Synthesis of iridaoxaphospholane complexes

Financiaciado para publicación en acceso aberto: Universidade de Vigo/CISUGAn alkenylphosphinite compound has been used to synthesize the unknown iridaoxaphospholane complexes which have been characterized in solution and solid state. The reactions took place in mild conditions and the product were obtained in good yields. The synthesis of the iridaoxaphospholane complexes is based on the capability of the alkenylphosphinite compound to behave as a κ1P or κ3(P, C, C) ligand when bonded to a metal complex. Theoretical calculations have been performed to explain the formation of the iridaoxaphospholane derivative due to a lower energy barrier for the nucleophilic attack at the terminal carbon of the olefin.Xunta de Galicia | Ref. GRC2019/2

Revisión crítica: “Estrategias de cuidado para prevenir problemas oculares en el adulto con ventilación mecánica en una unidad de cuidados intensivos”

El cuidado de los ojos forma parte del cuidado que enfermería debe brindar, pues es muy probable que los mecanismos naturales de protección, como ya se ha mencionado, estén dañados o comprometidos. La enfermera debe considerar que el paciente inconsciente, sedado o inmovilizado representa un grupo con riesgo elevado, ya que tienen disminuidos o abolidos los medios de protección primaria ocular como el cierre del párpado, el movimiento ocular, el parpadeo, la lubricación, etc. La presente investigación secundaria con metodología EBE formuló la siguiente pregunta clínica: ¿Qué estrategias de cuidado se pueden emplear para prevenir los problemas oculares en adultos con ventilación mecánica hospitalizados en una UCI? El objetivo fue: Determinar las estrategias de cuidado para prevenir los problemas oculares en adultos con ventilación mecánica hospitalizados en una UCI. La metodología de búsqueda partió de establecer las palabras clave del estudio, sus sinónimos para procurar encontrar la mayor posibilidad de respuestas en la búsqueda, se ingresaron ecuaciones de búsqueda en bibliotecas virtuales como: Cochrane, Scielo, Index, Google académico, Science Direct etc. Se encontraron 8 investigaciones. Sólo 2 pasaron la lista de verificación de Gálvez Toro. Se seleccionó una Guía de Práctica Clínica a la que se le realizó el comentario crítico con la lista AGREE II versión en español. La respuesta a la pregunta incluye los siguientes cuidados para prevenir los problemas oculares en UCI, se resumen a: limpieza regular de los ojos con solución salina y gasas estériles, asegurar el cerrado del párpado con el uso de cámaras húmedas, evitar exponer el ojo a secreciones Oro faríngeo, valoración y evaluación constante de la mucosa ocular, hisopado en caso de ojos rojos y aplicación de normas de bioseguridad.Tesis de segunda especialida

Optimising Energy Management in Hybrid Microgrids

This article deals with the optimization of the operation of hybrid microgrids. Both the problem of controlling the management of load sharing between the different generators and energy storage and possible solutions for the integration of the microgrid into the electricity market will be discussed. Solar and wind energy as well as hybrid storage with hydrogen, as renewable sources, will be considered, which allows management of the energy balance on different time scales. The Machine Learning method of Decision Trees, combined with ensemble methods, will also be introduced to study the optimization of microgrids. The conclusions obtained indicate that the development of suitable controllers can facilitate a competitive participation of renewable energies and the integration of microgrids in the electricity system

Study to find out the perception that first year students in engineering have about the Computational Thinking skills, and to identify possible factors related to the ability of Abstraction

Since the end of the 20th century, the digitalization of society, including the educational systems, has been growing exponentially. At the same time, education systems have been evolving towards competency-based assessment. Likewise, at the beginning of this century, the idea of Computational Thinking was resurrected by J. Wing, for solving problems and designing systems using concepts of computer science. Today, we can see how all these questions are taking shape in a new competence, called Computational Thinking, related to others that already exist. In this paper, we have studied the skills of Computational Thinking in university students, focusing on abstraction and its possible relationship with other factors. Results conclude that the students fail in relation to abstraction and in algorithmic thinking. Although the ability of abstraction is not easy to measure, a linear regression analysis has been carried out in order to determine its possible study.This article has been possible thanks to the help of the Vice-rectorate for Innovation, Social Commitment and Cultural Action, through the Educational Advice Service (SAE-HELAZ), of the University of the Basque Country (UPV/EHU), within the call for innovation projects IKD i3 Laborategia

