types of settlements. This study provides the most comprehensive evidence for correlations between large-scale environmental change and societal transformations on the Georgia coast during the Late Archaic period
Adaptation of peroxisome proliferator-activated receptor alpha to hibernation in bats
- Author
- A Doetzlhofer
- AJ Meijer
- AT Chinwalla
- B Desvergne
- B Lin
- BD Reed
- C Bernal-Mizrachi
- C Blanquart
- C Dreyer
- C-A Lim
- CJ Nelson
- CK Glass
- CP Lyman
- D Brawand
- Dong Dong
- EC Teeling
- F Geiser
- F Geiser
- G Zhang
- GS Hotamisligil
- Guantao Zheng
- H Carey
- HK Srere
- HV Carey
- I Romero-Calvo
- IG Romero
- IV Kulakovskiy
- J Berger
- J Felsenstein
- JD Thompson
- JN Feige
- JP Katz
- K Tamura
- KB Storey
- KJ Livak
- KM Wadosky
- L Yuan
- M Megraw
- M Thomas-Chollier
- ME Allan
- MT Andrews
- N Simmons
- NS Tan
- P Morin Jr
- P Yaqoob
- PJ Wittkopp
- R Martinelli
- RD Barber
- RG Melvin
- S Kersten
- SD Clarke
- SF Eddy
- SF Eddy
- SF Eddy
- Shuyi Zhang
- T Garland
- T Garland
- T Inagaki
- TD Schmittgen
- Tianxiao Yang
- W Wahli
- WJ Murphy
- WS Lim
- X Zhou
- Y Xu
- YH Pan
- Yi-Hsuan Pan
- Yijie Han
- Z El Kebbaj
- Z Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion.
- Author
- A Herm-Götz
- A Keeley
- AE Speers
- AM Alonso
- BA Fox
- BR Martin
- C Mueller
- Carolyn I Hall
- CI Hall
- D Soldati
- DS Roos
- E Garrison
- E Weerapana
- Eranthie Weerapana
- FJ Dekker
- G Arrizabalaga
- GR Prescott
- JA Duncan
- JA Duncan
- James C Powers
- JC Powers
- JJ Heynekamp
- JM McCoy
- John C Boothroyd
- Josh R Beck
- JR Beck
- K Frénal
- K Kremer
- KL Carey
- LD Sibley
- Leslie O Ofori
- Matthew A Child
- Matthew Bogyo
- MB Lodoen
- Megan Garland
- MG Del Carmen
- MH Huynh
- MH Huynh
- ML Jones
- MW Black
- O Billker
- Paul W Bowyer
- Peter J Bradley
- RG Donald
- RR Rees-Channer
- S Hirakawa
- S Lourido
- S Lourido
- U Haedke
- VB Carruthers
- VB Carruthers
- VB Carruthers
- Victoria E Albrow
- Y Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
Although there have been numerous advances in our understanding of how apicomplexan parasites such as Toxoplasma gondii enter host cells, many of the signaling pathways and enzymes involved in the organization of invasion mediators remain poorly defined. We recently performed a forward chemical-genetic screen in T. gondii and identified compounds that markedly enhanced infectivity. Although molecular dissection of invasion has benefited from the use of small-molecule inhibitors, the mechanisms underlying induction of invasion by small-molecule enhancers have never been described. Here we identify the Toxoplasma ortholog of human APT1, palmitoyl protein thioesterase-1 (TgPPT1), as the target of one class of small-molecule enhancers. Inhibition of this uncharacterized thioesterase triggered secretion of invasion-associated organelles, increased motility and enhanced the invasive capacity of tachyzoites. We demonstrate that TgPPT1 is a bona fide depalmitoylase, thereby establishing an important role for dynamic and reversible palmitoylation in host-cell invasion by T. gondii
Group B Streptococcus vaccine development: present status and future considerations, with emphasis on perspectives for low and middle income countries.
- Author
- A Bedford Russell
- A Berardi
- A Berardi
- A Carey
- A Dagnew
- A Filleron
- A Flores
- A Nilo
- A Nuccitelli
- A Nuccitelli
- A Onderdonk
- A Rodewald
- A Schuchat
- A Schuchat
- A Seale
- A Seale
- A Sheppard
- A Sinha
- A Sinha
- A Tazi
- A Tazi
- A Tita
- A Valkenburg-van den Berg
- A White
- B Afshar
- B Gray
- B Lee
- B Lindsey
- B Stoll
- C Adair
- C Baker
- C Baker
- C Baker
- C Baker
- C Baker
- C Baker
- C Baker
- C Baker
- C Baker
- C Baker
- C Baker
- C Baker
- C Baker
- C Baker
- C Baker
- C Cutland
- C Cutland
- C Cutland
- C Easmon
- C Epalza
- C Hellerqvist
- C Johnson
- C Joubrel
- C Lachenauer
- C Larsson
- C Larsson
- C Nan
- C Park
- C Pellegrini
- C Phares
- C Poyart
- C Rubens
- C Siegrist
- C Tann
- C Turner
- C Whidbey
- C Whitney
- C Wilson
- D Blancas
- D Desa
- D Feikin
- D Furtado
- D Kasper
- D Kasper
- D Maione
- D McKenna
- D Millard
- D Santillan
- D Wennerstrom
- E Giannoni
- E Herting
- E McClure
- E Persson
- E Philipson
- F Avci
- F Cox
- F Cox
- F Lin
- F Lin
- F Lin
- F Lin
- G Arakere
- G Chan
- G Di Renzo
- G Donders
- G Fischer
- G Kwatra
- G Kwatra
- G Kwatra
- G Kwatra
- G Leroux-Roels
- G Lindahl
- G Mancuso
- G Oster
- G Tyrrell
- G Wak
- G Wendel
- H Bergseng
- H Guttormsen
- H Jordan
- H Kim
- H Maisey
- H McDonald
- H Nitschke
- H Slotved
- H Trotman
- H Xu
- I Margarit
- I Okike
- J Bohnsack
- J Bohnsack
- J Buttery
- J Davies
- J Frøen
- J Hanley
- J Herbert
- J Kellogg
- J Larsen JW
- J Lawn
- J Longtin
- J Lounsbery
- J MacFarquhar
- J McDuffie RS
- J Mohle-Boetani
