234 research outputs found
Numerical modelling of oocytes partially covered by magnetic nanoparticles in external magnetic fields
Nanorep® is a novel device based on the magnetic tweezer concept that has been
developed for precise, fast, and non-aggressive oocytes and embryos manipulation. To
operate the reproductive cells, they are first immersed in a standard host medium with
ferrite containing nanoparticles. The magnetic particles are attached to the external
matrix of the oocytes/embryos thanks to a linked protein making possible to control
them by using external magnetic fields. Electron microscope photographs show
magnetic particle aggregates around the oocyte. The total mass and distribution of the
attached magnetic particles per oocyte show a wide range of variability, which strongly
affects their magnetic response. Despite the uncertainties on the attachment of
magnetic nanoparticles, the set formed by the oocyte and the nanoparticles can be
caught and transported by using standard neodymium magnets.
Here we present an initial study of the interaction between the set
oocyte/nanoparticles and the external magnetic field in aqueous environment. We are
going to discuss several relevant topics of the model such us the characterization of
magnetic field produced by cylindrical neodymium magnets, the model of the ferrite
magnetization as an effective spherical dipole or a magnetized spherical shell, the
measurement processes to obtain the temporal evolution of the particle position and
the different observed dynamic behaviours
Caracterización y cartografía fitoclimáticas del bosque nativo subantártico en la Isla Grande de Tierra del Fuego (Patagonia, Argentina)
Isla Grande de Tierra del Fuego is especially peculiar in phytoclimatic terms, situated as it is at an extreme southerly latitude, surrounded by large water masses and close to the great mass of Antarctic ice. Its main peculiarities in this sense are the coolness of its summers and a very narrow temperature range. As a result, the woodland landscapes in the parts with forest cover are dominated by microphyllous broadleaf physiognomies, both evergreen and deciduous, of the Nothofagus genus. This paper reports a more in-depth investigation of the hitherto little-known phytoclimatic conditions in that territory which included calibration and validation of a model of phytoclimatic suitability that addresses the principal plant physiognomic units and phytoclimatic mapping. It discusses the causes behind the presence of broadleaf formations in thermal conditions which in the northern hemisphere would allow only coniferous formations or no tree formations at all, and also the edaphic peculiarities that may explain the presence of a evergreen species like Nothofagus betuloides in subantarctic mixed forests.La Isla Grande de Tierra del Fuego presenta una muy marcada originalidad fitoclimática por su posición en latitudes muy australes, estar rodeada por grandes masas de agua y por su cercanía a la gran masa de hielo polar antártica. Esta originalidad se traduce en un escaso calor estival y una oscilación térmica muy reducida como principales peculiaridades, dando lugar en sus porciones arboladas a paisajes boscosos dominados por fisionomías planifolias de carácter micrófilo, tanto perennifolias como caducifolias del género Nothofagus. Este trabajo profundiza en las hasta hoy escasamente conocidas condiciones fitoclimáticas de este territorio, mediante la calibración y validación de un modelo de idoneidad fitoclimática respecto de las principales unidades fisionómicas de vegetación y el establecimiento de una cartografía fitoclimática. Se discuten las causas que provocan la existencia de formaciones planifolias en condiciones térmicas que darían lugar a formaciones aciculifolias o desarboladas en el hemisferio Norte, así como las particularidades edáficas que condicionan la presencia de la estrategia perennifolia representada por Nothofagus betuloides en los bosques mixtos subantárticos
Clinical guideline SEOM: cancer of unknown primary site
Cancer of unknown primary site is a histologically confirmed cancer which is manifested in advanced stage, with no identifiable primary site after the use of standard diagnostic procedures. Patients are initially placed into one of categories based upon the examination of the initial biopsy: adenocarcinoma, squamous cell carcinoma, neuroendocrine carcinoma and poorly differentiated carcinoma. Appropriate patient management requires an understanding of several clinicopathologic features that help to identify several subsets of patients with more responsive tumors
Simultaneous Surface Plasmon Resonance and X-ray Absorption Spectroscopy
We present here an experimental set-up to perform simultaneously measurements
of surface plasmon resonance (SPR) and X-ray absorption spectroscopy (XAS) in a
synchrotron beamline. The system allows measuring in situ and in real time the
effect of X-ray irradiation on the SPR curves to explore the interaction of
X-rays with matter. It is also possible to record XAS spectra while exciting
SPR in order to detect the changes in the electronic configuration of thin
films induced by the excitation of surface plasmons. Combined experiments
recording simultaneously SPR and XAS curves while scanning different parameters
