Experimental Study of the Effect of Hydrotreated Vegetable Oil and Oxymethylene Ethers on Main Spray and Combustion Characteristics under Engine Combustion Network Spray A Conditions

[EN] Featured Application This work contributes to the understanding of the macroscopic characteristics of the spray as well as to the evolution of the combustion process for alternative fuels. All these fuels have been studied under the same operating conditions than diesel therefore the comparison can be made directly, leaving in evidence that some fuels can achieve a similar behavior to diesel in terms of auto ignition but avoiding one of the biggest disadvantages of diesel such as the soot formation. Moreover, the quantification of characteristic parameters such as ignition delay, liquid length, vapor penetration and flame lift-off length represent the most important data to adjust and subsequently validate the computational models that simulate the spray evolution and combustion development of these alternative fuels inside the combustion chamber. The stringent emission regulations have motivated the development of cleaner fuels as diesel surrogates. However, their different physical-chemical properties make the study of their behavior in compression ignition engines essential. In this sense, optical techniques are a very effective tool for determining the spray evolution and combustion characteristics occurring in the combustion chamber. In this work, quantitative parameters describing the evolution of diesel-like sprays such as liquid length, spray penetration, ignition delay, lift-off length and flame penetration as well as the soot formation were tested in a constant high pressure and high temperature installation using schlieren, OH* chemiluminescence and diffused back-illumination extinction imaging techniques. Boundary conditions such as rail pressure, chamber density and temperature were defined using guidelines from the Engine Combustion Network (ECN). Two paraffinic fuels (dodecane and a renewable hydrotreated vegetable oil (HVO)) and two oxygenated fuels (methylal identified as OME(1)and a blend of oxymethylene ethers, identified as OMEx) were tested and compared to a conventional diesel fuel used as reference. Results showed that paraffinic fuels and OME(x)sprays have similar behavior in terms of global combustion metrics. In the case of OME1, a shorter liquid length, but longer ignition delay time and flame lift-off length were observed. However, in terms of soot formation, a big difference between paraffinic and oxygenated fuels could be appreciated. While paraffinic fuels did not show any significant decrease of soot formation when compared to diesel fuel, soot formed by OME(1)and OME(x)was below the detection threshold in all tested conditions.This research has been partly funded by the European Union's Horizon 2020 Programme through the ENERXICO project, grant agreement no 828947, and from the Mexican Department of Energy, CONACYT-SENER Hidrocarburos grant agreement no B-S-69926 and by Universitat Politecnica de Valencia through the Programa de Ayudas de Investigacion y Desarrollo (PAID-01-18).Pastor, JV.; García-Oliver, JM.; Mico Reche, C.; Garcia-Carrero, AA.; Gómez, A. (2020). Experimental Study of the Effect of Hydrotreated Vegetable Oil and Oxymethylene Ethers on Main Spray and Combustion Characteristics under Engine Combustion Network Spray A Conditions. Applied Sciences. 