DEL NIHILISMO EN LA LITERATURA DE ALBERT CAMUS A LA ÉTICA EN LA PESTE

La filosofía de Albert Camus, como expresión de los sentimientos y acciones humanas subyugados a la destrucción, se muestra como pensamiento crítico de los valores ontológicos y morales, siendo a su vez respuesta consiente y reflexiva al qué hacer humano. La presente investigación en torno a dicho autor se muestra justamente como reflexión en torno a los problemas primigenios de la filosofía, siendo que a existencia y la convivencia los más altos valores de la esta. Al igual que Camus ha elegido la literatura, no porqué este por encima de la filosofía sino por la oportunidad de expresividad que brinda, nos ocupamos en mostrar los matices, desarrollos y conclusiones de sus principales obras literarias, desde la óptica hermenéutica y filosófica de la realidad que de suyo engendra

Torres Quevedo's mechanical calculator for second-degree equations with complex coefficients

Leonardo Torres Quevedo worked intensively in analogue calculating machines during the last years of the 19th century. The algebraic calculators were calculating machines in which numbers are represented by quantities of a given physical magnitude(s). The physical result is a magnitude of a physical quantity whose measurement in the coherent unit is the result of the algebraic equation. This article shows the three-dimensional (3D) modelling, virtual reconstruction and simulation of the first mechanical calculating machine for solving second-degree equations with complex coefficients, to prove that the functionality was correct and the machine could be built. Sketches of said machine provide enough information on the shape and mechanisms of the machine. By means of the simulation, it has been possible to prove its operation and feasibility of construction so that it is possible to replicate it as a real physical model. The mechanical calculator for second-degree equations with complex coefficients constituted a major milestone in the technological development of the time and helped to originate and improve the design of other algebraic calculators like the machine for solving eighth-degree equations

A note on local bases and convergence in fuzzy metric spaces

In the context of fuzzy metrics in the sense of George and Veeramani, we study when certain families of open balls centered at a point are local bases at this point. This question is related to p-convergence and s-convergence. © 2013 Elsevier B.V. All rights reserved.Samuel Morillas acknowledges the support of Universitat Politenica de Valencia under Grant PAID-05-12 SP20120696.Gregori Gregori, V.; Miñana Prats, JJ.; Morillas Gómez, S. (2014). A note on local bases and convergence in fuzzy metric spaces. Topology and its Applications. 163:142-148. https://doi.org/10.1016/j.topol.2013.10.013S14214816

Some Research Questions and Results of UC3M in the E-Madrid Excellence Network

32 slides.-- Contributed to: 2010 IEEE Global Engineering Education Conference (EDUCON), Madrid, Spain, 14-16 April, 2010.-- Presented by C. Delgado Kloos.Proceedings of: 2010 IEEE Global Engineering Education Conference (EDUCON), Madrid, Spain, 14-16 April, 2010Universidad Carlos III de Madrid is one of the six main participating institutions in the eMadrid excellence network, as well as its coordinating partner. In this paper, the network is presented together with some of the main research lines carried out by UC3M. The remaining papers in this session present the work carried out by the other five universities in the consortium.The Excellence Network eMadrid, “Investigación y Desarrollo de Tecnologías para el e-Learning en la Comunidad de Madrid” is being funded by the Madrid Regional Government under grant No. S2009/TIC-1650. In addition, we acknowledge funding from the following research projects: iCoper: “Interoperable Content for Performance in a Competency-driven Society” (eContentPlus Best Practice Network No. ECP-2007-EDU-417007), Learn3: Hacia el Aprendizaje en la 3ª Fase (“Plan Nacional de I+D+I” TIN2008-05163/ TSI), Flexo: “Desarrollo de aprendizaje adaptativo y accesible en sistemas de código abierto” (AVANZA I+D, TSI-020301- 2008-19), España Virtual (CDTI, Ingenio 2010, CENIT, Deimos Space), SOLITE (CYTED 508AC0341), and “Integración vertical de servicios telemáticos de apoyo al aprendizaje en entornos residenciales” (Programa de creación y consolidación de grupos de investigación de la Universidad Carlos III de Madrid).Publicad

