Traits de personnalité et anxiété sociale chez les élèves de l'enseignement secondaire

International audienceL'anxiété sociale est l'un des problèmes le plus prévalent de l'inadaptation sociale des adolescents. Elle cause des difficultés considérables, notamment de la détresse sociale. Cependant, à ce jour, aucune étude n'a examiné l'impact des traits de personnalité sur l'anxiété sociale de la population étudiante espagnole. L'objectif de cette étude est de déterminer dans quelle mesure les traits de personnalité prédisent les scores d'anxiété sociale, et inversement, afin d'examiner la mesure dans laquelle les scores d'anxiété sociale prédisent l'extraversion, la névrose (neuroticism) et psychose (psychoticism) chez les élèves de l'enseignement secondaire. L'inventaire de la phobie et de l'anxiété sociale (SPAI, Turner, Beidel, Dancu, & Stanley, 1989) et le questionnaire de personnalité d'Eysenck (EPQ, Eysenck & Eysenck, 1997) ont été administrés à 2022 collégiens espagnols des classes de 5ème, 4ème et 3ème, l'âge variant de 12 à 16 ans (M = 13,81, SD = 1,35). Les relations prédictives bidirectionnelles entre l'anxiété sociale et les traits de personnalité ont été examinées à l'aide d'analyses de régression logistique, en suivant les procédures de régression (statistique de Wald). Les traits de personnalité prédisent de façon significative l'apparition de l'anxiété sociale au cours de l'adolescence, la névrose (neuroticism) étant un facteur positif ou de risque et l'extraversion un prédicteur négatif ou facteur de protection. De même, des scores élevés d'anxiété sociale prédisent une plus grande probabilité d'obtenir des scores élevés sur la névrose (neuroticism) et une plus faible probabilité de repérer une grande extraversion. Nous pouvons conclure que le " névrosisme " est un prédicteur significatif et positif de l'anxiété sociale, alors que l'extraversion est un prédicteur significatif mais négatif de l'anxiété sociale. A l'inverse, plus l'adolescent obtient un score élevé d'anxiété sociale, plus il sera susceptible d'avoir des tendances névrotiques et sera moins extraverti qu'un adolescent ayant un score faible d'anxiété sociale

Concept de soi social et estime de soi chez les élèves espagnols ayant de l'anxiété sociale

International audienceL'anxiété sociale est l'un des problèmes le plus prévalent de l'inadaptation sociale chez les adolescents, causant des difficultés considérables, dont la détresse sociale. Cependant, actuellement très peu d'études ont exploré l'impact de l'anxiété sociale sur l'adaptation personnelle chez les collégiens. L'objectif de cette étude est de déterminer si les niveaux de concept de soi social et d'estime de soi des élèves anxieux socialement se distinguent de ceux de leurs pairs sans anxiété sociale. L'inventaire de la phobie et de l'anxiété sociale (SPAI, Turner, Beidel, Dancu, & Stanley, 1989) et le questionnaire de personnalité d'Eysenck (EPQ, Eysenck & Eysenck, 1997) ont été administrés à 2022 élèves espagnols des classes de 5ème, 4ème et 3ème, l'âge variant de 12 à 16 ans (M = 13,81, SD = 1,35). Des analyses descriptives et des T tests pour vérifier les différences entre les moyennes ont été effectués. Le d de Cohen a été inclus afin d'évaluer la taille de l'effet des différences. Les collégiens anxieux socialement ont une plus faible estime de soi et un plus faible concept de soi dans les situations sociales comme les relations avec leurs parents (d = .27), avec des personnes du même sexe (d = .45), et avec des gens de l'autre sexe (d=.46) que les élèves sans anxiété sociale. Notre étude montre que les adolescents avec de l'anxiété sociale, en comparaison avec les adolescents sans anxiété sociale, se considèrent comme moins compétents socialement et présentent un niveau d'estime de soi plus faible. Ainsi, il serait nécessaire de proposer à ces jeunes une intervention professionnelle de soutien pour améliorer leurs compétences sociales

Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties

The origin and evolution of the complex regulatory landscapes of some vertebrate developmental genes, often spanning hundreds of Kbp and including neighboring genes, remain poorly understood. The Sonic Hedgehog (Shh) genomic regulatory block (GRB) is one of the best functionally characterized examples, with several discrete enhancers reported within its introns, vast upstream gene-free region and neighboring genes (Lmbr1 and Rnf32). To investigate the origin and evolution of this GRB, we sequenced and characterized the Hedgehog (Hh) loci from three invertebrate chordate amphioxus species, which share several early expression domains with Shh. Using phylogenetic footprinting within and between chordate lineages, and reporter assays in zebrafish probing >30 Kbp of amphioxus Hh, we report large sequence and functional divergence between both groups. In addition, we show that the linkage of Shh to Lmbr1 and Rnf32, necessary for the unique gnatostomate-specific Shh limb expression, is a vertebrate novelty occurred between the two whole-genome duplications