10(16):1-20. https://doi.org/10.3390/app10165460S1201016Reşitoğlu, İ. A., Altinişik, K., & Keskin, A. (2014). The pollutant emissions from diesel-engine vehicles and exhaust aftertreatment systems. Clean Technologies and Environmental Policy, 17(1), 15-27. doi:10.1007/s10098-014-0793-9Mohan, B., Yang, W., & Chou, S. kiang. (2013). Fuel injection strategies for performance improvement and emissions reduction in compression ignition engines—A review. Renewable and Sustainable Energy Reviews, 28, 664-676. doi:10.1016/j.rser.2013.08.051Leach, F., Kalghatgi, G., Stone, R., & Miles, P. (2020). The scope for improving the efficiency and environmental impact of internal combustion engines. Transportation Engineering, 1, 100005. doi:10.1016/j.treng.2020.100005Kim, H., Ge, J., & Choi, N. (2018). Application of Palm Oil Biodiesel Blends under Idle Operating Conditions in a Common-Rail Direct-Injection Diesel Engine. Applied Sciences, 8(12), 2665. doi:10.3390/app8122665Tziourtzioumis, D., & Stamatelos, A. (2017). Experimental Investigation of the Effect of Biodiesel Blends on a DI Diesel Engine’s Injection and Combustion. Energies, 10(7), 970. doi:10.3390/en10070970Merola, S. S., Tornatore, C., Iannuzzi, S. E., Marchitto, L., & Valentino, G. (2014). Combustion process investigation in a high speed diesel engine fuelled with n-butanol diesel blend by conventional methods and optical diagnostics. Renewable Energy, 64, 225-237. doi:10.1016/j.renene.2013.11.017Choi, K., Park, S., Roh, H. G., & Lee, C. S. (2019). Combustion and Emission Reduction Characteristics of GTL-Biodiesel Fuel in a Single-Cylinder Diesel Engine. Energies, 12(11), 2201. doi:10.3390/en12112201Dimitriadis, A., Seljak, T., Vihar, R., Žvar Baškovič, U., Dimaratos, A., Bezergianni, S., … Katrašnik, T. (2020). Improving PM-NOx trade-off with paraffinic fuels: A study towards diesel engine optimization with HVO. Fuel, 265, 116921. doi:10.1016/j.fuel.2019.116921Pastor, J. V., García, A., Micó, C., & Lewiski, F. (2020). An optical investigation of Fischer-Tropsch diesel and Oxymethylene dimethyl ether impact on combustion process for CI engines. Applied Energy, 260, 114238. doi:10.1016/j.apenergy.2019.114238Bergthorson, J. M., & Thomson, M. J. (2015). A review of the combustion and emissions properties of advanced transportation biofuels and their impact on existing and future engines. Renewable and Sustainable Energy Reviews, 42, 1393-1417. doi:10.1016/j.rser.2014.10.034Yehliu, K., Boehman, A. L., & Armas, O. (2010). Emissions from different alternative diesel fuels operating with single and split fuel injection. Fuel, 89(2), 423-437. doi:10.1016/j.fuel.2009.08.025Gómez, A., Soriano, J. A., & Armas, O. (2016). Evaluation of sooting tendency of different oxygenated and paraffinic fuels blended with diesel fuel. Fuel, 184, 536-543. doi:10.1016/j.fuel.2016.07.049Benajes, J., García, A., Monsalve-Serrano, J., & Martínez-Boggio, S. (2020). Potential of using OMEx as substitute of diesel in the dual-fuel combustion mode to reduce the global CO2 emissions. Transportation Engineering, 1, 100001. doi:10.1016/j.treng.2020.01.001Burger, J., Siegert, M., Ströfer, E., & Hasse, H. (2010). Poly(oxymethylene) dimethyl ethers as components of tailored diesel fuel: Properties, synthesis and purification concepts. Fuel, 89(11), 3315-3319. doi:10.1016/j.fuel.2010.05.014Iannuzzi, S. E., Barro, C., Boulouchos, K., & Burger, J. (2017). POMDME-diesel blends: Evaluation of performance and exhaust emissions in a single cylinder heavy-duty diesel engine. Fuel, 203, 57-67. doi:10.1016/j.fuel.2017.04.089Omari, A., Heuser, B., & Pischinger, S. (2017). Potential of oxymethylenether-diesel blends for ultra-low emission engines. Fuel, 209, 232-237. doi:10.1016/j.fuel.2017.07.107Bjørgen, K. O. P., Emberson, D. R., & Løvås, T. (2020). Combustion and soot characteristics of hydrotreated vegetable oil compression-ignited spray flames. Fuel, 266, 116942. doi:10.1016/j.fuel.2019.116942Marchitto, L., Merola, S. S., Tornatore, C., & Valentino, G. (2016). An Experimental Investigation of Alcohol/Diesel Fuel Blends on Combustion and Emissions in a Single-Cylinder Compression Ignition Engine. SAE Technical Paper Series. doi:10.4271/2016-01-0738Payri, R., Gimeno, J., Bardi, M., & Plazas, A. H. (2013). Study liquid length penetration results obtained with a direct acting piezo electric injector. Applied Energy, 106, 152-162. doi:10.1016/j.apenergy.2013.01.027Benajes, J., Payri, R., Bardi, M., & Martí-Aldaraví, P. (2013). Experimental