Coverage changes of pine trees at risk in collection sites in northern Mexico

Objective: Analyze changes in land use and vegetation (USyV; from 1985 to 2014) in the collection sites of 16 pines listed in NOM-059-SEMARNAT-2010 located in northern Mexico. Design/methodology/approach: We integrate a georeferenced database of the species under study from consultations of botanical collections. A point coverage was created to add USyV vector information from Series I (1985) and VI (2014). Subsequently, spatial analysis and geoprocessing identified class changes during the period. Results: A total of 2,242 georeferenced records of pine species were obtained. The results indicated that 50.0 % of the total number of pine records consulted in collections with Series I information are in other USyV categories than primary forest. At the same time, with Series VI, this condition rises to 58.7 %. Consequently, the most critical changes in the period under study occurred in converting primary forests to agriculture, pasture, secondary vegetation of coniferous and oak forests, and urban areas. Limitations/implications: The availability of larger scale cartographic material, to generate a risk analysis study of changes and threats to the conservation of pine species. Findings/conclusions: The number of collection sites recorded in primary coniferous, scrub, and oak forests in Series I decreased significantly compared to Series VI, shifting to agriculture, water bodies, grassland, and urban areas.Objective: To analyze the changes in land-use and vegetation (LUV), from 1985 to 2014, in the sites in northern Mexico where 16 pine trees listed in the NOM-059-SEMARNAT-2010 are collected. Design/Methodology/Approach: Based on consultations in botanical collections, a georeferenced database of the species under study was developed. A point coverage was created to which LUV vector information from Series I (1985) and VI (2014) was added. Subsequently, LUV class changes were identified during the evaluation period through spatial analysis and geoprocessing. Results: A total of 2,242 georeferenced records of pine species were obtained. Fifty percent of the pine records consulted in collections with Series I information belong to other non-primary forest categories of LUV, while with Series VI information with this condition rose to 58.7%. Consequently, in the study period major changes occurred in the conversion of primary forests to agricultural lands, pasture, secondary vegetation in coniferous and oak forests, and mainly urban areas. Limitations/Implications: The availability of larger-scale cartographic material limited the generation of a risk analysis study about the changes and threats to forest conservation. Findings/Conclusions: The number of collection sites registered in coniferous forest, scrubland, and primary oak forest in Series I —which are now agricultural lands, water bodies, pastures, and urban areas— was significantly lower than in Series VI

Regular Humoral and Cellular Immune Responses in Individuals with Chronic Myeloid Leukemia Who Received a Full Vaccination Schedule against COVID-19

Individuals with chronic myeloid leukemia (CML) constitute a unique group within individuals with oncohematological disease (OHD). They receive treatment with tyrosine kinase inhibitors (TKIs) that present immunomodulatory properties, and they may eventually be candidates for treatment discontinuation under certain conditions despite the chronic nature of the disease. In addition, these individuals present a lower risk of infection than other immunocompromised patients. For this study, we recruited a cohort of 29 individuals with CML in deep molecular response who were on treatment with TKIs (n = 23) or were on treatment-free remission (TFR) (n = 6), and compared both humoral and cellular immune responses with 20 healthy donors after receiving the complete vaccination schedule against SARS-CoV-2. All participants were followed up for 17 months to record the development of COVID-19 due to breakthrough infections. All CML individuals developed an increased humoral response, with similar seroconversion rates and neutralizing titers to healthy donors, despite the presence of high levels of immature B cells. On the whole, the cellular immune response was also comparable to that of healthy donors, although the antibody dependent cytotoxic activity (ADCC) was significantly reduced. Similar rates of mild breakthrough infections were observed between groups, although the proportion was higher in the CML individuals on TFR, most likely due to the immunomodulatory effect of these drugs. In conclusion, as with the healthy donors, the vaccination did not impede breakthrough infections completely in individuals with CML, although it prevented the development of severe or critical illness in this special population of individuals with OHD.This work was supported by projects PI21/00877 and PI22CIII/00059 funded by the Strategic Action in Health of the Instituto de Salud Carlos III (ISCIII) and co-funded by the European Regional Development Fund (ERDF) “A way to make Europe”. The work of Sara Rodríguez-Mora is financed by NIH grant R01AI143567. The work of Guiomar Casado is financed by the Consejería de Educación, Universidades, Ciencia y Portavocía of the Comunidad de Madrid. The work of Montserrat Torres is financed by CIBERINFEC (CB21/13/00015), co-financed by ERDF. The work of Clara Sánchez-Menéndez is financed by Programa Investigo, FIBio HRC-IRYCIS, co-financed by ERDF.S

