A multi-wavelength view of the central kiloparsec region in the Luminous Infrared Galaxy NGC1614

The Luminous Infrared Galaxy NGC1614 hosts a prominent circumnuclear ring of star formation. However, the nature of the dominant emitting mechanism in its central ~100 pc is still under debate. We present sub-arcsecond angular resolution radio, mid-infrared, Pa-alpha, optical, and X-ray observations of NGC1614, aimed at studying in detail both the circumnuclear ring and the nuclear region. The 8.4 GHz continuum emission traced by the Very Large Array (VLA) and the Gemini/T-ReCS 8.7 micron emission, as well as the Pa-alpha line emission, show remarkable morphological similarities within the star-forming ring, suggesting that the underlying emission mechanisms are tightly related. We used an HST/NICMOS Pa-alpha map of similar resolution to our radio maps to disentangle the thermal free-free and non-thermal synchrotron radio emission, from which we obtained the intrinsic synchrotron power-law for each individual region within the central kpc of NGC1614. The radio ring surrounds a relatively faint, steep-spectrum source at the very center of the galaxy, suggesting that the central source is not powered by an AGN, but rather by a compact (r < 90 pc) starburst. Chandra X-ray data also show that the central kpc region is dominated by starburst activity, without requiring the existence of an AGN. We also used publicly available infrared data to model-fit the spectral energy distribution of both the starburst ring and a putative AGN in NGC1614. In summary, we conclude that there is no need to invoke an AGN to explain the observed bolometric properties of the galaxy.Comment: 13 pages, 7 figures, 5 tables. Accepted for publication in Ap

A detailed look at the most obscured galactic nuclei in the mid-infrared

Context. Compact obscured nuclei (CONs) represent an extreme phase of galaxy evolution where rapid supermassive black hole growth and/or compact star-forming activity is completely obscured by gas and dust. Aims. We investigate the properties of CONs in the mid-infrared and explore techniques aimed at identifying these objects, such as through the equivalent width (EW) ratios of their polycyclic aromatic hydrocarbon (PAH) features. Methods. We modelled Spitzer spectra by decomposing the continua into nuclear and star-forming components, from which we then measured the nuclear optical depth, τN, of the 9.8 μm silicate absorption feature. We also used Spitzer spectral maps to investigate how PAH EW ratios vary with aperture size for objects that host CONs. Results. We find that the nuclear optical depth, τN, strongly correlates with the HCN-vib emission line in the millimetre for CONs, with a Pearson correlation coefficient of 0.91. We find the PAH EW ratio technique to be effective at selecting CONs and robust against highly inclined galaxies, where strong dust lanes may mimic a CON-like spectrum by producing a high τN. Our analysis of the Spitzer spectral maps shows that the efficacy of the PAH EW ratios in isolating CONs is reduced when there is a strong starforming component from the host galaxy. In addition, we find that the use of the inferred nuclear optical depth is a reliable method for identifying CONs in 36+8-7% of ultra-luminous infrared galaxies and 17+3-3% of luminous infrared galaxies, consistent with previous work. Conclusions. We confirm mid-infrared spectra to be a powerful diagnostic of CONs. The increased sensitivity of JWST will allow the identification of CONs at cosmic noon, revealing this extreme but hidden phase of galaxy evolution

Molecular Characteristics of Extraintestinal Pathogenic E. coli (ExPEC), Uropathogenic E. coli (UPEC), and Multidrug Resistant E. coli Isolated from Healthy Dogs in Spain. Whole Genome Sequencing of Canine ST372 Isolates and Comparison with Human Isolates Causing Extraintestinal Infections

Under a one health perspective and the worldwide antimicrobial resistance concern, we investigated extraintestinal pathogenic Escherichia coli (ExPEC), uropathogenic E. coli (UPEC), and multidrug resistant (MDR) E. coli from 197 isolates recovered from healthy dogs in Spain between 2013 and 2017. A total of 91 (46.2%) isolates were molecularly classified as ExPEC and/or UPEC, including 50 clones, among which (i) four clones were dominant (B2-CH14-180-ST127, B2-CH52-14-ST141, B2-CH103-9-ST372 and F-CH4-58-ST648) and (ii) 15 had been identified among isolates causing extraintestinal infections in Spanish and French humans in 2015 and 2016. A total of 28 (14.2%) isolates were classified as MDR, associated with B1, D, and E phylogroups, and included 24 clones, of which eight had also been identified among the human clinical isolates. We selected 23 ST372 strains, 21 from healthy dogs, and two from human clinical isolates for whole genome sequencing and built an SNP-tree with these 23 genomes and 174 genomes (128 from canine strains and 46 from human strains) obtained from public databases. These 197 genomes were segregated into six clusters. Cluster 1 comprised 74.6% of the strain genomes, mostly composed of canine strain genomes (p < 0.00001). Clusters 4 and 6 also included canine strain genomes, while clusters 2, 3, and 5 were significantly associated with human strain genomes. Finding several common clones and clone-related serotypes in dogs and humans suggests a potentially bidirectional clone transfer that argues for the one health perspective