- J Morgan
- J Pintye
- J Regan
- J Roberts
- J Rojas
- J Rojas
- J Siegel
- J Simoes
- J Stevens
- J Tieffenberg
- J Verani
- J Verani
- J Weeks
- K Adams Waldorf
- K Boyer
- K Boyer
- K Christensen
- K Christensen
- K Edmond
- K Gray
- K Hordnes
- K Hordnes
- K Joseph
- K Kimura
- K Le Doare
- K Le Doare
- K Matsubara
- K Matsubara
- K O'Brien
- K Patras
- K Patras
- K Persson
- K Rolland
- K Simonsen
- K Yao
- L Allesee
- L Cox
- L Downie
- L Lalioui
- L Lambertsen
- L Liu
- L Madoff
- L Manning
- L Maródi
- L McGee
- L Paoletti
- L Paoletti
- L Paoletti
- L Paoletti
- L Paoletti
- L Qin
- L Rivera
- M Aminu
- M Bland
- M Bolaños
- M Bressack
- M Bröker
- M Deutscher
- M Edwards
- M Edwards
- M Edwards
- M Edwards
- M Farley
- M Giménez
- M Hastings
- M Hauge
- M Imperi
- M Islam
- M Klegerman
- M Krohn
- M Macauley
- M Madzivhandila
- M Meehan
- M Pichichero
- M Trijbels-Smeulders
- M Yancey
- M Yow
- N Andrews
- N El Aila
- N Jones
- N Jones
- N Smith
- N Tharpe
- N Tuppurainen
- N Wang
- O Equils
- O Perovic
- P Ferrieri
- P Heath
- P Heath
- P Henneke
- P Melin
- P Palmeira
- P Pannaraj
- P Pannaraj
- P Sánchez
- Q Cheng
- R Ancona
- R Baltimore
- R Baltimore
- R Edwards
- R Feldman
- R Gibbs
- R Gibbs
- R Hancock
- R Heyderman
- R Karunakaran
- R Kessous
- R Lancefield
- R Lancefield
- R Libster
- R Macklin
- R McAdams
- R McAdams
- R McDuffie
- R Prentice
- R Schelonka
- S Bhengsri
- S Cnattingius
- S Dahesh
- S Garland
- S Gotoff
- S Gotoff
- S Håkansson
- S Kim
- S Landwehr-Kenzel
- S Lapinsky
- S Luck
- S Madhi
- S Madhi
- S Madhi
- S Oddie
- S Plotkin
- S Saha
- S Sarkar
- S Schrag
- S Schrag
- S Schrag
- S Schrag
- S Teatero
- S Velaphi
- T Colbourn
- T Connell
- T Divala
- T Fairlie
- T Fulton
- T Lamagni
- T Randis
- T Skoff
- V Chen
- V Hemming
- V Katz
- W Benitz
- W Petri
- X Carbonell-Estrany
- X Han
- X Shen
- X Shen
- X Shen
- X Shen
- Y Zheteyeva
- Z Dangor
- Z Dangor
- Z Dangor
- Z Dangor
- Z Dangor
- Z Dangor
- Publication venue
- 'F1000 Research Ltd'
- Publication date
- 01/09/2016
- Field of study
Globally, group B Streptococcus (GBS) remains the leading cause of sepsis and meningitis in young infants, with its greatest burden in the first 90 days of life. Intrapartum antibiotic prophylaxis (IAP) for women at risk of transmitting GBS to their newborns has been effective in reducing, but not eliminating, the young infant GBS disease burden in many high income countries. However, identification of women at risk and administration of IAP is very difficult in many low and middle income country (LMIC) settings, and is not possible for home deliveries. Immunization of pregnant women with a GBS vaccine represents an alternate pathway to protecting newborns from GBS disease, through the transplacental antibody transfer to the fetus in utero. This approach to prevent GBS disease in young infants is currently under development, and is approaching late stage clinical evaluation. This manuscript includes a review of the natural history of the disease, global disease burden estimates, diagnosis and existing control options in different settings, the biological rationale for a vaccine including previous supportive studies, analysis of current candidates in development, possible correlates of protection and current status of immunogenicity assays. Future potential vaccine development pathways to licensure and use in LMICs, trial design and implementation options are discussed, with the objective to provide a basis for reflection, rather than recommendations
The Science Performance of JWST as Characterized in Commissioning
- Author
- Abell J.
- Abney F.
- Abul-Huda Y.
- Adams E.
- Adler D.
- Aguilar J.
- Ahmed N.
- Albert L.
- Alberts S.
- Aldridge D.
- Allen M.
- Altenburg M.
- Alvarez-Marquez J.
- Alves de Oliveira C.
- Andersen G.
- Anderson H.
- Anderson S.
- Argyriou I.
- Armstrong A.
- Arribas S.
- Artigau E.
- Arvai A.
- Atkinson C.
- Bacon G.
- Bair T.
- Banks K.
- Barrientes J.
- Barringer B.
- Bartosik P.
- Bast W.
- Baudoz P.
- Beatty T.
- Bechtold K.
- Beck T.
- Bergeron E.
- Bergkoetter M.
- Bhatawdekar R.
- Birkmann S.
- Blazek R.
- Blome C.
- Boccaletti A.
- Boia J.
- Boker T.
- Bonaventura N.
- Bond N.
- Bosley K.
- Boucarut R.
- Bourque M.
- Bouwman J.
- Bower G.
- Bowers C.
- Boyer M.
- Bradley L.
- Brady G.
- Braun H.
- Breda D.
- Bresnahan P.
- Bright S.
- Britt C.
- Bromenschenkel A.
- Brooks B.
- Brooks K.
- Brown B.
- Brown M.
- Brown P.
- Bunker A.
- Burger M.
- Bushouse H.
- Cale S.
- Cameron A.
- Cameron P.
- Canipe A.
- Caplinger J.
- Caputo F.
- Cara M.
- Carey L.
- Carniani S.
- Carrasquilla M.
- Carruthers M.
- Case M.
- Catherine R.
- Chance D.
- Chapman G.
- Charlot S.
- Charlow B.
- Chayer P.
- Chen B.
- Cherinka B.
- Chichester S.
- Chilton Z.
- Chonis T.
