Diagnostic anténatal par biopsie de trophoblaste au premier trimestre de grossesse (implications de la mise en évidence d'une anomalie chromosomique en mosaïque)

FORT-DE-FRANCE-CHRU-BU (972332102) / SudocBORDEAUX2-BU Santé (330632101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Etat des lieux de la prise en charge diagnostique du Syndrome d'Alcoolisation Foetale dans le Finistère (évaluation des connaissances des professionnels de santé concernant le SAF)

BREST-BU Médecine-Odontologie (290192102) / SudocSudocFranceF

Impact of rotavirus vaccine on premature infants

International audienceInfants born preterm are at a higher risk of complications and hospitalization in cases of rotavirus diarrhea than children born at term. We evaluated the impact of a rotavirus vaccination campaign (May 2007 to May 2010) on hospitalizations for rotavirus gastroenteritis in a population of children under 3 years old born prematurely (before 37 weeks of gestation) in the Brest University Hospital birth zone. Active surveillance from 2002 to 2006 and a prospective collection of hospitalizations for rotavirus diarrhea were initiated in the pediatric units of Brest University Hospital until May 2010. Numbers of hospitalizations for rotavirus diarrhea among the population of children born prematurely, before and after the start of the vaccination program, were compared using a Poisson regression model controlling for epidemic-to-epidemic variation. A total of 217 premature infants were vaccinated from 2007 to 2010. Vaccine coverage for a complete course of three doses was 41.9%. The vaccine safety in premature infants was similar to that in term infants. The vaccination program led to a division by a factor of 2.6 (95% confidence interval [CI], 1.3 to 5.2) in the number of hospitalizations for rotavirus diarrhea during the first two epidemic seasons following vaccine introduction and by a factor of 11 (95% CI, 3.5 to 34.8) during the third season. We observed significant effectiveness of the pentavalent rotavirus vaccine on the number of hospitalizations in a population of prematurely born infants younger than 3 years of age. A multicenter national study would provide better assessment of this impact. (This study [Impact of Systematic Infants Vaccination Against Rotavirus on Gastroenteritis Hospitalization: a Prospective Study in Brest District, France (IVANHOE)] has been registered at ClinicalTrials.gov under registration no. NCT00740935.)

Clinical value of serial quantitative analysis of cytomegalovirus DNA in blood and saliva over the first 24 months of life congenital infection: the French Cymepedia Cohort

International audienceObjective: To evaluate cytomegalovirus (CMV) viral load dynamics in blood and saliva during the first two years of life in symptomatic and asymptomatic infected infants and to identify whether these kinetics could have practical clinical implications.Study design: The Cymepedia cohort prospectively included 256 congenitally infected neonates followed for two years. Whole blood and saliva were collected at inclusion, months 4 and 12, and saliva at months 18 and 24. Real-time CMV PCR was performed, results expressed as log10 IU/mL in blood and in copies/mL in saliva.Results: Viral load in saliva progressively decreased from 7.5 log10 at birth to 3.3 log10 at month 24. CMV PCR in saliva was positive in 100% and 96% of infants at 6 and 12 months, respectively. In the first month of life, neonatal saliva viral load <5 log10 was related to a late CMV transplacental passage. Detection in blood was positive in 92% (147/159) of neonates in the first month of life. No viral load threshold values in blood or saliva could be associated with a high risk of sequelae. Neonatal blood viral load <3 log10 IU/ml had a 100% negative predictive value (NPV) for long-term sequelae.Conclusions: Viral loads in blood and saliva by CMV PCR testing in congenital infection fall over the first 24 months. In this study of infants affected mainly after primary maternal infection during pregnancy, all salivary samples were positive in the first 6 months of life and sequelae were not seen in infants with neonatal blood viral load <3 log10 IU/mL

One-Year Outcome for Congenital Diaphragmatic Hernia: Results From the French National Register

International audienceTo evaluate the status of congenital diaphragmatic hernia (CDH) management in France and to assess predictors of adverse outcomes

A homozygous splice variant in ATP5PO , disrupts mitochondrial complex V function and causes Leigh syndrome in two unrelated families

International audienc