Circadian rhythms of proliferation events in two mouse carcinomas

We studied the index of DNA synthesis (DNAs) of two cellular carcinomas: the hepatocellular ES12a and the mammary TN60 of mice, throughout one circadian cycle. In the results, we observed that both tumors have circadian rhythms (CRs), but the peaks of DNAs vary. Besides, the mean of DNAs along 24 h shows significative differences, the TN60 has higher values than the ES12a. These observed CR in the DNAs index in both carcinomas mean that, at least in partly, the proliferation of cancer cells can be regulated by endocrine factor as it normally occurs in ordinary cells. The big problem we can find for the chronopharmacology is that it is impossible to know in advance the rate of proliferation of each tumor.Fil: Garcia, Marcela. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Andrini, Laura Beatríz. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Martinez, Marina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Inda, Ana. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Palma, Maria Belen. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Miriuka, Santiago Gabriel. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Errecalde, Ana Lia. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentin

As exportações brasileiras entre 1998 e 2018 uma análise sobre a reprimarização

Trabalho de Conclusão de Curso (Graduação)O presente trabalho tem como objetivo realizar uma análise da pauta exportadora brasileira durante o período 1998-2018 a fim de identificar se as mudanças ocorridas apontam para o fenômeno da reprimarização. Para isso, foram coletados dados em sites oficiais e uma análise descritiva de dados secundários foi realizada. Primeiramente foi feita uma revisão bibliográfica das teorias clássicas e neoclássicas do comércio internacional, em sequência foi apresentado o comportamento das exportações brasileiras no período de estudo. Por fim foi levado em consideração a influência dos preços das commodities na composição da pauta exportadora brasileira. Os resultados obtidos com a análise apontam que a crescente participação dos produtos básicos na estrutura exportadora brasileira pode estar ligada à alta dos preços mundiais das commodities, principalmente entre os anos 2001 e 2012

Methodology to design an economic and strategic offshore wind energy Roadmap in Portugal

The main objective of this paper is to establish a roadmap for offshore wind energy in Portugal. It will determine the best sea areas to install fixed and floating offshore wind farms in this region, using spatial analysis of four economic indexes: Internal Rate of Return (IRR), Net Present Value (NPV), Discounted Pay-Back Period (DPBP) and Levelized Cost Of Energy (LCOE). Several economic parameters will be considered (Portuguese offshore tariff, investment and O&M costs, credit values, etc.).Three different discount rates were used into the sensitivity analysis. Several types of physical restrictions will be taking into account: submarine electrical cables, bathymetry, seabed geology, environmental conditions, protected areas in terms of heritage, navigation areas, seismic fault lines, etc. Moreover, location settings as proximity to shipyards or ports will be considered to complement the strategy. All of them will define the resulting area to install offshore wind farms along Portuguese coast. Spatial operations, considering economic, physical and strategic issues, have been carried out using Model Builder of GIS (Geographic Information Systems) software. Results indicate the Portuguese areas economically suitable for installing offshore wind farms

The Levelized Cost of Energy (LCOE) of wave energy using GIS based analysis: the case study of Portugal

The main objective of this paper is to establish an economic modelling of wave energy through a Geographical Information System (GIS). Furthermore, this method has been tested for the particular case of the Portuguese coast. It determines the best sea areas to install wave energy converters in this region, using spatial analysis of the Levelized Cost of Energy (LCOE). Several economic parameters, as capital or O&M costs, have been considered. In addition, a sensitivity analysis has been performed by varying the discount rate in three different scenarios. Several types of physical restrictions have been taken into account: bathymetry, submarine electrical cables, seabed geology, environmental conditions, protected areas in terms of heritage, navigation areas, seismic fault lines, etc. Spatial operations have been carried out to complete the procedure, using Model Builder of GIS software. Results indicate the most suitable areas in economic terms in Portugal to install wave energy devices

Cytogenetic studies in species of Passiflora subgenus Passiflora (Passifloraceae)