- Clampin M.
- Clark C.
- Clark K.
- Coe D.
- Coleman B.
- Colon K.
- Comber B.
- Comeau T.
- Connolly D.
- Cooper J.
- Cooper R.
- Coppock E.
- Correnti M.
- Cossou C.
- Coulais A.
- Coyle L.
- Cracraft M.
- Curti M.
- Cuturic S.
- Davis K.
- Davis M.
- Dean B.
- DeLisa A.
- deMeester W.
- Dencheva N.
- Dencheva N.
- DePasquale J.
- Deschenes J.
- Diaz R.
- Dicken D.
- DiFelice A.
- Dillman M.
- Dixon W.
- Doggett J.
- Donaldson T.
- Douglas R.
- Doyon R.
- DuPrie K.
- Dupuis J.
- Durning J.
- Easmin N.
- Eck W.
- Edeani C.
- Egami E.
- Ehrenwinkler R.
- Eisenhamer J.
- Eisenhower M.
- Elie M.
- Elliott J.
- Elliott K.
- Ellis T.
- Engesser M.
- Espinoza N.
- Etienne O.
- Etxaluze M.
- Falini P.
- Feeney M.
- Feinberg L.
- Ferruit P.
- Ferry M.
- Filippazzo J.
- Fincham B.
- Fix M.
- Flagey N.
- Florian M.
- Flynn J.
- Fontanella E.
- Ford T.
- Forshay P.
- Fox O.
- Franz D.
- Friedman S.
- Fu H.
- Fullerton A.
- Galkin S.
- Galyer A.
- Garcia Marin M.
- Gardner J. P.
- Gardner L.
- Garland D.
- Garrett B.
- Gasman D.
- Gaspar A.
- Gaudreau D.
- Gauthier P.
- Geers V.
- Geithner P.
- Gennaro M.
- Giardino G.
- Girard J.
- Giuliano M.
- Glasse A.
- Glassmire K.
- Glauser A.
- Glazer S.
- Godfrey J.
- Golimowski D.
- Gollnitz D.
- Gong F.
- Gonzaga S.
- Gordon K.
- Gordon M.
- Goudfrooij P.
- Greene T.
- Greenhouse M.
- Grimaldi S.
- Groebner A.
- Grundy T.
- Guillard P.
- Gutman I.
- Ha K. Q.
- Haderlein P.
- Hagedorn A.
- Hainline K.
- Haley C.
- Hami M.
- Hamilton F.
- Hammel H.
- Hansen C.
- Harkins T.
- Harr M.
- Hart J.
- Hart Q.
- Hartig G.
- Hashimoto R.
- Haskins S.
- Hathaway W.
- Havey K.
- Hayden B.
- Hecht K.
- Heller-Boyer C.
- Henriques C.
- Henry A.
- Hermann K.
- Hernandez S.
- Hesman B.
- Hicks B.
- Hilbert B.
- Hines D.
- Hoffman M.
- Holfeltz S.
- Holler B. J.
- Hoppa J.
- Hott K.
- Howard J. M.
- Howard R.
- Hunor Detre I.
- Hunter A.
- Hunter D.
- Hurst B.
- Husemann B.
- Hustak L.
- Ilinca Ignat L.
- Illingworth G.
- Irish S.
- Jackson W.
- Jahromi A.
- Jakobsen P.
- James B.
- James L.
- Januszewski W.
- Jenkins A.
- Jirdeh H.
- Johnson P.
- Johnson T.
- Jones D.
- Jones O.
- Jones R.
- Jones V.
- Jordan I.
- Jordan M.
- Jurczyk S.
- Jurling A.
- Kaleida C.
- Kalmanson P.
- Kammerer J.
- Kang H.
- Kao S. -H.
- Karakla D.
- Kavanagh P.
- Kelly D.
- Kendrew S.
- Kennedy H.
- Kenny D.
- Keski-Kuha R.
- Keyes C.
- Kidwell R.
- Kimble R.
- Kinzel W.
- Kirk J.
- Kirkpatrick M.
- Kirshenblat D.
- Klaassen P.
- Knapp B.
- Knollenberg P.
- Koehler R.
- Koekemoer A.
- Kovacs A.
- Kulp T.
- Kumari N.
- Kyprianou M.
- La Massa S.
- Labador A.
- Labiano A.
- Lagage P. -O.
- Lajoie C. -P.
- Lallo M.
- Lallo M.
- Lam M.
- Lamb T.
- Lambros S.
- Lampenfield R.
- Langston J.
- Larson K.
- Law D.
- Lawrence J.
- Lee D.
- Leisenring J.
- Lepo K.
- Leveille M.
- Levenson N.
- Levine M.
- Levy Z.
- Lewis D.
- Lewis H.
- Libralato M.
- Lightsey P.
- Link M.
- Liu L.
- Lo A.
- Lockwood A.
- Logue R.
- Long C.
- Long D.
- Loomis C.
- Lopez-Caniego M.
- Lorenzo Alvarez J.
- Love-Pruitt J.
- Lucy A.
- Luetzgendorf N.
- Maghami P.
- Maiolino R.
- Major M.
- Malla S.
- Malumuth E.
- Manjavacas E.
- Mannfolk C.
- Marrione A.
- Marston A.
- Martel A.
- Maschmann M.
- Masci G.
- Masciarelli M.
- Maszkiewicz M.
- Mather J.
- McElwain M.
- McKenzie K.
- McLean B.
- McMaster M.
- Melbourne K.
- Melendez M.
- Menzel M.
- Merz K.
- Meyett M.
- Meza L.
- Milam S.
- Miskey C.
- Misselt K.
- Moller C.
- Morrison J.
- Morse E.
- Moseley H.
- Mosier G.
- Mountain M.
- Mueckay J.
- Mueller M.
- Mullally S.
- Murphy J.
- Murray C.
- Murray K.
- Mustelier D.
- Muzerolle J.
- Mycroft M.
- Myers R.
- Myrick K.
- Nanavati S.
- Nance E.
- Nayak O.
- Naylor B.
- Neff S.
- Nelan E.
- Nickson B.
- Nielson A.
- Nieto-Santisteban M.
- Nikolov N.
- Noriega-Crespo A.
- O'Shaughnessy B.
- O'Sullivan B.
