1,291 research outputs found
Tau neutrino magnetic moments from the Super-Kamiokande and e-scattering data
Combined results on oscillations and -scattering from the Super-Kamiokande and LAMPF experiments, respectively,
limit the Dirac diagonal magnetic moment to . For the scheme with 3 Majorana neutrinos the LAMPF
results allow the limitation of effective magnetic moment to
. The moments in the scheme with
additional Majorana light sterile neutrinos as well as experiments on
stimulated radiative neutrino conversion are also discussed.Comment: 12 pages, To appear in Phys. Lett.
Deciphering the complexity of human non-coding promoter-proximal transcriptome.
Long non-coding RNAs (lncRNAs) have gained increasing relevance in epigenetic regulation and nuclear functional organization. High-throughput sequencing approaches have revealed frequent non-coding transcription in promoter-proximal regions. However, a comprehensive catalogue of promoter-associated RNAs (paRNAs) and an analysis of the possible interactions with neighboring genes and genomic regulatory elements are missing.
Integrating data from multiple cell types and experimental platforms we identified thousands of paRNAs in the human genome. paRNAs are transcribed in both sense and antisense orientation, are mostly non-polyadenylated and retained in the cell nucleus. Transcriptional regulators, epigenetic effectors and activating chromatin marks are enriched in paRNA-positive promoters. Furthermore, paRNA-positive promoters exhibit chromatin signatures of both active promoters and enhancers. Promoters with paRNAs reside preferentially at chromatin loop boundaries, suggesting an involvement in anchor site recognition and chromatin looping. Importantly, these features are independent of the transcriptional state of neighboring genes. Thus, paRNAs may act as cis-regulatory modules with an impact on local recruitment of transcription factors, epigenetic state and chromatin loop organization. This study provides a comprehensive analysis of the promoter-proximal transcriptome and offers novel insights into the roles of paRNAs in epigenetic processes and human diseases.
Genomic coordinates of predicted paRNAs are available at https://figshare.com: https://doi.org/10.6084/m9.figshare.7392791.v1 and https://doi.org/10.6084/m9.figshare.4856630.v2.
Supplementary data are available at Bioinformatics online
On the ideals of equivariant tree models
We introduce equivariant tree models in algebraic statistics, which unify and
generalise existing tree models such as the general Markov model, the strand
symmetric model, and group based models. We focus on the ideals of such models.
We show how the ideals for general trees can be determined from the ideals for
stars. The main novelty is our proof that this procedure yields the entire
ideal, not just an ideal defining the model set-theoretically. A corollary of
theoretical importance is that the ideal for a general tree is generated by the
ideals of its flattenings at vertices.Comment: 23 pages. Greatly improved exposition, in part following suggestions
by a referee--thanks! Also added exampl
Carbon footprint of Power-to-X derived dimethyl ether using the sorption enhanced DME synthesis process
Dimethyl ether (DME) could have a promising future as a sustainable diesel fuel replacement as it requires only relatively minor engine modifications. It can be produced from renewable H2 and captured CO2 using Power-to-X technologies. To gain support through the EU Renewable Energy Directive, the production and use of CO2-derived DME as a fuel needs to produce emission savings of at least 70% over the petrodiesel alternative. This study assesses the carbon footprint of producing DME via the sorption-enhanced DME synthesis (SEDMES) process and using it as a transport fuel, compared to producing and using fossil-based petrodiesel. The cradle-to-grave (well-to-wheel) carbon footprint of using DME as a transport fuel is found to be 77% lower than for petrodiesel, if offshore wind power is used for H2 synthesis and DME production. If renewable energy is also used for CO2 capture and waste heat is used for the DME production and purification steps, the DME carbon footprint has the potential to be over 90% lower than that of the fossil-fuel comparator
Holographic Description of Gravitational Anomalies
The holographic duality can be extended to include quantum theories with
broken coordinate invariance leading to the appearance of the gravitational
anomalies. On the gravity side one adds the gravitational Chern-Simons term to
the bulk action which gauge invariance is only up to the boundary terms. We
analyze in detail how the gravitational anomalies originate from the modified
Einstein equations in the bulk. As a side observation we find that the
gravitational Chern-Simons functional has interesting conformal properties. It
is invariant under conformal transformations. Moreover, its metric variation
produces conformal tensor which is a generalization of the Cotton tensor to
dimension . We calculate the modification of the holographic