characterization of diesel ignition and lift-off length using a single-hole ECN injector. Applied Thermal Engineering, 58(1-2), 554-563. doi:10.1016/j.applthermaleng.2013.04.044Xuan, T., Desantes, J. M., Pastor, J. V., & Garcia-Oliver, J. M. (2019). Soot temperature characterization of spray a flames by combined extinction and radiation methodology. Combustion and Flame, 204, 290-303. doi:10.1016/j.combustflame.2019.03.023Pastor, J. V., Payri, R., Garcia-Oliver, J. M., & Briceño, F. J. (2013). Schlieren Methodology for the Analysis of Transient Diesel Flame Evolution. SAE International Journal of Engines, 6(3), 1661-1676. doi:10.4271/2013-24-0041Pastor, J. V., García, A., Micó, C., & García-Carrero, A. A. (2020). Experimental study of influence of Liquefied Petroleum Gas addition in Hydrotreated Vegetable Oil fuel on ignition delay, flame lift off length and soot emission under diesel-like conditions. Fuel, 260, 116377. doi:10.1016/j.fuel.2019.116377Reyes, M., Tinaut, F. V., Giménez, B., & Pastor, J. V. (2018). Effect of hydrogen addition on the OH* and CH* chemiluminescence emissions of premixed combustion of methane-air mixtures. International Journal of Hydrogen Energy, 43(42), 19778-19791. doi:10.1016/j.ijhydene.2018.09.005Xuan, T., Pastor, J. V., García-Oliver, J. M., García, A., He, Z., Wang, Q., & Reyes, M. (2019). In-flame soot quantification of diesel sprays under sooting/non-sooting critical conditions in an optical engine. Applied Thermal Engineering, 149, 1-10. doi:10.1016/j.applthermaleng.2018.11.112Choi, M. Y., Mulholland, G. W., Hamins, A., & Kashiwagi, T. (1995). Comparisons of the soot volume fraction using gravimetric and light extinction techniques. Combustion and Flame, 102(1-2), 161-169. doi:10.1016/0010-2180(94)00282-wLi, D., He, Z., Xuan, T., Zhong, W., Cao, J., Wang, Q., & Wang, P. (2017). Simultaneous capture of liquid length of spray and flame lift-off length for second-generation biodiesel/diesel blended fuel in a constant volume combustion chamber. Fuel, 189, 260-269. doi:10.1016/j.fuel.2016.10.058Lequien, G., Berrocal, E., Gallo, Y., Themudo e Mello, A., Andersson, O., & Johansson, B. (2013). Effect of Jet-Jet Interactions on the Liquid Fuel Penetration in an Optical Heavy-Duty DI Diesel Engine. SAE Technical Paper Series. doi:10.4271/2013-01-1615Kook, S., & Pickett, L. M. (2012). Liquid length and vapor penetration of conventional, Fischer–Tropsch, coal-derived, and surrogate fuel sprays at high-temperature and high-pressure ambient conditions. Fuel, 93, 539-548. doi:10.1016/j.fuel.2011.10.004Payri, R., Salvador, F. J., Manin, J., & Viera, A. (2016). Diesel ignition delay and lift-off length through different methodologies using a multi-hole injector. Applied Energy, 162, 541-550. doi:10.1016/j.apenergy.2015.10.118Pickett, L. M., & Siebers, D. L. (2005). Orifice Diameter Effects on Diesel Fuel Jet Flame Structure. Journal of Engineering for Gas Turbines and Power, 127(1), 187-196. doi:10.1115/1.1760525Pastor, J. V., García-Oliver, J. M., López, J. J., & Vera-Tudela, W. (2016). An experimental study of the effects of fuel properties on reactive spray evolution using Primary Reference Fuels. Fuel, 163, 260-270. doi:10.1016/j.fuel.2015.09.064Pickett, L. M., & Siebers, D. L. (2004). Non-Sooting, Low Flame Temperature Mixing-Controlled DI Diesel Combustion. SAE Technical Paper Series. doi:10.4271/2004-01-1399Aatola, H., Larmi, M., Sarjovaara, T., & Mikkonen, S. (2008). Hydrotreated Vegetable Oil (HVO) as a Renewable Diesel Fuel: Trade-off between NOx, Particulate Emission, and Fuel Consumption of a Heavy Duty Engine. SAE International Journal of Engines, 1(1), 1251-1262. doi:10.4271/2008-01-2500Marinov, N. M., Pitz, W. J., Westbrook, C. K., Vincitore, A. M., Castaldi, M. J., Senkan, S. M., & Melius, C. F. (1998). Aromatic and Polycyclic Aromatic Hydrocarbon Formation in a Laminar Premixed n-Butane Flame. Combustion and Flame, 114(1-2), 192-213. doi:10.1016/s0010-2180(97)00275-

Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR

The main targets for neutralizing anti-hepatitis C virus (HCV) antibodies (HCV-nAbs) are the E1 and E2 envelope glycoproteins. We have studied the characteristics of HCV-nAbs through a retrospective study involving 29 HIV/HCV-coinfected patients who achieved sustained virological response (SVR) with pegIFNα+ribavirin anti-HCV therapy. Plasma samples at baseline and week 24 after SVR were used to perform neutralization assays against fve JFH1-based HCV recombinant viruses coding for E1 and E2 from genotypes 1a (H77), 1b (J4), 2a (JFH1), 3a (S52) and 4a (ED43). At baseline, the majority of plasma samples neutralized 1a, 1b, 2a, and 4a, but not 3a, genotypes. Twenty-four weeks following SVR, most neutralizing titers declined substantially. Furthermore, titers against 3a and 2a were not detected in many patients. Plasma samples with high HCV-nAb titers neutralized all genotypes, and the highest titers at the starting point correlated with the highest titers at week 24 after SVR. In conclusion, high titers of broad-spectrum HCV-nAbs were detected in HIV/HCV-coinfected individuals, however, those titers declined soon after SVRThis study was supported by grants from Instituto de Salud Carlos III (ISCIII; grant numbers PI14/01094 and PI17/00657 to JB, PI17/00903 to JGG, PI14CIII/00011 and PI17CIII/00003 to SR) and Ministerio de Sanidad, Servicios Sociales e Igualdad (grant number EC11-241). Te study was also funded by the RD16CIII/0002/0002, RD16/0025/0018, and RD16/0025/0017 projects as part of the Plan Nacional R+D+I and co-funded by ISCIII- Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER

1,3,5-Triazines with aromatic amino acids: Exploring their potential as lectin mimetics

VII Escuela de verano de la SEQT, Sociedad Española de Química Terapeútica, Barcelona, 19-21 Julio, 202

Prevalence of hepatitis E infection in HIV/HCV-coinfected patients in Spain (2012-2014)