- Ochs W.
- Ogle P.
- Oleszczuk B.
- Olmsted J.
- Osborne S.
- Ottens R.
- Owens B.
- Pacifici C.
- Pagan A.
- Page J.
- Park S.
- Parrish K.
- Patapis P.
- Paul L.
- Pauly T.
- Pavlovsky C.
- Pedder A.
- Peek M.
- Pena-Guerrero M.
- Penanen K.
- Perez Y.
- Perna M.
- Perriello B.
- Perrin M.
- Phillips K.
- Pietraszkiewicz M.
- Pinaud J. -P.
- Pirzkal N.
- Pitman J.
- Piwowar A.
- Platais V.
- Player D.
- Plesha R.
- Pollizi J.
- Polster E.
- Pontoppidan K.
- Porterfield B.
- Proffitt C.
- Pueyo L.
- Pulliam C.
- Quirt B.
- Quispe Neira I.
- Ramos Alarcon R.
- Ramsay L.
- Rapp G.
- Rapp R.
- Rauscher B.
- Ravindranath S.
- Rawle T.
- Regan M.
- Reichard T. A.
- Reis C.
- Ressler M. E.
- Rest A.
- Reynolds P.
- Rhue T.
- Richon K.
- Rickman E.
- Ridgaway M.
- Rieke G.
- Rieke M.
- Rigby J.
- Ritchie C.
- Rix H. -W.
- Robberto M.
- Robinson G.
- Robinson M.
- Robinson O.
- Rock F.
- Rodriguez D.
- Rodriguez Del Pino B.
- Roellig T.
- Rohrbach S.
- Roman A.
- Romelfanger F.
- Rose P.
- Roteliuk A.
- Roth M.
- Rothwell B.
- Rowlands N.
- Roy A.
- Royer P.
- Royle P.
- Rui C.
- Rumler P.
- Runnels J.
- Russ M.
- Rustamkulov Z.
- Ryden G.
- Ryer H.
- Sabata M.
- Sabatke D.
- Sabbi E.
- Samuelson B.
- Sapp B.
- Sappington B.
- Sargent B.
- Sauer A.
- Scheithauer S.
- Schlawin E.
- Schlitz J.
- Schmitz T.
- Schneider A.
- Schreiber J.
- Schulze V.
- Schwab R.
- Scott Acton D.
- Scott J.
- Scott Knight J.
- Sembach K.
- Shanahan C.
- Shaughnessy B.
- Shaw R.
- Shawger N.
- Shay C.
- Sheehan E.
- Shen S.
- Sherman A.
- Shiao B.
- Shih H. -Y.
- Shivaei I.
- Sienkiewicz M.
- Sing D.
- Sirianni M.
- Sivaramakrishnan A.
- Skipper J.
- Sloan G. C.
- Slocum C.
- Slowinski S.
- Smith C.
- Smith D.
- Smith E.
- Smith E.
- Snyder G.
- Soh W.
- Soto C.
- Spencer R.
- Stallcup S.
- Stansberry J.
- Stark C.
- Starr C.
- Starr E.
- Stewart A.
- Stiavelli M.
- Straughn A.
- Strickland D.
- Stys J.
- Summers F.
- Sun F.
- Sunnquist B.
- Swade D.
- Swam M.
- Swaters R.
- Swoish R.
- Taylor J. M.
- Taylor R.
- Te Plate M.
- Tea M.
- Teague K.
- Telfer R.
- Temim T.
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- Publication date
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- Field of study
This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies
Whole-genome sequencing reveals host factors underlying critical COVID-19
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- Wyllie D. H.
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- Zaki A.
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- Zanella I.
- Zborowski A. C.
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- Zhao J. H.
- Zheng C.
- Zhou W.
- Zitter L.
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- Zongo O.
- Zucchi P.
- Zyndorf M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat Rüdeger
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Étienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
- Bouchet Patrice
- Bouwman Jeroen
- Bower Gary
- Bowers Ariel S.
- Bowers Charles W.
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- Boyer Martha L.
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- Cara Mihai
- Carey Larkin
- Case Michael Eli
- Cesari Thaddeus
- Cetorelli Lee D.
- Chance Don R.
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- Cheezum Jeffrey I.
- Chen Bin
- Chen Christine H.
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- Chichester Sarah C.
- Chilton Zachary S.
- Chittiraibalan Dharini
- Clampin Mark
- Clark Charles R.
- Clark Kerry W.
- Clark Stephanie M.
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- Coleman Benee L.
- Colina Luis
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- Cossou Christophe
- Costanza Brian F.
- Costas Maria Begoña Vila
- Coulais Alain
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- Coyle Ray T.
- Cracraft Misty M.
- Crew Keith A.
- Curtis Gary J.
- Cusveller Bianca
- Dailey Christopher T.
- Darveau-Bernier Antoine
- Daugeron Frédéric
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- Dressler Alan
- Driggers Jennifer
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- Etienne Odessa
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- Glasse Alistair
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- Greenhouse Matthew A.
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- Grimaldi Stefano
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- Guillard Pierre
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- Gutman Irvin Meyer
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- Guyot Benjamin
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- Güdel Manuel
- Hack Warren J.
- Haderlein Peter
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- Hami Maryam
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- Hammel Heidi B.
- Hanley Christopher J.
- Hansen Carl August
- Hardy Bruce
- Harnisch Bernd
- Harr Michael Hunter
- Harris Pamela
- Hart Jessica Ann
- Hartig George F.
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- Hawkins Robert Edward
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- Kendrew Sarah
- Kennedy Herbert V.
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- Klaassen Pamela
- Klingemann Lana
- Klintworth Paul U.
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- Lander Matthew Ed
- Langston James Hutton
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- Leisenring Jarron
- Leveille Michael Dunlap
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- Libralato Mattia
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- Lipinski Jamie L.
- Litten Oi In Tam
- Liu XiaoLi
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- Logue Ryan M.
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- Rowlands Neil
- Roy Arpita
- Royer Pierre
- Rui Chunlei
- Rumler Peter
- Rumpl William
- Russ Melissa L.
- Ryan Michael B.
- Ryan Richard M.
- Saad Karl
- Sabata Modhumita
- Sabatino Rick
- Sabbi Elena
- Sabelhaus Phillip A.