Early hydration of belite-ye’elimite-ferrite cements: Role of admixtures

The effect of TIPA and CaCl2 on early hydration, i.e. 24 h, of a B-BYF cement has been studied by in situ synchrotron X-ray powder diffraction, calorimetry, thermal analysis, NMR, and rheological measurements of the pastes and mechanical strength of the corresponding mortars. The addition of 0.05 %bwc (by weight of cement) of TIPA reduced the viscosity of the paste during the first minutes of hydration but, after the end of the induction period, ~7 h, it favored the formation of AFt compared to the reference paste. The latter is likely due to the acceleration of the dissolution of the amorphous aluminates and sulfates by the presence of TIPA. These results correlate with the increase of ~169% of the 1-day mechanical strengths. The addition of 2.0 %bwc of CaCl2 accelerated the dissolution rate of ye’elimite, causing an increase of the amount of precipitated ettringite even before the end of the induction period, which has been shorted to ~6 h. The 1-day mechanical strengths of the mortars with this admixture outperforms that of the reference mortar by 181%. Finally, ferrite and α’ H-belite reactivities were not affected by the addition of any of these admixtures during the first 24 h of hydration of this cement.P18-RT-720 from the Andalusian regional government and PID2019-104378RJ-I00 from the Spanish government are gratefully acknowl-edged. ALBA synchrotron is acknowledged for providing with beamtime at MSPD beamline. Funding for open access charge: Universidad de Málaga / CBUA

Cell Fusion Reprogramming Leads to a Specific Hepatic Expression Pattern during Mouse Bone Marrow Derived Hepatocyte Formation In Vivo

The fusion of bone marrow (BM) hematopoietic cells with hepatocytes to generate BM derived hepatocytes (BMDH) is a natural process, which is enhanced in damaged tissues. However, the reprogramming needed to generate BMDH and the identity of the resultant cells is essentially unknown. In a mouse model of chronic liver damage, here we identify a modification in the chromatin structure of the hematopoietic nucleus during BMDH formation, accompanied by the loss of the key hematopoietic transcription factor PU.1/Sfpi1 (SFFV proviral integration 1) and gain of the key hepatic transcriptional regulator HNF-1A homeobox A (HNF-1A/Hnf1a). Through genome-wide expression analysis of laser captured BMDH, a differential gene expression pattern was detected and the chromatin changes observed were confirmed at the level of chromatin regulator genes. Similarly, Tranforming Growth Factor-β1 (TGF-β1) and neurotransmitter (e.g. Prostaglandin E Receptor 4 [Ptger4]) pathway genes were over-expressed. In summary, in vivo BMDH generation is a process in which the hematopoietic cell nucleus changes its identity and acquires hepatic features. These BMDHs have their own cell identity characterized by an expression pattern different from hematopoietic cells or hepatocytes. The role of these BMDHs in the liver requires further investigation