Hepatitis E virus (HEV) has emerged as a relevant pathogen for HIV-infected patients. However, there is scarce data on HEV infection in HIV/HCV-coinfected individuals with advanced fibrosis, which seems to increase the risk of HEV infection and worsen the prognosis of liver disease. We aimed to determine the prevalence of anti-HEV antibodies, acute hepatitis E, resolved hepatitis E, and exposure to HEV in HIV/HCV-coinfected patients and to evaluate associations with clinical and epidemiological characteristics. We performed a cross-sectional study on 198 HIV/HCV-coinfected patients, 30 healthy controls and 36 HIV-monoinfected patients. We found a low concordance between techniques used for detection of anti-HEV antibodies (ELISA versus Immunoblot), particularly in HIV/HCV-coinfected patients. HIV/HCV-coinfected patients showed the highest prevalence of IgG against HEV, resolved hepatitis E, and exposure to HEV (19.2%, 17.2%, and 22.2% respectively). However, we did not find any samples positive for HEV-RNA nor significant differences between groups. Moreover, HIV/HCV-coinfected patients with CD4 T-cells <350 cells/mm3 had higher prevalence for anti-HEV IgG antibodies, resolved hepatitis E, and exposure to HEV than healthy controls or those with CD4 T-cells ≥ 350 cells/mm3 (p = 0.034, p = 0.035, and p = 0.053; respectively). In conclusion, HIV/HCV-coinfected patients in Spain have a high prevalence for IgG anti-HEV antibodies, resolved hepatitis E, and exposure to HEV; particularly patients with CD4+T-cells <350 cells/mm3.The HIV BioBank, integrated in the Spanish AIDS Research Network, is supported by the Institute of Health Carlos III, ISCIII, Spanish Health Ministry (Grant n° RD06/0006/0035 and RD12/0017/0037) as part of the State Plan for Scientific and Technical Research and Innovation and co-financed by ISCIII- Sub-Directorate General for Research Assessment and Promotion and European Regional Development Fund (ERDF) and Foundation for Research and Prevention of AIDS in Spain (FIPSE). The RIS Cohort (CoRIS) is funded by the ISCIII through the Spanish AIDS Research Network (RIS C03/173 and RD12/0017/0018) as part of the State Plan for Scientific and Technical Research and Innovation and co-financed by ISCIII- Sub-Directorate General for Research Assessment and Promotion and European Regional Development Fund (ERDF). This study was supported by grants from Instituto de Salud Carlos III (ISCII; grant numbers grant numbers PI14/01094 and PI17/00657 to JB, PI14/01581, and PI17/00903 to JGG, PI14CIII/00011, and PI17CIII/00003 to SR), Ministerio de Sanidad, Servicios Sociales e Igualdad (grant number EC11–241). The RD16CIII/0002/0002, RD16/0025/0017, and RD16/0025/0018 projects also funded the study as part of the Plan Nacional R + D + I and co-funded by ISCIII- Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER). JB is an investigator from the Programa de Intensificación de la Actividad Investigadora en el Sistema Nacional de Salud (I3SNS), Refs INT15/00079 and INT16/00100.S

HCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV/HCV-coinfected patients.

To evaluate the impact of hepatitis C virus (HCV) elimination via interferon (IFN)-based therapy on gene expression profiles related to the immune system in HIV/HCV-coinfected patients. We conducted a prospective study in 28 HIV/HCV-coinfected patients receiving IFN-based therapy at baseline (HIV/HCV-b) and week 24 after sustained virological response (HIV/HCV-f). Twenty-seven HIV-monoinfected patients (HIV-mono) were included as a control. RNA-seq analysis was performed on peripheral blood mononuclear cells (PBMCs). Genes with a fold-change (FC) ≥ 1.5 (in either direction) and false discovery rate (FDR) ≤ 0.05 were identified as significantly differentially expressed (SDE). HIV/HCV-b showed six SDE genes compared to HIV-mono group, but no significantly enriched pathways were observed. For HIV/HCV-f vs. HIV/HCV-b, we found 58 SDE genes, 34 upregulated and 24 downregulated in the HIV/HCV-f group. Of these, the most overexpressed were CXCL2, PDCD6IP, ATP5B, IGSF9, RAB26, and CSRNP1, and the most downregulated were IFI44 and IFI44L. These 58 SDE genes revealed two significantly enriched pathways (FDR < 0.05), one linked to Epstein-Barr virus infection and another related to p53 signaling. For HIV/HCV-f vs. HIV-mono group, we found 44 SDE genes that revealed 31 enriched pathways (FDR < 0.05) related to inflammation, cancer/cell cycle alteration, viral and bacterial infection, and comorbidities associated with HIV/HCV-coinfection. Five genes were overrepresented in most pathways (JUN, NFKBIA, PIK3R2, CDC42, and STAT3). HIV/HCV-coinfected patients who eradicated hepatitis C with IFN-based therapy showed profound gene expression changes after achieving sustained virological response. The altered pathways were related to inflammation and liver-related complications, such as non-alcoholic fatty liver disease and hepatocellular carcinoma, underscoring the need for active surveillance for these patients.This study was supported by grants from Instituto de Salud Carlos III (ISCII; Grant Numbers PI20/00474 and PI17/00657 to JB, PI20/00507 and PI17/00903 to JGG, PI18CIII/00020 to AFR, and PI20CIII/00004 and PI17CIII/00003 to SR). The study was also funded by the RD16CIII/0002/0002 and RD16/0025/0017, and RD16/0025/0018 projects as part of the Plan Nacional R + D + I and co-funded by ISCIII- Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER). JB is an investigator from the Programa de Intensificación de la Actividad Investigadora en el Sistema Nacional de Salud (I3SNS), Ref. INT16/00100.S