Trends and models of Media literacy in Europe : between digital competence and critical understanding

This research focuses on models and strategies the EU has developed over the last decade in order to deal with these new and changing conditions. This is an important fact due to these strategies also have guided the actions of the European Union in promoting digital and media literacy. In order to understand how it has got to the current position in Europe, we identify and describe the models of literacy (digital and its gradual transformation in media literacy) that have emerged along more than a decade.El presente artículo se centra en el estudio y análisis de los diferentes modelos y estrategias que la Unión Europea (UE) ha desarrollado en la última década con el objetivo de adaptarse a la nueva y cambiante coyuntura comunicativa y social. Con el objetivo de establecer cómo la UE se ha adaptado a este nuevo panorama, se identifican y describen los principales modelos de alfabetización (desde la digital hasta la mediática) aplicados en los últimos diez años

Intermittent inotropic support with levosimendan in advanced heart failure as destination therapy: The LEVO-D registry

Advanced heart failure; Inotropes; Palliative careInsuficiencia cardiaca avanzada; Inotropos; Cuidados paliativosInsuficiència cardíaca avançada; Inòtrops; Cures pal·liativesAim Patients with advanced heart failure (AHF) who are not candidates to advanced therapies have poor prognosis. Some trials have shown that intermittent levosimendan can reduce HF hospitalizations in AHF in the short term. In this real-life registry, we describe the patterns of use, safety and factors related to the response to intermittent levosimendan infusions in AHF patients not candidates to advanced therapies. Methods and results Multicentre retrospective study of patients diagnosed with advanced heart failure, not HT or LVAD candidates. Patients needed to be on the optimal medical therapy according to their treating physician. Patients with de novo heart failure or who underwent any procedure that could improve prognosis were not included in the registry. Four hundred three patients were included; 77.9% needed at least one admission the year before levosimendan was first administered because of heart failure. Death rate at 1 year was 26.8% and median survival was 24.7 [95% CI: 20.4–26.9] months, and 43.7% of patients fulfilled the criteria for being considered a responder lo levosimendan (no death, heart failure admission or unplanned HF visit at 1 year after first levosimendan administration). Compared with the year before there was a significant reduction in HF admissions (38.7% vs. 77.9%; P 12 g/dL (+1.5), amiodarone use (−1.5) HF visit 1 year before levosimendan (−1.5) and heart rate >70 b.p.m. (−2). Patients with a score less than −1 had a very low probability of response (21.5% free of death or HF event at 1 year) meanwhile those with a score over 1.5 had the better chance of response (68.4% free of death or HF event at 1 year). LEVO-D score performed well in the ROC analysis. Conclusion In this large real-life series of AHF patients treated with levosimendan as destination therapy, we show a significant decrease of heart failure events during the year after the first administration. The simple LEVO-D Score could be of help when deciding about futile therapy in this population

Key Genes of the Immune System and Predisposition to Acquired Hemophilia A: Evidence from a Spanish Cohort of 49 Patients Using Next-Generation Sequencing

Acquired hemophilia A (AHA) is a rare bleeding disorder caused by the presence of autoantibodies against factor VIII (FVIII). As with other autoimmune diseases, its etiology is complex and its genetic basis is unknown. The aim of this study was to identify the immunogenetic background that predisposes individuals to AHA. HLA and KIR gene clusters, as well as KLRK1, were sequenced using next-generation sequencing in 49 AHA patients. Associations between candidate genes involved in innate and adaptive immune responses and AHA were addressed by comparing the alleles, genotypes, haplotypes, and gene frequencies in the AHA cohort with those in the donors' samples or Spanish population cohort. Two genes of the HLA cluster, as well as rs1049174 in KLRK1, which tags the natural killer (NK) cytotoxic activity haplotype, were found to be linked to AHA. Specifically, A*03:01 (p = 0.024; odds ratio (OR) = 0.26[0.06-0.85]) and DRB1*13:03 (p = 6.8 x 103, OR = 7.56[1.64-51.40]), as well as rs1049174 (p = 0.012), were significantly associated with AHA. In addition, two AHA patients were found to carry one copy each of the low-frequency allele DQB1*03:09 (nallele = 2, 2.04%), which was completely absent in the donors. To the best of our knowledge, this is the first time that the involvement of these specific alleles in the predisposition to AHA has been proposed. Further molecular and functional studies will be needed to unravel their specific contributions. We believe our findings expand the current knowledge on the genetic factors involved in susceptibility to AHA, which will contribute to improving the diagnosis and prognosis of AHA patients

Hemodynamic performance of different stent strategies for coronary bifurcations. Evaluation with a mathematical model