can be carried out. The relative variations in the SPR and XAS spectra that can
be detected with this set-up ranges from 10-3 to 10-5, depending on the
particular experiment
Olive oil consumption and all-cause, cardiovascular and cancer mortality in an adult mediterranean population in Spain
Objective: We assessed the association between usual olive oil consumption (OOC) and all-cause, cardiovascular (CVD) and cancer mortality in an adult population in Spain. Materials and methods: OOC was evaluated at baseline in 1,567 participants aged 20 years and older from the Valencia Nutrition Study in Spain using validated food frequency questionnaires. During an 18-year follow-up period, 317 died, 115 due to CVD and 82 due to cancer. Cox regression models were used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (95%CI). Results: After adjusting for demographic and lifestyle factors, the OOC was associated with a lower risk of all-cause, CVD and cancer mortality. Compared to the less than once per month consumption, the consumption of up to one tablespoon per day was associated with a 9% lower risk of all-cause mortality (HR: 0.91; 95%CI: 0.68-1.22) and the consumption of 2 or more tablespoons with a 31% lower risk of all-cause mortality (HR: 0.69; 95%CI: 0.50–0.93; p-trend = 0.011). The consumption of 2 or more tablespoons per day was also associated with lower risk of mortality for CVD (HR: 0.54; 95%CI: 0.32–0.91; p-trend = 0.018) and cancer (HR: 0.49, 95%CI: 0.26–0.94; p-trend = 0.019). Conclusion: Higher olive oil consumption was associated with lower long-term risk of all-cause, CVD and cancer mortality in an adult Mediterranean population. The maximum benefit was observed for the consumption of two or more tablespoons per day. Copyright © 2022 Torres-Collado, García-de la Hera, Lopes, Compañ-Gabucio, Oncina-Cánovas, Notario-Barandiaran, González-Palacios and Vioque.The VNS study was supported by a grant from the Dirección General de Salud Pública, Generalitat Valenciana 1994 and the Fondo Investigacion Sanitaria (FIS 00/0985). This study has also received support from the Instituto de Salud Carlos III FEDER funds (FIS PI13/00654), CIBER of Epidemiology and Public Health (CIBERESP), CB06/02/0013 and ISABIAL
Continuity of Nursing Care in Patients with Coronary Artery Disease: A Systematic Review
Coronary artery disease is the leading cause of death worldwide and patient continuity
of care is essential. Health professionals can help in the transition stage by providing resources to
achieve pharmacological treatment adherence, as well as social and emotional support. The objective
was to analyse the effects of nursing interventions based on continuity of care in patients with
coronary artery disease after hospital discharge. A systematic review of randomised controlled trials
and quasi-experimental studies was carried out. Cochrane, CINAHL, Health & medical collection,
Medline, and Scopus databases were consulted in January 2022. PRISMA guidelines were followed
with no time limits. In total, 16 articles were included with a total of 2950 patients. Nurse-led
continuity of care programs improved the monitoring and control of the disease. Positive effects
were found in the quality of life of patients, and in mental health, self-efficacy, and self-care capacity
dimensions. Clinical parameters such as blood pressure and lipid levels decreased. The continuity
of care provided by nurses had a positive influence on the quality of life of patients with coronary
artery disease. Nurse-led care focused on the needs and resources, including continuity of care, plays
a key role
Revista de Vertebrados de la Estación Biológica de Doñana
The structure of a mediterranean lizard communityDiet of the eagle owl (Bubo bubo) in mediterranean SpainTamaño de la puesta y mortalidad entre los pollos del Aguila Real ibérica (Aquila chrysaetos homeyeriDistribución y frecuencia de la cópula del buitre leonado (Gyps fulvus) en el Sur de EspañaRégimen alimenticio del calamón (Porphyrio porphyrio) en las Marismas del GuadalquivilVisible migration over the Colo Doñana, Spring 1973Diet of the Red Fox (Vulpes vulpes) in the western Sierra Morena (South Spain).Microestructura del esmalte en los incisivos de Roedores. l. Variaciones con la edadDistribution and habitat of the Barbary macaque (Macaca sylvana) in North MoroccoNotas sobre distribución de los peces fluviales en el Suroeste de España.Nuevas localidades de Valencia hispanica (Pisces:Ciprinodontidae) en el Suroeste de España.Hallazgo de Natrix mauro albinaNidificación del Phoenicopterus ruber en las Marismas del Bajo GuadalquivirNido de Aythya ferina parasitado por Fulica atraNuevos datos sobre la distribución de algunos micromamífesl ibéricos (Microtus arvalís ,M. cabrerae, M. agrestís y Sorex minutus).Neomys anomalus: Nueva localidad en el Suroeste de EspañaPeer reviewe
Compliance with current dietary recommendations and geographical variability of diet in women participating in 7 screening programs for breast cancer in Spain
Introducción: Una dieta saludable es especialmente
importante durante la menopausia, periodo en el que
aumenta el riesgo de varios problemas de salud. Analizamos
la dieta de mujeres peri y postmenopáusicas españolas
y el grado de cumplimiento de las recomendaciones
actuales.
