The spectroscopic orbits and the geometrical configuration of the symbiotic binary AR Pavonis

We analyze optical and near infrared spectra of intermediate and high resolution of the eclipsing symbiotic system AR Pavonis. We have obtained the radial velocity curves for the red and the hot component from the M-giant absorption lines and from the wings of Halpha, H and He II4686 emission profiles, respectively. From the orbital elements we have derived the masses, Mgiant=2.5 and Mhot =1.0 solar masses, for the red giant and the hot component, respectively. We also present and discuss radial velocity patterns in the blue cF absorption spectrum as well as various emission lines. In particular, we confirm that the blue absorption lines are associated with the hot component. The radial velocity curve of the blue absorption system, however, does not track the hot companion's orbital motion in a straightforward way, and its departures from an expected circular orbit are particularly strong when the hot component is active. We suggest that the cF-type absorption system is formed in material streaming from the giant presumably in a region where the stream encounters an accretion disk or an extended envelope around the hot component. The broad emission wings originate from the inner accretion disk or the envelope around the hot star.We also suggest that the central absorption in H profiles is formed in a neutral portion of the cool giant's wind which is strongly concentrated towards the orbital plane. The nebula in AR Pav seems to be bounded by significant amount of neutral material in the orbital plane. The forbidden emission lines are probably formed in low density ionized regions extended in polar directions and/or the wind-wind interaction zone.Comment: 12 pages, 5 figures, accepted by A&

The symbiotic binary system RX Puppis: a possible recurrent nova with a Mira companion

We present an analysis of photometric and spectroscopic observations of the symbiotic binary system RX Pup with the aims of developing a reliable binary for the system and identifying mechanisms responsible for its spectacular activity. The binary is composed of a long-perod Mira variable surrounded by a thick dust shell and a hot white dwarf companion. The hot component produces practically all activity observed in the UV, optical and radio range, while variable obscuration of the Mira by circumstellar dust is responsible for long-term changes in the near-IR magnitudes. The observations show RX Pup underwent a nova-like eruption during the last three decades. The hot component contracted in radius at roughly constant luminosity from 1975 to 1986, and was the source of a strong stellar wind which prevented it from accreting material lost in the Mira wind. Around 1988/9 the hot component turned over in the HR diagram and by 1991 its luminosity had faded by a factor of about 30 with respect to the maximum plateau value and the hot wind had practically ceased. By 1995 the nova remnant started to accrete material from the Mira wind, as indicated by a general increase in intensity of the optical continuum and HI emission. The quiescent spectrum resembles the quiescent spectra of symbiotic recurrent novae, and its intensity indicates the hot component must accrete as much as about 1 per cent of the Mira wind, which is more or less the amount predicted by Bondi-Hoyle theory. The earliest observational records from the 1890s suggest that another nova-like eruption of RX Pup occurred around 1894.Comment: 23 pages, 12 figues, MNRAS - accepte

Evolution of the symbiotic nova RX Puppis

We present and discuss a hundred year history of activity of the hot component of RX Pup based on optical photometry and spectroscopy. The outburst evolution of RX Pup resembles that of other symbiotic novae whereas at quiescence the hot component shows activity (high and low activity states) resembling that of symbiotic recurrent novae T CrB and RS Oph.Comment: To appear in in M. Hernanz, J. Jose, eds, Classical Novae Explosions, AIP; 5 pages, 2 figure

Evolution of the symbiotic nova RX Puppis

We present and discuss a hundred year history of activity of the hot component of RX Pup based on optical photometry and spectroscopy. The outburst evolution of RX Pup resembles that of other symbiotic novae whereas at quiescence the hot component shows activity (high and low activity states) resembling that of symbiotic recurrent novae T CrB and RS Oph.Comment: To appear in in M. Hernanz, J. Jose, eds, Classical Novae Explosions, AIP; 5 pages, 2 figure

Satisfação dos pais em relação ao cuidado em unidade de terapia intensiva pediátrica

