13 research outputs found

    The economic relevance of climate variables in agriculture: The case of Spain

    Get PDF
    We estimate the impact of the different climate variables on the value of Spanish farmland. We distinguish between irrigated and non-irrigated lands and use data on temperature, precipitations, physical and socioeconomic characteristics to measure these effects on farm prices and in the number of hectares of farmland. We conclude presenting the main results of our analysis, region by region, and examining the policies that could be more effective to prevent undesired effects.Land Economics/Use,

    Characterization of an enhanced antigenic change in the pandemic 2009 H1N1 influenza virus haemagglutinin

    Get PDF
    Murine hybridomas producing neutralizing mAbs specific to the pandemic influenza virus A/California/07/2009 haemagglutinin (HA) were isolated. These antibodies recognized at least two different but overlapping new epitopes that were conserved in the HA of most Spanish pandemic isolates. However, one of these isolates (A/Extremadura/RR6530/2010) lacked reactivity with the mAbs and carried two unique mutations in the HA head (S88Y and K136N) that were required simultaneously to eliminate reactivity with the murine antibodies. This unusual requirement directly illustrates the phenomenon of enhanced antigenic change proposed previously for the accumulation of simultaneous amino acid substitutions at antigenic sites of the influenza A virus HA during virus evolution (Shih et al., Proc Natl Acad Sci USA, 104 , 6283-6288, 2007). The changes found in the A/Extremadura/RR6530/2010 HA were not found in escape mutants selected in vitro with one of the mAbs, which contained instead nearby single amino acid changes in the HA head. Thus, either single or double point mutations may similarly alter epitopes of the new antigenic site identified in this work in the 2009 H1N1 pandemic virus HA. Moreover, this site is relevant for the human antibody response, as shown by competition of mAbs and human post-infection sera for virus binding. The results are discussed in the context of the HA antigenic structure and challenges posed for identification of sequence changes with possible antigenic impact during virus surveillance.This work was supported in part by grants GR09/0023 (A. N.), GR09/0039 (J. A. M.) and GR09/0040 (I. C.) from Instituto de Salud Carlos III under a special research programme on pandemic flu. Additionally, the Biología Viral Unit is supported currently by grant SAF2012-31217 from Plan Nacional I+D+i.S

    Short- and Long-Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature

    Get PDF
    Background Takotsubo syndrome (TTS) is an acute reversible heart condition initially believed to represent a benign pathology attributable to its self-limiting clinical course; however, little is known about its prognosis based on different triggers. This study compared short- and long-term outcomes between TTS based on different triggers, focusing on various physical triggering events. Methods and Results We analyzed patients with a definitive TTS diagnosis recruited for the Spanish National Registry on TTS (RETAKO [Registry on Takotsubo Syndrome]). Short- and long-term outcomes were compared between different groups according to triggering factors. A total of 939 patients were included. An emotional trigger was detected in 340 patients (36.2%), a physical trigger in 293 patients (31.2%), and none could be identified in 306 patients (32.6%). The main physical triggers observed were infections (30.7%), followed by surgical procedures (22.5%), physical activities (18.4%), episodes of severe hypoxia (18.4%), and neurological events (9.9%). TTS triggered by physical factors showed higher mortality in the short and long term, and within this group, patients whose physical trigger was hypoxia were those who had a worse prognosis, in addition to being triggered by physical factors, including age >70 years, diabetes mellitus, left ventricular eyection fraction <30% and shock on admission, and increased long-term mortality risk. Conclusions TTS triggered by physical factors could present a worse prognosis in terms of mortality. Under the TTS label, there could be as yet undiscovered very different clinical profiles, whose differentiation could lead to individual better management, and therefore the perception of TTS as having a benign prognosis should be generally ruled out

    Prevalence and Associated Factors to Non-Carious Cervical Lesions in Brazilian University Students: A Cross-Sectional Survey

    Get PDF
    Objective: To identify the prevalence, severity, hypersensitivity, and distribution of Non-carious cervical lesions (NCCL) among university students in Brazil. Material and Methods: 179 participants answered an anamnesis with twenty questions about the presence or absence of habits associated with NCCL. The participants' teeth were evaluated to identify the presence or absence of the lesion, its classification, involved surfaces, severity, hypersensitivity, and tooth wear index. A hypersensitivity test was performed with ice water. Data were analyzed using the chi-square test and simple logistic regression (p<0.01). Results: 179 participants answered an anamnesis with twenty questions about the presence or absence of habits associated with NCCL. The participants' teeth were evaluated to identify the presence or absence of the lesion, its classification, involved surfaces, severity, hypersensitivity, and tooth wear index. A hypersensitivity test was performed with ice water. Data were analyzed using the chi-square test and simple logistic regression (p<0.01). Conclusion: The prevalence of NCCL was 15.1% and abfraction was the most frequent lesion. Premolars were the teeth most affected by non-carious cervical lesions

    The economic relevance of climate variables in agriculture: The case of Spain

    No full text
    We estimate the impact of the different climate variables on the value of Spanish farmland. We distinguish between irrigated and non-irrigated lands and use data on temperature, precipitations, physical and socioeconomic characteristics to measure these effects on farm prices and in the number of hectares of farmland. We conclude presenting the main results of our analysis, region by region, and examining the policies that could be more effective to prevent undesired effects

    Educacion, nombre comun femenino

    No full text
    Ridefinizione del senso dell'educare e del far ricerca in educazione alla luce di un ordine simbolico femminile. Nuovo pensiero sulla scuola e l'educazione costruito attorno a parole chiave (geneaologia, agio e piacere, fiducia, sapere per vivere, tempo della relazione, ecc.)

    Formação pedagógica de professores de nutrição: uma omissão consentida? Teacher training for nutrition professors: a tacitly accepted omission?

    No full text
    Apesar dos novos papéis preconizados pelas Diretrizes Curriculares Nacionais aos profissionais de Nutrição, pouca atenção tem sido dada ao desenvolvimento docente para atuação nos novos cenários. O objetivo deste ensaio é o de discutir um dos desafios à formação do nutricionista, a prática docente e a formação pedagógica do professor da área da saúde, para pensar formas de oportunizar um ensino de melhor qualidade, com base em autores que discutem a docência universitária. Identificam-se como causas da resistência docente às mudanças, a desvalorização das atividades de ensino e a supremacia das atividades de pesquisa nas universidades. O estudo permitiu sugerir a necessidade de reflexão por parte dos professores de Nutrição sobre as questões da docência universitária e sobre o desenvolvimento docente em uma perspectiva crítica e reflexiva, que possa ancorar mudanças pedagógicas necessárias à formação de nutricionistas.<br>Despite the new roles called in for the National Curricular Guidelines for teachers in nutrition courses, little attention has been paid to the professional development of the nutrition professional acting as a teacher. Based on the work of authors who discuss university teaching, this essay discusses some of the challenges involved in training nutritionists, such as teaching practice and teacher training for the professor in the health field, with the goal of providing higher-quality teaching. The devaluation of teaching and the supremacy of research at universities have been identified as the causes of teachers' resistance to change. This study reveals the need for professors of nutrition to reflect on the questions of university teaching and teacher development from a critical and reflective perspective which can anchor the pedagogical changes needed to train the nutritionist
    corecore