Material y métodos: Estudio transversal en 3.574 mujeres
de 45-68 años que acuden al cribado de cáncer de
mama en 7 centros (A Coruña, Barcelona, Burgos, Palma
de Mallorca, Pamplona, Valencia y Zaragoza). Se recogió
la dieta mediante un cuestionario de frecuencia de alimentos
validado para población española. Para la valoración
del cumplimiento de las recomendaciones actuales se
utilizaron los rangos recomendados por la Sociedad
Española de Nutrición Comunitaria para ingesta de grupos
de alimentos y las Ingestas Diarias Recomendadas
(IDR) para energía, vitaminas y minerales de la Federación
Española de Nutrición, Alimentación y Dietética.
Resultados: El 29% de las mujeres eran obesas y un
42% tenía sobrepeso. El aporte calórico medio fue de
2.053 kcal (DE: 480). El perfil calórico general fue de:
43% de la energía aportada por lo carbohidratos, 36%
por las grasas, 20% por las proteínas. Se evidenció una
ingesta deficiente de vitamina D en todos los nodos del
estudio, con una ingesta media general de 2,14 μg/día. Se
detectó a su vez una ingesta deficitaria de vitamina E en A
Coruña y Burgos. Todos los centros presentaron una
ingesta elevada de productos lácteos y de legumbres. El
consumo de frutas y verduras fue muy heterogéneo
siendo especialmente elevada su ingesta en Mallorca y
Valencia mientras que fue baja para ambos grupos de alimentos
en A Coruña. La ingesta de aceite de oliva fue elevada
en todos los centros exceptuando Burgos con un
74,3% de las mujeres estudiadas por debajo de las 3
raciones al día recomendadas.
Conclusiones: Una dieta con menos grasas y proteínas
y más rica en vegetales, frutos secos y alimentos ricos en
hidratos de carbono equilibraría el balance energético y
mejoraría la calidad de la dieta corrigiendo las bajas
ingestas de vitaminas D y E. Estas recomendaciones son
especialmente importantes en las ciudades más alejadas
de la costa mediterránea donde se han detectado mayores
incumplimientos de las recomendaciones vigentes y una
dieta más alejada de la dieta mediterránea.Introduction: A healthy diet is especially important
during menopause, a period which increases the risk of
various health problems. We analyzed the diet of periand
postmenopausal Spanish women and the degree of
compliance with current recommendations.
Material and methods: We studied 3574 women 45-68
years old who attended breast cancer screening programmes
in 7 centres (A Coruña, Barcelona, Burgos,
Palma de Mallorca, Pamplona, Valencia and Zaragoza).
Diet information was collected using a food frequency
questionnaire validated for the Spanish population. For
the assessment of compliance with current guidelines we
used the recommendations by the Spanish Society of
Community Nutrition for food groups intake and by the
Spanish Federation of Nutrition, Food and Dietetics for
energy, vitamins and minerals intake.
Results: The 29% of women were obese and 42% overweight.
The average caloric intake was 2.053 kcal (SD
480). The general energy profile was: 43% of the energy
from the carbohydrates, 36% from fats, and 20% from
proteins. There was a low vitamin D intake in all centres
of the study, with an overall mean intake of 2.14 mg/day.
A deficit of vitamin E intake in A Coruña and Burgos was
also detected. Intake of dairy products and vegetables
was high in all the study centers. The consumption of
fruits and vegetables was very heterogeneous, with high
intakes observed in Mallorca and Valencia and low for
both food groups in A Coruña. The olive oil intake was
high in all centers except Burgos with 74.3% of the
women studied below the recommended 3 servings per
day.
Conclusions: A diet with less fat and protein and a
higher consumption of vegetables, nuts and foods rich in
carbohydrate might balance the energy intake and
improve the quality of the diet correcting the low intakes
of vitamins D and E. These recommendations are especially
important in cities far from the Mediterranean
coast where more breaches have been detected over the
current recommendations with a lower adherence to the
Mediterranean diet.Este estudio ha recibido financiación del Fondo de
Investigación Sanitaria (proyecto PI060386) y de
Astra-Zéneca (convenio de colaboración entre Astra-
Zeneca y el Instituto de salud Carlos III 1306-1306
EPY
Supplementary Materials for U-Th dating of carbonate crusts reveals Neanderthal origin of Iberian cave art
Materiales suplementarios al artículo de Science 2018 sobre las dataciones de arte rupestre en la Península Ibérica mediante U-TH
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