- Sabia Stephen
- Sahu Kailash C.
- Saif Babak N.
- Salvignol Jean-Christophe
- Samara-Ratna Piyal
- Samuelson Bridget S.
- Sanders Felicia A.
- Santos Tony Dos
- Sappington Bradley
- Sargent B. A.
- Sauer Arne
- Savadkin Bruce J.
- Sawicki Marcin
- Schappell Tina M.
- Scheffer Caroline
- Scheithauer Silvia
- Scherer Ron
- Schiff Conrad
- Schlawin Everett
- Schmeitzky Olivier
- Schmitz Tyler S.
- Schmude Donald J.
- Schneider Analyn
- Schreiber Jürgen
- Schroeven-Deceuninck Hilde
- Schultz John J.
- Schwab Ryan
- Schwartz Curtis H.
- Scoccimarro Dario
- Scott John F.
- Scott Michelle B.
- Seaton Bonita L.
- Seely Bruce S.
- Seery Bernard
- Seidleck Mark
- Sembach Kenneth
- Shanahan Clare Elizabeth
- Shaughnessy Bryan
- Shaw Richard A.
- Shay Christopher Michael
- Sheehan Even
- Sheth Kartik
- Shih Hsin-Yi
- Shivaei Irene
- Siegel Noah
- Sienkiewicz Matthew G.
- Simmons Debra D.
- Simon Bernard P.
- Sirianni Marco
- Sivaramakrishnan Anand
- Slade Jeffrey E.
- Sloan G. C.
- Slocum Christine E.
- Slowinski Steven E.
- Smith Corbett T.
- Smith Eric P.
- Smith Erin C.
- Smith Koby
- Smith Robert
- Smith Stephanie J.
- Smolik John L.
- Soderblom David R.
- Sohn Sangmo Tony
- Sokol Jeff
- Sonneborn George
- Sontag Christopher D.
- Sooy Peter R.
- Soummer Remi
- Southwood Dana M.
- Spain Kay
- Sparmo Joseph
- Speer David T.
- Spencer Richard
- Sprofera Joseph D.
- Stallcup Scott S.
- Stanley Marcia K.
- Stansberry John A.
- Stark Christopher C.
- Starr Carl W.
- Stassi Diane Y.
- Steck Jane A.
- Steeley Christine D.
- Stephens Matthew A.
- Stephenson Ralph J.
- Stewart Alphonso C.
- Stiavelli Massimo
- Stockman Jr. Hervey
- Strada Paolo
- Straughn Amber N.
- Streetman Scott
- Strickland David Kendal
- Strobele Jingping F.
- Stuhlinger Martin
- Stys Jeffrey Edward
- Such Miguel
- Sukhatme Kalyani
- Sullivan Joseph F.
- Sullivan Pamela C.
- Sumner Sandra M.
- Sun Fengwu
- Sunnquist Benjamin Dale
- Swade Daryl Allen
- Swam Michael S.
- Swenton Diane F.
- Swoish Robby A.
- Tamas Laszlo
- Tao Andrew
- Taylor David K.
- Taylor Joanna M.
- Teague Kelly K.
- Telfer Randal C.
- Temim Tea
- Texter Scott C.
- Thatte Deepashri G.
- Thompson Christopher Lee
- Thompson Linda M.
- Thomson Shaun R.
- Thronson Harley
- Tierney C. M.
- Tikkanen Tuomo
- Tinnin Lee
- Tippet William Thomas
- Todd Connor William
- Tran Hien D.
- Trauger John
- Trejo Edwin Gregorio
- Truong Justin Hoang Vinh
- Tsukamoto Christine L.
- Tufail Yasir
- Tumlinson Jason
- Tustain Samuel
- Tyra Harrison
- Ubeda Leonardo
- Underwood Kelli
- Uzzo Michael A.
- Vaclavik Steven
- Valenduc Frida
- Valenti Jeff A.
- Van Campen Julie
- van de Wetering Inge
- Van Der Marel Roeland P.
- van Dishoeck Ewine F.
- van Haarlem Remy
- Van Tea Mason
- Vandenbussche Bart
- Vanterpool Dona D.
- Vernoy Michael R.
- Volk Kevin
- Voorzaat Piet
- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Walker Jr. Frederick E.
- Wander Michel
- Warfield Christine K.
- Warner Gerald
- Wasiak Francis C.
- Wasiak Matthew F.
- Wehner James
- Weiler Kevin R.
- Weilert Mark
- Weiss Stanley B.
- Wells Martyn
- Welty Alan D.
- Wheate Lauren
- Wheeler Thomas P.
- White Christy L.
- Whitehouse Paul
- Whiteleather Jennifer Margaret
- Whitman William Russell
- Williams Christina C.
- Willmer Christopher N. A.
- Willott Chris J.
- Willoughby Scott P.
- Wilson Andrew
- Wilson Debra
- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
- Wolfe Michael A.
- Wolff Schuyler
- Wondel Amancio
- Woo Cindy
- Woods Robert T.
- Worden Elaine
- Workman William
- Wright Gillian S.
- Wu Carl
- Wu Chi-Rai
- Wun Dakin D.
- Wymer Kristen B.
- Yadetie Thomas
- Yan Isabelle C.
- Yang Keith C.
- Yates Kayla L.
- Yeager Christopher R.
- Yerger Ethan John
- Young Erick T.
- Young Gary
- Yu Gene
- Yu Susan
- Zak Dean S.
- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Álvarez-Márquez Javier
- Östlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
The Science Performance of JWST as Characterized in Commissioning
- Author
- Abell Jim
- Abney Faith
- Abul-Huda Yasin
- Acton D. Scott
- Adams Evan
- Adler David
- Aguilar Jonathan
- Ahmed Nasif
- Alarcon Rafael Ramos
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Marsha
- Altenburg Martin
- Alvarez Jose Lorenzo
- Andersen Greg
- Anderson Harry
- Anderson Sara
- Argyriou Ioannis
- Armstrong Amber
- Arribas Santiago
- Artigau Etienne
- Arvai Amanda
- Atkinson Charles
- Bacon Gregory
- Bair Thomas
- Banks Kimberly
- Barrientes Jaclyn
- Barringer Bruce
- Bartosik Peter
- Bast William
- Baudoz Pierre
- Beatty Thomas
- Bechtold Katie
- Beck Tracy
- Bergeron Eddie
- Bergkoetter Matthew
- Bhatawdekar Rachana
- Birkmann Stephan
- Blazek Ronald
- Blome Claire
- Boccaletti Anthony
- Boeker Torsten
- Boia John
- Bonaventura Nina
- Bond Nicholas
- Bosley Kari
- Boucarut Ray
- Bourque Matthew
- Bouwman Jeroen
- Bower Gary
- Bowers Charles
- Boyer Martha
- Bradley Larry
- Brady Greg
- Braun Hannah
- Breda David
- Bresnahan Pamela
- Bright Stacey
- Britt Christopher
- Bromenschenkel Asa
- Brooks Brian
- Brooks Keira
- Brown Bob
- Brown Matthew
- Brown Patricia
- Bunker Andy
- Burger Matthew
- Bushouse Howard
- Cale Steven
- Cameron Alex
- Cameron Peter
- Canipe Alicia
- Caplinger James
- Caputo Francis
- Cara Mihai
- Carey Larkin
- Carniani Stefano
- Carrasquilla Maria
- Carruthers Margaret
- Case Michael
- Catherine Riggs
- Chance Don
- Chapman George
- Charlot Stéphane
- Charlow Brian
- Chayer Pierre
- Chen Bin
- Cherinka Brian
- Chichester Sarah
- Chilton Zack
- Chonis Taylor
- Clampin Mark
- Clark Charles
- Clark Kerry
- Coe Dan
- Coleman Benee
- Colon Knicole
- Comber Brian
- Comeau Tom
- Connolly Dennis
- Cooper James
- Cooper Rachel
- Coppock Eric
- Correnti Matteo
- Cossou Christophe
- Coulais Alain
- Coyle Laura
- Cracraft Misty
- Curti Mirko
- Cuturic Steven
- Davis Katherine
- Davis Michael
- de Oliveira Catarina Alves
- Dean Bruce
- Del Pino Bruno Rodriguez
- DeLisa Amy
- deMeester Wim
- Dencheva Nadezhda
- Dencheva Nadia
- DePasquale Joseph
- Deschenes Jeremy
- Detre Örs Hunor
- Diaz Rosa
- Dicken Dan
- DiFelice Audrey
- Dillman Matthew
- Dixon William
- Doggett Jesse
- Donaldson Tom
- Douglas Rob
- Doyon René
- DuPrie Kimberly
- Dupuis Jean
- Durning John
- Easmin Nilufar
- Eck Weston
- Edeani Chinwe
- Egami Eiichi
- Ehrenwinkler Ralf
- Eisenhamer Jonathan
- Eisenhower Michael
- Elie Michelle
- Elliott James
- Elliott Kyle
- Ellis Tracy
- Engesser Michael
- Espinoza Nestor
- Etienne Odessa
- Etxaluze Mireya
- Falini Patrick
- Feeney Matthew
- Feinberg Lee
- Ferruit Pierre
- Ferry Malcolm
- Filippazzo Joseph
- Fincham Brian
- Fix Mees
- Flagey Nicolas
- Florian Michael
- Flynn Jim
- Fontanella Erin
- Ford Terrance
- Forshay Peter
- Fox Ori
- Franz David
- Friedman Scott
- Fu Henry
- Fullerton Alexander
- Galkin Sergey
- Galyer Anthony
- Gardner Jonathan
- Gardner Lisa
- Garland Dennis
- Garrett Bruce
- Gasman Danny
- Gaspar Andras
- Gaudreau Daniel
- Gauthier Peter
- Geers Vincent
- Geithner Paul
- Gennaro Mario
- Giardino Giovanna
- Girard Julien
- Giuliano Mark
- Glasse Alistair
- Glassmire Kirk
- Glauser Adrian
- Glazer Stuart
- Godfrey John
- Golimowski David
- Gollnitz David
- Gong Fan
- Gonzaga Shireen
- Gordon Karl
- Gordon Michael
- Goudfrooij Paul
- Greene Thomas
- Greenhouse Matthew
- Grimaldi Stefano
- Groebner Andrew
- Grundy Timothy
- Guillard Pierre
- Gutman Irvin
- Ha Kong Q.
- Haderlein Peter
- Hagedorn Andria
- Hainline Kevin
- Haley Craig
- Hami Maryam
- Hamilton Forrest
- Hammel Heidi
- Hansen Carl
- Harkins Tom
- Harr Michael
- Hart Jessica
- Hart Quyen
- Hartig George
- Hashimoto Ryan
- Haskins Sujee
- Hathaway William
- Havey Keith
- Hayden Brian
- Hecht Karen
- Heller-Boyer Chris
- Henriques Caroline
- Henry Alaina
- Hermann Karl
- Hernandez Scarlin
- Hesman Brigette
- Hicks Brian
- Hilbert Bryan
- Hines Dean
- Hoffman Melissa
- Holfeltz Sherie
- Holler Bryan J.
