Optimization of micromachined relex klystrons for operation at terahertz frequencies

New micromachining techniques now provide us with the technology to fabricate reflex klystron oscillators with dimensions suitable for operation in the terahertz region of the electromagnetic spectrum. For the success of these devices, accurate designs are required since the optimization of certain parameters is critical to obtaining useful amounts of ac power. Classical models for device design have long been in existence, but these are no longer valid at terahertz frequencies. For this reason, we have developed a simulation tool, specifically aimed at the design of terahertz frequency reflex klystrons. The tool, based on the Monte Carlo algorithm, includes loss mechanisms and takes into account the main peculiarities expected for device operation at terahertz frequencies. In this study, the tool is used to study the influence of the electron beam aperture angle and cavity dimensions (particularly the grid spacing) on ac power generation. The results demonstrate that aperture angles of less than 10 are necessary for the optimization of output power. It is also found that the power output is highly sensitive to the distance between the grids

Collective oscillations in optical matter

Atom and nanoparticle arrays trapped in optical lattices are shown to be capable of sustaining collective oscillations of frequency proportional to the strength of the external light field. The spectrum of these oscillations determines the mechanical stability of the arrays. This phenomenon is studied for dimers, strings, and two-dimensional planar arrays. Laterally confined particles free to move along an optical channel are also considered as an example of collective motion in partially-confined systems. The fundamental concepts of dynamical response in optical matter introduced here constitute the basis for potential applications to quantum information technology and signal processing. Experimental realizations of these systems are proposed.Comment: 4 figures. Optics Express (in press

Modulated rotating waves in the magnetized spherical Couette system

We present a study devoted to a detailed description of modulated rotating waves (MRW) in the magnetized spherical Couette system. The set-up consists of a liquid metal confined between two differentially rotating spheres and subjected to an axially applied magnetic field. When the magnetic field strength is varied, several branches of MRW are obtained by means of three dimensional direct numerical simulations (DNS). The MRW originate from parent branches of rotating waves (RW) and are classified according to Rand's (Arch. Ration. Mech. Anal 79:1-37, 182) and Coughling & Marcus (J. Fluid Mech. 234:1-18,1992) theoretical description. We have found relatively large intervals of multistability of MRW at low magnetic field, corresponding to the radial jet instability known from previous studies. However, at larger magnetic field, corresponding to the return flow regime, the stability intervals of MRW are very narrow and thus they are unlikely to be found without detailed knowledge of their bifurcation point. A careful analysis of the spatio-temporal symmetries of the most energetic modes involved in the different classes of MRW will allow in the future a comparison with the HEDGEHOG experiment, a magnetized spherical Couette device hosted at the Helmholtz-Zentrum Dresden-Rossendorf.Comment: Contains 3 tables and 8 figures. Published in the Journal of Nonlinear Scienc

Enhancement of collagen deposition and cross-linking by coupling lysyl oxidase with bone morphogenetic protein-1 and its application in tissue engineering

Cultured cell-derived extracellular matrices (ECM)-based biomaterials exploit the inherent capacity of cells to create highly sophisticated supramolecular assemblies. However, standard cell culture conditions are far from ideal given the fact that the diluted microenvironment does not favor the production of ECM components, a circumstance particularly relevant for collagen. An incomplete conversion of procollagen by C-proteinase/bone morphogenetic protein 1 (BMP1) has been proposed to severely limit in vitro collagen deposition. BMP1 also catalyzes the proteolytic activation of the precursor of the collagen cross-linking enzyme, lysyl oxidase (LOX) to yield the active form, suggesting a deficit in cross-linking activity under standard conditions. We hypothesized that the implementation of fibroblast cultures with LOX and BMP1 may be an effective way to increase collagen deposition. To test it, we have generated stable cell lines overexpressing LOX and BMP1 and studied the effect of supernatants enriched in LOX and BMP1 on collagen synthesis and deposition from fibroblasts. Herein, we demonstrate that the supplementation with LOX and BMP1 strongly increased the deposition of collagen onto the insoluble matrix at the expense of the soluble fraction in the extracellular medium. Using decellularization protocols, we also show that fibroblast-derived matrices regulate adipogenic and osteogenic differentiation of human mesenchymal stem cells (MSC), and this effect was modulated by LOX/BMP1. Collectively, these data demonstrate that we have developed a convenient protocol to enhance the capacity of in vitro cell cultures to deposit collagen in the ECM, representing this approach a promising technology for application in tissue engineeringTis work was supported by grants from Ministerio de Economía y Competitividad (Plan Nacional de I+D+I: SAF2012-34916, and SAF2015-65679-R to F.R-P