Gene Editing in Adult Hematopoietic Stem Cells

Over the last years, an important development has allowed the scientific community to address a precise and accurate modification of the genome. The first probe of concept appeared with the design and use of engineered zinc-finger nucleases (ZFNs), which was expanded later on with the discovery and engineering of meganucleases and transcription activator-like effector nucleases (TALENs) and finally democratized and made easily available to the whole scientific community with the discovery of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease combination technology. The availability of these tools has allowed a precise gene editing, such as knockout of a specific gene or the correction of a defective gene by means of homologous recombination (HR), taking advantage of the endogenous cell repair machinery. This process was already known and used but was inefficient—efficiency that has been increased more than 100-fold with the addition of the mentioned specific nucleases to the process. Apart from the proper design of the nucleases to recognize and cut the selected site in the cell genome, two main goals need to be adequately addressed to optimize its function: the delivery of the tools into the desired cells and the selection of those where the gene editing process has occurred correctly. Both steps can be easily solved when the source of cells is extensive or can be expanded and manipulated in vitro extensively, such as immortalized cell lines or pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells). However, both steps are critical in the case of primary cells, such as the hematopoietic stem cells (HSCs). HSCs are a rare cell population present in the bone marrow (BM) of higher mammals, and it is the responsible for the maintenance and replenishment of all hematopoietic cells for the lifespan of the animals by means of two fundamental properties: self-renewal and multipotency. HSC population is then the ideal target for the correction of hematopoietic genetic diseases and also for the knockout of the responsible genes to in vitro and in vivo model those hematopoietic diseases. This rare population cannot be expanded and its in vitro manipulation and culture negatively affects their fundamental properties of self-renewal and multipotency. These factors challenge the application of gene editing to HSCs. Important efforts are now ongoing trying to optimize the protocols of gene delivery and selection for HSCs. This chapter will review and discuss how researchers are trying to solve them, all attempts that are ongoing and the potential application of the technology to the patients affected with hematopoietic genetic diseases

Thyroid function is associated with insulin resistance markers in healthy adolescents with risk factors to develop diabetes

Introduction: The prevalence of obesity and Type 2 diabetes mellitus (T2DM) among children and adolescents is rising. Thyroid function has been associated with insulin resistance. There is scarce information about how thyroid function could be related with cardiovascular risk or glucose homeostasis in adolescent. Aim: To analyze how thyroid function is associated with insulin resistance and another cardiovascular risk factors in healthy adolescents with risk factors to develop diabetes. Methods: A prospective cross-sectional analysis was carried out on euthyroid, adolescents. considered at high risk to develop Type 2 diabetes. Fasting blood samples were obtained. Thyroid function test and another cardiometabolic parameters were assessed. A 75 grams oral glucose tolerance test was performed to calculate insulin resistance. Results: One hundred adolescents were evaluated. The mean age was 15.9 ± 0.8 years, There is a negative correlation between Fasting insulin, post glucose load insulin and HOMA IR. There were no correlation with Matsuda index. We could not found any correlation with TSH values. Conclusions: We found a correlation between fasting insulin, HOMA IR and serum thyroid hormones, we did not find any relation with serum TSH. In euthyroid adolescents with risk factors to develop diabetes

Long-term results of sirolimus treatment in lymphangioleiomyomatosis: a single referral centre experience

Diagnòstic; Farmacoteràpia; Malalties del tracte respiratoriDiagnóstico; Farmacoterapia; Enfermedades del tracto respiratorioDiagnosis; Drug therapy; Respiratory tract diseasesThere are few published data on long-term treatment with sirolimus in lymphangioleiomyomatosis (LAM). The objective of this study was to describe the long-term effect of sirolimus in a series of LAM patients followed up in a referral centre, focusing on pulmonary function. We retrospectively reviewed a series of 48 patients with LAM diagnosed, followed up and treated with sirolimus in a single centre. Response to sirolimus was evaluated at 1 and 5 years. A negative sirolimus response was defined as an FEV1 decline greater than − 75 ml/year. A mixed-effects model was used to estimate the longitudinal changes in FEV1 (average slope), both as absolute (ml/year) and as predicted values (%predicted/year). From a total of 48 patients, 9 patients underwent lung transplantation and 4 died during the study. Mean (95% CI) FEV1 slope over 5 years was − 0.14 (− 26.13 to 25.85) ml/year in the whole LAM group, 42.55 (14.87 to 70.22) ml/year in the responder group, − 54.00 (− 71.60 to − 36.39) ml/year in the partial responder group and − 84.19 (− 113.5 to − 54.0) ml/year in the non-responder group. After 5 years of sirolimus treatment 59% had a positive response, 30% had a partial response and 11% had a negative response. Our study found that sirolimus treatment had a positive long-term effect on most LAM patients.E.R.L. received a pre-doctoral Grant from the Spanish Society of Pulmonology and Thoracic Surgery