Objetivo: Verificar a satisfação dos pais em relação ao cuidado prestado ao filho internado na unidade de terapia intensiva pediátrica e fatores clínicos associados.Método: Pesquisa exploratória, transversal, com 84 pais, em hospital privado de São Paulo, Brasil. A coleta de dados ocorreu de março de 2019 a janeiro de 2020, no pós-alta. Os dados foram analisados por estatística descritiva e Coeficiente de Correlação de Spearman.Resultados: A média de satisfação foi alta (5,75) (DP=0,35). Não houve correlação da satisfação dos pais com tempo de internação, gravidade e doença.Conclusão: Os pais apresentaram altos níveis de satisfação com o cuidado recebido na terapia intensiva pediátrica, independentemente da classificação da doença, tempo de internação ou gravidade. Observou-se maior satisfação nos domínios atitude profissional, cuidado e cura, informação e participação dos pais. Palavras-chave: Unidades de terapia intensiva pediátrica. Qualidade da assistência à saúde. Satisfação do paciente. Enfermagemfamiliar

On the relationship between head circumference, brain size, prenatal long-chain PUFA/5-methyltetrahydrofolate supplementation and cognitive abilities during childhood

Head circumference in infants has been reported to predict brain size, total grey matter volume (GMV) and neurocognitive development. However, it is unknown whether it has predictive value on regional and subcortical brain volumes. We aimed to explore the relationship between several head circumference measurements since birth and distributions of GMV and subcortical volumes at later childhood. We examined seventy-four, Caucasian, singleton, term-born infants born to mothers randomised to receive fish oil and/or 5-methyltetrahydrofolate or placebo prenatal supplementation. We assessed head circumference at birth and at 4 and 10 years of age and cognitive abilities at 7 years of age. We obtained brain MRI at 10 years of age, on which we performed voxel-based morphometry, cortical surface extraction and subcortical segmentation. Analyses were controlled for sex, age, height, weight, family status, laterality and total intracranial volume. Prenatal supplementation did not affect head circumference at any age, cognitive abilities or total brain volumes. Head circumference at 4 years presented the highest correlation with total GMV, white matter volume and brain surface area, and was also strongly associated with GMV of frontal, temporal and occipital areas, as well as with caudate nucleus, globus pallidus, putamen and thalamus volumes. As relationships between brain volumes in childhood and several outcomes extend into adulthood, we have found that ages between 0 and 4 years as the optimal time for brain growth; postnatal factors might have the most relevant impact on structural maturation of certain cortical areas and subcortical nuclei, independent of prenatal supplementation

Targeted next generation sequencing in patients with inborn errors of metabolism

BACKGROUND: Next-generation sequencing (NGS) technology has allowed the promotion of genetic diagnosis and are becoming increasingly inexpensive and faster. To evaluate the utility of NGS in the clinical field, a targeted genetic panel approach was designed for the diagnosis of a set of inborn errors of metabolism (IEM). The final aim of the study was to compare the findings for the diagnostic yield of NGS in patients who presented with consistent clinical and biochemical suspicion of IEM with those obtained for patients who did not have specific biomarkers. METHODS: The subjects studied (n = 146) were classified into two categories: Group 1 (n = 81), which consisted of patients with clinical and biochemical suspicion of IEM, and Group 2 (n = 65), which consisted of IEM cases with clinical suspicion and unspecific biomarkers. A total of 171 genes were analyzed using a custom targeted panel of genes followed by Sanger validation. RESULTS: Genetic diagnosis was achieved in 50% of patients (73/146). In addition, the diagnostic yield obtained for Group 1 was 78% (63/81), and this rate decreased to 15.4% (10/65) in Group 2 (X2 = 76.171; p < 0.0001). CONCLUSIONS: A rapid and effective genetic diagnosis was achieved in our cohort, particularly the group that had both clinical and biochemical indications for the diagnosis