In Fed meetings, decision making is free – but not equal.

With its ability to influence interest rates globally, the Federal Open Market Committee (FOMC) of the US Federal Reserve is arguably one of the most important decision making bodies on the planet. But how does it come to its decisions? In new research which analyses transcripts of FOMC deliberations over nearly 30 years, Joseph Gardner and John T. Woolley find that women speak less than men for nearly their entire tenure on the FOMC. While women are free to speak, they write, they do not participate equally in FOMC deliberations, and this could be influencing policy choices

Short-sighted virus evolution and a germline hypothesis for chronic viral infections

This work was funded by The Wellcome Trust and The Royal Society grant numbers wtvm055984 (KAL) and 107653/Z/15/Z (JG), The Natural Environment Research Council grant number NE/K009524/1 (AG), and The European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC grant number 614725-PATHPHYLODYN (OGP).With extremely short generation times and high mutability, many viruses can rapidly evolve and adapt to changing environments. This ability is generally beneficial to viruses as it allows them to evade host immune responses, evolve new behaviours, and exploit ecological niches. However, natural selection typically generates adaptation in response to the immediate selection pressures that a virus experiences in its current host. Consequently, we argue that some viruses, particularly those characterised by long durations of infection and ongoing replication, may be susceptible to short-sighted evolution, whereby a virus’ adaptation to its current host will be detrimental to its onward transmission within the host population. Here we outline the concept of short-sighted viral evolution and provide examples of how it may negatively impact viral transmission among hosts. We also propose that viruses that are vulnerable to short-sighted evolution may exhibit strategies that minimise its effects. We speculate on the various mechanisms by which this may be achieved, including viral life history strategies that result in low rates of within-host evolution, or the establishment of a ‘germline’ lineage of viruses that avoids short-sighted evolution. These concepts provide a new perspective on the way in which some viruses have been able to establish and maintain global pandemics.Publisher PDFPeer reviewe

How to validate machine-learned interatomic potentials

Machine learning (ML) approaches enable large-scale atomistic simulations with near-quantum-mechanical accuracy. With the growing availability of these methods there arises a need for careful validation, particularly for physically agnostic models - that is, for potentials which extract the nature of atomic interactions from reference data. Here, we review the basic principles behind ML potentials and their validation for atomic-scale materials modeling. We discuss best practice in defining error metrics based on numerical performance as well as physically guided validation. We give specific recommendations that we hope will be useful for the wider community, including those researchers who intend to use ML potentials for materials "off the shelf"

Mars habitat

The objective of this study is to develop a conceptual design for a permanently manned, self-sustaining Martian facility, to accommodate a crew of 20 people. The goal is to incorporate the major functions required for long term habitation in the isolation of a barren planet into a thriving ecosystem. These functions include living, working, service, and medical facilities as well as a green house. The main design task was to focus on the internal layout while investigating the appropriate structure, materials, and construction techniques. The general concept was to create a comfortable, safe living environment for the crew members for a stay of six to twelve months on Mars. Two different concepts were investigated, a modular assembly reusable structure (MARS) designated Lavapolis, and a prefabricated space frame structure called Hexamars. Both models take into account factors such as future expansion, radiation shielding, and ease of assembly

Impact of Li-Ion Battery on System’s Overall Impedance and Received Signal Strength for Power Line Communication (PLC)

In anticipation of the hybrid utilisation of the radio frequency (RF) wireless transceiver technology embedded in future smart Li-ion battery cells to deliver hybrid links based on power line communication (PLC) and wireless connections, herein we present an empirical high-frequency investigation of the direct current (DC) bus. The focus is to determine, via statistical tools including correlation coefficient (CC), root mean squared error (RMSE) and feature selective validation (FSV) method, the impedance and signal change impact on a possible communication link when fully charged cells are present or completely missing from the bus. Moreover, to establish if technological differences may be accounted for during the empirical experiments, Li-ion cells from two different manufacturers were selected and connected via three subsequent capacitive couplings of 1 µF, 1 nF and 1 pF. According to a methodical comparison by employing CC, RMSE, and FSV over the measured impedance and signal attenuation, this study has shown that the physical DC network is the dominant impedance at high frequencies and that the signal attenuation on the DC line supports communication in the investigated spectrum. The reported findings are critical for in situ hybrid PLC and wireless communication implementation of BMS for Li-ion systems supported through only one RF transceiver

A satellite view of spatial points in conversation 1

It can be difficult for external analysts without knowledge of the local environment to understand what conversationalists are talking about when they point to locations outside their immediate environment. Our geospatial framework for analysing directional points provides the external analyst with a panoramic view of the conversational setting, so that the world which members inhabit can be seen from space. By rotating the satellite imagery to align with bearing of the video cameras, the locations being pointed to and spoken about can be visualised within the context of the topography that surrounds the setting of the talk. We demonstrate these procedures using data from conversations conducted in the remote Australian outback, in Australian English, and in three distantly related Aboriginal languages

A satellite view of spatial points in conversation 1

It can be difficult for external analysts without knowledge of the local environment to understand what conversationalists are talking about when they point to locations outside their immediate environment. Our geospatial framework for analysing directional points provides the external analyst with a panoramic view of the conversational setting, so that the world which members inhabit can be seen from space. By rotating the satellite imagery to align with bearing of the video cameras, the locations being pointed to and spoken about can be visualised within the context of the topography that surrounds the setting of the talk. We demonstrate these procedures using data from conversations conducted in the remote Australian outback, in Australian English, and in three distantly related Aboriginal languages

Validating written feedback in clinical formative assessment

Formative assessment is widely accepted as being crucial to promoting student learning and, since 2010, the UK General Medical Council has mandated its use in workplace-based clinical training for all new doctors. As a result, the Royal College of Radiologists (RCR) instituted a range of formative workplace-based assessments including the Radiology Direct Observation of Procedural Skills (Rad-DOPS), in which supervisors appraise trainees’ performance in carrying out clinical procedures. This paper reports on the quality of the written feedback in 2,500 Rad-DOPS online feedback forms in addressing the aims of the new assessment approach. Random samples of 500 were selected from the first three years of the new assessment implementation, 2010–13, and from 2016 to 17. Using an appropriate coding frame, the feedback was analysed across the samples against key trainee attributes including stage of training and level of adjudged competence. Criteria for identifying high quality feedback were derived from the literature and a simplified form of qualitative comparative analysis was used to identify the conditions associated with high quality feedback. An average of 97% of the assessments contained written feedback but the number of instances of high quality feedback was found to be exceedingly small at around 5%. The paper offers suggestions for making the feedback process more purposeful in achieving the aims of formative assessment