- Hoppa Jennifer
- Hott Kyle
- Howard Joseph
- Howard Rick
- Hunter Alexander
- Hunter David
- Hurst Brendan
- Husemann Bernd
- Hustak Leah
- Ignat Luminita Ilinca
- Illingworth Garth
- Irish Sandra
- Jackson Wallace
- Jahromi Amir
- Jakobsen Peter
- James Bryan
- James LeAndrea
- Januszewski William
- Jenkins Ann
- Jirdeh Hussein
- Johnson Phillip
- Johnson Timothy
- Jones Danny
- Jones Olivia
- Jones Ron
- Jones Vicki
- Jordan Ian
- Jordan Margaret
- Jurczyk Sarah
- Jurling Alden
- Kaleida Catherine
- Kalmanson Phillip
- Kammerer Jens
- Kang Huijo
- Kao Shaw-Hong
- Karakla Diane
- Kavanagh Patrick
- Kelly Doug
- Kendrew Sarah
- Kennedy Herbert
- Kenny Deborah
- Keski-kuha Ritva
- Keyes Charles
- Kidwell Richard
- Kimble Randy
- Kinzel Wayne
- Kirk Jeff
- Kirkpatrick Mark
- Kirshenblat Danielle
- Klaassen Pamela
- Knapp Bryan
- Knight J. Scott
- Knollenberg Perry
- Koehler Robert
- Koekemoer Anton
- Kovacs Aiden
- Kulp Trey
- Kumari Nimisha
- Kyprianou Mark
- La Massa Stephanie
- Labador Aurora
- Lagage Pierre-Olivier
- Lajoie Charles-Phillipe
- Lallo Matt
- Lallo Matthew
- Lam May
- Lamb Tracy
- Lambros Scott
- Lampenfield Richard
- Langston James
- Larson Kirsten
- Law David
- Lawrence Jon
- Lee David
- Leisenring Jarron
- Lepo Kelly
- Leveille Michael
- Levenson Nancy
- Levine Marie
- Levy Zena
- Lewis Dan
- Lewis Hannah
- Libralato Mattia
- Lightsey Paul
- Link Miranda
- Liu Lily
- Lo Amy
- Lockwood Alexandra
- Logue Ryan
- Long Chris
- Long Douglas
- Loomis Charles
- Lopez-Caniego Marcos
- Love-Pruitt Jennifer
- Lucy Adrian
- Luetzgendorf Nora
- Maghami Peiman
- Maiolino Roberto
- Major Melissa
- Malla Sunita
- Malumuth Eliot
- Manjavacas Elena
- Mannfolk Crystal
- Marin Macarena Garcia
- Marquez Javier Alvarez
- Marrione Amanda
- Marston Anthony
- Martel André
- Maschmann Marc
- Masci Gregory
- Masciarelli Michaela
- Maszkiewicz Michael
- Mather John
- McElwain Michael
- McKenzie Kenny
- McLean Brian
- McMaster Matthew
- Melbourne Katie
- Meléndez Marcio
- Menzel Michael
- Merz Kaiya
- Meyett Michele
- Meza Luis
- Milam Stefanie
- Miskey Cherie
- Misselt Karl
- Moller Christopher
- Morrison Jane
- Morse Ernie
- Moseley Harvey
- Mosier Gary
- Mountain Matt
- Mueckay Julio
- Mueller Michael
- Mullally Susan
- Murphy Jess
- Murray Claire
- Murray Katherine
- Mustelier David
- Muzerolle James
- Mycroft Matthew
- Myers Richard
- Myrick Kaila
- Nanavati Shashvat
- Nance Elizabeth
- Nayak Omnarayani
- Naylor Bret
- Neff Susan
- Neira Irma Quispe
- Nelan Edmund
- Nickson Bryony
- Nielson Alethea
- Nieto-Santisteban Maria
- Nikolov Nikolay
- Noriega-Crespo Alberto
- O'Shaughnessy Brian
- O'Sullivan Brian
- Ochs William
- Ogle Patrick
- Oleszczuk Brenda
- Olmsted Joseph
- Ortega Alvaro Labiano
- Osborne Shannon
- Ottens Richard
- Owens Beverly
- Pacifici Camilla
- Pagan Alyssa
- Page James
- Park Sang
- Parrish Keith
- Patapis Polychronis
- Paul Lee
- Pauly Tyler
- Pavlovsky Cheryl
- Pedder Andrew
- Peek Matthew
- Pena-Guerrero Maria
- Pennanen Konstantin
- Perez Yesenia
- Perna Michele
- Perriello Beth
- Perrin Marshall
- Phillips Kevin
- Pietraszkiewicz Martin
- Pinaud Jean-Paul
- Pirzkal Norbert
- Pitman Joseph
- Piwowar Aidan
- Platais Vera
- Plate Maurice Te
- Player Danielle
- Plesha Rachel
- Pollizi Joe
- Polster Ethan
- Pontoppidan Klaus
- Porterfield Blair
- Proffitt Charles
- Pueyo Laurent
- Pulliam Christine
- Quirt Brian
- Ramsay Leah
- Rapp Greg
- Rapp Robert
- Rauscher Bernard
- Ravindranath Swara
- Rawle Timothy
- Regan Michael
- Reichard Timothy A.
- Reis Carl
- Ressler Michael E.
- Rest Armin
- Reynolds Paul
- Rhue Timothy
- Richon Karen
- Rickman Emily
- Ridgaway Michael
- Rieke George
- Rieke Marcia
- Rigby Jane
- Ritchie Christine
- Rix Hans-Walter
- Robberto Massimo
- Robinson Gregory
- Robinson Michael
- Robinson Orion
- Rock Frank
- Rodriguez David
- Roellig Thomas
- Rohrbach Scott
- Roman Anthony
- Romelfanger Fred
- Rose Perry
- Roteliuk Anthony
- Roth Marc
- Rothwell Braden
- Rowlands Neil
- Roy Arpita
- Royer Pierre
- Royle Patricia
- Rui Chunlei
- Rumler Peter
- Runnels Joel
- Russ Melissa
- Rustamkulov Zafar
- Ryden Grant
- Ryer Holly
- Sabata Modhumita
- Sabatke Derek
- Sabbi Elena
- Samuelson Bridget
- Sapp Benjamin
- Sappington Bradley
- Sargent B.
- Sauer Arne
- Scheithauer Silvia
- Schlawin Everett
- Schlitz Joseph
- Schmitz Tyler
- Schneider Analyn
- Schreiber Jürgen
- Schulze Vonessa
- Schwab Ryan
- Scott John
- Sembach Kenneth
- Shanahan Clare
- Shaughnessy Bryan
- Shaw Richard
- Shawger Nanci
- Shay Christopher
- Sheehan Evan
- Shen Sharon
- Sherman Allan
- Shiao Bernard
- Shih Hsin-Yi
- Shivaei Irene
- Sienkiewicz Matthew
- Sing David
- Sirianni Marco
- Sivaramakrishnan Anand
- Skipper Joy
- Sloan Gregory
- Slocum Christine
- Slowinski Steven
- Smith Corbett
- Smith Denise
- Smith Eric
- Smith Erin
- Snyder Gregory
- Soh Warren
- Sohn Tony
- Soto Christian
- Spencer Richard
- Stallcup Scott
- Stansberry John
- Stark Christopher
- Starr Carl
- Starr Elysia
- Stewart Alphonso
- Stiavelli Massimo
- Straughn Amber
- Strickland David
- Stys Jeff
- Summers Francis
- Sun Fengwu
- Sunnquist Ben
- Swade Daryl
- Swam Michael
- Swaters Robert
- Swoish Robby
- Taylor Joanna M.