Purpose: Best percutaneous treatment strategy for lesions in coronary bifurcations is an ongoing subject of debate. There is limited data that analyses the effect of the different bifurcation strategies on coronary flow. Our aim is to evaluate the influence of different bifurcation stenting strategies on hemodynamic parameters, both in the main vessel (MV) and side branch (SB)

Information and communication technologies for approaching smokers : a descriptive study in primary healthcare

Background: Common interventions for smoking cessation are based on medical advice and pharmacological aid. Information and communication technologies may be helpful as interventions by themselves or as complementary tools to quit smoking. The objective of the study was to determine the use of information and communication technologies (ICTs) in the smoking population attended in primary care, and describe the major factors associated with its use. Methods: Descriptive observational study in 84 health centres in Cataluña, Aragon and Salamanca. We included by simple random sampling 1725 primary healthcare smokers (any amount of tobacco) aged 18-85. Through personal interview professionals collected Socio-demographic data and variables related with tobacco consumption and ICTs use were collected through face to face interviews Factors associated with the use of ICTs were analyzed by logistic regression. Results: Users of at least one ICT were predominantly male, young (18-45 years), from most favoured social classes and of higher education. Compared with non-ICTs users, users declared lower consumption of tobacco, younger onset age, and lower nicotine dependence. The percentages of use of email, text messages and web pages were 65.3%, 74.0% and 71.5%, respectively. Factors associated with the use of ICTs were age, social class, educational level and nicotine dependence level. The factor most closely associated with the use of all three ICTs was age; mainly individuals aged 18-24. Conclusions: The use of ICTs to quit smoking is promising, with the technology of mobile phones having a broader potential. Younger and more educated subjects are good targets for ICTs interventions on smoking cessation

CD32 Expression is not Associated to HIV-DNA content in CD4 cell subsets of individuals with Different Levels of HIV Control

A recent study has pointed out to CD32a as a potential biomarker of HIV-persistent CD4 cells. We have characterized the level and phenotype of CD32+ cells contained in different subsets of CD4 T-cells and its potential correlation with level of total HIV-DNA in thirty HIV patients (10 typical progressors naive for cART, 10 cART-suppressed patients, and 10 elite controllers). Total HIV-DNA was quantified in different subsets of CD4 T-cells: Trm and pTfh cells. Level and immunephenotype of CD32+ cells were analyzed in these same subsets by flow cytometry. CD32 expression in Trm and pTfh subsets was similar in the different groups, and there was no significant correlation between the level of total HIV-DNA and the level of CD32 expression in these subsets. However, total HIV-DNA level was correlated with expression of CD127 (rho = -0.46, p = 0.043) and of CCR6 (rho = -0.418, p = 0.027) on CD32+ cells. Our results do not support CD32 as a biomarker of total HIV-DNA content. However, analyzing the expression of certain markers by CD32+ cells could improve the utility of this marker in the clinical setting, prompting the necessity of further studies to both validate our results and to explore the potential utility of certain markers expressed by CD32+ cells.We would like to thank all patients and healthy donors who participated in the study. This study has been funded by projects CP14/00198, PI16/01769, and RD16/0025/0013 integrated in the State Plan for Scientific and Technical Research and Innovation and co-funded by ISCIII-Sub-Directorate General for Research Assessment and Promotion and European Regional Development Fund (ERDF). N Rallon is a Miguel Servet investigator from the Spanish Carlos III Institute of Health (ISCIII), grant CP14/00198, Madrid, Spain. Maria Angeles Navarrete-Munoz was funded by RD16/0025/0013 and the Intramural Research Scholarship from IIS-FJD. Clara Restrepo was funded by project RD16/0025/0013. M Garcia is a predoctoral student co-funded by CP14/00198 project and the Intramural Research Scholarship from IIS-FJD.S

Tecnologías de materiales con aplicaciones en fusión y su desarrollo en la instalación TechnoFusión

El futuro Centro Nacional de Tecnologías para la Fusión, TechnoFusión, tiene como objetivo desarrollar aquellas tecnologías, relacionadas con materiales, metales líquidos, manipulación remota y simulación, que permitan avanzar en los actuales retos que supone el uso de la fusión nuclear. Sus instalaciones, abiertas al servicio de la comunidad científica externa, garantizarán una destacada participación de empresas y grupos de investigación españoles. En esta contribución se describirán y analizarán las instalaciones que TechnoFusión construirá con capacidad para abordar: la fabricación y procesado de nuevas aleaciones a escala semiindustrial; el comportamiento de materiales, simulando las condiciones durante operación mediante una instalación de triple irradiación (iones pesados, hidrógeno y helio), generadores de plasma lineal (continuo y pulsado) y un circuito de litio líquido; y la caracterización del efecto que las severas condiciones de experimentación producen en las propiedades, en la composición y en la microestructura de materiales estructurales y funcionales (técnicas convencionales e in-situ)