Gradient, UC3M

En este artículo se presenta un resumen de las líneas de investigación que se realizan en el Laboratorio Gradient perteneciente al Grupo GAST (Grupo de Aplicaciones y Servicios Telemáticos) del Departamento de Ingeniería Telemática de la Universidad Carlos III de Madrid. La temática principal de investigación es la aplicación de tecnologías para la mejora de la enseñanza y el aprendizaje. El resumen se centra en tres líneas: Personalización del aprendizaje, uso de dispositivos móviles con fines educativos y aplicaciones de Realidad Virtual y Realidad Aumentada en educación.En este artículo se presenta un resumen de las líneas de investigación que se realizan en el Laboratorio Gradient perteneciente al Grupo GAST (Grupo de Aplicaciones y Servicios Telemáticos) del Departamento de Ingeniería Telemática de la Universidad Carlos III de Madrid. La temática principal de investigación es la aplicación de tecnologías para la mejora de la enseñanza y el aprendizaje. El resumen se centra en tres líneas: Personalización del aprendizaje, uso de dispositivos móviles con fines educativos y aplicaciones de Realidad Virtual y Realidad Aumentada en educación.Publicad

Sustained Cytotoxic Response of Peripheral Blood Mononuclear Cells from Unvaccinated Individuals Admitted to the ICU Due to Critical COVID-19 Is Essential to Avoid a Fatal Outcome

The main objective of this study was to determine the influence of the cytotoxic activity of peripheral blood mononuclear cells (PBMCs) on the outcome of unvaccinated individuals with critical COVID-19 admitted to the ICU. Blood samples from 23 individuals were collected upon admission and then every 2 weeks for 13 weeks until death (Exitus group) (n = 13) or discharge (Survival group) (n = 10). We did not find significant differences between groups in sociodemographic, clinical, or biochemical data that may influence the fatal outcome. However, direct cellular cytotoxicity of PBMCs from individuals of the Exitus group against pseudotyped SARS-CoV-2-infected Vero E6 cells was significantly reduced upon admission (−2.69-fold; p = 0.0234) and after 4 weeks at the ICU (−5.58-fold; p = 0.0290), in comparison with individuals who survived, and it did not improve during hospitalization. In vitro treatment with IL-15 of these cells did not restore an effective cytotoxicity at any time point until the fatal outcome, and an increased expression of immune exhaustion markers was observed in NKT, CD4+, and CD8+ T cells. However, IL-15 treatment of PBMCs from individuals of the Survival group significantly increased cytotoxicity at Week 4 (6.18-fold; p = 0.0303). Consequently, immunomodulatory treatments that may overcome immune exhaustion and induce sustained, efficient cytotoxic activity could be essential for survival during hospitalization due to critical COVID-19.This work was supported by the Coordinated Research Activities at the National Center of Microbiology (CNM, Instituto de Salud Carlos III) (COV20_00679) to promote an integrated response against SARS-CoV-2 in Spain (Spanish Ministry of Science and Innovation) that is coordinated by Dr Inmaculada Casas (WHO National Influenza Center of the CNM); a generous donation provided by Chiesi España, S.A.U. (Barcelona, Spain); the Spanish Ministry of Science and Innovation (PID2019-110275RB-I00). The work of Guiomar Casado is financed by CIBERINFEC, co-financed by the European Regional Development Fund (FEDER) “A way to make Europe”. The work of Montserrat Torres is supported by Instituto de Salud Carlos III (COV20_00679). The work of Fernando Ramos Martín is financed by the Spanish Ministry of Science and Innovation (PID2019-110275RB-I00). The work of Mario Manzanares is supported by a pre-doctoral grant from Instituto de Salud Carlos III (ISCIII-PFIS FI20CIII/00021). The work of Lorena Vigón is supported by a pre-doctoral grant from Instituto de Salud Carlos III (FIS PI16CIII/00034-ISCIII-FEDER). The work of Sara Rodríguez-Mora is financed by NIH grant R01AI143567.N

Strong Humoral but Not Cellular Immune Responses against SARS-CoV-2 in Individuals with Oncohematological Disease Who Were Treated with Rituximab before Receiving a Vaccine Booster