- Taylor Rolanda
- Tea Mason
- Teague Kelly
- Telfer Randal
- Temim Tea
- Thatte Deepashri
- Thompson Christopher
- Thompson Linda
- Thomson Shaun
- Tikkanen Tuomo
- Tippet William
- Todd Connor
- Toolan Sharon
- Tran Hien
- Trejo Edwin
- Truong Justin
- Tsukamoto Chris
- Tustain Samuel
- Tyra Harrison
- Ubeda Leonardo
- Underwood Kelli
- Uzzo Michael
- Valenti Jeff
- Van Campen Julie
- Vandal Thomas
- Vandenbussche Bart
- Vila Begoña
- Volk Kevin
- Wahlgren Glenn
- Waldman Mark
- Walker Chanda
- Wander Michel
- Warfield Christine
- Warner Gerald
- Wasiak Matthew
- Watkins Mitchell
- Weaver Andrew
- Weilert Mark
- Weiser Nick
- Weiss Ben
- Weissman Sarah
- Welty Alan
- West Garrett
- Wheate Lauren
- Wheatley Elizabeth
- Wheeler Thomas
- White Rick
- Whiteaker Kevin
- Whitehouse Paul
- Whiteleather Jennifer
- Whitman William
- Williams Christina
- Willmer Christopher
- Willott Chris
- Willoughby Scott
- Wilson Andrew
- Wirth Gregory
- Wislowski Emily
- Wolf Erin
- Wolfe David
- Wolff Schuyler
- Workman Bill
- Wright Gillian
- Wright Ray
- Wu Carl
- Wu Rai
- Wymer Kristen
- Yates Kayla
- Yeager Christopher
- Yeates Jared
- Yerger Ethan
- Yoon Jinmi
- Young Alice
- Yu Susan
- Zak Dean
- Zeidler Peter
- Zhou Julia
- Zielinski Thomas
- Zincke Cristian
- Zonak Stephanie
- Publication venue
- 'IOP Publishing'
- Publication date
- 10/04/2023
- Field of study
This paper characterizes the actual science performance of the James Webb
Space Telescope (JWST), as determined from the six month commissioning period.
We summarize the performance of the spacecraft, telescope, science instruments,
and ground system, with an emphasis on differences from pre-launch
expectations. Commissioning has made clear that JWST is fully capable of
achieving the discoveries for which it was built. Moreover, almost across the
board, the science performance of JWST is better than expected; in most cases,
JWST will go deeper faster than expected. The telescope and instrument suite
have demonstrated the sensitivity, stability, image quality, and spectral range
that are necessary to transform our understanding of the cosmos through
observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures;
https://iopscience.iop.org/article/10.1088/1538-3873/acb29
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M.S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G.R.
- Abecasis G.R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N.S.
- Acquilini D.
- Adams C.
- Adams E.L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Agüero D.
- Ahmad N.
- Ahmadi S.
- Ahmed A.
- Ahmed C.
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich A.
- Al Harthi F.
- Al Mutairi A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha A.E.
- Alexander P.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali A.
- Ali I.A.M.
- Ali S.
- Aliannejad R.
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Z.
- Allen L.
- Allen M.
- Allen S.
- Allibone S.
- Allison K.S.
- Allos R.
- Almaden-Boyle C.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A.M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
- Altabaibeh A.
- Alvaro A.
- AlZahrani D.
- Amin V.
- Amirsavadkouhi A.
- Amitrano S.
- Anastasescu E.
- Anderson F.
- Anderson J.
- Anderson M.
- Anderson P.
- Anderson S.
- Anderson S.
- Anderson T.
- Andolfo I.
- Andretta F.
- Andreucci E.
- Andrew A.
- Andrew B.
- Andrew G.
- Andrews E.
- Andrews S.J.
- Anedda F.
- Anemoli V.
- Annis A.
- Antcliffe D.
- Antinori A.
- Antoni M.D.
- Anumakonda V.
- Apetri E.
- Aquino M.
- Arabi Y.M.
- Aravindan L.
- Arbane G.
- Archer K.
- Arden T.
- Arias S.S.
- Arif S.
- Armstrong J.
- Armstrong L.
- Armstrong R.
- Arning N.
- Arnold S.
- Arranz M.J.
- Arribas E.
- Artuso R.
- Arumugam P.
- Arumugam P.
- Ascolillo S.
- Ashraf S.
- Ashton L.
- Aslibekyan S.
- Astin-Chamberlain R.
- Atkinson E.G.
- Attwood B.
- Aucella F.
- Auld D.
- Auld F.
- Austin K.
- Austin P.
- Auton A.
- Ayers A.
- Azarzar S.
- Bachetti T.
- Baikady R.R.
- Baillie J.K.
- Baillie J.K.
- Baillie J.K.
- Baines B.
- Baines D.
- Baines K.
- Baird Y.
- Bakthavatsalam D.
- Balaconis M.K.
- Baldassarri M.
- Ball C.A.
- Baltzell A.H.
- Bamford A.
- Bamford P.
- Banach D.
- Bancroft H.
- Band G.
- Bandini M.
- Bandla N.
- Bano S.
- Baptista D.
- Barakeh D.
- Baras A.
- Baras A.
- Baratti S.
- Barber R.
- Barberis L.
- Barberis L.
- Barbieri C.
- Barclay L.
- Bargagli E.
- Barhoush E.
- Barker J.
- Barnes K.C.
- Baroni S.
- Barrett F.
- Barron A.
- Barry P.
- Bartels M.
- Bartley S.
- Baruah R.
- Bashyal A.
- Basikolo C.
- Bassetti M.
- Bastion V.
- Bates H.
- Bates M.
- Batini C.
- Battle C.
- Bauchmuller K.
- Baxter N.
- Baya N.
- Bayo L.-A.
- Beadle J.
- Bean S.
- Beaumont K.
- Beavis S.
- Beck A.
- Beckmann N.D.
- Bedini J.L.
- Bee C.E.
- Beech E.
- Beech V.
- Beekes M.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
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