The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets

Chemokines are small proteins that primarily regulate the traffic of leukocytes under homeostatic conditions and during specific immune responses. The chemokine-chemokine receptor system comprises almost 50 chemokines and approximately 20 chemokine receptors; thus, there is no unique ligand for each receptor and the binding of different chemokines to the same receptor might have disparate effects. Complicating the system further, these effects depend on the cellular milieu. In cancer, although chemokines are associated primarily with the generation of a protumoral microenvironment and organ-directed metastasis, they also mediate other phenomena related to disease progression, such as angiogenesis and even chemoresistance. Therefore, the chemokine system is becoming a target in cancer therapeutics. We review the emerging data and correlations between chemokines/chemokine receptors and breast cancer, their implications in cancer progression, and possible therapeutic strategies that exploit the chemokine system

Effects of HCV Eradication on Bone mineral density in HIV/HCV Coinfected Patients

Little is known about the effects of eradication of HCV on bone mineral density (BMD) and biomarkers of bone remodeling in HIV/HCV coinfected patients. We prospectively assessed standardized BMD (sBMD) at the lumbar spine and femoral neck, World Health Organization (WHO) BMD categories at both sites, and plasma concentrations of soluble receptor activator of nuclear factor-kappaβ ligand (sRANKL), and osteoprotegerin (OPG) at baseline (the date of initiation of anti-HCV therapy) and at 96 weeks. A total of 238 patients were included, median age 49.5 years, 76.5% males, 48.3% with cirrhosis, 98.3% on antiretroviral therapy, median CD4+ cell count 527 cells/mm 3, 86.6% with HIV-1 RNA < 50 copies/mL. The prevalence of osteoporosis at baseline at the lumbar spine (LS) and femoral neck (FN) was 17.6% and 7.2%, respectively. Anti-HCV therapy comprised pegylated interferon and ribavirin (PegIFN-RBV) plus one direct-acting antiviral in 53.4%, PegIFN-RBV in 34.5%, and sofosbuvir/RBV in 12.2%. A total of 145 (60.9%) patients achieved sustained viral response (SVR). No significant effect of SVR was observed on sBMD for the interaction between time and SVR either in the LS (P=0.801) or the FN (P=0.911). Likewise, no significant effect of SVR was observed in plasma levels of sRANKL (P=0.205), OPG (P=0.249), and sRANKL/OPG ratio (P=0.123) for the interaction between time and SVR. No significant correlation was found between fibrosis by transient elastography, and LS and FN sBMD, at baseline, and week 96. SVR was not associated with significant changes in BMD nor biomarkers of bone remodeling in HIV/HCV-coinfected persons.This study was supported by Instituto de Salud Carlos III (ISCII), grant numbers PI11/01556, PI14/01094, PI14/01581, and PI14CIII/00011, and by Ministerio de Sanidad, Servicios Sociales e Igualdad, grant number EC11-241. The study was also funded by the RD16/0025/0017, RD16/0025/0018 and RD16CIII/0002/0002 projects as part of the Plan Nacional R + D + I and cofunded by ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER).S

