Hyperonic crystallization in hadronic matter

Published in Hadrons, Nuclei and Applications, World Scientific, Singapore, Proc.of the Conference Bologna2000. Structure of the Nucleus at the Dawn of the Century, G. Bonsignori, M. Bruno, A. Ventura, D. Vretenar Editors, pag. 319.Comment: 4 pages, 2figure

L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling.

During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits. How such a system works in coordination is not well understood. Cross-regulatory interactions between different signalling pathways and redundancy between them can increase precision and fidelity of guidance systems. Immunoglobulin superfamily proteins of the NCAM and L1 families couple specific substrate recognition and cell adhesion with the activation of receptor tyrosine kinases. Thus it has been shown that L1CAM-mediated cell adhesion promotes the activation of the EGFR (erbB1) from Drosophila to humans. Here we explore the specificity of the molecular interaction between L1CAM and the erbB receptor family. We show that L1CAM binds physically erbB receptors in both heterologous systems and the mammalian developing brain. Different Ig-like domains located in the extracellular part of L1CAM can support this interaction. Interestingly, binding of L1CAM to erbB enhances its response to neuregulins. During development this may synergize with the activation of erbB receptors through L1CAM homophilic interactions, conferring diffusible neuregulins specificity for cells or axons that interact with the substrate through L1CAM

FeNi-based magnetoimpedance multilayers: Tailoring of the softness by magnetic spacers

The microstructure and magnetic properties of sputtered permalloy films and FeNi(170 nm)/X/FeNi(170 nm) (X=Co, Fe, Gd, Gd-Co) sandwiches were studied. Laminating of the thick FeNi film with various spacers was done in order to control the magnetic softness of FeNi-based multilayers. In contrast to the Co and Fe spacers, Gd and Gd-Co magnetic spacers improved the softness of the FeNi/X/FeNi sandwiches. The magnetoimpedance responses were measured for [FeNi/Ti(6 nm)] 2/FeNi and [FeNi/Gd(2 nm)] 2/FeNi multilayers in a frequency range of 1-500 MHz: for all frequencies under consideration the highest magnetoimpedance variation was observed for [FeNi/Gd(2 nm)] 2/FeNi multilayers. © 2012 American Institute of Physics

Development of low-pH cementitious materials for HLRW repositories. Resistance against ground waters aggression

One of the most accepted engineering construction concepts of underground repositories for high radioactive waste considers the use of low-pH cementitious materials. This paper deals with the design of those based on Ordinary Portland Cements with high contents of silica fume and/or fly ashes that modify most of the concrete “standard” properties, the pore fluid composition and the microstructure of the hydrated products. Their resistance to long-term groundwater aggression is also evaluated. The results show that the use of OPC cement binders with high silica content produces low-pH pore waters and the microstructure of these cement pastes is different from the conventional OPC ones, generating C–S–H gels with lower CaO/SiO2 ratios that possibly bind alkali ions. Leaching tests show a good resistance of low-pH concretes against groundwater aggression although an altered front can be observe

BBIPED: BCAM-Baltogar Industrial Platform for Engineering Design

Currently, commercial software for computational fluid dynamics offers a good set of features to deal with traditional designs. Within a competitive market industrial innovation is a key factor that must be faced by companies. However, the design of solutions to deal with industrial challenges cannot be done within commercial software due to the lack of flexibility. Open source initiatives are a good option but the learning curve is high, specially for industrial engineers profiles. In this paper, we present the BBIPED platform which has been designed to deal with turbomachinery applications in a simple and friendly way. The main goal is to keep the platform as simpler as possible providing the enough flexibility to include out-of-the-box solutions to cope with industrial challenges. BBIPED platform provides links with currently existing remarkable open source initiatives altogether with our own developments. Particularly, it is remarkable a first approach for automatic mesh generation based on geometry parametrization solution, and the provision of novel techniques to deal with multiple rotating frame (MRF): Multizone MRF an Virtual MRF. Case tests were designed to test the solutions and to assess and validate the results against commercial suites with promising results

Outflows of hot molecular gas in ultra-luminous infra-red galaxies mapped with VLT-SINFONI