The humoral immune response developed after receiving the full vaccination schedule against COVID-19 is impaired in individuals who received anti-CD20 therapy 6-9 months before vaccination. However, there is little information about the cellular immune responses elicited in these individuals. In this study, we analyzed the humoral and cellular immune responses in 18 individuals with hematological disease who received the last dose of rituximab 13.8 months (IQR 9.4-19) before the booster dose. One month after receiving the booster dose, the seroconversion rate in the rituximab-treated cohort increased from 83.3% to 88.9% and titers of specific IgGs against SARS-CoV-2 increased 1.53-fold (p = 0.0098), while the levels of neutralizing antibodies increased 3.03-fold (p = 0.0381). However, the cytotoxic activity of peripheral blood mononuclear cells (PBMCs) from rituximab-treated individuals remained unchanged, and both antibody-dependent cellular cytotoxicity (ADCC) and direct cellular cytotoxicity (CDD) were reduced 1.7-fold (p = 0.0047) and 2.0-fold (p = 0.0086), respectively, in comparison with healthy donors. Breakthrough infections rate was higher in our cohort of rituximab-treated individuals (33.33%), although most of the infected patients (83.4%) developed a mild form of COVID-19. In conclusion, our findings confirm a benefit in the humoral, but not in the cellular, immune response in rituximab-treated individuals after receiving a booster dose of an mRNA-based vaccine against COVID-19.This work was supported by the Strategic Action in Health 2017–2020 of the Instituto de Salud Carlos III (PI21/00877), by the Coordinated Research Activities at the National Center of Microbiology (CNM, Instituto de Salud Carlos III) (COV20_00679) to promote an integrated response against SARS-CoV-2 in Spain (Spanish Ministry of Science and Innovation) that is coordinated by Dr Inmaculada Casas (WHO National Influenza Center of the CNM), and by a generous donation provided by Chiesi España, S.A.U. (Barcelona, Spain). The work of Montserrat Torres is financed by the Hematology and Hemotherapy Service, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Universitario Ramón y Cajal (Madrid, Spain). The work of Sara Rodríguez-Mora is financed by NIH grant R01AI143567. The work of Guiomar Casado is financed by CIBERINFEC, co-financed by the European Regional Development Fund (FEDER) “A way to make Europe”. The work of Fernando Ramos-Martín is financed by the Spanish Ministry of Science and Innovation (PID2019-110275RB-I00).S

Association between HLA-C alleles and COVID-19 severity in a pilot study with a Spanish Mediterranean Caucasian cohort

The clinical presentations of COVID-19 may range from an asymptomatic or mild infection to a critical or fatal disease. Several host factors such as elderly age, male gender, and previous comorbidities seem to be involved in the most severe outcomes, but also an impaired immune response that causes a hyperinflammatory state but is unable to clear the infection. In order to get further understanding about this impaired immune response, we aimed to determine the association of specific HLA alleles with different clinical presentations of COVID-19. Therefore, we analyzed HLA Class I and II, as well as KIR gene sequences, in 72 individuals with Spanish Mediterranean Caucasian ethnicity who presented mild, severe, or critical COVID-19, according to their clinical characteristics and management. This cohort was recruited in Madrid (Spain) during the first and second pandemic waves between April and October 2020. There were no significant differences in HLA-A or HLA-B alleles among groups. However, despite the small sample size, we found that HLA-C alleles from group C1 HLA-C*08:02, -C*12:03, or -C*16:01 were more frequently associated in individuals with mild COVID-19 (43.8%) than in individuals with severe (8.3%; p = 0.0030; pc = 0.033) and critical (16.1%; p = 0.0014; pc = 0.0154) disease. C1 alleles are supposed to be highly efficient to present peptides to T cells, and HLA-C*12:03 may present a high number of verified epitopes from abundant SARS-CoV-2 proteins M, N, and S, thereby being allegedly able to trigger an efficient antiviral response. On the contrary, C2 alleles are usually poorly expressed on the cell surface due to low association with β2-microglobulin (β2M) and peptides, which may impede the adequate formation of stable HLA-C/β2M/peptide heterotrimers. Consequently, this pilot study described significant differences in the presence of specific HLA-C1 alleles in individuals with different clinical presentations of COVID-19, thereby suggesting that HLA haplotyping could be valuable to get further understanding in the underlying mechanisms of the impaired immune response during critical COVID-19.This work was supported by the Coordinated Research Activities at the Centro Nacional de Microbiologı´a (CNM, Instituto de Salud Carlos III) (COV20_00679) to promote an integrated response against SARS-CoV-2 in Spain (Spanish Ministry of Science and Innovation) that is coordinated by Dr Inmaculada Casas (WHO National Influenza Center of the CNM); donation provided by Chiesi España, S.A.U. (Barcelona, Spain); the Spanish Ministry of Science and Innovation (PID2019-110275RB-I00); and grant MPY509/19 provided by Instituto de Salud Carlos III. The work of MRLH and SRM is financed by NIH grant R01AI143567. The work of LV is supported by a pre-doctoral contract from Instituto de Salud Carlos III (FIS PI16CIII/00034-ISCIII-FEDER). The work of MT is supported by Instituto de Salud Carlos III (COV20_00679). AJMG is the recipient of a post-doctoral contract“Miguel Servet” supported by the Instituto de Salud Carlos III.S