Passiflora comprende alrededor de 525 especies con x = 9 ó 6. Se realizó un estudio citogenético de cuatro especies del subgénero Passiflora que crecen en la Argentina. Se utilizaron las técnicas de Giemsa, bandeo cromosómico fluorescente CMA/DAPI y FISH (sonda 18-5,8-26S y 5S) en cromosomas mitóticos. P. caerulea, P. tucumanensis y P. cincinnata resultaron diploides (2n = 18) mientras que P. mooreana, tetraploide (2n=36). Los cariotipos fueron altamente simétricos con la fórmula 8 m + 1 sm, duplicada en P. mooreana. Con CMA/DAPI, todos los diploides presentaron dos o tres pares de bandas terminales CMA+ /DAPI- , mientras que la especie tetraploide presentó cinco pares, asociadas a NOR. Con FISH, los loci 18-5,8-26S coincidieron en número y posición con las bandas CMA+ /DAPI- . En cada especie, el número de sitios para los genes de 5S ADNr concordaron con el nivel de ploidía. Los datos de P. tucumanensis y P. mooreana se reportan por primera vez, siendo esta última el primer tetraploide conocido para el subgénero Passiflora. Los patrones de FISH y las bandas heterocrómaticas variaron entre las especies de Passiflora estudiadas, principalmente en el número y distribución de las señales.Cytogenetic studies in species of Passiflora subgenus Passiflora (Passifloraceae). Passiflora has nearly 525 spp. with x = 9 or 6. A cytogenetic study of four species from subgenus Passiflora thatgrow in Argentina was performed. Giemsa technique, fluorescent chromosome banding CMA/DAPI and FISH (probe 18-5,8-26S and 5S) were used in mitotic chromosomes. P. caerulea, P. tucumanensis and P. cincinnata resulted diploid (2n = 18) while P. mooreana tetraploid (2n = 36). The karyotypes were highly symmetrical, with the formula 8 m + 1 sm, duplicated in P. mooreana. With CMA/DAPI, diploids showed 2-3 pairs of terminal bands CMA+DAPI', whereas the tetraploid five bands, associated to NOR in all cases. With FISH, the loci 18-5.8-26S coincided in number and position with the CMA+/DAPI- bands. In each species, the number of sites for 5S rDNA genes agreed with the ploidy level. Data of P. tucumanensis and P. mooreana are here reported for the first time, being this last species the first known tetraploid for subgenus Passiflora. FISH patterns and heterochromatic bands varied among the Passiflora species studied, mainly with respect to the number and distribution of the signals.Fil: Chiapero, Ana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina;Fil: Las Peñas, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina;Fil: Amela Garcia, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Plantas Tóxicas y Medicinales, Metabolismo de Compuestos Sintéticos y Naturales - Hongos que Intervienen en la Degradación Biológica; Argentina;Fil: Bernardello, Gabriel Luis Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina

MODELO DE REGRESIÓN Y ESTADÍSTICA, PARA LA SINIESTRALIDAD DE AUTOS DE UNA EMPRESA, DENTRO DE LA VIGENCIA 2012 – 2013

Lo antes mencionado es el objetivo del trabajo, sin embargo a lo largo de las siguientes páginas, mencionaremos temas de suma importancia para comprender mejor el entorno y contexto del seguro y la importancia y relación que tiene con los análisis de su siniestralidad. En el capítulo 1 se hace una exposición breve de la historia del seguro desde la antigüedad, pasando por las diferentes etapas de su progreso y desarrollo hasta llegar a la época actual, conociendo la importancia de este en cada una de sus etapas. Así como también el impacto del seguro en la sociedad y en la economía del país, también se mencionarán temas de relevancia como son las leyes que regulan al sector asegurador y se conocerá el objeto del seguro. En este capítulo se incluirá un apartado en el cual mencionaremos las actividades de la compañía Lockton México y algunos datos relevantes respecto a esta, con la finalidad de ubicarla en el sector asegurador, esto como parte de los antecedentes del trabajo. En el capítulo 2, se introducirán algunos conceptos fundamentales del seguro, empezando por definir el riesgo, su clasificación y el tratamiento del mismo. Después se mencionará la definición del seguro, así como su clasificación, conceptos importantes para su comprensión y finalmente los ramos del seguro. Aunque se tocarán todos los ramos o por lo menos los más comunes en el mercado asegurador, solo nos delimitaremos a estudiar el análisis de siniestralidad del ramo de autos a través de un ejemplo, esto por cuestiones de experiencia en dicha área. En el capítulo 3 se adentrarán a la importancia de los estudios de siniestralidad y la relación de estos con el seguro, conociendo los datos que afectaron la siniestralidad de la empresa a analizar, así como un análisis con estadística descriptiva, identificaremos las variables que consideraremos para el modelo de regresión tanto las explicativas, como las dependientes y las variables dicotómicas y se proporcionarán los resultados de dicha estimación, la cual se realizará a través del programa estadístico denominado Eviews y la respectiva evaluación de resultados. Para finalizar en el capítulo 4 se incluirán las conclusiones, en donde se podrá corroborar que las variables consideradas no fueron las más asertivas y no tienen significancia relevante para explicar las causas por colisión y por rotura de cristales de la siniestralidad, así como las conclusiones del reporte estadístico en donde se indica que la empresa que se analizó tiene una siniestralidad relativamente sana. En otro apartado del capítulo 4 se menciona como se vincula la experiencia adquirida en el campo laboral a través de 4 años 2 meses con las áreas del plan de estudios cursado en la Licenciatura en Actuaría