Factors influencing erythrocyte sedimentation rate in adults New evidence for an old test

The erythrocyte sedimentation rate (ESR) is a routine test for inflammation. Few studies have investigated the potential influence of lifestyle factors and common metabolic abnormalities on the ESR. This study investigates the influence of demographic factors, alcohol consumption, smoking, physical activity, obesity, and metabolic syndrome on the ESR in adults.This cross-sectional study covered 1472 individuals (44.5% males; age range, 18-91 years) randomly selected from the population of a Spanish municipality. The ESR was measured using a standardized method. We assessed habitual alcohol consumption in standard drinking units, along with tobacco smoking, regular physical exercise (by questionnaire), body mass index, and variables defining metabolic syndrome. Multivariate analyses were performed, including mean corpuscular volume and hemoglobin concentration in the models.The ESR was higher in females than in males, and increased steadily with age. Median ESR of females was 2-fold higher than that of males, and median ESR of individuals aged >65 years was 2-fold higher than that of individuals in the youngest category (ages 18-35 years). Body mass index, presence of metabolic syndrome, and smoking were independently and positively associated with higher ESR values. Light alcohol drinkers and individuals with high regular physical activity displayed lower ESR values than did alcohol abstainers and individuals with low physical activity, respectively.ESR varies greatly with age and sex, and corresponding reference values are proposed. Lifestyle factors (physical activity, smoking, and alcohol consumption) and common metabolic abnormalities (obesity and related metabolic syndrome) may also influence ESR values

High Prevalence of ST131 Subclades C2-H30Rx and C1-M27 Among Extended-Spectrum beta-Lactamase-Producing Escherichia coli Causing Human Extraintestinal Infections in Patients From Two Hospitals of Spain and France During 2015

The present study was carried out to evaluate the prevalence of sequence type 131 (ST131) among 188 extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) collected in 2015 in Lucus Augusti University hospital (Lugo, Spain) and AP-HP Beaujon hospital (Clichy, France) with regard to other STs and to characterize, the types of ESBL produced, serotypes, virulence factor (VF)-encoding genes and the ST131 clades and subclades. ST131 was detected in 33 (39.1%) and 46 (47.9%) of the isolates in Lucus Augusti and Beaujon, respectively. The 109 remaining isolates displayed 57 other STs, the following STs being displayed by at least three isolates: ST10 (8 isolates), ST23 (3), ST38 (4), ST58 (3), ST88 (5), ST95 (4), ST167 (3), ST354 (5), ST361 (3), ST410 (6), ST648 (4), ST744 (3), and ST1615 (6). ST354, ST410, and ST1615 were significantly (P < 0.05) more frequent in Lucus Augusti (5.4%, 6.5%, and 6.5%) than in Beaujon (0% for the three STs). The new globally emerging clone ST1193 among extraintestinal clinical ESBL-EC was identified in one isolate from France and one from Spain. CTX-M-15 was the commonest ESBL detected in the two hospitals (44.6% in Lucus Augusti and 50.0% in Beaujon). CTX-M-14 was significantly (P = 0.0003) more frequent in Lucus Augusti (31.5%) than in Beaujon (10.4%), whereas CTX-M-1 (20.8 vs. 7.6%; P = 0.008) and CTX-M-27 (15.6 vs. 6.5%; P = 0.0389) were more frequent in Beaujon than in Lucus Augusti. The ST131 isolates showed a higher virulence score (mean 13.367) compared with the non-ST131 isolates (mean 7.661) (P < 0.001). Among the 79 ST131 isolates, most of them (52; 65.8%) belonged to subclade C2 (also known as subclone H30Rx) followed by those belonging to subclade C1 (cluster C1-M27: 16 isolates, 20.3%; cluster non-C1-M27: 6 isolates, 7.6%) and clade A (4 isolates; 5.1%). The C2 subclade isolates showed a higher VF-encoding gene score (mean 14.250) compared with the C1-M27 cluster isolates (mean 10.875) (P < 0.001). In conclusion, this study highlights the epidemiological differences between the ESBL-EC isolated from two hospitals of France and Spain obtain in 2015 and reports, for the first time, the presence of clone ST1193 in Spain