HERMES-TDT: Herramientas de monitorización y control de servicios de accesibilidad para la TDT

Los servicios de accesibilidad a la televisión digital constituyen un medio para acceder al audio o vídeo de los programas de TV y son necesarios para un número creciente de personas

Nutrición enteral domiciliaria en España: registro Nadya del año 2011-2012

Objective: To describe the results of the home enteral nutrition (HEN) registry of the NADYA-SENPE group in 2011 and 2012. Material and methods: We retrieved the data of the patients recorded from January 1st 2011 to December 31st 2012. Results: There were 3021 patients in the registry during the period from 29 hospitals, which gives 65.39 per million inhabitants. 97.95% were adults, 51.4% male. Mean age was 67.64 ± 19.1, median age was 72 years for adults and 7 months for children. Median duration with HEN was 351 days and for 97.5% was their first event with HEN. Most patients had HEN because of neurological disease (57.8%). Access route was nasogastric tube for 43.5% and gastrostomy for 33.5%. Most patients had limited activity level and, concerning autonomy, 54.8% needed total help. Nutritional formula was supplied from chemist’s office to 73.8% of patients and disposables, when necessary, was supplied from hospitals to 53.8% of patients. HEN was finished for 1,031 patients (34.1%) during the period of study, 56.6% due to decease and 22.2% due to recovery of oral intake. Conclusions: Data from NADYA-SENPE registry must be explained cautiously because it is a non-compulsory registry. In spite of the change in the methodology of the registry in 2010, tendencies regarding HEN have been maintained, other than oral routeObjetivos: Describir los resultados del registro de nutrición enteral domiciliaria (NED) del grupo NADYASENPE de los años 2011 y 12. Material y métodos: Se recopilaron los datos introducidos en el registro desde el 1 de enero de 2011 al 31 de diciembre de 2012. Resultados: Hubo 3021 pacientes en el registro durante el periodo, procedentes de 29 hospitales, lo que da una prevalencia de 65,39 casos por millón de habitantes. 97.95% fueron adultos, 51,4% varones. La edad media fue 67,64 ± 19,1 años y la mediana 72 años para los adultos y 7 meses para los niños. La duración media de la NED fue 351 días y para el 97,5% fue el primer episodio con NED. La mayoría de pacientes tenían NED por una enfermedad neurológica (57,8%). La vía de acceso fue sonda nasogástrica para el 43,5% y gastrostomía para el 33,5%. La mayoría de pacientes tuvieron un nivel de actividad física limitado y, respecto a la autonomía, 54,8% necesitaba ayuda total. La fórmula de nutrición se suministró desde las oficinas de farmacia para el 73,8% y los fungibles, cuando fueron necesarios, desde los hospitales para el 53,8%. La NED se suspendió en 1.031 pacientes (34,1%) durante el periodo de estudio, 56,6% debido a fallecimiento y 22,2% debido a recuperación de la vía oral. Conclusiones: Los datos del registro NADYA-SENPE deben ser interpretados con precaución ya que se trata de un registro voluntario. A pesar del cambio de metodología del registro en 2010, las tendencias en NED se han mantenido, salvo la importancia cuantitativa de la vía ora

Uso de los museos de Madrid para el estudio de la evolución de los conceptos de “ciudadanía”, “audiencias” y “opinión pública” en estudios de grado y de postgrado de la Universidad Complutense

Proyecto de mejora de recursos disponibles para la docencia. El proyecto muestra la experiencia de aprovechar recursos de museos cercanos a las aulas de la Ciudad Universitaria de Madrid para explicar y ejemplificar críticamente la evolución histórica de conceptos-clave en Ciencias Sociales. En concreto se ha trabajado con los conceptos de ciudadanía, audiencias y opinión pública