stress-energy tensor that is due to the Chern-Simons term and use the bulk
Einstein equations to find its divergence and thus reproduce the gravitational
anomaly. Explicit calculation of the anomaly is carried out in dimensions
and . The result of the holographic calculation is compared with that of
the descent method and agreement is found. The gravitational Chern-Simons term
originates by Kaluza-Klein mechanism from a one-loop modification of M-theory
action. This modification is discussed in the context of the gravitational
anomaly in six-dimensional theory. The agreement with earlier
conjectured anomaly is found.Comment: 24 pages, Latex; presentation re-structured, new references adde
Role of fractal dimension in random walks on scale-free networks
Fractal dimension is central to understanding dynamical processes occurring
on networks; however, the relation between fractal dimension and random walks
on fractal scale-free networks has been rarely addressed, despite the fact that
such networks are ubiquitous in real-life world. In this paper, we study the
trapping problem on two families of networks. The first is deterministic, often
called -flowers; the other is random, which is a combination of
-flower and -flower and thus called hybrid networks. The two
network families display rich behavior as observed in various real systems, as
well as some unique topological properties not shared by other networks. We
derive analytically the average trapping time for random walks on both the
-flowers and the hybrid networks with an immobile trap positioned at an
initial node, i.e., a hub node with the highest degree in the networks. Based
on these analytical formulae, we show how the average trapping time scales with
the network size. Comparing the obtained results, we further uncover that
fractal dimension plays a decisive role in the behavior of average trapping
time on fractal scale-free networks, i.e., the average trapping time decreases
with an increasing fractal dimension.Comment: Definitive version published in European Physical Journal
Electronic properties of ordered and disordered linear clusters of atoms and molecules
The electronic properties of one-dimensional clusters of N atoms or molecules
have been studied. The model used is similar to the Kronig-Penney model with
the potential offered by each ion being approximated by an attractive delta
function. The energy eigenvalues, the eigenstates and the density of states are
calculated exactly for a linear cluster of N atoms or molecules. The dependence
of these quantities on the various parameters of the problem show interesting
behavior. Effects of random distribution of the positions of the atoms and
random distribution of the strengths of the potential have also been studied.
The results obtained in this paper can have direct applications for linear
chain of atoms produced on metal surfaces or artificially created chain of
atoms by using scanning tunneling microscope or in studying molecular
conduction of electrons across one-dimensional barriers.Comment: A shorter version of this paper to be published in Physica
Stability of trapped Bose-Einstein condensates
In three-dimensional trapped Bose-Einstein condensate (BEC), described by the
time-dependent Gross-Pitaevskii-Ginzburg equation, we study the effect of
initial conditions on stability using a Gaussian variational approach and exact
numerical simulations. We also discuss the validity of the criterion for
stability suggested by Vakhitov and Kolokolov. The maximum initial chirp
(initial focusing defocusing of cloud) that can lead a stable condensate to
collapse even before the number of atoms reaches its critical limit is obtained
for several specific cases. When we consider two- and three-body nonlinear
terms, with negative cubic and positive quintic terms, we have the conditions
for the existence of two phases in the condensate. In this case, the magnitude
of the oscillations between the two phases are studied considering sufficient
large initial chirps. The occurrence of collapse in a BEC with repulsive
two-body interaction is also shown to be possible.Comment: 15 pages, 11 figure
Limits on the magnetic moment of sterile neutrino and two-photon neutrino decay
It is shown that the non-zero transition magnetic moment ()
between the sterile neutrino () and the muon neutrino ()
could be effectively searched for via the Primakoff effect, in the process of
conversion in the external Coulomb field of a
nucleus , with the subsequent decay. From
the recent results of the NOMAD neutrino detector at CERN a model-independent
constraint of is obtained depending
on the value of mass. For the region these
bounds are comparable with the present experimental ones on and
diagonal magnetic moments and are more sensitive than those on
magnetic moment.
From the same analysis the constraint on decay lifetime
is obtained. The limit is valid for neutrino masses up to .Comment: 13 pages, LaTex, 2 eps fugures included. 2 references are added.
Submitted to Phys. Lett.
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