Psychiatric comorbidities in Asperger syndrome are related with polygenic overlap and differ from other Autism subtypes

There is great phenotypic heterogeneity within autism spectrum disorders (ASD), which has led to question their classification into a single diagnostic category. The study of the common genetic variation in ASD has suggested a greater contribution of other psychiatric conditions in Asperger syndrome (AS) than in the rest of the DSM-IV ASD subtypes (Non_AS). Here, using available genetic data from previously performed genome-wide association studies (GWAS), we aimed to study the genetic overlap between five of the most related disorders (schizophrenia (SCZ), major depression disorder (MDD), attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorders (OCD) and anxiety (ANX)), and AS, comparing it with the overlap in Non_AS subtypes. A Spanish cohort of autism trios (N = 371) was exome sequenced as part of the Autism Sequencing Consortium (ASC) and 241 trios were extensively characterized to be diagnosed with AS following DSM-IV and Gillberg's criteria (N = 39) or not (N = 202). Following exome imputation, polygenic risk scores (PRS) were calculated for ASD, SCZ, ADHD, MDD, ANX, and OCD (from available summary data from Psychiatric Genomic Consortium (PGC) repository) in the Spanish trios' cohort. By using polygenic transmission disequilibrium test (pTDT), we reported that risk for SCZ (Pscz = 0.008, corrected-PSCZ = 0.0409), ADHD (PADHD = 0.021, corrected-PADHD = 0.0301), and MDD (PMDD = 0.039, corrected-PMDD = 0.0501) is over-transmitted to children with AS but not to Non_AS. Indeed, agnostic clustering procedure with deviation values from pTDT tests suggested two differentiated clusters of subjects, one of which is significantly enriched in AS (P = 0.025). Subsequent analysis with S-Predixcan, a recently developed software to predict gene expression from genotype data, revealed a clear pattern of correlation between cortical gene expression in ADHD and AS (P < 0.001) and a similar strong correlation pattern between MDD and AS, but also extendable to another non-brain tissue such as lung (P < 0.001). Altogether, these results support the idea of AS being qualitatively distinct from Non_AS autism and consistently evidence the genetic overlap between AS and ADHD, MDD, or SCZ

Elucidating the role of shape anisotropy in faceted magnetic nanoparticles using biogenic magnetosomes as a model

Shape anisotropy is of primary importance to understand the magnetic behavior of nanoparticles, but a rigorous analysis in polyhedral morphologies is missing. In this work, a model based on finite element techniques has been developed to calculate the shape anisotropy energy landscape for cubic, octahedral, and truncated octahedral morphologies. In all cases, a cubic shape anisotropy is found that evolves to quasi uniaxial anisotropy when the nanoparticle is elongated amp; 8805;2 . This model is tested on magnetosomes, amp; 8764;45 nm truncated octahedral magnetite nanoparticles forming a chain inside Magnetospirillum gryphiswaldense MSR 1 bacteria. This chain presents a slightly bent helical configuration due to a 20 tilting of the magnetic moment of each magnetosome out of chain axis. Electron cryotomography images reveal that these magnetosomes are not ideal truncated octahedrons but present amp; 8776;7.5 extrusion of one of the 001 square faces and amp; 8776;10 extrusion of an adjacent 111 hexagonal face. Our model shows that this deformation gives rise to a quasi uniaxial shape anisotropy, a result of the combination of a uniaxial Ksh u 7 kJ m amp; 8722;3 and a cubic Ksh c 1.5 kJ m amp; 8722;3 contribution, which is responsible for the 20 tilting of the magnetic moment. Finally, our results have allowed us to accurately reproduce, within the framework of the Landau Lifshitz Gilbert model, the experimental AC loops measured for these magnetotactic bacteri

Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial

The potential role of the lipidome in atrial fibrillation (AF) development is still widely unknown. We aimed to assess the association between lipidome profiles of the Prevenci\uf3n con Dieta Mediterr\ue1nea (PREDIMED) trial participants and incidence of AF. We conducted a nested case–control study (512 incident centrally adjudicated AF cases and 735 controls matched by age, sex, and center). Baseline plasma lipids were profiled using a Nexera X2 U-HPLC system coupled to an Exactive Plus orbitrap mass spectrometer. We estimated the association between 216 individual lipids and AF using multivariable conditional logistic regression and adjusted the p values for multiple testing. We also examined the joint association of lipid clusters with AF incidence. Hitherto, we estimated the lipidomics network, used machine learning to select important network-clusters and AF-predictive lipid patterns, and summarized the joint association of these lipid patterns weighted scores. Finally, we addressed the possible interaction by the randomized dietary intervention. Forty-one individual lipids were associated with AF at the nominal level (p &lt; 0.05), but no longer after adjustment for multiple-testing. However, the network-based score identified with a robust data-driven lipid network showed a multivariable-adjusted ORper+1SD of 1.32 (95% confidence interval: 1.16–1.51; p &lt; 0.001). The score included PC plasmalogens and PE plasmalogens, palmitoyl-EA, cholesterol, CE 16:0, PC 36:4;O, and TG 53:3. No interaction with the dietary intervention was found. A multilipid score, primarily made up of plasmalogens, was associated with an increased risk of AF. Future studies are needed to get further insights into the lipidome role on AF. Current Controlled Trials number, ISRCTN35739639

Low-mass members of the young cluster IC 4665 and pre-main-sequence lithium depletion

We have used fibre spectroscopy to establish cluster membership and examine pre-main-sequence (PMS) lithium depletion for low-mass stars (spectral types F to M) in the sparse young (~30 Myr) cluster IC 4665. We present a filtered candidate list of 40 stars that should contain 75 per cent of single cluster members with V of 11.5 to 18 in the central square degree of the cluster. Whilst F- and G-type stars in IC 4665 have depleted little or no lithium, the K- and early M-type stars have depleted more Li than expected when compared with similar stars in other clusters of known age. An empirical age estimate based on Li-depletion among the late-type stars of IC 4665 would suggest it is older than 100 Myr. This disagrees entirely with ages determined either from the nuclear turn-off, from isochronal matches to low-mass stars or from the re-appearance of lithium previously found in much lower mass stars (the ``lithium depletion boundary''). We suggest that other parameters besides age, perhaps composition or rotation, are very influential in determining the degree of PMS Li-depletion in stars with M greater than 0.5 Msun. Further work is required to identify and assess the effects of these additional parameters, particularly to probe conditions at the interface between the sub-photospheric convection zone and developing radiative core. Until then, PMS Li depletion in F- to early M-type stars cannot be confidently used as a precise age indicator in young clusters, kinematic groups or individual field stars.Comment: Accepted for publication in MNRA

Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission: study protocol of a prospective, multicentre, randomized clinical trial

Background: Patients with inflammatory bowel disease who achieve remission with anti-tumour necrosis factor (anti-TNF) drugs may have treatment withdrawn due to safety concerns and cost considerations, but there is a lack of prospective, controlled data investigating this strategy. The primary study aim is to compare the rates of clinical remission at 1?year in patients who discontinue anti-TNF treatment versus those who continue treatment. Methods: This is an ongoing, prospective, double-blind, multicentre, randomized, placebo-controlled study in patients with Crohn?s disease or ulcerative colitis who have achieved clinical remission for ?6?months with an anti-TNF treatment and an immunosuppressant. Patients are being randomized 1:1 to discontinue anti-TNF therapy or continue therapy. Randomization stratifies patients by the type of inflammatory bowel disease and drug (infliximab versus adalimumab) at study inclusion. The primary endpoint of the study is sustained clinical remission at 1?year. Other endpoints include endoscopic and radiological activity, patient-reported outcomes (quality of life, work productivity), safety and predictive factors for relapse. The required sample size is 194 patients. In addition to the main analysis (discontinuation versus continuation), subanalyses will include stratification by type of inflammatory bowel disease, phenotype and previous treatment. Biological samples will be obtained to identify factors predictive of relapse after treatment withdrawal. Results: Enrolment began in 2016, and the study is expected to end in 2020. Conclusions: This study will contribute prospective, controlled data on outcomes and predictors of relapse in patients with inflammatory bowel disease after withdrawal of anti-TNF agents following achievement of clinical remission. Clinical trial reference number: EudraCT 2015-001410-1