We present the detection and morphological characterization of hot molecular gas outflows in nearby ultra-luminous infrared galaxies, using the near-IR integral-field spectrograph SINFONI on the VLT. We detect outflows observed in the 2.12 micron H$_{2}$ 1-0 S(1) line for three out of four ULIRGs analyzed; IRAS 12112+0305, 14348-1447, and 22491-1808. The outflows are mapped on scales of 0.7-1.6 kpc, show typical outflow velocities of 300-500 km/s, and appear to originate from the nuclear region. The outflows comprise hot molecular gas masses of ~6-8x10$^3$ M(sun). Assuming a hot-to-cold molecular gas mass ratio of 6x10$^{-5}$, as found in nearby luminous IR galaxies, the total (hot+cold) molecular gas mass in these outflows is expected to be ~1x10$^{8}$ M(sun). This translates into molecular mass outflow rates of ~30-85 M(sun)/yr, which is a factor of a few lower than the star formation rate in these ULIRGs. In addition, most of the outflowing molecular gas does not reach the escape velocity of these merger systems, which implies that the bulk of the outflowing molecular gas is re-distributed within the system and thus remains available for future star formation. The fastest H$_{2}$ outflow is seen in the Compton-thick AGN of IRAS 14348-1447, reaching a maximum outflow velocity of ~900 km/s. Another ULIRG, IRAS 17208-0014, shows asymmetric H$_{2}$ line profiles different from the outflows seen in the other three ULIRGs. We discuss several alternative explanations for its line asymmetries, including a very gentle galactic wind, internal gas dynamics, low-velocity gas outside the disk, or two superposed gas disks. We do not detect the hot molecular counterpart to the outflow previously detected in CO(2-1) in IRAS 17208-0014, but we note that our SINFONI data are not sensitive enough to detect this outflow if it has a small hot-to-cold molecular gas mass ratio of < 9x10$^{-6}$.Comment: Accepted for publication in A&A (11 pages, 10 figures

High-resolution imaging of the molecular outflows in two mergers: IRAS17208-0014 and NGC1614

Galaxy evolution scenarios predict that the feedback of star formation and nuclear activity (AGN) can drive the transformation of gas-rich spiral mergers into ULIRGs, and, eventually, lead to the build-up of QSO/elliptical hosts. We study the role that star formation and AGN feedback have in launching and maintaining the molecular outflows in two starburst-dominated advanced mergers, NGC1614 and IRAS17208-0014, by analyzing the distribution and kinematics of their molecular gas reservoirs. We have used the PdBI array to image with high spatial resolution (0.5"-1.2") the CO(1-0) and CO(2-1) line emissions in NGC1614 and IRAS17208-0014, respectively. The velocity fields of the gas are analyzed and modeled to find the evidence of molecular outflows in these sources and characterize the mass, momentum and energy of these components. While most (>95%) of the CO emission stems from spatially-resolved (~2-3kpc-diameter) rotating disks, we also detect in both mergers the emission from high-velocity line wings that extend up to +-500-700km/s, well beyond the estimated virial range associated with rotation and turbulence. The kinematic major axis of the line wing emission is tilted by ~90deg in NGC1614 and by ~180deg in IRAS17208-0014 relative to their respective rotating disk major axes. These results can be explained by the existence of non-coplanar molecular outflows in both systems. In stark contrast with NGC1614, where star formation alone can drive its molecular outflow, the mass, energy and momentum budget requirements of the molecular outflow in IRAS17208-0014 can be best accounted for by the existence of a so far undetected (hidden) AGN of L_AGN~7x10^11 L_sun. The geometry of the molecular outflow in IRAS17208-0014 suggests that the outflow is launched by a non-coplanar disk that may be associated with a buried AGN in the western nucleus.Comment: Final version in press, accepted by A&A. Reference list updated. Minor typos correcte

PTMcode v2: a resource for functional associations of post-translational modifications within and between proteins

The post-translational regulation of proteins is mainly driven by two molecular events, their modification by several types of moieties and their interaction with other proteins. These two processes are interdependent and together are responsible for the function of the protein in a particular cell state. Several databases focus on the prediction and compilation of protein-protein interactions (PPIs) and no less on the collection and analysis of protein post-translational modifications (PTMs), however, there are no resources that concentrate on describing the regulatory role of PTMs in PPIs. We developed several methods based on residue co-evolution and proximity to predict the functional associations of pairs of PTMs that we apply to modifications in the same protein and between two interacting proteins. In order to make data available for understudied organisms, PTMcode v2 (http://ptmcode.embl.de) includes a new strategy to propagate PTMs from validated modified sites through orthologous proteins. The second release of PTMcode covers 19 eukaryotic species from which we collected more than 300 000 experimentally verified PTMs (>1 300 000 propagated) of 69 types extracting the post-translational regulation of >100 000 proteins and >100 000 interactions. In total, we report 8 million associations of PTMs regulating single proteins and over 9.4 million interplays tuning PPIs