CAR T-Cell Therapy Predictive Response Markers in Diffuse Large B-Cell Lymphoma and Therapeutic Options After CART19 Failure

Immunotherapy with T cells genetically modified with chimeric antigen receptors (CARs) has shown significant clinical efficacy in patients with relapsed/refractory B-cell lymphoma. Nevertheless, more than 50% of treated patients do not benefit from such therapy due to either absence of response or further relapse. Elucidation of clinical and biological features that would predict clinical response to CART19 therapy is of paramount importance and eventually may allow for selection of those patients with greater chances of response. In the last 5 years, significant clinical experience has been obtained in the treatment of diffuse large B-cell lymphoma (DLBCL) patients with CAR19 T cells, and major advances have been made on the understanding of CART19 efficacy mechanisms. In this review, we discuss clinical and tumor features associated with response to CART19 in DLBCL patients as well as the impact of biological features of the infusion CART19 product on the clinical response. Prognosis of DLBCL patients that fail CART19 is poor and therapeutic approaches with new drugs are also discussed

A modelling framework to support power architecture trade-off studies for More-Electric Aircraft

Abstract This work presents a modelling framework to enable comparison and trade-off study of different aircraft system architectures. The framework integrates a computational module to select feasible architectures with a modelling platform that simulates the power generation, distribution and fuel consumption of the aircraft as well as system-level models for the system being evaluated. Its capabilities are demonstrated for the case of the electrification of the primary flight control system (PFCS) using different electric technologies (EHA, EMA) and different levels of electrification ranging from the conventional hydraulic to the all-electric. The performances of different architectures are analysed with respect to the change in the mechanical power extracted from the engine, the weight and the fuel burn of the aircraft. The framework demonstrates the capability of evaluating multiple, different, system architectures in a way that is scalable for different systems or different aircraft. It supports a designer evaluating the aircraft-level impact of their design choice at system-level, and it can aid in assessing technology options early in the design process

Low X-Ray Luminosity Galaxy Clusters. II. Optical properties and morphological content at 0.18 < z < 0.70

This is the second of a series of papers on low X-ray luminosity galaxy clusters, in which we present the $r^\prime$, $g^\prime$ and $i^\prime$ photometry obtained with GMOS-IMAGE at Gemini North and South telescopes for seven systems in the redshift range of 0.18 to 0.70. Optical magnitudes, colours and morphological parameters, namely, concentration index, ellipticity and visual morphological classification, are also given. At lower redshifts, the presence of a well-defined red cluster sequence extending by more than 4 magnitudes showed that these intermediate-mass clusters had reached a relaxed stage. This was confirmed by the small fraction of blue galaxy members observed in the central regions of $\sim$ 0.75 Mpc. In contrast, galaxy clusters at higher redshifts had a less important red cluster sequence. We also found that the galaxy radial density profiles in these clusters were well fitted by a single power law. At 0.18 $<$ z $<$ 0.70, we observed an increasing fraction of blue galaxies and a decreasing fraction of lenticulars, with the early-type fraction remaining almost constant. Overall, the results of these intermediate-mass clusters are in agreement with those for high mass clusters.Comment: 16 pages, 13 figures, 5 tables. Accepted for publication in MNRA